Review
Chemistry, Medicinal
Oron Goldstein, Edna Ayerim Mandujano-Tinoco, Tom Levy, Shani Talice, Tal Raveh, Orly Gershoni-Yahalom, Ayelet Voskoboynik, Benyamin Rosental
Summary: Botryllus schlosseri, a colonial tunicate closest to vertebrates, lacks adaptive immunity but possesses unique characteristics making it a valuable model for studying innate immunity mechanisms. Studies in B. schlosseri have revealed a framework underlying the loss of tolerance to allogeneic tissues and provided insights into hematopoietic stem cell transplantation. Understanding the successful innate immune tolerance in B. schlosseri can potentially offer novel insights and modulations of immune processes in humans.
Review
Immunology
Qingqing Jia, Shihua Li, Xiao-Jiang Li, Peng Yin
Summary: Huntington's disease is a progressive neurodegenerative disorder characterized by loss of neurons in the striatum, leading to motor and cognitive impairments. The cause of the disease is the expansion of a glutamine repeat in the huntingtin protein, but the mechanism underlying neuronal death is still unclear. Inflammation is one of the contributing factors in the pathogenesis of Huntington's disease. This review summarizes the evidence on immune and inflammatory changes in Huntington's disease, providing insights for the development of novel strategies for its treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Veterinary Sciences
Hafiz Ishfaq Ahmad, Abdul Jabbar, Nadia Mushtaq, Zainab Javed, Muhammad Umar Hayyat, Javaria Bashir, Iqra Naseeb, Zain Ul Abideen, Nisar Ahmad, Jinping Chen
Summary: The immune system reduces the harmful impact of infections on the host by using immune-driven resistance and disease tolerance mechanisms. Disease tolerance controls tissue damage and allows the body to fight infections more effectively.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Quanyu Chen, Yu You, Yujun Zhang, Hongyu Zhang, Lianhua Bai
Summary: In this study, the transplantation of NG2(+) HSPs secreting HGF showed prolonged survival times and improved graft functions in a xenogeneic rat acute liver rejection model. The effects were likely associated with HGF secretion and could target recipient CD8(+) T cells by inducing their apoptosis.Interestingly, injection of cHGF also prolonged the survival times of recipient rats and increased the number of apoptotic xenoreactive CD8(+) T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Qiao Zhou, Ting Li, Kaiwen Wang, Qi Zhang, Zhuowen Geng, Shaoping Deng, Chunming Cheng, Yi Wang
Summary: Transplantation is a last resort for end-stage organ failures, but the shortage of donor organs limits its success. Xenotransplantation of pig organs is an alternative, but immune rejection is a major challenge. This review comprehensively discusses the mechanisms of immune rejection and strategies to prevent it, such as gene knockout donors and immunosuppressive regimens.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Oncology
Feiya Ma, Jensen Vayalil, Grace Lee, Yuqi Wang, Guangyong Peng
Summary: Tumor-derived extracellular vesicles (EVs) are a major factor inducing T cell dysfunction in the tumor microenvironment, playing a crucial role in cancer immunity. By carrying immune suppressive signals, tumor-derived EVs can drive T cell dysfunction and promote tumor immunity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Po-Tsang Lee, Fernando Y. Yamamoto, Chen-Fei Low, Jiun-Yan Loh, Chou-Min Chong
Summary: The gastrointestinal immune system plays a crucial role in regulating the symbiotic host-microbiome interactions and maintaining immune homeostasis. Fish gastrointestinal immune system has specialized gut-associated lymphoid tissues that establish tolerance towards commensal gut microbiome while mounting immune responses against enteric pathogens. Understanding the intestinal immune system is essential for developing oral vaccines and immunostimulants in aquaculture.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaowu Bai, Weixin Liu, Hongxia Chen, Tao Zuo, Xiaojian Wu
