Article
Pharmacology & Pharmacy
Rongjie Zhang, Yuanfeiyi Wang, Dan Liu, Qing Luo, Peixin Du, Haiyan Zhang, Wenshuang Wu
Summary: Sodium tanshinone IIA sulfonate (STS) acts as an immunotherapy agent by inhibiting both IDO1 and TDO2 in colorectal cancer (CRC).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Peipei Chen, Qiyuan An, Yuxin Huang, Minzhou Zhang, Shuai Mao
Summary: This study demonstrates that STS can increase survival rates in mice, improve compromised cardiac function, reduce myocardial inflammatory injury, and promote autophagy while attenuating NLRP3 inflammasome activation. Additionally, STS may alleviate endotoxemia-induced mortality and cardiomyopathy by promoting autophagy and inhibiting NLRP3 inflammasome overactivation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Maolin Sun, Chaoming Liang, Liming Cao, Yaguo Wang, Jiasheng Yang, Shiyu Hou, Wei Yu, Yueyue Ma, Ruihua Cheng, Jinxing Ye
Summary: A sustainable and practical approach is presented for the direct synthesis of sodium tanshinone IIA sulfonate (STS). A two-step continuous flow platform was constructed, which achieved a higher yield and improved procedural safety compared to the batch synthetic route. The proposed method also reduced the required acid content and wastewater production.
CHINESE CHEMICAL LETTERS
(2024)
Article
Medicine, Research & Experimental
Jiazhen Xu, Pei Zhang, Yao Chen, Yulan Xu, Pengwei Luan, Yuying Zhu, Jiange Zhang
Summary: In a rat model of ischemic stroke, STS showed therapeutic effects similar to edaravone in promoting angiogenesis and inhibiting neuronal apoptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jiao Lan, Ke Li, Austin Gresham, Jifei Miao
Summary: The study found that TSS exerts anti-inflammatory effects by upregulating circ-Sirt1 expression to inhibit the translocation of NF-kappa B. In vivo experiments confirmed the protective function of TSS on inflammation, suggesting that TSS may be a potential treatment for inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Plant Sciences
Huikai Shao, Chuanyan Fang, Yang Huang, Yulong Ye, Rongsheng Tong
Summary: The meta-analysis revealed that STS injection as adjunctive therapy is more effective in treating heart failure compared to western medicine alone, showing improvements in overall effective rate, cardiac function parameters, and reductions in ventricular dimensions and BNP levels.
Article
Cardiac & Cardiovascular Systems
Yan-Yan Heng, Hui-Juan Shang, Xia-ze Zhang, Wei Wei
Summary: The study demonstrated that STS protects EPCs by inhibiting the NLRP3 pathway, preserving their proliferation and differentiation functions, and preventing senescence. STS also restores the expression of key proteins in EPCs and prevents neointima formation in diabetic mice.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Endocrinology & Metabolism
Hui-Han Ma, Can Wan, Lu-Di Zhang, Rong-Rong Zhang, Dong Peng, Li-Jun Qiao, Shi-Jie Zhang, Ye-Feng Cai, Hong-Qiang Huang
Summary: This study found that STS can improve learning and memory abilities in APP/PS1 mice and ameliorate AD pathology through multiple pathways, including reducing oxidative stress levels, enhancing antioxidant enzyme activity, inhibiting acetylcholinesterase activity, and increasing the expression of synaptic-related proteins.
METABOLIC BRAIN DISEASE
(2022)
Article
Multidisciplinary Sciences
Ryuta Kanai, Flemming Cornelius, Bente Vilsen, Chikashi Toyoshima
Summary: Cryo-electron microscopy was used to study the structure of Na+, K+-ATPase and its variations. The results showed that different reaction states exhibited different biochemical characteristics, and the presence of Mg2+ ions in the transmembrane cation binding sites played a crucial role in the reactions. The binding mechanism of the new-generation cardiotonic steroids (CTSs) did not significantly affect the structure of NKA, and the phospholipid molecules were better resolved in the electron microscopy maps compared to X-ray structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Santiago E. Faraj, Wanda M. Valsecchi, Mariela Ferreira-Gomes, Mercedes Centeno, Elina Malen Saint Martin, Natalya U. Fedosova, Juan Pablo FC. Rossi, Monica R. Montes, Rolando C. Rossi
Summary: The Na+/K+-ATPase is a plasma membrane glycoprotein that exchanges intracellular Na+ for extracellular K+ by hydrolyzing ATP. The asymmetric distribution of Na+ and K+ is essential for cellular life. Current research indicates that Na+ becomes spontaneously occluded in the E1 dephosphorylated form of the Na+/K+-ATPase, showing positive interactions between binding sites. Adding ATP does not increase Na+ occlusion.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Ryuta Kanai, Flemming Cornelius, Haruo Ogawa, Kanna Motoyama, Bente Vilsen, Chikashi Toyoshima
Summary: The sodium pump (Na+, K+-ATPase, NKA) is crucial for maintaining ion gradients across cell membranes, with cardiotonic steroids (CTSs) acting as specific inhibitors. Different structural features of CTSs result in diverse inhibitory properties, with crystal structures providing insights into their mechanism of action and potential for isoform specific targeting.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Victoria C. Young, Hanayo Nakanishi, Dylan J. Meyer, Tomohiro Nishizawa, Atsunori Oshima, Pablo Artigas, Kazuhiro Abe
Summary: This study investigates ion transport mechanisms by introducing mutations to convert an electroneutral proton/potassium pump into a prototypical electrogenic sodium/potassium pump, explaining their selectivity and phosphorylation mechanisms.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Baoli Zhang, Peng Yu, Enyong Su, Jianguo Jia, Chunyu Zhang, Shiyao Xie, Zhenhui Huang, Ying Dong, Jinguo Ding, Yunzeng Zou, Hong Jiang, Junbo Ge
Summary: Sodium tanshinone IIA sulfonate (STS) can improve pathological cardiac remodeling after myocardial infarction (MI) through reducing myocardial necrosis, modulating inflammation, and increasing angiogenesis.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pharmacology & Pharmacy
Jian Wang, Wenyan Liu, Wenju Lu, Xiaoyun Luo, Yongrui Lin, Shiyun Liu, Jing Qian, Chenting Zhang, Haixia Chen, Yi Li, Xiang Li, Jiyuan Chen, Yuqin Chen, Qian Jiang, Chunli Liu, Cheng Hong, Tao Wang, Haiyang Tang, Nanshan Zhong, Jun Yang, Kai Yang, Dejun Sun
Summary: This study demonstrates that STS exerts anti-apoptotic effects in pulmonary endothelium and PMVECs by inducing the BMP9-BMPR2-Smad1/5/9 signaling transduction.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shreya T. Mukherji, Luca Brambilla, Kailey B. Stuart, Isabella Mayes, Laura C. Kutz, Yiliang Chen, Leandro A. Barbosa, Ibrahim Elmadbouh, Jeff P. McDermott, Steven T. Haller, Michael F. Romero, Manoocher Soleimani, Jiang Liu, Joseph I. Shapiro, Gustavo V. Blanco, Zijian Xie, Sandrine V. Pierre
Summary: Through ATP-dependent ion pumping, basolateral Na/K-ATPase (NKA) generates a Na+ gradient that drives apical Na+ reabsorption in the renal proximal tubule (RPT), while NKA signaling function triggers cellular redistribution and decreases Na+ reabsorption. Knockdown of RPT NKA leads to increased membrane NHE3 and NBCe1A, resulting in decreased urine output and Na+ excretion, elevated blood pressure, and increased RPT Na+ reabsorption. NKA signaling plays an important role in regulating Na+ reabsorption in RPT, functioning dominantly over NKA ion pumping.