Article
Peripheral Vascular Disease
Brasilina Caroccia, Paul-Emmanuel Vanderriele, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Selene Prisco, Francesca Torresan, Oliver Domenig, Maurizio Iacobone, Marko Poglitsch, Gian Paolo Rossi
Summary: This study found that ACE-2 mRNA and Ang II were present in human adrenocortical tissues, but not Ang-(1-7) and Ang-(1-5). Ang-(1-7) and ACE-2 do not seem to play a significant role in regulating aldosterone and cortisol biosynthesis.
JOURNAL OF HYPERTENSION
(2021)
Review
Endocrinology & Metabolism
Yuanyuan Liu, Haomeng Hao, Tingting Lan, Rui Jia, Mingya Cao, Liang Zhou, Zhiming Zhao, Wensen Pan
Summary: The local Renin-Angiotensin System (RAS) plays a role in the female reproductive system, regulating follicle development and physiological functions of the placenta and uterus. Ang II and Ang-(1-7) have similar functions in this system and can influence the occurrence and development of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Larissa M. Macedo, Renato de Avila, Gustavo R. Pedrino, Diego B. Colugnati, Marize C. Valadares, Eliana M. Lima, Clayton L. Borges, Gregory T. Kitten, Elisandra Gava, Carlos H. Castro
Summary: This study identified the RAS components expressed in SCAPs and investigated the effects of Ang II and Ang-(1-7) on cell proliferation. Both Ang II and Ang-(1-7) treatments increased cell proliferation in SCAPs through AT2 activation via different intracellular mechanisms.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Nan-Nan Sha, Jia-Li Zhang, Christina Chui-Wa Poon, Wen-Xiong Li, Yue Li, Yi-Fei Wang, Wei Shi, Fu-Hui Lin, Wen-Ping Lin, Yong-Jun Wang, Yan Zhang
Summary: In this study, it was found that ANG II and ANG(1-7) had different effects on osteoblasts and osteoclasts under high-glucose conditions, playing different roles in the development of osteoporosis, with ANG(1-7) showing a protective effect against diabetes-induced osteoporosis.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Bartosz Pilecki, Paulo V. S. D. de Carvalho, Katrine L. Kirketerp-Moller, Anders Schlosser, Karin Kejling, Magdalena Dubik, Nicklas P. Madsen, Jane Stubbe, Pernille B. L. Hansen, Thomas L. Andersen, Jesper B. Moeller, Niels Marcussen, Vasco Azevedo, Svend Hvidsten, Christina Baun, Guo-Ping Shi, Jes S. Lindholt, Grith L. Sorensen
Summary: MFAP4 plays a crucial role in promoting the development of AAA by inducing macrophage-rich inflammation and MMP activity within the vessel wall. Its deficiency leads to reduced AAA incidence and ameliorates pathological changes in AAA, implicating regulation of monocyte influx and MMP production as key mechanisms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dominga Lapi, Maurizio Cammalleri, Massimo Dal Monte, Martina Di Maro, Mariarosaria Santillo, Anna Belfiore, Gilda Nasti, Simona Damiano, Rossella Trio, Martina Chiurazzi, Barbara De Conno, Nicola Serao, Paolo Mondola, Antonio Colantuoni, Bruna Guida
Summary: The study found that Ang II and Ang 1-7 trigger different mechanisms through different receptors to affect cerebral microvascular injury in rats. Ang II exacerbates damage, while Ang 1-7 protects the microcirculation and can be regulated by specific receptor antagonists and activators.
