Targeting cellular drivers and counter-regulators of hyperglycaemia- and transforming growth factor-β1-associated profibrotic responses in diabetic kidney disease

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses

(2013) James B. Corcoran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diabetic kidney disease and immune modulation

(2013) Fionnuala B Hickey et al.   CURRENT OPINION IN PHARMACOLOGY

The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications

(2013) S. Madsbad   DIABETES OBESITY & METABOLISM

Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGF R1

(2013) E. P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney Disease and Increased Mortality Risk in Type 2 Diabetes

(2013) M. Afkarian et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b

(2013) Bo Wang et al.   KIDNEY INTERNATIONAL

Gremlin Is a Downstream Profibrotic Mediator of Transforming Growth Factor-Beta in Cultured Renal Cells

(2013) Raquel Rodrigues-Diez et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Metabolic syndrome and associated chronic kidney diseases: Nutritional interventions

(2013) P. Anil Kumar et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Epigenetic Modifications in the Pathogenesis of Diabetic Nephropathy

(2013) Marpadga A. Reddy et al.   SEMINARS IN NEPHROLOGY

Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus

(2012) Steven G. Coca et al.   ARCHIVES OF INTERNAL MEDICINE

Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension

(2012) Edwina Cahill et al.   CIRCULATION

Lipoxin A4 attenuates adipose inflammation

(2012) Emma Börgeson et al.   FASEB JOURNAL

GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases

(2012) Hari Hendarto et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA Circuits in Transforming Growth Factor-β Actions and Diabetic Nephropathy

(2012) Mitsuo Kato et al.   SEMINARS IN NEPHROLOGY

Can We Target Tubular Damage to Prevent Renal Function Decline in Diabetes?

(2012) Joseph V. Bonventre   SEMINARS IN NEPHROLOGY

TGF-β/Smad Signaling in Kidney Disease

(2012) Hui Y. Lan et al.   SEMINARS IN NEPHROLOGY

The proximal tubule in the pathophysiology of the diabetic kidney

(2011) Volker Vallon   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis

(2011) Emma Börgeson et al.   FASEB JOURNAL

Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1–7)masreceptor expression associated with its PPAR-γ agonist action

(2011) Arun Prasath Lakshmanan et al.   FREE RADICAL RESEARCH

Glucose handling by the kidney

(2011) Amanda Mather et al.   KIDNEY INTERNATIONAL

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Glycemic memory associated epigenetic changes

(2010) Andrew L. Siebel et al.   BIOCHEMICAL PHARMACOLOGY

Cost-Effectiveness of Interventions to Prevent and Control Diabetes Mellitus: A Systematic Review

(2010) R. Li et al.   DIABETES CARE

The magnitude of association between overweight and obesity and the risk of diabetes: A meta-analysis of prospective cohort studies

(2010) Asnawi Abdullah et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A GREM1 Gene Variant Associates with Diabetic Nephropathy

(2010) A. J. McKnight et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial

(2010) Faramarz Ismail-Beigi et al.   LANCET

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

In Vivo Delivery of Gremlin siRNA Plasmid Reveals Therapeutic Potential against Diabetic Nephropathy by Recovering Bone Morphogenetic Protein-7

(2010) Qingxian Zhang et al.   PLoS One

Macrophages in Renal Development, Injury, and Repair

(2010) Timothy M. Williams et al.   SEMINARS IN NEPHROLOGY

Extracellular BMP-antagonist regulation in development and disease: tied up in knots

(2010) David W. Walsh et al.   TRENDS IN CELL BIOLOGY

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease

(2009) S. A. Roxburgh et al.   DIABETES

Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes

(2009) B. E. de Galan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IHG-1 Amplifies TGF- 1 Signaling and Is Increased in Renal Fibrosis

(2008) M. Murphy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

(2008) Peter Gæde et al.   NEW ENGLAND JOURNAL OF MEDICINE

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE