Article
Clinical Neurology
Janina Krell-Roesch, Martin Rakusa, Jeremy A. Syrjanen, Argonde C. van Harten, Val J. Lowe, Clifford R. Jack, Walter K. Kremers, David S. Knopman, Gorazd B. Stokin, Ronald C. Petersen, Maria Vassilaki, Yonas E. Geda
Summary: This study examined the association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms in older non-demented adults. The results showed that lower CSF Aβ42 and higher t-tau/Aβ42 and p-tau/Aβ42 ratios were associated with depression, anxiety, and other NPS.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Fardin Nabizadeh, Kasra Pirahesh, Parya Valizadeh
Summary: The study found that the changes in CSF alpha-syn, t-tau, and p-tau were not significant enough to distinguish PD patients with and without RBD. However, CSF A beta 1-42 decreased in the short term and showed a significant difference after a while in PD patients with and without RBD.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Zhen Hong, Chen Tian, Tessandra Stewart, Patrick Aro, David Soltys, Matt Bercow, Lifu Sheng, Kayla Borden, Tarek Khrisat, Catherine Pan, Cyrus P. Zabetian, Elaine R. Peskind, Joseph F. Quinn, Thomas J. Montine, Jan Aasly, Min Shi, Jing Zhang
Summary: This study developed a reliable and fast assay to quantify alpha-syn-containing EVs in CSF for Parkinson disease diagnosis, using nanoscale flow cytometry technology. The results showed that total alpha-syn-positive and aggregated alpha-syn-positive EVs in CSF may serve as a helpful tool in PD diagnosis, with a diagnostic accuracy that reached clinical relevance.
Article
Multidisciplinary Sciences
Min Seok Baek, Myung Jun Lee, Han-Kyeol Kim, Chul Hyoung Lyoo
Summary: Longitudinal changes in biomarkers in Parkinson's disease patients can be influenced by cognitive impairment and Aβ burden at baseline. Patients with Aβ pathology may show early appearance of α-synuclein pathology, rapid progression of neurodegeneration, and greater cognitive decline.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Aonan Zhao, Yang Jiao, Guanyu Ye, Wenyan Kang, Lan Tan, Yuanyuan Li, Yulei Deng, Jun Liu
Summary: This study found that sTREM2 may serve as a potential predictive biomarker of the conversion from MCI to AD. Low levels of CSF sTREM2 and Aβ1-42 were associated with an increased risk of MCI-to-AD conversion, while elevated CSF sTREM2 levels were associated with a decreased risk. In the NRHAD cohort, individuals in the MCI group with high plasma sTREM2 levels were more likely to progress to AD, and those with low Aβ1-42 and high plasma sTREM2 levels had a faster cognitive decline. CSF sTREM2 levels were highly correlated with plasma sTREM2 levels in the CABLE database.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Lawrence S. Honig, Min Suk Kang, Annie J. Lee, Dolly Reyes-Dumeyer, Angel Piriz, Belisa Soriano, Yahaira Franco, Zoraida Dominguez Coronado, Patricia Recio, Diones Rivera Mejia, Martin Medrano, Rafael A. Lantigua, Andrew F. Teich, Jeffrey L. Dage, Richard Mayeux
Summary: This study aimed to evaluate validated plasma biomarkers for detecting Alzheimer's disease (AD) among Caribbean Hispanic individuals. The results showed that plasma P-tau181 and P-tau181/A beta 42 measurements could correctly classify whether Caribbean Hispanic individuals had AD, suggesting that plasma biomarkers can improve the detection of preclinical AD among asymptomatic individuals and the specificity of AD diagnosis.
Article
Clinical Neurology
Oskar Hansson, Richard Batrla, Britta Brix, Maria C. Carrillo, Veronika Corradini, Rebecca M. Edelmayer, Rianne N. Esquivel, Christina Hall, John Lawson, Nathalie Le Bastard, Jose Luis Molinuevo, Laura K. Nisenbaum, Sandra Rutz, Salvatore J. Salamone, Charlotte E. Teunissen, Christopher Traynham, Robert M. Umek, Hugo Vanderstichele, Manu Vandijck, Simone Wahl, Christopher J. Weber, Henrik Zetterberg, Kaj Blennow
Summary: To address variability in measurements across laboratories, a workgroup led by the Alzheimer's Association developed a simplified and standardized pre-analytical protocol for CSF collection and handling, aiming to improve AD diagnostic accuracy and reduce patient misclassification rates.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Nour Majbour, Jan Aasly, Ilham Abdi, Simona Ghanem, Daniel Erskine, Wilma van de Berg, Omar El-Agnaf
Summary: This study demonstrated the quantification of aSyn aggregates in PD patients through a combination of seed amplification assay and ELISA, showing that this method is more effective than using SAA alone and can reflect the disease stage of patients.
Review
Biochemistry & Molecular Biology
Wade K. Self, David M. Holtzman
Summary: Alzheimer disease (AD) is the leading cause of dementia worldwide, and until recently, effective strategies to slow or prevent its clinical progression have been elusive. This review examines the latest advancements in biomarker technologies and therapeutic development for improving AD diagnosis and treatment. It discusses the use of neuroimaging and fluid-based biomarkers to stage AD pathology, focusing on the role of amyloid, tau, and neuroinflammation in disease progression. The review also highlights potential disease-modifying treatment targets and their implications for AD clinical care.
Article
Clinical Neurology
Alexa Pichet Binette, Shorena Janelidze, Nicholas Cullen, Jeffrey L. Dage, Randall J. Bateman, Henrik Zetterberg, Kaj Blennow, Erik Stomrud, Niklas Mattsson-Carlgren, Oskar Hansson
Summary: This study found that creatinine and body mass index are associated with certain plasma biomarker levels, but they do not have clinically relevant confounding effects for the majority of individuals.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Michelle M. Mielke, Jeremiah A. Aakre, Alicia Algeciras-Schimnich, Nicholas K. Proctor, Mary M. Machulda, Udo Eichenlaub, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Clifford R. Jack, Ronald C. Petersen, Jeffrey L. Dage
Summary: CSF phosphorylated tau 217 and p-tau181 have subtle differences in predicting Alzheimer's disease, CSF MSD p-tau181 and p-tau217 are associated with MCI risk among amyloid-positive individuals, and there are subtle differences in predicting cortical thickness.
ALZHEIMERS & DEMENTIA
(2022)
Review
Biochemistry & Molecular Biology
Henrik Zetterberg, Barbara B. Bendlin
Summary: Clinical trial results indicate that antibody-based removal of Aβ plaques may slow cognitive decline in symptomatic AD, highlighting the need to identify suitable biomarkers for treatment. Further research into copathologies is necessary to facilitate the development and implementation of novel drug candidates against AD.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
B. Saatian, K. Deshpande, R. Herrera, S. Sedighi, R. Eisenbarth, M. Iyer, D. Das, A. Julian, V. Martirosian, A. Lowman, P. LaViolette, J. Remsik, A. Boire, E. Sankey, P. E. Fecci, M. S. Shiroishi, F. Chow, K. Hurth, J. Neman
Summary: This study investigates the impact of chemotherapy on breast-to-brain metastasis and the promotion of tumor-driven neurofibrillary tangles. The results show that chemotherapy increases brain-barrier permeability and facilitates tumor infiltration. Chemotherapy also contributes to the formation of neurofibrillary tangles that destabilize the brain barrier.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Virology
Peter Hermann, Philip Haller, Stefan Goebel, Timothy Bunck, Christian Schmidt, Jens Wiltfang, Inga Zerr
Summary: CSF t-tau is a reliable biomarker for sCJD, but false positive results may occur, especially in rpAD and acute encephalopathies. The t-tau/p-tau ratio may improve the diagnostic accuracy in centers where specific biomarkers are not available.