Article
Hematology
Michele Silvestro, Cristobal F. Rivera, Dornazsadat Alebrahim, John Vlahos, Muhammad Yogi Pratama, Cuijie Lu, Claudia Tang, Zander Harpel, Rayan Sleiman Tellaoui, Ariadne L. Zias, Delphina J. Maldonado, Devon Byrd, Mukundan Attur, Paolo Mignatti, Bhama Ramkhelawon
Summary: The cytoplasmic domain of MT1-MMP protects against the development of AAA and atherosclerotic plaques through a nonproteolytic signaling mechanism. This finding reveals a novel mechanism of synchronous onset of AAA and atherogenesis and highlights the importance of MT1-MMP in the control of vascular wall homeostasis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matus Sykora, Vojtech Kratky, Libor Kopkan, Narcisa Tribulova, Barbara Szeiffova Bacova
Summary: The extracellular matrix (ECM) plays a vital role in heart muscle function. Overload-induced ECM remodeling leads to impaired cardiomyocyte adhesion and electrical coupling, resulting in cardiac dysfunction and arrhythmias. This study investigated the signaling pathways of ECM and connexin-43 (Cx43) in rat hearts with hemodynamic overload, as well as the potential protective effects of angiotensin (1-7) (Ang (1-7)) in preventing adverse myocardial remodeling. The findings suggest that Ang (1-7) has cardio-protective and anti-fibrotic effects in conditions of cardiac volume overload.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ikram Omar Osman, Clea Melenotte, Philippe Brouqui, Matthieu Million, Jean-Christophe Lagier, Philippe Parola, Andreas Stein, Bernard La Scola, Line Meddeb, Jean-Louis Mege, Didier Raoult, Christian A. Devaux
Summary: SARS-CoV-2 infection can lead to variations in ACE2 expression and Ang II plasma concentration, potentially affecting blood pressure regulation and COVID-19 outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Damiano Rocchi, Cristina Blazquez-Barbadillo, Mariangela Agamennone, Antonio Laghezza, Paolo Tortorella, David Vicente-Zurdo, Noelia Rosales-Conrado, Paula Moyano, Javier del Pino, Juan F. Gonzalez, J. Carlos Menendez
Summary: Matrix metalloproteinases (MMPs) play a key role in neuroinflammatory events and brain damage associated with stroke. The study revealed a new compound with inhibitory effects on MMPs and potential neuroprotective activity against oxidative stress, providing a promising lead for future drug development. The compounds showed some selectivity for specific MMP enzymes and a noncompetitive inhibition mechanism was observed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Kohei Karasaki, Hiroki Kokubo, Batmunkh Bumdelger, Nobuchika Kaji, Chiemi Sakai, Mari Ishida, Masao Yoshizumi
Summary: This study found that Angiotensin II type 1 receptor blockers (ARBs) can prevent the progression of abdominal aortic aneurysm (AAA) by upregulating angiotensin (1-7), suggesting that angiotensin (1-7) may play a key role in mediating the protective effect of ARBs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Critical Care Medicine
Bruno Garcia, Fuhong Su, Francesca Manicone, Laurence Dewachter, Raphael Favory, Amina Khaldi, Alexander Moiroux-Sahroui, Anthony Moreau, Antoine Herpain, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone, Filippo Annoni
Summary: The aim of this study was to investigate the effects of Ang-(1-7) infusion on the development and severity of septic shock. The results showed that early Ang-(1-7) infusion can prevent the development of septic shock, reduce norepinephrine requirements, limit the increase of interleukin-6 levels, and prevent renal dysfunction.
Article
Physiology
Julia Schrankl, Michaela Fuchs, Katharina Broeker, Christoph Daniel, Armin Kurtz, Charlotte Wagner
Summary: This study investigated the cell-specific localization of AT(1) receptor expression in rodent and human kidneys, revealing conserved AT(1) receptor mRNA expression sites in the (juxta)glomerular areas and tubulointerstitium across species, potentially serving as main target sites for ANG II in adult kidneys.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Immunology
Jyotsana Kaushal, Akhil Kamboj, Kumari Anupam, Ankit Tandon, Aman Sharma, Archana Bhatnagar
Summary: This study evaluates the role of polymorphonuclear neutrophils (PMNs) in patients with rheumatoid arthritis (RA) and healthy controls. The results demonstrate that PMNs play an important role in mediating immune responses and are associated with gene regulation involved in oxidative and degradative pathways. Additionally, the study found significantly elevated levels of pro-inflammatory cytokines in the serum of RA patients, which correlated with disease severity.
CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Katharina Joechle, Huda Jumaa, Kerstin Thriene, Claus Hellerbrand, Birte Kulemann, Stefan Fichtner-Feigl, Sven A. Lang, Jessica Guenzle
Summary: The study showed that OSI-027, a dual kinase inhibitor targeting mTOR complexes, can significantly impact the migratory and metastatic capacity of cholangiocarcinoma cells by reducing cell mobility and migration, decreasing colony-forming ability, and downregulating MMP2 and MMP9 expression. Additionally, OSI-027 impaired survival and anti-apoptotic signaling as determined by AKT and MAPK blotting, suggesting that dual targeting of mTORC1/2 may be a viable option for anti-neoplastic therapy in CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Chun-Hsu Pan, Shu-Chen Chien, Chang-Jui Chen, Chun-Ming Shih, Ming-Hsiung Hsieh, Chun-Yao Huang, Wei-Fung Bi, Chao-Shun Chan, Yung-Ta Kao, Cheng-Yi Hsiao, Shuo-Ju Chiang, Kuang-Hsing Chiang, Jen-Hung Huang, Yun-Ru Liu, Ji-Dung Luo, Hui-Yu Huang, Chieh-Hsi Wu
Summary: The study revealed that the circulating level of miR-142-5p has the potential application as a clinical biomarker for predicting the development of ISR in stent-implanted patients. The ROC curve analysis demonstrated superior discriminatory ability of miR-142-5p in predicting patients' restenotic status. Circulating levels of miR-15b, miR-24-2, and miR-424 had differential expressions in participants with diabetes, hyperlipidemia, and hypertension.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Chemistry, Analytical
Meng-Ju Lin, Cheng Hao Wen
Summary: A simple, inexpensive method was developed to manufacture a microlens array using nonsilicon-based micromachining. The machined microlens profiles closely matched the designed ones, with only an average 1.5% error in focal lengths. The results suggest that this method is feasible for producing microlenses with moderate roughness.
Article
Cell & Tissue Engineering
Huai-En Lu, Yu-Ling Pan, Hui-Wen Ko, Shih-Han Hsu, Cheng-Hao Wen, Yi-Chao Hsu
Summary: The production of ALDH2-pE487K iPSCs will be valuable for investigating the pathogenic mechanisms linking ALDH2 polymorphism to alcohol-related diseases.
STEM CELL RESEARCH
(2021)
Article
Nutrition & Dietetics
Li-Han Chen, Ming-Fu Wang, Chun-Chao Chang, Shih-Yi Huang, Chun-Hsu Pan, Yao-Tsung Yeh, Cheng-Hsieh Huang, Ching-Hung Chan, Hui-Yu Huang
Summary: This study assessed the effects of probiotic Lacticaseibacillus paracasei PS23 (LPPS23) on gut microbiota (GM) and gastrointestinal (GI) function in aged mice. Results showed that LPPS23 enriched beneficial bacteria, improved intestinal function, and decreased levels of inflammatory factors, indicating the potential of LPPS23 in modulating GM composition and enhancing GI function in elderly individuals.
Article
Integrative & Complementary Medicine
Chun-Hsu Pan, Yu-Pei Lin, Jie-Yu Wang, Hui-Yu Huang, Shun-Cheng Huang, Ji-Mehng Lo, Chieh-Hsi Wu
Summary: The study found that the Crossostephium chinense extract CCE3 effectively inhibits balloon angioplasty-induced neointimal hyperplasia by blocking relevant signaling pathways and suppressing inflammation-related molecules.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chun-Hsu Pan, Yi-Chung Chien, Min-Shan Sung, Hui-Yu Huang, Ming-Jyh Sheu, Chieh-Hsi Wu
Summary: PGK1 plays a role in promoting neointima formation under hypoxic conditions, and its inhibition may have a beneficial effect in preventing restenosis by suppressing vascular smooth muscle cell proliferation and migration. Blocking the PDGFRB pathway can also reduce PGK1 expression and have a significant impact on neointimal hyperplasia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Ming-Heng Tsai, Yueh-Ting Chiu, Darien Zhing-Herr Chan, Cheng-Hao Wen, Shih-Han Syu, Huai-En Lu, Chi-Ying F. Huang, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Ching-Ying Huang, Yu-Feng Hu, Patrick C. H. Hsieh, Shih-Ann Chen
Summary: The study generated induced pluripotent stem cell lines with the homozygous form of ALDH2, which can be used as a useful platform to study alcohol metabolism and chronic diseases associated with alcohol consumption.
