Article
Biology
Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li, Songhe Jiang
Summary: Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain. Electroacupuncture (EA) has a beneficial effect on the treatment of neuropathic pain, but the specific mechanism remains unclear.
BIOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ewa Baczynska, Katarzyna Karolina Pels, Subhadip Basu, Jakub Wlodarczyk, Blazej Ruszczycki
Summary: This article reviews experimental approaches designed to assess quantitative features of dendritic spines under physiological stimuli and in pathological conditions. By comparing various methodological pipelines and systematically summarizing the methodology and results of relevant experiments, the focus is on quantitative data regarding the number of animals, cells, dendritic spines, types of studied parameters, size of observed changes, and their statistical significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xingfeng Liu, Site Li, Wenyu Zhang, Zhuo Xie, Jingxin He, Xuanwei Zhang, Shouyang Yu, Song Cao, Tian Yu, Zhi Xiao
Summary: Repetitive noxious stimuli in neonates have long-term harmful effects on nociceptive processing, learning, and memory. Plasticity-related gene 1 (PRG-1) regulates synaptic plasticity and functional reorganization in the brain. This study shows that neonatal repetitive noxious stimuli lead to hyperalgesia, allodynia, and impairments in learning and memory, which are associated with the interaction between PRG-1 and N-ethylmaleimide sensitive fusion protein (NSF), enhanced glutamate release, and deficiency in AMPAR GluR2 trafficking.
Article
Neurosciences
Qiaoyun Wu, Jingjing Yue, Li Lin, Xiaolan Yu, Ye Zhou, Xinwang Ying, Xiaolong Chen, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Kecheng Zhou, Songhe Jiang
Summary: Electroacupuncture (EA) treatment reduces abnormal dendritic spine/synaptic remodeling and inflammation in neuropathic pain by downregulating P2X7 receptor expression. The experiment showed that EA has a significant positive effect on neuropathic pain, while the P2X7 receptor agonist BzATP has a negative impact on it.
Article
Multidisciplinary Sciences
Kathryn J. Bjornson, Amanda M. Vanderplow, Yezi Yang, Danielle R. Anderson, Bailey A. Kermath, Michael E. Cahill
Summary: This study found that repeated stress leads to increased levels of synaptic Rapt protein in the hippocampal region, resulting in changes in dendritic spines and cognitive phenotypes. By using super resolution imaging, the study revealed how the Rapt protein affects the stability of specific dendritic spines. These findings highlight the involvement of aberrant Rapt regulation in the hippocampus in contributing to the psychobiological effects of stress.
Article
Neurosciences
Norbert Hogrefe, Sigrid M. Blom, Kristina Valentinova, Niels R. Ntamati, Lotte J. E. Jonker, Natalie E. Nevian, Thomas Nevian
Summary: Malfunctioning synaptic plasticity is a major mechanism in the development of chronic pain. This study shows that even after recovery, the impact of chronic compression injury on synaptic plasticity persists.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Jessica Taubert, Shruti Japee
Summary: The review highlights the potential of using FACS to compare mechanisms responsible for facial behaviors across species and to study facial behavior recognition in nonhuman subjects. By utilizing FACS-rated images in awake neuroimaging experiments, researchers can identify brain mechanisms responsible for recognizing expressions across mammalian species, which deepens our understanding of nonverbal social communication evolution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Charalampos Labrakakis
Summary: The transition from normal to chronic pain involves changes in multiple brain areas associated with pain perception. The insular cortex is consistently activated in pain studies of both normal and chronic pain patients. This review provides an overview of the insular function and its role in pain perception, highlighting the need for further studies on the mechanisms underlying the involvement of the insula in chronic pain and comorbid disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Wei Cui, Yize Li, Zhen Wang, Chengcheng Song, Yonghao Yu, Guolin Wang, Jing Li, Chunyan Wang, Linlin Zhang
Summary: The study showed that after orthopedic surgery, chronic postoperative pain can hinder functional recovery. This is related to the role of caspase-6 and netrin-1 in excitatory synaptic plasticity and pain. Caspase-6 modulation and netrin-1 secretion play key roles in the development of fracture-related postsurgical pain in mice by affecting AMPAR activation and spine morphology.
Editorial Material
Biochemistry & Molecular Biology
David Colameo, Gerhard Schratt
Summary: This article investigates the plasticity mechanisms of neurons in the face of network activity disruptions. The study reveals that individual synapses are tagged for future strengthening during periods of chronic inactivity. These findings support the role of local mechanisms in homeostatic synaptic plasticity.
Review
Anesthesiology
Annina B. B. Schmid, Brigitte Tampin, Ralf Baron, Nanna B. B. Finnerup, Per Hansson, Aki Hietaharju, Kika Konstantinou, Chung-Wei Christine Lin, John Markman, Christine Price, Blair H. H. Smith, Helen Slater
Summary: This article presents the outcomes of a working group commissioned by the Neuropathic Pain Special Interest Group (NeuPSIG) of the International Association for the Study of Pain (IASP), which aimed to revise the use of terminology for classifying spine-related leg pain and propose a way forward on the identification of neuropathic pain in this context.