Summary: By analyzing RNA-seq data from patients with IBD (including CD and UC) and healthy individuals, this study revealed increased numbers of immune cells in different intestinal regions and disease-specific immune features in CD and UC. These findings provide important insights into the pathogenesis of IBD and serve as a valuable resource for future targeted studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Xiaodong Du, Mingqian Li, Chen Huan, Guoyue Lv
Summary: This review discusses the origin, maturation, migration, and pathological effects of dendritic cell subsets in liver transplantation, as well as their roles in transplant rejection and tolerance. The latest progress in dendritic cell-based treatment regimens is also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Nathalie Boulanger, Stephen Wikel
Summary: Ticks and tick-borne infectious agents are increasing global public health threats due to various factors, such as the abundance of vectors and pathogens. Understanding the interactions between ticks, hosts, and pathogens can lead to the development of novel strategies for tick control and disease prevention. Gaps in our understanding of these relationships were identified as areas for further research to successfully disrupt both tick feeding and pathogen transmission.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Michael Eigenschink, Isabelle Wessely, Marco Dijmarescu, Elisabeth Foerster-Waldl, Alex Farr, Herbert Kiss, Angelika Berger, Lukas Wisgrill
Summary: This study investigated the transcriptional changes induced by human lactoferrin in neonatal monocyte-derived macrophages. It was found that the presence of lactoferrin led to cell cycle arrest in the G2/M phase, induction of IL-4/IL-13-like signaling, altered extracellular matrix interaction, and enhanced propensity for cell-cell interaction. Additionally, lactoferrin treatment resulted in near-complete abrogation of transcriptional changes induced by TLR4 engagement with LPS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Mepur H. Ravindranath, Fatiha El Hilali, Edward J. Filippone
Summary: This review focuses on the effects of inflammation on immune balance following solid organ transplantation. It discusses inflammatory mediators, extracellular vesicles, cell surface antigen changes, and the role of specific inflammatory mediators like Interleukin-6 in determining tolerance or rejection post-transplantation. The objective is to differentiate between inflammatory events that enhance rejection and those that promote tolerance for potential therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Peiyu Zheng, Yongqing Dou, Qinying Wang
Summary: Chronic hepatitis B virus (HBV) infection poses a major threat to global public health, despite increasing vaccination rates. The outcome of HBV infection depends on the interaction between viral replication and host immune response. While innate immunity plays an initial role, long-term immunity is lacking due to HBV's ability to evade detection. Therefore, adaptive immunity involving T cells and B cells is crucial in controlling and clearing HBV infections. However, the persistence of HBV leads to immune tolerance and makes achieving a functional cure challenging.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Michael Dougan
Summary: Immune checkpoint inhibitor (ICI) therapy has revolutionized the field of oncology, but it also leads to immune-related adverse events (irAEs), such as colitis. The mechanisms driving ICI colitis and the risk factors for its development are not yet fully understood. There is a need for collaborative trials to further investigate ICI colitis and improve its management without interfering with antitumor responses.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Paula Perez-Pardo, Tessa Kliest, Hemraj B. Dodiya, Laus M. Broersen, Johan Garssen, Ali Keshavarzian, Aletta D. Kraneveld
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Neurosciences
Paula Perez-Pardo, Hemraj B. Dodiya, Laus M. Broersen, Hidde Douna, Nick van Wijk, Sofia Lopes da Silva, Johan Garssen, Ali Keshavarzian, Aletta D. Kraneveld
NUTRITIONAL NEUROSCIENCE
(2018)
Article
Neurosciences
Phillip A. Engen, Hemraj B. Dodiya, Ankur Naqib, Christopher B. Forsyth, Stefan J. Green, Robin M. Voigt, Jeffrey H. Kordower, Ece A. Mutlu, Kathleen M. Shannon, Ali Keshavarzian
JOURNAL OF PARKINSONS DISEASE
(2017)
Article
Multidisciplinary Sciences
Amanda L. Persons, Brinda D. Bradaric, Hemraj B. Dodiya, Michael Ohene-Nyako, Christopher B. Forsyth, Ali Keshavarzian, Maliha Shaikh, T. Celeste Napier
Article
Microbiology
P. Perez-Pardo, H. B. Dodiya, P. A. Engen, A. Naqib, C. B. Forsyth, S. J. Green, J. Garssen, A. Keshavarzian, A. D. Kraneveld
BENEFICIAL MICROBES
(2018)
Article
Cell & Tissue Engineering
Dustin R. Wakeman, D. Eugene Redmond, Hemraj B. Dodiya, John R. Sladek, Csaba Leranth, Yang D. Teng, R. Jude Samulski, Evan Y. Snyder
STEM CELLS TRANSLATIONAL MEDICINE
(2014)
Article
Gastroenterology & Hepatology
Paula Perez-Pardo, Hemraj B. Dodiya, Phillip A. Engen, Christopher B. Forsyth, Andrea M. Huschens, Maliha Shaikh, Robin M. Voigt, Ankur Naqib, Stefan J. Green, Jeffrey H. Kordower, Kathleen M. Shannon, Johan Garssen, Aletta D. Kraneveld, Ali Keshavarzian
Article
Neurosciences
Hemraj B. Dodiya, Christopher B. Forsyth, Robin M. Voigt, Phillip A. Engen, Jinal Patel, Maliha Shaikh, Stefan J. Green, Ankur Naqib, Avik Roy, Jeffrey H. Kordower, Kalipada Pahan, Kathleen M. Shannon, Ali Keshavarzian
NEUROBIOLOGY OF DISEASE
(2020)
Article
Immunology
Hemraj B. Dodiya, Thomas Kuntz, Shabana M. Shaik, Caroline Baufeld, Jeffrey Leibowitz, Xulun Zhang, Neil Gottel, Xiaoqiong Zhang, Oleg Butovsky, Jack A. Gilbert, Sangram S. Sisodia
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Multidisciplinary Sciences
Hemraj B. Dodiya, Mary Frith, Ashley Sidebottom, Yajun Cao, Jason Koval, Eugene Chang, Sangram S. Sisodia
SCIENTIFIC REPORTS
(2020)
Review
Microbiology
Irina Spacova, Hemraj B. Dodiya, Anna-Ursula Happel, Conall Strain, Dieter Vandenheuvel, Xuedan Wang, Gregor Reid
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Immunology
Hemraj B. Dodiya, Holly L. Lutz, Ian Q. Weigle, Priyam Patel, Julia Michalkiewicz, Carlos J. Roman-Santiago, Can Martin Zhang, Yingxia Liang, Abhinav Srinath, Xulun Zhang, Jessica Xia, Monica Olszewski, Xiaoqiong Zhang, Matthew John Schipma, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, Sangram S. Sisodia
Summary: Researchers characterized a mouse model of A beta amyloidosis with a perturbed microbiome and demonstrated the causality between gut microbiota, microglia, A beta, and neurodegeneration using fecal transplantation approaches and microglial depletion studies. They found that short-term high-dose antibiotic treatment in preweaned male mice led to reductions in A beta amyloidosis and degenerative changes, and fecal microbiota transplantation from donor mice restored these changes. Microglia play a critical role in driving gut microbiome-mediated alterations of cerebral A beta deposition.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Yogesh Garg, Navjot Kanwar, Shruti Chopra, Murtaza M. Tambuwala, Hemraj Dodiya, Amit Bhatia, Abhinav Kanwal
Summary: The gut microbiome has a significant impact on heart health, with metabolic pathways and interactions with the immune system playing a key role. Alterations in the gut microbiome can lead to cholesterol deposition and damage heart health. By targeting the gut microbiome and regulating metabolic pathways, heart function can be improved and cardiovascular diseases can be prevented.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Substance Abuse
Christopher B. Forsyth, Maliha Shaikh, Faraz Bishehsari, Garth Swanson, Robin M. Voigt, Hemraj Dodiya, Peter Wilkinson, Beata Samelco, Shiwen Song, Ali Keshavarzian
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2017)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
