Article
Biochemistry & Molecular Biology
Yaswanthi Yanamadala, Mahdi Y. Saleh, Afrika A. Williams, Yuri Lvov, Teresa A. Murray
Summary: The blood-brain barrier prevents most therapeutic drugs from entering the brain, but drugs loaded within halloysite nanotubes can overcome this barrier. Halloysite nanotubes, with their needle-like shape, were used as a nano-torpedo to deliver drugs across the blood-brain barrier when administered intranasally. By loading halloysite nanotubes with diazepam or xylazine and delivering them to mice intranasally, sedative effects were observed. This study confirms that halloysite can permeate the blood-brain barrier to deliver drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Jinming Zhao, Jingxing Yang, Jian Jiao, Xiangdong Wang, Yan Zhao, Luo Zhang
Summary: Intranasal administration is a feasible and non-invasive method of delivering therapeutic drugs to the brain. Artificial exosomes as carriers offer innovative medication delivery methods and have potential applications in treating brain diseases and chronic inflammatory nose disorders.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Joana Goncalves, Soraia Silva, Filipa Gouveia, Joana Bicker, Amilcar Falcao, Gilberto Alves, Ana Fortuna
Summary: The study characterized the interaction between new-generation AEDs and BCRP, finding zonisamide as a BCRP substrate and lacosamide as a BCRP inhibitor. In vivo experiments showed that intranasal administration reduced the impact of BCRP on zonisamide brain distribution.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Lais Ribovski, Naomi M. Hamelmann, Jos M. J. Paulusse
Summary: Safe and reliable entry into the brain is crucial for successful treatment of central nervous system disorders, but remains challenging. Nano-sized systems as drug carriers show significant improvements in therapy delivery. Careful design of NP properties is essential for successful brain delivery, affecting the ability to overcome multiple barriers.
Article
Chemistry, Multidisciplinary
Yadan Zhang, Junlin He, Liao Shen, Tao Wang, Jun Yang, Yao Li, Yongan Wang, Dongqin Quan
Summary: The study developed transferrin receptor aptamer-functionalized liposomes (Apt-LP) to deliver AChE reactivator across the blood-brain barrier, showing promising results in treating organophosphorus poisoning by improving drug transport efficiency to the brain.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Sophie Morse, Aishwarya Mishra, Tiffany G. Chan, Rafael T. M. de Rosales, James J. Choi
Summary: The study investigates a noninvasive method of using ultrasound pulses to deliver liposomes across the blood-brain barrier for efficient drug delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Xiaoqing Li, Vamsidhara Vemireddy, Qi Cai, Hejian Xiong, Peiyuan Kang, Xiuying Li, Monica Giannotta, Heather N. Hayenga, Edward Pan, Shashank R. Sirsi, Celine Mateo, David Kleinfeld, Chris Greene, Matthew Campbell, Elisabetta Dejana, Robert Bachoo, Zhenpeng Qin
Summary: The study successfully synthesized gold nanoparticles for increasing blood-brain barrier permeability, demonstrating that transcranial picosecond laser stimulation can regulate BBB permeability, enabling drug delivery without disrupting the structure of the neurovascular unit.
Article
Medicine, Research & Experimental
Zahraa S. Al-Ahmady, Ben R. Dickie, Isabelle Aldred, Dhifaf A. Jasim, Jack Barrington, Michael Haley, Eloise Lemarchand, Graham Coutts, Satinderdeep Kaur, Jessica Bates, Sarah Curran, Ruth Goddard, Megan Walker, Adrian Parry-jones, Kostas Kostarelos, Stuart M. Allan
Summary: This study provides compelling evidence that haemorrhagic stroke induces blood-brain barrier injury and offers a unique opportunity to selectively deliver therapeutic molecules using lipid nanoparticles.
Review
Pharmacology & Pharmacy
Zhiyu Jin, Yu Han, Danshen Zhang, Zhongqiu Li, Yongshuai Jing, Beibei Hu, Shiguo Sun
Summary: Depression is a growing mental disease in modern society, with low cure rates and high recurrence rates. The current treatment methods, primarily drug therapy combined with psychological and physical therapy, have limitations. Intranasal administration may provide a better option for the delivery of antidepressant medication.
Review
Pharmacology & Pharmacy
Raquel Talens-Visconti, Jesus Vicente de Julian-Ortiz, Ofelia Vila-Buso, Octavio Diez-Sales, Amparo Nacher
Summary: Alzheimer-type dementia (ATD) treatments are limited in their ability to cross the blood-brain barrier and can have adverse effects on the body. Intranasal administration provides a direct route to the brain through the nasal cavity. However, drug absorption and bioavailability can be hindered by nasal physiology, so technological strategies are needed to optimize the physicochemical properties of formulations. Among the strategies explored, lipid-based nanosystems, specifically nanostructured lipid carriers, show promise in preclinical studies with minimal toxicity and therapeutic efficacy. This review focuses on the use of nanostructured lipid carriers for intranasal administration in the treatment of ATD. Currently, no drugs for intranasal administration in ATD have received marketing approval, but three candidates (insulin, rivastigmine, and APH-1105) are being clinically investigated. Further studies with other candidates will help confirm the potential of intranasal administration in the treatment of ATD.
Article
Biotechnology & Applied Microbiology
Barbara Sanchez-Dengra, Maria Alfonso, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Ramon Martinez-Manez
Summary: The two types of nanoparticles loaded with ponatinib have been proven to be non-toxic to blood-brain barrier cells and have shown improved drug delivery to the brain compared to the free drug when administered intranasally. This research is significant for the treatment of brain cancer.
Review
Biochemistry & Molecular Biology
Paul Kawak, Nour M. Al Sawaftah, William G. Pitt, Ghaleb A. Husseini, Christian Celia, Chiara Laezza
Summary: Glioblastoma (GBM) is a highly aggressive brain tumor with limited treatment options due to the blood-brain barrier (BBB). Liposomes offer potential solutions to the limitations of chemotherapy, but passive targeting strategies have been ineffective. The upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics, which show promise in GBM therapy. This review discusses the role of Tf-conjugated liposomes in GBM therapy, recent studies on their drug delivery efficiency, challenges faced, and potential improvements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Georg C. Terstappen, Axel H. Meyer, Robert D. Bell, Wandong Zhang
Summary: The blood-brain barrier presents a challenge for delivering therapeutics to the central nervous system, particularly for biopharmaceuticals. Non-invasive approaches have been developed to help overcome this challenge, with increasing research efforts focusing on technologies to deliver therapeutics to the CNS, some of which have entered clinical testing. Developing effective strategies for crossing the blood-brain barrier is crucial for treating CNS disorders, with a particular emphasis on non-invasive methods such as receptor-mediated transcytosis and the use of neurotropic viruses, nanoparticles, and exosomes.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Review
Pharmacology & Pharmacy
Shiv Bahadur, Manas Kumar Jha
Summary: The blood-brain barrier plays a crucial role in drug delivery to the brain, but conventional drug delivery systems have limitations. However, nanotechnology and intranasal routes offer potential solutions to enhance drug bioavailability and effectiveness in the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Leonor C. Fonseca, Joao A. Lopes, Joao Vieira, Claudia Viegas, Claudia S. Oliveira, Rafael P. Hartmann, Pedro Fonte
Summary: Alzheimer's disease is a neurodegenerative condition with severe consequences on patient quality of life. The intranasal route is suggested as a promising alternative for improving treatment of Alzheimer's disease, but there is currently no clear alternative delivery system in the market with advantageous bioavailability and safety.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Christopher Francis, Liliana Wroblewska, Pamela Pegman, Mansoor Amiji
Summary: The goal of this study was to evaluate hepatocyte-specific gene editing using hyaluronic acid-based nanoparticles. The results showed that the nanoparticles were primarily taken up by the liver, and the addition of mannose increased uptake in both the liver and spleen. The study also demonstrated successful delivery and transfection of gene editing plasmids in hepatocytes, with encouraging results for the development of a non-viral polymeric delivery system targeting hepatocytes.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Review
Biochemical Research Methods
Amit Singh, Mansoor M. Amiji
Summary: Nanotechnology has greatly impacted the advancement in disease imaging, early detection, diagnosis, and prognosis. The unique properties of nanoparticles enable contrast enhancement for biomedical imaging and molecular level tissue-specific diagnosis. Small variations in nanoparticle size or composition can result in significant changes in their optical, magnetic, or electrical properties, allowing for unique possibilities of multiplexing.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Allergy
Angela L. Nocera, Sarina K. Mueller, Alan D. Workman, Dawei Wu, Kristen McDonnell, Peter M. Sadow, Mansoor M. Amiji, Benjamin S. Bleier
Summary: CST1 is a potent upstream initiator of epithelial-derived type 2 inflammation in CRSwNP, which is characterized by overexpression of cysteine protease inhibitors. Integrated polyomics and a murine exposure model were used to explore the link between cystatin overexpression and type 2 inflammation in CRSwNP.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Aatman S. Doshi, Susan Cantin, Laura B. Prickett, Deanna A. Mele, Mansoor Amiji
Summary: In this study, a systemically administered CD103+ dendritic cell (DCs) targeted liposomal formulation was developed, which enhanced anti-tumor immune response and reduced off-target toxicities by targeted delivery of CDNs. The results showed significant anti-tumor efficacy of the liposomal formulation at low dose.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Srujan K. Gandham, Mounika Rao, Aayushi Shah, Malav S. Trivedi, Mansoor M. Amiji
Summary: This study reports a hyaluronic acid-based nanoparticle formulation that can deliver Let7b miRNA mimic to tumor cells, achieving cellular programming in both vitro and in vivo. Combined with chemotherapy, this approach significantly improves anti-tumor efficacy in relapsed ovarian cancer.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Medicine, Research & Experimental
Mansoor M. Amiji, Srujan K. Gandham, Husain Z. Attarwala
Summary: This article discusses the transfer and functional effects of extracellular vesicle (EV)-mediated microRNA in the tumor microenvironment, and investigates the transfer kinetics and concentration-effect relationship through mathematical models and experiments. The research findings are important for understanding the mechanism of drug resistance in tumors.
MOLECULAR PHARMACEUTICS
(2022)
Review
Medicine, Research & Experimental
Shallu Kutlehria, Anisha D'Souza, Benjamin S. Bleier, Mansoor M. Amiji
Summary: Increased life expectancy has led to a higher prevalence of age-related disorders, including neurological diseases. The development of clinically useful therapies for these diseases has been limited, in part due to challenges such as the blood-brain barrier and complexities of the brain. 3D printing is a promising technology for drug delivery, offering customizable solutions and high throughput capabilities. However, there are still technical and regulatory obstacles to be addressed for successful translation of 3D-printed systems to clinical use.
MOLECULAR PHARMACEUTICS
(2022)
Review
Biotechnology & Applied Microbiology
Neha N. Parayath, Srujan K. Gandham, Mansoor M. Amiji
Summary: miRNAs are important messenger molecules in the tumor microenvironment, playing key roles in immune suppression, tumor progression, metastasis, and resistance. This review discusses nanomedicine strategies for achieving cell-specific delivery of miRNAs. The main goal of delivery is to activate the tumor immune landscape and prevent chemotherapy resistance. Specifically, the use of hyaluronic acid-based nanoparticle miRNA delivery to the tumor microenvironment is discussed.
Article
Biochemistry & Molecular Biology
Kevin Craig, Marc Abrams, Mansoor Amiji
Summary: Despite current clinical programs focusing on reducing hepatic fat accumulation to prevent inflammation and fibrosis in nonalcoholic fatty liver disease (NAFLD), research suggests that liver inflammation may play a critical role in the development of the disease. A simple cholesterol-siRNA conjugate system has shown potential in targeting liver inflammation and preventing the hallmarks of NAFLD in preclinical models, providing evidence for a novel therapeutic approach using RNA interference.
NUCLEIC ACID THERAPEUTICS
(2023)
Article
Allergy
Di Huang, Maie S. Taha, Angela L. Nocera, Alan D. Workman, Mansoor M. Amiji, Benjamin S. Bleier
Summary: Nasal epithelium-derived extracellular vesicles (EVs) play a crucial role in antiviral immunity by delivering functional miR-17 and directly neutralizing viral infections. However, cold exposure can impair EV secretion, microRNA packaging, and antiviral binding, leading to weakened antiviral effects.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Maie S. Taha, Shallu Kutlehria, Anisha D'Souza, Benjamin S. Bleier, Mansoor M. Amiji
Summary: Verapamil, a calcium channel blocker, shows potential for treating chronic rhinosinusitis (CRS) with or without nasal polyps. However, its dose is limited by side effects, making localized intranasal administration preferable. The challenge with intranasal administration is mucociliary clearance, which reduces localized drug availability. To overcome this challenge, verapamil was loaded into mucoadhesive cationic polyethylene glycol-modified (PEGylated) liposomes. This formulation increased tissue residence time and nasal tissue accumulation of verapamil, making it a promising intranasal delivery system for CRS therapy.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Anisha D'Souza, Saeideh Nozohouri, Benjamin S. Bleier, Mansoor M. Amiji
Summary: Nucleic acid-based therapeutic molecules have great potential for treating diseases in the CNS, but delivering them to the brain's target cells and sub-cellular compartments is a challenge. This review discusses the challenges and recent advances in cellular and sub-cellular delivery using various mechanisms and routes of administration.
PHARMACEUTICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Hiba Hussain, Aishwarya Ganesh, Lara Milane, Mansoor Amiji
Summary: This article mainly discusses the biology of SARS-CoV-2, vaccine formulations and trials, the concept of 'herd resistance,' and the vaccination divide. The COVID-19 pandemic has changed the landscape of medicine, with the rapid approval of vaccines leading to more accelerated trials. However, the low efficacy of current vaccines and the rapid mutation rate of the virus are preventing herd immunity and leading to the acquisition of herd resistance. Even with future, more effective vaccines, anti-vaccination attitudes will continue to challenge the quest for SARS-CoV-2 herd immunity.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Engineering, Biomedical
Kanika Suri, Anisha D'Souza, Di Huang, Aashray Bhavsar, Mansoor Amiji
Summary: Cancer therapy is shifting towards immunotherapy that activates the host immune system. Bacterial extracellular vesicles (BEVs) are being studied as a potential tool for controlling immune responses and for drug delivery. However, there are still unanswered questions regarding the use of BEVs, especially for long-term immunotherapies.
BIOACTIVE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Andy J. Chua, Valentina Di Francesco, Di Huang, Anisha D'Souza, Benjamin S. Bleier, Mansoor M. Amiji
Summary: Chronic rhinosinusitis (CRS) is a prevalent and burdensome inflammatory disease that affects patients' quality of life. Nanotechnology provides potential solutions to enhance the effectiveness of topical therapies and overcome the limitations of current treatments. This review discusses the successful application of nanomedicine in CRS therapeutics, current limitations, and future opportunities.