Article
Biochemistry & Molecular Biology
Qiaoyun Wu, Jie Chen, Jingjing Yue, Xinwang Ying, Ye Zhou, Xiaolong Chen, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Kecheng Zhou, Songhe Jiang
Summary: Electroacupuncture promotes neuronal plasticity and suppresses SNL-induced neuropathic pain by upregulating the A2AR/cAMP/PKA signaling pathway.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Neurosciences
Gary Jean, Joseph Carton, Kaleem Haq, Alberto E. Musto
Summary: Epilepsy is a chronic CNS disease with no known disease-modifying therapy. The generation of aberrant neuronal networks is considered a leading mechanism of epileptogenesis. Changes in dendritic spine morphology, associated with altered expression of various proteins and molecules, may contribute to the hyperexcitability and abnormal synaptic connections seen in epilepsy. Targeting dendritic spine machinery could potentially limit or reverse the development of epilepsy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Editorial Material
Psychology, Multidisciplinary
Thomas A. Widiger, Joshua D. Miller, Donald R. Lynam, Douglas B. Samuel
Summary: The article proposes replacing personality disorders with a new classification of interpersonal disorders. It suggests that the trait model effectively addresses the limitations of categorical syndromes in personality disorders and incorporates the dynamics emphasized in the interpersonal model. Weaknesses of the interpersonal model that have prevented its official adoption are identified.
AMERICAN PSYCHOLOGIST
(2023)
Review
Clinical Neurology
Manmin Zhu, Hao Huang
Summary: Pain disrupts sleep and sleep deprivation can alter pain perception. The mechanism by which sleep affects neuropathic pain remains unclear, but there is evidence that sleep deprivation affects various injurious systems involved in neuropathic pain regulation.
NATURE AND SCIENCE OF SLEEP
(2023)
Article
Anesthesiology
Nilesh M. Agalave, Resti Rudjito, Alex Bersellini Farinotti, Payam Emami Khoonsari, Katalin Sandor, Yuki Nomura, Thomas A. Szabo-Pardi, Carlos Morado Urbina, Vinko Palada, Theodore J. Price, Helena Erlandsson Harris, Michael D. Burton, Kim Kultima, Camilla Svensson
Summary: The study explored the differential effects of TLR4-activating HMGB1 on microglia in male and female mice, finding higher cytokine and chemokine expression in males. Only male mice were protected from HMGB1-induced mechanical hypersensitivity with TLR4 ablation in myeloid-derived cells and minocycline treatment. Liquid chromatography-mass spectrometry revealed upregulation of antinociceptive proteins in male mice after minocycline administration, with alpha-1-antitrypsin offering partial protection against HMGB1-induced pain specifically in males.
Article
Anesthesiology
Resti Rudjito, Nilesh M. Agalave, Alex Bersellini Farinotti, Peter Lundback, Thomas A. Szabo-Pardi, Theodore J. Price, Helena Erlandsson Harris, Michael D. Burton, Camilla Svensson
Summary: The study found elevated expression of HMGB1 in ankle joints of male and female mice with collagen antibody-induced arthritis. Blocking peripheral HMGB1 reversed hypersensitivity only in male mice. The study also showed a sex- and cellular location-dependent roles of HMGB1 and TLR4 in peripheral pain mechanisms.
Article
Clinical Neurology
Jacob Lackovic, Theodore J. Price, Gregory Dussor
Summary: This study indicates that protein synthesis plays a critical role in the development of priming in preclinical models of migraine, suggesting that targeting the regulation of protein synthesis may offer new approaches for migraine treatment strategies.
Article
Clinical Neurology
Juliet Mwirigi, Moeno Kume, Shayne N. Hassler, Ayesha Ahmad, Pradipta R. Ray, Changyu Jiang, Alexander Chamessian, Nakleh Mseeh, Breya P. Ludwig, Benjamin D. Rivera, Marvin T. Nieman, Thomas van de Ven, Ru-Rong Ji, Gregory Dussor, Scott Boitano, Josef Vagner, Theodore J. Price
Summary: PAR3, a member of the PAR family of GPCRs, is expressed widely in DRG neurons and may act as a coreceptor for other PARs in the peripheral sensory nervous system. Its selective activation by a peptide agonist suggests a contribution to nociception in various contexts and modulation of other PARs' activity.
Article
Anesthesiology
Paulino Barragan-Iglesias, Nikesh Kunder, Andi Wanghzou, Bryan Black, Pradipta R. Ray, Tzu-Fang Lou, June Bryan de la Pena, Rahul Atmaramani, Tarjani Shukla, Joseph J. Pancrazio, Theodore J. Price, Zachary T. Campbell
Summary: The study reveals widespread translation in regions annotated as noncoding in nociceptors, as well as in regulatory regions of mRNAs. A specific uORF-encoded peptide promotes pain sensitization through GPCR signaling.
