Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Allen P. F. Chen, Lu Chen, Thomas A. Kim, Qiaojie Xiong
Summary: Dopamine plays a crucial role in controlling CNS function and its dysregulation can lead to various cognitive symptoms associated with neuropsychiatric diseases. Different brain areas have varying functions and roles for dopamine, suggesting potential differential dysregulation in different disease states.
Article
Biochemistry & Molecular Biology
Merel Dagher, Katie A. Perrotta, Sara A. Erwin, Ayaka Hachisuka, Rahul Iyer, Sotiris C. Masmanidis, Hongyan Yang, Anne M. Andrews
Summary: Targeting neurons with light-driven opsins is a commonly used approach to study cell-specific responses. In this study, the activation of dopamine neurons resulted in the release of dopamine and serotonin in the striatum, suggesting a potential interaction between these two neurotransmitters.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Ziying Yu, Lishuang Huang, Yinyin Xia, Shuqun Cheng, Cantao Yang, Chengzhi Chen, Zhen Zou, Xiaoliang Wang, Xin Tian, Xuejun Jiang, Lixiao Zhou
Summary: Parkinson's disease (PD) is a neurodegenerative disorder in which m6A modification may play a role. By establishing a PD mouse model, researchers found abnormalities in m6A regulators in learning, memory, and motor functions, as well as significant loss of TH+ neurons in the substantia nigra and striatum.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Vignayanandam Ravindernath-Jayashree Muddapu, Karthik Vijayakumar, Keerthiga Ramakrishnan, V. Srinivasa Chakravarthy
Summary: Parkinson's disease is caused by the progressive loss of dopaminergic cells in the substantia nigra pars compacta, possibly linked to metabolic deficiency. L-DOPA treatment for PD may have toxic effects on neurons. A proposed computational model aims to investigate the mechanism behind neurodegeneration and offer insights for therapeutic development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Kenan Steidel, Marina C. Ruppert, Andrea Greuel, Masoud Tahmasian, Franziska Maier, Jochen Hammes, Thilo van Eimeren, Lars Timmermann, Marc Tittgemeyer, Alexander Drzezga, David J. Pedrosa, Carsten Eggers
Summary: The network perspective of Parkinson's disease (PD) can be observed using a multimodal imaging approach. The study found that PD patients showed decreased metabolism in the midbrain, dopamine depletion in the striatum, and reduced functional connectivity between the striatum and sensorimotor and frontal areas. PD patients also exhibited stronger decline in striatocortical functional connectivity compared to healthy subjects. The severity of PD was correlated with deterioration in motor scores.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Article
Biochemistry & Molecular Biology
Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo
Summary: This study suggests a potential association between reduced ITGA7 expression and increased alpha-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. This is the first study to show a link between ITGA7 and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Peibo Xu, Hui He, Qinqin Gao, Yingying Zhou, Ziyan Wu, Xiao Zhang, Linyu Sun, Gang Hu, Qian Guan, Zhiwen You, Xinyue Zhang, Wenping Zheng, Man Xiong, Yuejun Chen
Summary: This study provides insights into the cellular heterogeneity during midbrain dopaminergic (mDA) neuron differentiation and establishes a strategy to generate highly purified donor cells for stable and predictable therapeutic outcomes.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liesbeth Reneman, Marieke van der Pluijm, Anouk Schrantee, Elsmarieke van de Giessen
Summary: The dopamine system in the brain plays a crucial role in various neurologic and psychiatric disorders, with PET and SPECT being used to visualize and measure different aspects of the system. New developments in MR imaging offer alternative ways to assess the dopamine system, with techniques like phMRI and NM-MRI showing promise for clinical application.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Cell Biology
Jie Zhao, Manish Kumar, Jeevan Sharma, Zhihai Yuan
Summary: Arbutin may improve the performance of PD mouse models by inhibiting the function of the A(2A)R and enhancing the effects of cyclic adenosine monophosphate.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Emanuela Paldino, Vincenza D'angelo, Mariangela Massaro Cenere, Ezia Guatteo, Simone Barattucci, Giorgia Migliorato, Nicola Berretta, Olaf Riess, Giuseppe Sancesario, Nicola Biagio Mercuri, Francesca Romana Fusco
Summary: This study used immunohistochemical studies to investigate neuropathological changes in a rat transgenic model of Parkinson's disease (PD). It found that in the advanced stages of the disease, there was neuronal loss in the dorsolateral part of the striatum, along with a dramatic loss of parvalbumin interneurons. A marked decrease in the neurotrophic factor called glial-derived neurotrophic factor (GDNF) was also observed in the striatum and substantia nigra of these animals. This confirms the involvement of the striatum in PD pathophysiology and the importance of GDNF in maintaining the health of the substantia nigra.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Paola Imbriani, Giuseppina Martella, Paola Bonsi, Antonio Pisani
Summary: Parkinson's disease (PD) is a multifactorial disorder with genetic and environmental factors playing a part. Mitochondrial impairment and oxidative stress are important mechanisms in PD, supported by PD-associated genes involved in mitochondrial function. Dysfunction of mitochondria is closely linked to synaptic dysfunction, which is an early event before nigrostriatal neurodegeneration in PD.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biology
Marina Yu. Kopaeva, Anton B. Cherepov, Mikhail V. Nesterenko, Irina Yu. Zarayskaya
Summary: The study showed that pretreatment with human lactoferrin significantly alleviated MPTP toxicity in mice, improving motor functions and exploratory behavior, as well as partially recovering the number of TH-positive cells in the substantia nigra and TH-positive fibers in the striatum. This suggests a neuroprotective effect and potential for neuroregeneration with lactoferrin in the treatment of neurodegenerative diseases.
Review
Cell Biology
Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Singh
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor and non-motor dysfunctions. Platelets play an important role in Parkinson's disease and may be a target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jeffrey S. Stehouwer, Matthew S. Birnbaum, Ronald J. Voll, Michael J. Owens, Susan J. Plott, Chase H. Bourke, Michael A. Wassef, Clinton D. Kilts, Mark M. Goodman
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Chemistry, Medicinal
Jeffrey S. Stehouwer, Chase H. Bourke, Michael J. Owens, Ronald J. Voll, Clinton D. Kilts, Mark M. Goodman
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2015)
Article
Chemistry, Organic
Jeffrey S. Stehouwer, Mark M. Goodman
TETRAHEDRON LETTERS
(2015)
Review
Chemistry, Medicinal
Jeffrey S. Stehouwer
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2013)
Article
Psychology, Clinical
Jonathon A. Nye, David Purselle, Christophe Plisson, Ronald J. Voll, Jeffrey S. Stehouwer, John R. Votaw, Clinton D. Kilts, Mark M. Goodman, Charles B. Nemeroff
DEPRESSION AND ANXIETY
(2013)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alice Nicol, Rajeev Krishnadas, Sue Champion, Gilles Tamagnan, Jeffrey S. Stehouwer, Mark M. Goodman, Donald M. Hadley, Sally L. Pimlott
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2012)
Review
Biochemical Research Methods
Jeffrey S. Stehouwer, Mark M. Goodman
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2013)
Article
Chemistry, Medicinal
Jeffrey S. Stehouwer, Lauryn M. Daniel, Ping Chen, Ronald J. Voll, Larry Williams, Susan J. Plott, John R. Votaw, Michael J. Owens, Leonard Howell, Mark M. Goodman
JOURNAL OF MEDICINAL CHEMISTRY
(2010)
Article
Neurosciences
Eileen K. Sawyer, Jiyoung Mun, Jonathon A. Nye, Heather L. Kimmel, Ronald J. Voll, Jeffrey S. Stehouwer, Kenner C. Rice, Mark M. Goodman, Leonard L. Howell
NEUROPSYCHOPHARMACOLOGY
(2012)
Article
Neurosciences
M. Embree, V. Michopoulos, J. R. Votaw, R. J. Voll, J. Mun, J. S. Stehouwer, M. M. Goodman, M. E. Wilson, M. M. Sanchez
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeffery Batis, Olivier Barret, David Alagille, Andrei O. Koren, Jeffrey S. Stehouwer, Kelly Cosgrove, Mark Goodman, John Seibyl, Gilles Tamagnan
NUCLEAR MEDICINE AND BIOLOGY
(2012)
Article
Neurosciences
Heather L. Kimmel, Jonathon A. Nye, Ronald Voll, Jiyoung Mun, Jeffrey Stehouwer, Mark M. Goodman, John R. Votaw, F. I. Carroll, Leonard L. Howell
Article
Psychiatry
L. L. Howell, J. A. Nye, J. S. Stehouwer, R. J. Voll, J. Mun, D. Narasimhan, J. Nichols, R. Sunahara, M. M. Goodman, F. I. Carroll, J. H. Woods
TRANSLATIONAL PSYCHIATRY
(2014)
Meeting Abstract
Biochemistry & Molecular Biology
Heather L. Kimmel, Jonathon A. Nye, Ronald J. Voll, Jeffrey S. Stehouwer, Mark M. Goodman, John Votaw, F. Ivy Carroll, Leonard L. Howell
Meeting Abstract
Psychiatry
R. Krishnadas, A. Nicol, S. Champion, S. Pimlott, J. Stehouwer, G. Tamagnan, M. Goodman, D. Hadley
EUROPEAN PSYCHIATRY
(2011)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)