Review
Biochemistry & Molecular Biology
Cristina Solana-Manrique, Francisco Jose Sanz, Guillermo Martinez-Carrion, Nuria Paricio
Summary: Neurodegenerative diseases pose a significant challenge and burden to human health globally, and carnosine, a natural molecule, shows potential neuroprotective effects, particularly in the most common neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Article
Neurosciences
Suleyman Serdar Alkanli, Nevra Alkanli, Arzu Ay, Isil Albeniz
Summary: Understanding the pathogenic mechanisms of neurological disorders is crucial for their treatment. The CRISPR/Cas9 system combined with iPSCs plays a crucial role in treating Huntington's disease by correcting disease-related phenotypic abnormalities and gene expression changes.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mansoureh Tavan, Parichehr Hanachi, Maria de la Luz Cadiz-Gurrea, Antonio Segura Carretero, Mohammad Hossein Mirjalili
Summary: Neurodegenerative disorders are characterized by mitochondrial dysfunction, which leads to oxidative stress, inflammation, and apoptosis, causing neuronal cytotoxicity and degeneration. Researchers have discovered various natural phytochemicals that can potentially treat these diseases. Natural phenolic compounds, particularly polyphenols, have gained attention due to their diverse biological activities and therapeutic efficacy in human health. By modulating cellular functions, polyphenols play an important role in neuroprotection and can counteract the effects of oxidative stress, inflammation, and apoptosis in animal models.
NEUROCHEMICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Awanish Mishra, Pragya Shakti Mishra, Ritam Bandopadhyay, Navneet Khurana, Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi
Summary: Chrysin, a herbal bioactive molecule, demonstrates various pharmacological effects including antioxidant, anti-inflammatory, neuroprotective, and anti-cancer properties. It has been studied for potential benefits in treating neurological disorders, with a focus on molecular mechanisms and challenges and opportunities in neurotherapeutics.
Article
Nutrition & Dietetics
Elena Gonzalez-Burgos, Isabel Urena-Vacas, Marta Sanchez, M. Pilar Gomez-Serranillos
Summary: Moringa oleifera leaf powder methanol extracts possess high phenolic content and antioxidant activity, providing neuroprotective effects against H2O2-induced oxidative stress and safeguarding mitochondrial function.
Review
Nutrition & Dietetics
Yadong Zheng, Laura Bonfili, Tao Wei, Anna Maria Eleuteri
Summary: The gut-brain axis is a complex communication network between the gut and brain, involving neural, immune, and endocrine pathways. The gut microbiota plays an important role in this axis and its dysbiosis has been associated with neurodegenerative disorders. Manipulating the gut microbiota shows promise as a potential therapeutic target for these diseases.
Review
Neurosciences
Yu Yang, Xuan Zhou, Xinpeng Liu, Ruying Song, Yiming Gao, Shuai Wang
Summary: This article summarizes the importance of UPS in the nervous system, as well as the role and mechanism of FBXW7 in neurodevelopment and neurodegenerative disorders, highlighting the prospect of targeting FBXW7 as a therapeutic target.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Altair Brito Dos Santos, Siganya Thaneshwaran, Lara Kamal Ali, Cesar Ramon Romero Leguizamon, Yang Wang, Morten Pilgaard Kristensen, Annette E. Langkilde, Kristi A. Kohlmeier
Summary: This study found that a-syn(M) has different effects on female LDT neurons compared to male. In females, a-syn(M) decreases membrane excitability and reduces intracellular calcium, which depends on inhibitory acid transmission and leads to decreased amplitude and frequency of sEPSCs, as well as reduced action potential firing rate. It was also found that a-syn(M) induces higher neurodegeneration in males compared to females through inhibitory amino acid transmission. GABA receptor agonists were associated with reduced cell death in males.
CELL AND BIOSCIENCE
(2023)
Review
Neurosciences
Arezoo Faridzadeh, Yasaman Salimi, Hamidreza Ghasemirad, Meraj Kargar, Ava Rashtchian, Golnaz Mahmoudvand, Mohammad Amin Karimi, Nasibeh Zerangian, Negar Jahani, Anahita Masoudi, Bahare Sadeghian Dastjerdi, Marieh Salavatizadeh, Hamidreza Sadeghsalehi, Niloofar Deravi
Summary: Neurological disorders are prevalent worldwide, with expensive traditional treatments and many side effects. However, herbal medications such as sage, lavender, and rosemary are popular due to their affordability and fewer side effects. These plants show potential in treating common neurological disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Ekta Yadav, Pankajkumar Yadav, Mohd Masih Uzzaman Khan, HariOm Singh, Amita Verma
Summary: Polyphenols, such as resveratrol, have the ability to cross the blood-brain barrier and are widely used in the treatment of neurodegenerative diseases by targeting mitochondria. These diseases, including Alzheimer's and Parkinson's, are primarily caused by mitochondrial dysfunction and have significant public health implications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yun-Jeong Ji, Hyung Don Kim, Eun Suk Lee, Gwi Yeong Jang, Hyun-A Seong
Summary: This study analyzes the effects of thermal processing on the bioactivities of crude ginseng saponin. Heat treatment increases the contents of minor ginsenosides in crude saponins. Heat-treated crude ginseng saponin (HGS) has better neuroprotective effects than non-treated crude saponin (NGS). HGS reduces glutamate-induced apoptosis and reactive oxygen species generation by upregulating Nrf2-mediated antioxidant signaling and downregulating MAPK-mediated apoptotic signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Sueun Lee, Seung Mok Ryu, Do-Hyun Kim, Ye Eun Lee, Sung-Jun Lee, Sohi Kang, Joong Sun Kim, Soong-In Lee
Summary: The study aimed to evaluate the therapeutic efficacy of GDT for TMT-induced hippocampal neurodegeneration and seizures at the molecular level.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Yue Zhang, Meiyan Sun, Hongxiang Zhao, Zhengyan Wang, Yanan Shi, Jianxin Dong, Kaifang Wang, Xi Wang, Xingyue Li, Haiyan Qi, Xiaoyong Zhao
Summary: This review discusses the multiple pharmacological activities of DCA in neuroprotection and its therapeutic effects on different diseases. The causes and solutions of DCA's adverse effects are also explored.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Chemistry, Medicinal
Ahmed S. S. Al-Shami, Amina E. E. Essawy, Heba-Tallah Abd Elrahim Abd Elkader
Summary: Neurodegenerative disorders are a heterogeneous and incurable group of brain disorders characterized by progressive degeneration of the nervous system. Phytoestrogenic-isoflavones, particularly those found in Trifolium pratense, have been identified as potential therapeutic agents for neurodegenerative disorders. This review article highlights the molecular mechanisms and pharmacological findings regarding the neuroprotective properties of phytoestrogenic-isoflavones.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nutrition & Dietetics
Seong-Lae Jo, Hyun Yang, Kang-Joo Jeong, Hye-Won Lee, Eui-Ju Hong
Summary: Inflammation is a natural defense mechanism, but chronic inflammation can lead to various chronic diseases. Neuroinflammation in the central nervous system is important in the development of neurodegenerative diseases. Polyphenol-rich natural products, such as Ecklonia cava, have anti-inflammatory and antioxidant properties and can be used to control neuroinflammation in the treatment of neurodegenerative diseases. In this study, we found that Ecklonia cava extract can reduce the levels of pro-inflammatory cytokines and markers of inflammation and neurodegeneration in mice with chronic inflammation induced by lipopolysaccharide.