STEM CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Li-Han Chen, Chun-Hsu Pan, Shih-Yi Huang, Ching-Hung Chan, Hui-Yu Huang
Summary: This study found that the immunomodulatory effects of Lactobacillus casei Shirota fermented beverage (LcSFB) depend on the mode of antigen presentation, enhancing immune response in mice injected with OVA, but attenuating it in mice treated with injection plus intranasal administration.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Li-Han Chen, Shy-Shin Chang, Hsin-Yi Chang, Chieh-Hsi Wu, Chun-Hsu Pan, Chun-Chao Chang, Ching-Hung Chan, Hui-Yu Huang
Summary: This study demonstrated that supplementation with Lactobacillus casei Shirota can alleviate age-related declines in muscle mass, strength, and mitochondrial function, prevent inflammation, and oxidative stress, as well as modulate the gut microbiota composition and predicted bacterial functions. These results suggest that LcS may represent a promising strategy for mitigating age-related muscle impairments through the gut-muscle axis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Chieh-Hsi Wu, Chun-Hsu Pan, Irene Chu
Article
Biotechnology & Applied Microbiology
Heyu Yang, Hui Wang, Chenghao Wen, Shun Bai, Pengfei Wei, Bo Xu, Yunjun Xu, Chaozhao Liang, Yunjiao Zhang, Guilong Zhang, Huiqin Wen, Li Zhang
Summary: This study aimed to evaluate the effects of iron oxide nanoparticles (IONPs) on the male reproductive system of mice. The results showed that IONPs did not affect the major organs, but caused damage to Sertoli cells in the blood-testis barrier (BTB) at a relatively high concentration. This led to a temporary reduction in sperm quantity and quality, which was attributed to increased oxidative stress and apoptotic activity in the epididymis. However, these effects were reversible and returned to normal within 14 days after injection of IONPs.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Ram Sharma, Esha Chatterjee, Jacob Mathew, Sachin Sharma, N. Vijayakameswara Rao, Chun-Hsu Pan, Sung-Bau Lee, Ashwani Dhingra, Ajmer S. Grewal, Jing Ping Liou, Santosh K. Guru, Kunal Nepali
Summary: A suitable fragment was selected and incorporated into the HDAC inhibitory template to develop potential lung cancer treatment drugs through a fragment recruitment process. Compound 6, a fused quinazolinone, exhibited potent anticancer activity against KRAS and EGFR mutant lung cancer cell lines. Mechanistic studies revealed that compound 6 inhibited the activity of HDAC6, HDAC1, and HDAC3, leading to cell growth inhibition, apoptosis induction, and increased autophagic flux. Furthermore, a pH-responsive nanocarrier showed selective cytotoxicity against lung cancer cells under acidic conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Yu-Tang Tung, Chieh-Hsi Wu, Wen-Chao Chen, Chun-Hsu Pan, Yi-Wen Chen, Shu-Ping Tsao, Chia-Jung Chen, Hui-Yu Huang
Summary: This study found that phlorotannins from Ascophyllum nodosum and Fucus vesiculosus significantly reduced blood sugar, cholesterol, and triglyceride levels in rats with hyperlipidemia. It also increased insulin and high-density lipoprotein cholesterol levels while promoting lipase activity. Moreover, phlorotannins reduced adipocyte size, decreased inflammatory factors, and increased antioxidant enzyme activity. These results suggest that Ascophyllum nodosum and Fucus vesiculosus could be potential sources of anti-hyperlipidemia drugs and functional foods.
Article
Biochemistry & Molecular Biology
Bira Arumndari Nurrahma, Tu-Hsueh Yeh, Rong-Hong Hsieh, Shu-Ping Tsao, Chia-Wen Chen, Yen-Peng Lee, Chun-Hsu Pan, Hui-Yu Huang
Summary: The study suggests that mangosteen pericarp extract may delay the progression of Parkinson's disease by counteracting oxidative stress and improving gut microbiota composition.
Article
Chemistry, Multidisciplinary
Hui Wang, Yu Guan, Chun Li, Jia Chen, Shaoyu Yue, Jieying Qian, Bangshun Dai, Changqin Jiang, Chenghao Wen, Longping Wen, Chaozhao Liang, Yunjiao Zhang, Li Zhang
Summary: This study designed magnetic PEGylated manganese-zinc ferrite nanocrystals (PMZFNs) to actively attract and retain the drug in prostate cancer by implanting micromagnets into tumor tissues. The PMZFNs accumulate in prostate cancer and elicit potent ferroptosis and the activation of cGAS-STING pathway, achieving targeted therapy.