Article
Immunology
Dominique Endres, Luciana Hannibal, Benjamin Zaltenbach, Miriam A. Schiele, Kimon Runge, Kathrin Nickel, Benjamin Berger, Katharina Domschke, Nils Venhoff, Harald Pruess, Ludger Tebartz van Elst
Summary: This article presents a rare case of postpartum autoimmune obsessive-compulsive disorder (OCD). MRI revealed multiple juxtacortical hyperintensities that may have resulted from post-inflammatory processes. Tissue-based assays showed the presence of novel anti-nucleoli autoantibodies in cerebellar Purkinje cells and cortical neurons in the patient's cerebrospinal fluid (CSF). The CSF concentrations of dopamine and glutamate were dysregulated. The clinical course and diagnostic findings are consistent with a potential autoimmune etiology for postpartum OCD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Ophthalmology
Jenny Nij Bijvank, Lucas Maillette de Buy Wenniger, Pim de Graaf, Axel Petzold
Summary: This review discusses Dr. Gordon T. Plant's contributions to understanding optic nerve pathology, based on two observations made almost three decades apart. Through the combination of OCT and MRI technology, it is now possible to trace axonal degeneration throughout the visual system at a high resolution, providing new opportunities for distinguishing incidental findings from sinister pathology.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Liling Delila, Ouada Nebie, Nhi Thao Ngoc Le, Lassina Barro, Ming-Li Chou, Yu-Wen Wu, Naoto Watanabe, Masayasu Takahara, Luc Buee, David Blum, David Devos, Thierry Burnouf
Summary: This study evaluated the virus removal properties of a nanofiltration process on human platelet lysates (HPL) and found that it effectively reduced viral and procoagulant risks while preserving the neuroprotective and anti-inflammatory properties of HPL.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Hematology
Steve Raoul Noumegni, Cecile Tromeur, Clement Hoffmann, Raphael Le Mao, Emmanuelle Le Moigne, Claire de Moreuil, Vincent Mansourati, Bahaa Nasr, Jean-Christophe Gentric, Marie Guegan, Elise Poulhazan, Luc Bressollette, Karine Lacut, Romain Didier, Francis Couturaud
Summary: Patients with first episodes of VTE are at increased risk of recurrent VTE and ATE during and after anticoagulation. Risk factors include age, cancer-associated VTE, and unprovoked VTE.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric McDade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen
Summary: This study found that plasma GFAP levels increase a decade before symptom onset in AD and are associated with Aβ load, neurodegeneration, and cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Kiran Samra, Amy Macdougall, Georgia Peakman, Arabella Bouzigues, Martina Bocchetta, David M. Cash, Caroline Greaves, Rhian S. Convery, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Fermin Moreno, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonca, Christopher R. Butler, Alexander Gerhard, Simon Ducharme, Isabelle Le Ber, Pietro Tiraboschi, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jonathan D. Rohrer, Lucy L. Russell
Summary: A study on frontotemporal dementia found that neuropsychiatric symptoms occur in mutation carriers at all disease stages, with hallucinations and delusions providing additional staging benefit. The inclusion of these features in rating scales could improve the evaluation of disease progression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Patrick Oeckl, Marina Bluma, Marco Bucci, Steffen Halbgebauer, Konstantinos Chiotis, Anna Sandebring-Matton, Nicholas J. Ashton, Guglielmo Di Molfetta, Lana Grotschel, Miia Kivipelto, Kaj Blennow, Henrik Zetterberg, Irina Savitcheva, Agneta Nordberg, Markus Otto
Summary: Plasma beta-synuclein levels were found to be higher in individuals with Alzheimer's disease and mild cognitive impairment with amyloid-beta positivity. It demonstrated good discrimination and prediction of amyloid-beta status. The correlation between plasma beta-synuclein and amyloid-beta PET was observed in multiple cortical regions. These findings suggest that beta-synuclein is not a direct marker of amyloid-beta pathology and highlight the different longitudinal dynamics of synaptic degeneration and amyloid deposition in Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Patrick Oeckl, Shorena Janelidze, Steffen Halbgebauer, Erik Stomrud, Sebastian Palmqvist, Markus Otto, Oskar Hansson
Summary: Beta-synuclein can serve as a synaptic blood biomarker for Alzheimer's disease, even in the preclinical stages. Higher levels of plasma beta-synuclein are observed in preclinical AD, mild cognitive impairment, and AD dementia. The levels are associated with amyloid and tau pathology, as well as cognitive impairment and temporal cortical thinning.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Babak Hooshmand, Franziska Appold, Patrick Fissler, Robert Perneczky, Markus Otto, Hayrettin Tumani, Miia Kivipelto, Christine A. F. von Arnim
Summary: This study investigated the association between vitamin B12 status and biomarkers of Alzheimer's disease. The results suggest that vitamin B12-related markers are associated with AD biomarkers and cognitive performance. Vitamin B12 supplementation may be important in slowing down brain changes and cognitive decline.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Aurelie P. Bussy, Jake P. Levy, Tristin Best, Raihaan Patel, Lani Cupo, Tim Van Langenhove, Jorgen E. Nielsen, Yolande Pijnenburg, Maria Landqvist M. Waldo, Anne M. L. Remes, Matthias L. Schroeter, Isabel Santana, Florence Pasquier, Markus Otto, Adrian Danek, Johannes Levin, Isabelle Le Ber, Rik Vandenberghe, Matthis Synofzik, Fermin Moreno, Alexandre de Mendonca, Raquel Sanchez-Valle, Robert Laforce, Tobias Langheinrich, Alexander Gerhard, Caroline R. Graff, Chris R. Butler, Sandro Sorbi, Lize Jiskoot, Harro C. Seelaar, John C. van Swieten, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, Pietro Tiraboschi, Daniela Galimberti, Barbara B. Borroni, James B. Rowe, Martina D. Bocchetta, Jonathan D. A. Rohrer, Gabriel A. Devenyi, M. Mallar Chakravarty, Simon Ducharme
Summary: Recent studies have shown that early cerebellar and subcortical changes are seen in the progression of genetic frontotemporal dementia due to specific gene mutations. This study aimed to investigate the relationship between cerebellar and subcortical atrophy and neuropsychiatric symptoms across different genetic mutations in FTD.