Article
Agriculture, Multidisciplinary
Min Li, Laura E. Griffin, Sydney Corbin, Andrew P. Neilson, Mario G. Ferruzzi
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Agriculture, Multidisciplinary
Sydney E. Moser, Jin-E Shin, Prabhakar Kasturi, Bruce R. Hamaker, Mario G. Ferruzzi, Nicolas Bordenave
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Psychiatry
Chad Smith, Kyle J. Trageser, Henry Wu, Francis J. Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinetti
Summary: Research on the impact of sleep deprivation on anxiety and anxiolytic properties reveals that a flavanol-rich dietary preparation can alleviate neuroimmune activation and reduce anxiety. Additionally, the study found that sleep deprivation alters the expression of circadian genes, leading to changes in NLRP3 expression and IL-1 beta production.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Maria Sebastian-Valverde, Henry Wu, Md Al Rahim, Roberto Sanchez, Kunal Kumar, Robert J. De Vita, Giulio Maria Pasinetti
Summary: Inflammasomes are involved in host response to danger signals, with potential therapeutic implications for autoimmune diseases, diabetes, and neurodegenerative disorders. Inhibiting the ATPase activity of NLRP3 disrupts inflammasome function, highlighting the need for new compounds with therapeutic potential. Computational modeling and virtual screening identified novel compounds as potential NLRP3 inhibitors, setting the basis for rational design of inflammasome-targeting drugs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Food Science & Technology
Aurelie Bechoff, Apurba Shee, Brighton M. Mvumi, Patrick Ngwenyama, Hawi Debelo, Mario G. Ferruzzi, Loveness K. Nyanga, Sarah Mayanja, Keith I. Tomlins
Summary: Postharvest losses (PHLs) have a significant impact on food security and nutrient availability in low- and middle-income countries. This study developed a methodology and tool to estimate nutritional postharvest losses (NPHLs) for various food commodities in sub-Saharan Africa. The findings suggest that reducing PHLs along food value chains could greatly improve access to nutritious food for vulnerable populations.
Review
Agriculture, Multidisciplinary
Mary Ann Lila, Roberta Targino Hoskin, Mary H. Grace, Jia Xiong, Renee Strauch, Mario Ferruzzi, Massimo Iorizzo, Colin Kay
Summary: Protein-polyphenol aggregate particles can enhance the health effects of functional food products. Evidence suggests that the complexation of polyphenolic compounds can protect them during transit in the gastrointestinal tract, allowing them to exert their health benefits in the colon.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
John R. N. Taylor, Mario G. Ferruzzi, Cheikh Ndiaye, Djibril Traor, Violet K. Mugalavai, Hugo De Groote, Cheryl O. ' Brien, Timothy J. Rendall, Bruce R. Hamaker
Summary: Small and micro food enterprises are important partners for fortification strategies to address micronutrient deficiencies in low-income countries. This paper discusses Entrepreneur-led Food Fortification (ElFF), which involves collaborations between US and African food and nutrition R&D organizations and African small-scale food processors. ElFF can overcome challenges faced by these enterprises and achieve business scale and nutritional impact through providing value propositions, product distribution and marketing. The example of entrepreneur-led production of fortified grain-based instant porridge flour illustrates a framework for successful implementation of ElFF in local markets and government nutrition strategies.
GLOBAL FOOD SECURITY-AGRICULTURE POLICY ECONOMICS AND ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Michael P. Dzakovich, Hawi Debelo, Marc C. Albertsen, Ping Che, Todd J. Jones, Marissa K. Simon, Zuo-Yu Zhao, Kimberly Glassman, Mario G. Ferruzzi
Summary: Vitamin A, iron, and zinc deficiencies are common in sub-Saharan Africa, particularly among women and children. Biotechnology has been used to enhance the content and bioaccessibility of provitamin A carotenoids and minerals in staple crops, but the simultaneous enhancement of both carotenoids and minerals has not been thoroughly studied. This research evaluated genetically engineered constructs containing heterologous genes to improve carotenoid stability and pathway flux, and phytase to increase mineral bioaccessibility. The results showed significant increases in carotenoid content and improved mineral bioaccessibility in the transgenic events compared to control groups. These findings suggest that combined approaches to enhance micronutrient content and bioaccessibility are feasible and should be further studied in human trials.
Article
Biochemistry & Molecular Biology
Abigayle M. R. Simpson, Mary Jane De Souza, Janhavi Damani, Connie Rogers, Nancy I. Williams, Connie Weaver, Mario G. Ferruzzi, Sydney Chadwick-Corbin, Cindy H. Nakatsu
Summary: This study aims to characterize the effect of prune supplementation on the gut microbiome of postmenopausal women. The results show that prune consumption leads to a decrease in gut microbiome diversity, and different doses of prunes have different effects on the gut microbiome. In addition, prune consumption may enrich beneficial bacterial taxa and correlate with urinary phenolic metabolites and inflammatory markers. These findings suggest that prunes may exert health effects by modulating the gut microbiome.
Article
Biochemistry & Molecular Biology
Micaela Hayes, Zulfiqar Mohamedshah, Sydney Chadwick-Corbin, Roberta Hoskin, Massimo Iorizzo, Mary Ann Lila, Andrew P. Neilson, Mario G. Ferruzzi
Summary: Insights into the impact of food matrix factors on the bioavailability of bioactive carotenoids and chlorophylls from fruits and vegetables are crucial. In vitro models were used to assess the stability, bioaccessibility, and intestinal absorption of carotenoids and chlorophylls in different forms of spinach. The results showed that spinach forms created by various drying technologies deliver similar levels of bioaccessible bioactives, and the lower gastrointestinal tract may play a significant role in the absorption of these compounds.
Article
Biochemistry & Molecular Biology
Zulfiqar Mohamedshah, Micaela Hayes, Sydney Chadwick-Corbin, Andrew P. Neilson, Mario G. Ferruzzi
Summary: The study compared the bioavailability and metabolism of phenolics between grapes and grape juice. It found that phenolics in grape juice were more easily absorbed compared to whole grapes. However, overall, the absorbable phenolics from 100% grape juice were similar to those from whole grapes, suggesting that consuming whole fruit and juice may have similar health benefits.
Article
Biochemistry & Molecular Biology
Olivia G. L. Coelho, Rita de Cassia G. Alfenas, Hawi Debelo, JoLynne D. Wightman, Mario G. Ferruzzi, Richard D. Mattes
Summary: This study found that beverages with customary flavor essence (CGJ and LP) consumed with a meal can reduce hunger, appetite, and prospective consumption, while consumption of a low polyphenolic content beverage with reduced flavor essence is associated with higher 24-hour blood glucose levels. When consumed alone, CGJ can lower glycemic responses in individuals excreting higher concentrations of phenolic metabolite, but beverages without CG polyphenols and reduced flavor essence lead to higher blood glucose responses in individuals excreting higher concentrations of caffeic acid-O-sulfate.
Article
Biochemistry & Molecular Biology
Micaela Hayes, Sydney Corbin, Candace Nunn, Marti Pottorff, Colin D. Kay, Mary Ann Lila, Massimo Iorrizo, Mario G. Ferruzzi
Summary: The study investigated the impact of genetic differences and various processing methods on the bioaccessibility of carotenoids and chlorophylls in spinach. Results showed that both genotype and processing techniques significantly influenced the bioaccessibility of these phytochemicals, with juicing having the lowest bioaccessibility and blanching having the highest.
Article
Biochemistry & Molecular Biology
Dennis P. Cladis, Abigayle M. R. Simpson, Kaitlyn J. Cooper, Cindy H. Nakatsu, Mario G. Ferruzzi, Connie M. Weaver
Summary: Research suggests that consuming polyphenol-rich fruits and vegetables, such as blueberries, is beneficial for health. However, the effects of polyphenols from dietary supplements on gut microbiota and phenolic metabolism are still unclear. It has been found that blueberry polyphenols in fruit and supplements lead to differences in gut microbial communities and phenolic metabolism.
Article
Chemistry, Multidisciplinary
Maite L. Docampo-Palacios, Anislay Alvarez-Hernandez, Angelo de Fatima, Luciano Morais Liao, Giulio M. Pasinetti, Richard A. Dixon
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
