Review
Cell Biology
John-Patrick Alao, Luc Legon, Aleksandra Dabrowska, Anne-Marie Tricolici, Juhi Kumar, Charalampos Rallis
Summary: Cells regulate their metabolism and ensure survival and growth under stress conditions by balancing growth and anabolism with stress programs and catabolism. Autophagy, an essential quality control mechanism, plays a pivotal role in cell survival and lifespan by clearing damaged macromolecules and organelles in response to nutrient levels and cellular damage.
Article
Endocrinology & Metabolism
Manfred J. Mueller, Steven B. Heymsfield, Anja Bosy-Westphal
Summary: Adaptive thermogenesis is the mass-independent decrease in energy expenditure during caloric restriction and weight loss, which persists during weight maintenance. It occurs in resting and nonresting energy expenditure as AT(REE) and AT(NREE), respectively. AT(REE) has different mechanisms in different phases of weight loss, while AT(NREE) exceeds AT(REE) during weight maintenance. Some mechanisms of AT are known, but others remain unknown. Future studies on AT require an appropriate conceptual framework for experiment design and result interpretation.
Review
Nutrition & Dietetics
Julia Voglhuber, Senka Ljubojevic-Holzer, Mahmoud Abdellatif, Simon Sedej
Summary: Global life expectancy is increasing, as is the burden of cardiovascular disease. Dietary restriction can improve cardiovascular risk factors, but challenges in adherence have led to the investigation of alternative eating patterns and pharmacological alternatives.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Erik M. Anderson, Jared M. Rozowsky, Brian J. Fazzone, Emilie A. Schmidt, Bruce R. Stevens, Kerri A. O'Malley, Salvatore T. Scali, Scott A. Berceli
Summary: Short-term dietary restriction can modulate the gut microbiome, causing relative dysbiosis, which is quickly restored after resuming a normal diet. This study highlights the importance of understanding the impact of nutritional interventions on the microbiome in order to improve surgical outcomes.
Review
Food Science & Technology
Luanfeng Wang, Fang Wang, Ling Xiong, Haizhao Song, Bo Ren, Xinchun Shen
Summary: In recent years, dietary restriction (DR) has gained popularity for its potential to improve metabolism and promote longevity. However, the role of gut microbiota in DR has been less explored. This review discusses the effects of different DR patterns on the gut microbiota and the underlying mechanisms by which DR affects metabolic health. It also suggests the development of personalized microbiome-directed DR and advanced sequencing technologies for accurate analysis. DR effectively modulates the gut microbiota and improves metabolic syndrome, inflammatory bowel disease, and cognitive impairment. Further research is needed to fully understand the mechanisms behind the benefits of DR.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Medicine, Research & Experimental
Taiana Campos Leite, Rebecca Jean Watters, Kurt Richard Weiss, Giuseppe Intini
Summary: Osteosarcoma is the most common primary bone cancer in children and adolescents, with a poor survival rate for metastatic cases. Tumor metabolism plays a crucial role in tumor growth and metastasis, offering a potential target for novel therapies. Dietary interventions targeting cancer cell metabolism may be an effective approach.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Immunology
Lukai Zhai, Connie M. Krawczyk
Summary: The reduction of SPARC during caloric restriction (CR) is found to offer beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.
Article
Multidisciplinary Sciences
Meixian Wang, Yichen Shen, Zhicheng Tan, Ayinuer Yasen, Bingyan Fan, Xingjia Shen
Summary: Dietary restriction has been proven to prolong the lifespan of silkworms by affecting metabolic pathways and antioxidant capacity. The study also found sex differences in response to dietary restriction, providing valuable insights for future anti-aging research.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Irislene Costa Pereira, Isabele Frazao Mascarenhas, Vinicius Cooper Capetini, Paulo Michel Pinheiro Ferreira, Marcelo Macedo Rogero, Francisco Leonardo Torres-Leal
Summary: This review provides an overview of metabolic changes in breast cancer, including the impact of restrictive diets on chemotherapy resistance, the therapeutic potential of diet on tumor progression, pathways related to metabolic health in oncology, and future perspectives in the field of oncological nutrition.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Nutrition & Dietetics
Carmen Purdel, Denisa Margina, Ines Adam-Dima, Anca Ungurianu
Summary: This article discusses the effects of different dietary interventions on the gut microbiota and their importance for human health.
