Article
Biochemistry & Molecular Biology
Xiaolong Han, Yi Han, Yujuan Jin, Huafeng Tian, Zhao Wang, Jiawei Huang, Shuang Men, Rakesh Kumar
Summary: This study synthesized bio-based engineering polyester elastomers (BEPE) to enhance the toughness of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and prepared fully bio-based blends. The results showed that the addition of BEPE significantly improved the elongation at break, impact strength, and tensile toughness of the PHBV blends.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Harsha Ramaraju, Danielle Massarella, Courtney Wong, Adam S. Verga, Emily C. Kish, Martin L. Bocks, Scott J. Hollister
Summary: This study investigates the changes in polymer structure, tissue coverage, endothelialization, and inflammation of percutaneously implanted PGD patches in the branch pulmonary arteries of pigs. The results show that PGD patches achieve good tissue coverage and have a favorable inflammatory response, validating their suitability as cardiovascular repair materials.
Article
Materials Science, Multidisciplinary
Yunfei Guo, Anna M. M. Cristadoro, Julian Kleemann, Stefan Bokern, Rint P. P. Sijbesma, Zeljko Tomovic
Summary: Polyurethane can be modified with thermally stable aromatic imide structures to enhance its mechanical and thermal properties. In this study, imide-containing isocyanate-terminated prepolymers were synthesized in solvent-free conditions and used to prepare PUI elastomers with improved char formation and stiffness. The aromatic PUI elastomer also showed enhanced flame retardancy. This work demonstrates the potential use of imide prepolymers in high thermal stability and flame retardant PU applications.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Polymer Science
Liraz Avraham, Rajashekharayya A. Sanguramath, Orit Cohen, Luba Perry, Shulamit Levenberg, Michael S. Silverstein
Summary: This study successfully synthesized macroporous polymer monoliths based on four different polysaccharides using a template synthesis method in oil-in-water high internal phase emulsions. The nature of the polysaccharide and the polymerization catalyst significantly affected the porous structure. Cells were able to adhere to the walls and penetrate into the porous structures in amine-catalyzed monoliths.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Maykel Gonzalez-Torres, Cristina Velasquillo, Adrian Camacho-Lopez, Margarita Rivera, Roberto Sanchez-Sanchez, Gerardo Leyva-Gomez, Yaaziel Melgarejo-Ramirez, Clemente Ibarra, Susana Vargas-Munoz, Rogelio Rodriguez Talavera, Enrique Lima, Jose Gonzalez-Valdez
Summary: This study investigated the bio-interfacial properties of poly(ester-urethane) composite scaffolds modified by surface plasma-radiation-induced graft polymerization of N-isopropylacrylamide (NIPAAm) based on poly (3-hydroxybutyrate) [PHB]. The results showed that scaffolds with moderate hydrophilicity exhibited better attachment and growth of fibroblasts. In vivo experiments indicated that plasma-treated scaffolds reduced inflammatory infiltrate, leading to improved acceptance compared to untreated PHB polyurethane.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Brian M. Howell, Caitlyn C. Cook, Michael D. Grapes, Karen Dubbin, Emily L. Robertson, John D. Sain, Kyle T. Sullivan, Eric B. Duoss, Eric Bukovsky
Summary: This study presents a method for 3D printing functional materials with spatial control of structure and composition using direct ink writing (DIW), showcasing exquisite control over structure, composition, and ink robustness. By incorporating micro- or nanosized solid fillers in the inks, a wide range of structural and mechanical properties can be achieved, demonstrating the versatility and power of these process permutations in creating complex components for various applications.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Sohail Sarwar, Abdul Ghaffar, Qingrong Huang, Meraj Khalid, Aneela Anwar, Abdulfatah M. Alayoubi, Muhammad Latif
Summary: Blending natural polysaccharides with synthetic polymers to create composite films for drug delivery systems has received much attention due to their biodegradability and biocompatibility. This study focuses on the easy preparation of Starch/Poly(allylamine hydrochloride) (ST/PAH) blend films and their potential as a sustained-release DDS for various biomedical applications. The films exhibited intermolecular H-bonding and hydrophobic characteristics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Andreas Samourides, Andreas Anayiotos, Konstantinos Kapnisis, Zacharoula Xenou, Vanessa Hearnden, Biqiong Chen
Summary: This study demonstrates the fabrication of poly(glycerol sebacate urethane) (PGSU) scaffolds with hierarchical multilayer microstructures to replicate various native soft tissues using ice-templating via freeze drying with custom-made moulds and air brushing. The scaffolds show anisotropic microstructures mimicking tissues like tendon and skeletal muscle, with mechanical properties varied by altering the reactants' molar ratio and polymer concentration. By combining freeze drying with airbrushing, scaffolds were created with thin non-porous layers on top of porous layers for three-dimensional cell co-culture, highlighting the potential for tailored PGSU scaffolds in tissue engineering applications.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Martyna Zagorska-Dziok, Patrycja Kleczkowska, Ewa Oledzka, Ramona Figat, Marcin Sobczak
Summary: Polymeric hydrogels play an increasingly important role in medicine, pharmacy, and cosmetology due to their favorable physicochemical properties and biocompatibility. This study synthesized new poly(chitosan-ester-ether-urethane) hydrogels and studied the kinetic release of genistein from these biomaterials. The developed hydrogels show non-toxicity to skin cells and a relatively highly controlled release profile of genistein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaolong Han, Yi Han, Yujuan Jin, Zhao Wang, Huafeng Tian, Jiawei Huang, Maolin Guo, Shuang Men, Haibo Lei, Rakesh Kumar, Jing Hu
Summary: The major challenge of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is its brittleness, which limits its current applications. In this research, bio-based engineering polyester elastomers (BEPE) were successfully synthesized and combined with PHBV to enhance its toughness. The modified microcrystalline cellulose, called MCHBP, had abundant terminal hydroxyl groups that dispersed between PHBV and BEPE. The interaction between the terminal hydroxyl groups of MCHBP and the carbonyl groups of PHBV or BEPE significantly improved the adhesion and stress transfer between the two materials. The PHBV/BEPE composites with 0.5phr MCHBP exhibited a remarkable improvement in tensile toughness and elongation at break compared to PHBV/BEPE composites. This research also demonstrated that MCHBP can act as a heterogeneous nucleation agent for the crystallization of PHBV.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Annesha Kar, Muzamil Ahmad Rather, Manabendra Mandal, Niranjan Karak
Summary: Poly(ester amide urethane) resins were synthesized to overcome the shortcomings of poly(ester amide) and impart new features. The synthesized material showed excellent elongation, toughness, thermal stability, and chemical resistance. Aging tests proved their enhanced tensile strength parameters, making them suitable for outdoor applications. They also demonstrated good biodegradability and cytocompatibility.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Engineering, Biomedical
Mengting Shi, Lang Bai, Meiguang Xu, Zhenlong Li, Tianli Hu, Juan Hu, Zixi Zhang, Zhanhai Yin, Baolin Guo
Summary: In this study, a micropatterned elastomer film that can simulate the mechanical properties, anisotropy, and electroactivity of natural myocardial tissues was developed. The film has sufficient mechanical strength, complies with the anisotropy of myocardium, and possesses conductivity and good cytocompatibility. In vivo experiments showed that the film with graphene can significantly promote myocardial function recovery. This electroactive micropatterned anisotropic elastomer film has potential applications in cardiac tissue engineering.
Article
Engineering, Biomedical
Caroline D. Hoemann, Javier Rodriguez Gonzalez, Jessica Guzman-Morales, Gaoping Chen, Ebrahim Jalali Dil, Basil D. Favis
Summary: This study found that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold, and were compatible with trabecular bone integration. Compared to drill-only defects, the 83-99-PCL scaffold induced angiogenesis and slight bone resorption, with the smallest change in bone volume fraction.
BIOACTIVE MATERIALS
(2022)
Article
Polymer Science
Monica Boffito, Lucia Servello, Marcela Arango-Ospina, Serena Miglietta, Martina Tortorici, Susanna Sartori, Gianluca Ciardelli, Aldo R. Boccaccini
Summary: This study proposed the use of custom-made polyurethanes (PURs) as coating materials for Bioglass-based scaffolds. The coated scaffolds exhibited biocompatibility, high porosity, and improved mechanical properties compared to the uncoated scaffolds. The presence of PEG in the coating resulted in a decrease in mechanical reliability in an aqueous environment.
Article
Materials Science, Composites
Monika Bil, Piotr Mrowka, Dorota Kolbuk, Wojciech Swieszkowski
Summary: The study designed multifunctional composite biomaterials consisting of chitosan microspheres and crosslinked polyester-urethane, confirming their superior shape memory properties and drug release functionality. The in vitro experiments also demonstrated their excellent biocompatibility with cells, indicating potential as controlled drug delivery systems.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
