Article
Multidisciplinary Sciences
Xiaodong Liu, Jia Ping Tan, Jan Schroder, Asma Aberkane, John F. Ouyang, Monika Mohenska, Sue Mei Lim, Yu B. Y. Sun, Joseph Chen, Guizhi Sun, Yichen Zhou, Daniel Poppe, Ryan Lister, Amander T. Clark, Owen J. L. Rackham, Jennifer Zenker, Jose M. Polo
Summary: The study describes a method to reprogram fibroblasts into human blastocyst models, known as iBlastoids. This model can mimic the overall structure of blastocysts, including inner cell mass, epiblast, primitive endoderm-like cells, blastocoel-like cavity, and trophectoderm-like cells. The iBlastoids system is believed to facilitate the study of early human development, the effects of gene mutations and toxins during early embryogenesis, and the development of new therapies associated with in vitro fertilization.
Article
Chemistry, Multidisciplinary
Deogil Kim, Byung-Hyun Cha, Jinsung Ahn, Yoshie Arai, Bogyu Choi, Soo-Hong Lee
Summary: Understanding the biophysical relationships between stem cells and applied biomaterials is crucial in controlling stem cell functions. This study highlights the significant role of 3D microenvironment, particularly methacrylated hyaluronic acid (HA) hydrogel, in improving cellular reprogramming into iPSCs. The incorporation of cues from the 3D microenvironment accelerates the reprogramming process, offering potential advantages for translational applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Cell Biology
Bogdan B. Grigorash, Dominic van Essen, Guixian Liang, Laurent Grosse, Alexander Emelyanov, Zhixin Kang, Alexey Korablev, Benoit Kanzler, Clement Molina, Elsa Lopez, Oleg N. Demidov, Carmen Garrido, Feng Liu, Simona Saccani, Dmitry V. Bulavin
Summary: Depletion of senescent cells can promote the reprogramming of somatic cells into totipotent-like stem cells and have positive effects on tissue rejuvenation.
NATURE CELL BIOLOGY
(2023)
Article
Cell Biology
Miguel Salinas-Saavedra, Gabriel Krasovec, Helen R. Horkan, Andreas D. Baxevanis, Uri Frank
Summary: Cell fate stability is important for complex animals but reduces plasticity and regenerative ability. Signals from senescent cells can reprogram neighboring cells into stem cells that drive whole-body regeneration. Understanding the effects of senescence on cellular reprogramming can enhance regeneration.
Review
Multidisciplinary Sciences
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: Reprogramming astrocytes into functional dopaminergic neurons has shown promise in increasing dopamine levels and alleviating symptoms of Parkinson's disease in mouse models.
Review
Pharmacology & Pharmacy
Zheng-ping Huang, Shu-fen Liu, Jian-long Zhuang, Lin-yi Li, Mi-mi Li, Ya-li Huang, Yan-hong Chen, Xiang-rong Chen, Shu Lin, Li-chao Ye, Chun-nuan Chen
Summary: Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by damage to dopaminergic neurons. The specific pathogenesis of PD is still unknown, and current treatment methods have deficiencies. Microglial metabolic reprogramming plays a role in PD pathogenesis by affecting neuroinflammation and tissue repair. Strategies targeting specific metabolic pathways in microglia have shown potential for PD treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Y. -r. Su, S. -m. Gu, Y. -r. Liu, Y. -. Cheng, Q. . Wan, X. Sang, M. -h. Chen, W. Q. Liu, Q. Shi, C. Liu, Y. Liu, Z. -c. Wang, C. -y. LI, X. -r. Wang
Summary: Partial reprogramming can restore the self-renewal ability of senescent adult stem cells and alleviate age-related hallmarks, offering a new therapeutic approach for age-associated diseases.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Tomoaki Hishida, Mako Yamamoto, Yuriko Hishida-Nozaki, Changwei Shao, Ling Huang, Chao Wang, Kensaku Shojima, Yuan Xue, Yuqing Hang, Maxim Shokhirev, Sebastian Memczak, Sanjeeb Kumar Sahu, Fumiyuki Hatanaka, Ruben Rabadan Ros, Matthew B. Maxwell, Jasmine Chavez, Yanjiao Shao, Hsin-Kai Liao, Paloma Martinez-Redondo, Isabel Guillen-Guillen, Reyna Hernandez-Benitez, Concepcion Rodriguez Esteban, Jing Qu, Michael C. Holmes, Fei Yi, Raymond D. Hickey, Pedro Guillen Garcia, Estrella Nunez Delicado, Antoni Castells, Josep M. Campistol, Yang Yu, Diana C. Hargreaves, Akihiro Asai, Pradeep Reddy, Guang-Hui Liu, Juan Carlos Izpisua Belmonte
Summary: Mammals have limited regenerative capacity, but inducing specific factor expression can enhance liver regeneration. This study provides a new avenue for tissue regeneration.