HUMAN BRAIN MAPPING
(2023)
Article
Geriatrics & Gerontology
Jemma Hazan, Simon Hall, Alex Pemberton, Ian Sherriffs, Suzanne Joels, Amanda Heslegrave, Elena Veleva, Mamoona Ghauri, Rhiannon Laban, Emily Abel, Henrik Zetterberg, Nick C. C. Fox, Robert Howard
Summary: This study explored the utility of plasma phosphorylated-tau181 (p-tau181) as a blood-based biomarker for Alzheimer's disease pathology. The results showed that 86% of clinicians found the p-tau181 result to be helpful and 44% of cases found it useful in making the diagnosis. However, further education and training are needed for clinicians to understand and interpret ambiguity in biomarker results.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Marie Tautou, Florian Descamps, Paul-Emmanuel Larchanche, Luc Buee, Jamal El Bakali, Patricia Melnyk, Nicolas Sergeant
Summary: This study demonstrates the potential of a polyaminobiaryl-based compound, PEL24-199, in treating Alzheimer's disease by targeting both amyloid plaques and neurofibrillary tangles. The compound showed pharmacologic activity by modulating beta-secretase and resulted in the restoration of spatial memory and reduction of neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jemma Hazan, Kathy Y. Liu, Nick Fox, Robert Howard
Summary: Changes in diagnostic certainty can be evaluated by assessing the impact of a diagnostic test in driving decision making. Diagnostic tests can be appraised using validated measures of accuracy, i.e., sensitivity, specificity, and positive or negative predictive values against a known reference standard. However, other less well formalized factors affect diagnostic certainty.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Badrieh Fazeli, Andre Huss, Nerea Gomez de San Jose, Markus Otto, Hayrettin Tumani, Steffen Halbgebauer
Summary: This study developed a sensitive and easy-to-use microfluidic assay to measure GFAP in blood, and confirmed previous findings of elevated GFAP levels in AD by applying the assay in a cohort of clinically characterized patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Clinical Neurology
Samir Abu-Rumeileh, Steffen Halbgebauer, Giuseppe Mario Bentivenga, Lorenzo Barba, Simone Baiardi, Andrea Mastrangelo, Patrick Oeckl, Petra Steinacker, Angela Mammana, Sabina Capellari, Markus Otto, Piero Parchi
Summary: Beta-synuclein is a promising biomarker for synaptic damage in cerebrospinal fluid and blood, and it can accurately distinguish sporadic Creutzfeldt-Jakob disease from non-prion rapidly progressive dementias. It outperforms protein 14-3-3 and total tau in cerebrospinal fluid, and has similar diagnostic value as cerebrospinal fluid biomarkers in plasma. Beta-synuclein may serve as the first highly accurate blood biomarker for the diagnosis of sporadic Creutzfeldt-Jakob disease.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Samir Abu-Rumeileh, Lorenzo Barba, Matthias Bache, Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Antje Guettler, Jacqueline Kessler, Joerg Illert, Christian Strauss, Dirk Vordermark, Markus Otto
Summary: The concentrations and prognostic roles of plasma β-synuclein, glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) were analyzed in 33 patients with malignant gliomas. GFAP and NfL levels were higher in glioblastoma patients compared to other tumor cases. Post-surgery, β-syn, NfL, and NfH increased, while GFAP decreased in long-term follow-up. Surgery and/or radiotherapy regimens influenced β-syn and neurofilament concentrations. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and have distinct trajectories after surgical and adjuvant therapy.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