Article
Nutrition & Dietetics
Rafael Ferraz-Bannitz, Rebeca A. Beraldo, A. Augusto Peluso, Morten Dall, Parizad Babaei, Rayana Cardoso Foglietti, Larissa Marfori Martins, Patricia Moreira Gomes, Julio Sergio Marchini, Vivian Marques Miguel Suen, Luiz C. Conti de Freitas, Luiz Carlos Navegantes, Marco Antonio M. Pretti, Mariana Boroni, Jonas T. Treebak, Marcelo A. Mori, Milton Cesar Foss, Maria Cristina Foss-Freitas
Summary: This study aimed to investigate the benefits of dietary restriction in patients with metabolic syndrome and determine whether it is the calorie or protein restriction that mediates the effects. The findings showed that isocaloric dietary protein restriction can achieve similar clinical outcomes as calorie restriction, making it a more attractive and less drastic dietary strategy for patients with metabolic syndrome and has potential as an adjuvant therapy.
Article
Biochemistry & Molecular Biology
Artem P. Gureev, Nadezda V. Andrianova, Irina B. Pevzner, Ljubava D. Zorova, Ekaterina V. Chernyshova, Irina S. Sadovnikova, Dmitry V. Chistyakov, Vasily A. Popkov, Dmitry S. Semenovich, Valentina A. Babenko, Denis N. Silachev, Dmitry B. Zorov, Egor Y. Plotnikov, Vasily N. Popov
Summary: This study found that in aging rats, mtDNA in the brain and kidneys was the most susceptible to age-related damage, while the liver, testis, and lungs were the least affected. Dietary restriction (DR) can prevent the accumulation of mtDNA damage in the cortex and reduce it in the lungs and testes.
Article
Cell Biology
Natasha A. Grande de Franca, Yves Rolland, Sophie Guyonnet, Philipe de Souto Barreto
Summary: The hallmarks of aging are a set of interconnected mechanisms that can be influenced by lifestyle factors, such as dietary strategies. This review aimed to summarize the evidence on the impact of dietary restriction or specific dietary patterns on these hallmarks. Dietary restriction has been shown to modulate genomic instability, proteostasis, nutrient sensing, cellular senescence, and intercellular communication. Limited evidence exists on the role of dietary patterns, with studies mainly focusing on the Mediterranean Diet, plant-based diets, and the ketogenic diet. It is crucial to determine the effects of nutritional strategies on lifespan and healthspan considering feasibility, long-term adherence, and potential side effects.
AGEING RESEARCH REVIEWS
(2023)
Article
Cell Biology
Mark T. Mc Auley
Summary: Dietary restriction is an effective intervention for extending lifespan, but the mechanism behind it is still unclear. The prevailing belief is that dietary restriction promotes longevity through resource reallocation, but recent findings suggest this belief might be incomplete and there could be other factors influencing the evolutionary trade-offs of dietary restriction.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Biochemistry & Molecular Biology
Sabrina Folie, Bernhard Radlinger, Georg Goebel, Karin Salzmann, Gabriele Staudacher, Claudia Ress, Herbert Tilg, Susanne Kaser
Summary: The study suggests that switching from a metabolically harmful Western diet to a balanced standard diet can improve adipose tissue inflammation, while long-term consumption of a Western diet negatively impacts the thermogenic capacity of brown adipose tissue and inhibits beiging of white adipose tissue.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Cell Biology
Yajun Liu, I-Ju Lee, Mingzhai Sun, Casey A. Lower, Kurt W. Runge, Jianjie Ma, Jian-Qiu Wu
MOLECULAR BIOLOGY OF THE CELL
(2016)
Editorial Material
Genetics & Heredity
Kurt W. Runge, Arthur J. Lustig
FRONTIERS IN GENETICS
(2016)
Article
Genetics & Heredity
Yanhui Li, Jinyu Wang, Gang Zhou, Michael Lajeunesse, Nga Le, Brittany N. Stawicki, Yalitza Lopez Corcino, Kathleen L. Berkner, Kurt W. Runge
Article
Genetics & Heredity
Yanhui Li, Jinyu Wang, Gang Zhou, Michael Lajeunesse, Nga Le, Brittany N. Stawicki, Yalitza Lopez Corcino, