4.7 Article

Multifunctional composite combining chitosan microspheres for drug delivery embedded in shape memory polyester-urethane matrix

期刊

COMPOSITES SCIENCE AND TECHNOLOGY
卷 201, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.compscitech.2020.108481

关键词

Multifunctional composites; Smart materials; Shape memory behavior; Multifunctional properties; Drug release

资金

  1. National Science Centre (Poland) [DEC-2012/07/D/ST8/02588]

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The study designed multifunctional composite biomaterials consisting of chitosan microspheres and crosslinked polyester-urethane, confirming their superior shape memory properties and drug release functionality. The in vitro experiments also demonstrated their excellent biocompatibility with cells, indicating potential as controlled drug delivery systems.
Multifunctional composite biomaterials (3b-PU/CH_M) consisting of chitosan microspheres (CH-M) that provide drug release functionality and crosslinked polyester-urethane (3b-PU) matrix responsible for shape memory properties were designed. A series of 3b-PU/CH_M bio-composites with varying weight fraction of CH-M (2.5, 5, and 10 wt %) embedded into 3b-PU matrix were synthesized. The ATR-FTIR confirmed the presence of covalent bonds between 3b-PU matrix and CH-M as well as enhanced hydrogen bonds interaction within bio-composites matrix in comparison to neat 3b-PU. It was found that CH-M had not impaired the shape memory properties of 3b-PU matrix and even slightly improved the shape recovery (R-r %). The R-r value increased to 100% for 3b-PU/CH 2.5% M and 3b-PU/CH 5% M after the third thermo-mechanical cycle. Moreover, the transition temperature (T-trans) of shape recovery tailored to 30 degrees C by the chemical composition of the 3b-PU network was not affected by CH-M. Effectiveness of the application of the composites as a controlled drug delivery system at various pH conditions was confirmed in an in vitro release study of ciprofloxacin hydrochloride (Cpx-HCl) used as a model drug. In vitro biocompatibility studies revealed that the materials do not alter the cells' ability to proliferate and differentiate.

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