Review
Neurosciences
Sahar Avazzadeh, Jara Maria Baena, Cameron Keighron, Yajaira Feller-Sanchez, Leo R. Quinlan
Summary: Parkinson's Disease is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms, with the underlying cause being degeneration of dopaminergic neurons. By using human induced pluripotent stem cell technology, it has become possible to recapitulate the myriad of phenotypes underlying the PD pathology. This offers an opportunity to study many aspects of PD phenotypes in a dish and understand the pathogenesis of PD.
Article
Cell Biology
Gracia Mendoza, Rebeca Gonzalez-Pastor, Juan Miguel Sanchez, Altamira Arce-Cerezo, Miguel Quintanilla, Gema Moreno-Bueno, Anna Pujol, Carolina Belmar-Lopez, Alba de Martino, Efren Riu, Tristan A. Rodriguez, Pilar Martin-Duque
Summary: The induction of pluripotency can be achieved by enforced expression of different gene combinations in somatic cells. A previous report showed that the adenoviral E1a gene can induce the expression of two Yamanaka factors and epigenetic changes. In this study, the over-expression of E1a-12S was found to be sufficient to induce pluripotent-like characteristics in mouse embryonic fibroblasts through the activation of the pluripotency gene regulatory network. These findings provide empirical evidence for partial reprogramming with a single factor and a potential mechanistic explanation for viral-induced neoplasia.
Article
Multidisciplinary Sciences
Stefanie Koster, Rajendra Kumar Gurumurthy, Naveen Kumar, Pon Ganish Prakash, Jayabhuvaneshwari Dhanraj, Sofia Bayer, Hilmar Berger, Shilpa Mary Kurian, Marina Drabkina, Hans-Joachim Mollenkopf, Christian Goosmann, Volker Brinkmann, Zachary Nagel, Mandy Mangler, Thomas F. Meyer, Cindrilla Chumduri
Summary: Using cervical organoid models, this study explores the dynamics of individual and coinfection with Human papillomavirus (HPV) and Chlamydia. The findings reveal that Chlamydia can interfere with HPV-induced mechanisms and potentially contribute to carcinogenesis.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Nitzan Gonen, Caroline Eozenou, Richard Mitter, Maeva Elzaiat, Isabelle Stevant, Rona Aviram, Andreia Sofia Bernardo, Almira Chervova, Somboon Wankanit, Emmanuel Frachon, Pierre-Henri Commere, Sylvie Brailly-Tabard, Leo Valon, Laura Barrio Cano, Romain Levayer, Inas Mazen, Samy Gobaa, James C. Smith, Kenneth McElreavey, Robin Lovell-Badge, Anu Bashamboo
Summary: During embryonic development, signaling cascades determine the fate of gonads. Errors in this process result in disorders of sex development. This study provides a protocol for differentiating pluripotent cells into gonadal progenitors and demonstrates their equivalence to embryonic progenitors. The study also shows the potential of using induced pluripotent stem cells to model DSDs and investigate sex determination mechanisms.
Article
Neurosciences
Yu-Chen Yan, Yan-hua Li, Bao-Guo Xiao, Jian Wang, Jian-Ying Xi, Wen-Bo Yu
Summary: Bone marrow-derived neural stem cells (BM-NSCs) have shown potential as a therapeutic approach for Parkinson's disease (PD). This study demonstrated that the combination of fasudil, a Rho-kinase inhibitor, and BM-NSCs has a synergistic effect in restoring neuron loss in a PD mouse model. The cellular mechanisms underlying this synergy include promoting the proliferation and migration of endogenous NSCs and inducing microglia to shift into the M2 phenotype. Corresponding molecular mechanisms involve inhibiting inflammation, increasing neurotrophic factors, and activating WNT/beta-catenin and PI3K/Akt/mTOR signaling pathways.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David A. Yefroyev, Sha Jin
Summary: Neurodegenerative diseases are severe pathologies that affect cognitive ability, motor control, and everyday function. Pluripotent stem cell technology offers hope in addressing this problem, with induced pluripotent stem cells providing an alternative and endless source without the ethical and practical concerns of embryonic stem cells. This review focuses on iPSC technology, the pathophysiology of Alzheimer's and Parkinson's diseases, and current state-of-the-art approaches using iPSCs for treatment.
