Dual Inhibition of mTORC1/2 Reduces Migration of Cholangiocarcinoma Cells by Regulation of Matrixmetalloproteinases
出版年份 2022 全文链接
标题
Dual Inhibition of mTORC1/2 Reduces Migration of Cholangiocarcinoma Cells by Regulation of Matrixmetalloproteinases
作者
关键词
-
出版物
Frontiers in Cell and Developmental Biology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-01-13
DOI
10.3389/fcell.2021.785979
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Role of mTOR Signaling as a Therapeutic Target in Cancer
- (2021) Nadezhda V. Popova et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cholangiocarcinoma
- (2021) Paul J. Brindley et al. Nature Reviews Disease Primers
- Differential roles and activation of mammalian target of rapamycin complexes 1 and 2 during cell migration in prostate cancer cells
- (2020) Smrruthi Vaidegi Venugopal et al. PROSTATE
- Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma
- (2020) Jessica Guenzle et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cyclooxygenase (COX) Inhibition by Acetyl Salicylic Acid (ASA) Enhances Antitumor Effects of Nitric Oxide in Glioblastoma In Vitro
- (2019) Jessica Guenzle et al. MOLECULAR NEUROBIOLOGY
- Targeting mTOR and Metabolism in Cancer: Lessons and Innovations
- (2019) Cedric Magaway et al. Cells
- Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma
- (2018) Xinhua Song et al. CLINICAL CANCER RESEARCH
- Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis
- (2018) Katharina M. Schmidt et al. NEOPLASIA
- Rictor regulates the vasculogenic mimicry of melanoma via the AKT-MMP-2/9 pathway
- (2017) Xingmei Liang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice
- (2017) Shanshan Zhang et al. JOURNAL OF HEPATOLOGY
- Overexpression of Rictor protein in colorectal cancer is correlated with tumor progression and prognosis
- (2017) Lifeng Wang et al. Oncology Letters
- Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models
- (2017) Katharina M. Schmidt et al. Oncotarget
- Rapamycin-insensitive companion of mTOR ( RICTOR ) Amplification Defines a Subset of Advanced Gastric Cancer and is Sensitive to AZD2014-mediated mTORC1/2 Inhibition
- (2016) S. T. Kim et al. ANNALS OF ONCOLOGY
- A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies
- (2016) Joaquin Mateo et al. BRITISH JOURNAL OF CANCER
- 4E-BP1, a multifactor regulated multifunctional protein
- (2016) Xiaoyu Qin et al. CELL CYCLE
- Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration
- (2016) Tatsuhiro Sato et al. GENES TO CELLS
- mTOR Inhibitors in Castration-Resistant Prostate Cancer: A Systematic Review
- (2016) Cara M. Statz et al. Targeted Oncology
- RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR
- (2016) Nneha Sakre et al. Oncotarget
- Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells
- (2016) Xiwei Ding et al. Oncotarget
- Elevated Rictor expression is associated with tumor progression and poor prognosis in patients with gastric cancer
- (2015) Yuhai Bian et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma
- (2015) Johanna C. Bendell et al. CANCER
- RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia
- (2015) Austin Y. Shull et al. Oncotarget
- Formononetin Inhibits Migration and Invasion of MDA-MB-231 and 4T1 Breast Cancer Cells by Suppressing MMP-2 and MMP-9 Through PI3K/AKT Signaling Pathways
- (2014) R. Zhou et al. HORMONE AND METABOLIC RESEARCH
- Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
- (2014) Florian Ewald et al. INVESTIGATIONAL NEW DRUGS
- 11-epi-Sinulariolide Acetate Reduces Cell Migration and Invasion of Human Hepatocellular Carcinoma by Reducing the Activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR Signaling Pathways
- (2014) Jen-Jie Lin et al. Marine Drugs
- Clonogenicity: Holoclones and Meroclones Contain Stem Cells
- (2014) Charlotte M. Beaver et al. PLoS One
- mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
- (2011) P. Gulhati et al. CANCER RESEARCH
- ATP-Competitive Inhibitors of mTOR: An Update
- (2011) S. Schenone et al. CURRENT MEDICINAL CHEMISTRY
- Preclinical Characterization of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2: Distinct from Rapamycin
- (2011) S. V. Bhagwat et al. MOLECULAR CANCER THERAPEUTICS
- Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells
- (2010) Sven A. Lang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- mTOR Complex Component Rictor Interacts with PKC and Regulates Cancer Cell Metastasis
- (2010) F. Zhang et al. CANCER RESEARCH
- Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony
- (2010) Kathryn G. Foster et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9
- (2009) Jing-song Chen et al. HEPATOLOGY RESEARCH
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started