Review
Pharmacology & Pharmacy
Muhammad Saad Yousuf, Stephanie Shiers, James J. Sahn, Theodore J. Price, Robert Dantzer
Summary: Translation dysregulation is recognized as a characteristic of many diseases, including chronic pain. Current treatments for chronic pain are not effective and have adverse effects, necessitating the development of novel approaches. Pharmacologically targeting specific translation regulation mechanisms may offer promising new treatments for chronic pain disorders by reversing key neuronal phenotypic changes.
PHARMACOLOGICAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Woo Seok Kim, Sungcheol Hong, Milenka Gamero, Vivekanand Jeevakumar, Clay M. Smithhart, Theodore J. Price, Richard D. Palmiter, Carlos Campos, Sung Il Park
Summary: The study introduces a novel wireless optoelectronic device for precise and chronic in vivo optogenetic manipulations of peripheral neural circuits. The research uncovers the role of specific stomach neural fibers in suppressing appetite.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Stephanie Shiers, Ishwarya Sankaranarayanan, Vivek Jeevakumar, Anna Cervantes, Jeffrey C. Reese, Theodore J. Price
Summary: The study found that most nociceptors in humans express multiple markers and exhibit differences in central projection patterns compared to mice. Understanding how human nociceptors connect to subsets of dorsal horn neurons is crucial for understanding the physiological consequences of species differences.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Clinical Neurology
Amanda Avona, Bianca N. Mason, Carolina Burgos-Vega, Anahit H. Hovhannisyan, Sergei N. Belugin, Jennifer Mecklenburg, Vincent Goffin, Naureen Wajahat, Theodore J. Price, Armen N. Akopian, Gregory Dussor
Summary: This study found an interaction between prolactin and CGRP in the meninges of rodents, leading to female-specific migraine behaviors, potentially explaining the higher prevalence of migraines in women.
ANNALS OF NEUROLOGY
(2021)
Article
Clinical Neurology
Amanda Avona, Theodore J. Price, Gregory Dussor
Summary: The study found that stimulation of upper body regions with IL-6 can cause widespread hypersensitivity spreading to the paws, but similar stimulation of the lower body does not cause the spread of hypersensitivity into the head. These findings are consistent with whole body hypersensitivity being specific to conditions such as migraine where pain is present in the head.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Cell Biology
Katelyn E. Sadler, Francie Moehring, Stephanie Shiers, Lauren J. Laskowski, Alexander R. Mikesell, Zakary R. Plautz, Allison N. Brezinski, Christina M. Mecca, Gregory Dussor, Theodore J. Price, John D. McCorvy, Cheryl L. Stucky
Summary: The study identified TRPC5 as a key contributor to tactile and spontaneous pain in multiple rodent pain models, particularly in conditions characterized by elevated LPC concentrations. 75% of human sensory neurons express TRPC5, and its activity is directly modulated by LPC.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Summary: This study investigates the astrocyte heterogeneity in the spinal cord and its potential role in synaptic generation. The results suggest that the distribution of astrocyte subpopulations and the expression of synapse formation-associated genes did not change significantly after spinal cord injury in mice. These findings indicate a possible conservation of spinal cord astrocyte heterogeneity across species.
Review
Clinical Neurology
Steven J. Middleton, Allison M. Barry, Maddalena Comini, Yan Li, Pradipta R. Ray, Stephanie Shiers, Andreas C. Themistocleous, Megan L. Uhelski, Xun Yang, Patrick M. Dougherty, Theodore J. Price, David L. Bennett
Summary: Studying human nociceptors has led to significant advances in understanding chronic pain mechanisms and identifying potential new therapeutic targets. However, challenges remain in implementing these techniques at scale, generating a full diversity of nociceptor populations from induced pluripotent stem cells, and understanding inter-individual variation in nociceptors.
Article
Medicine, Research & Experimental
Jenolyn F. Alexander, Alexandre Seua, Luis D. Arroyo, Pradipta R. Ray, Andi Wangzhou, Laura Heiss-Lueckemann, Manfred Schedlowski, Theodore J. Price, Annemieke Kavelaars, Cobi J. Heijnen
Summary: The study demonstrated that nasal administration of mitochondria isolated from human mesenchymal stem cells restored cognitive function in mice and reversed cisplatin-induced cognitive deficits by altering gene expression in the hippocampus.
Review
Neurosciences
Amelia J. McFarland, Muhammad S. Yousuf, Stephanie Shiers, Theodore J. Price
Summary: COVID-19 infection interacts with the peripheral nervous system to induce pain through multiple potential mechanisms, including direct and indirect effects on neuronal excitability to promote and worsen pain states.
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