Review
Biochemistry & Molecular Biology
Quentin Alle, Enora Le Borgne, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Aging is traditionally seen as an unavoidable process, but new strategies have been developed to delay or reverse aging. Some of these approaches may have medical applications to improve healthspan and longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Sarah L. Mason, Richard E. Daws, Eyal Soreq, Eileanoir B. Johnson, Rachael I. Scahill, Sarah J. Tabrizi, Roger A. Barker, Adam Hampshire
ANNALS OF NEUROLOGY
(2018)
Review
Oncology
Thomas B. Stoker, Roger A. Barker
Article
Neurosciences
Valentina Castiglioni, Andrea Faedo, Marco Onorati, Vittoria Dickinson Bocchi, Zhen Li, Raffaele Iennaco, Romina Vuono, Gaetano P. Bulfamante, Luca Muzio, Gianvito Martino, Nenad Sestan, Roger A. Barker, Elena Cattaneo
Article
Immunology
C. H. Williams-Gray, R. S. Wijeyekoon, K. M. Scott, S. Hayat, R. A. Barker, J. L. Jones
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Clinical Neurology
Lucy M. Collins, Caroline H. Williams-Gray, Elizabeth Morris, Patrick Deegan, Timothy M. Cox, Roger A. Barker
JOURNAL OF NEUROLOGY
(2018)
Article
Neurosciences
Julia C. Greenland, Caroline H. Williams-Gray, Roger A. Barker
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Clinical Neurology
Mayke Oosterloo, Emilia Bijlsma, Sander van Kuijk, Floor Minkes, Raymund Roos, C. E. M. de Die-Smulders
PARKINSONISM & RELATED DISORDERS
(2019)
Review
Neurosciences
Thomas B. Stoker, Kelli M. Torsney, Roger A. Barker
FRONTIERS IN NEUROSCIENCE
(2018)
Editorial Material
Cell & Tissue Engineering
Jeremy Sugarman, Roger A. Barker, Ian Kerridge, Tamra Lysaght, Graziella Pellegrini, Douglas Sipp, Claire Tanner
Article
Clinical Neurology
Alice J. White, Ruwani S. Wijeyekoon, Kirsten M. Scott, Nushan P. Gunawardana, Shaista Hayat, I. H. Solim, H. T. McMahon, Roger A. Barker, Caroline H. Williams-Gray
FRONTIERS IN NEUROLOGY
(2018)
Editorial Material
Clinical Neurology
Roger Barker, Sarah L. Mason
Article
Neurosciences
Jerome Lamontagne-Proulx, Isabelle St-Amour, Richard Labib, Jeremie Pilon, Helena L. Denis, Nathalie Cloutier, Florence Roux-Dalvai, Antony T. Vincent, Sarah L. Mason, Caroline Williams-Gray, Anne-Claire Duchez, Arnaud Droit, Steve Lacroix, Nicolas Dupre, Melanie Langlois, Sylvain Chouinard, Michel Panisset, Roger A. Barker, Eric Boilard, Francesca Cicchetti
NEUROBIOLOGY OF DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Roger A. Barker, Krista Farrell, Natalie Valle Guzman, Xiaoling He, Stanley E. Lazic, Sarah Moore, Robert Morris, Pamela Tyers, Ruwani Wijeyekoon, Danielle Daft, Sam Hewitt, Viswas Dayal, Thomas Foltynie, Zinovia Kefalopoulou, Philipp Mahlknecht, Nick P. Lao-Kaim, Paola Piccini, Hjalmar Bjartmarz, Anders Bjorklund, Olle Lindvall, Jenny Nelander-Wahlestedt, Malin Parmar, Gesine Paul, Hakan Widner, Alistair Church, Stephen Dunnett, Kathryn Peall, Anne Rosser, Jean Marc Gurruchaga, Stephane Palfi, Tobias Piroth, Christian Winkler
Article
Public, Environmental & Occupational Health
Valentina Gallo, Paolo Vineis, Mariagrazia Cancellieri, Paolo Chiodini, Roger A. Barker, Carol Brayne, Neil Pearce, Roel Vermeulen, Salvatore Panico, Bas Bueno-de-Mesquita, Nicola Vanacore, Lars Forsgren, Silvia Ramat, Eva Ardanaz, Larraitz Arriola, Jesper Peterson, Oskar Hansson, Diana Gavrila, Carlotta Sacerdote, Sabina Sieri, Tilman Kuehn, Verena A. Katzke, Yvonne T. van der Schouw, Andreas Kyrozis, Giovanna Masala, Amalia Mattiello, Robert Perneczky, Lefkos Middleton, Rodolfo Saracci, Elio Riboli
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Neurosciences
Paul McNulty, Richard Pilcher, Raviram Ramesh, Renata Necuiniate, Alis Hughes, Daniel Farewell, Peter Holmans, Lesley Jones
JOURNAL OF HUNTINGTONS DISEASE
(2018)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
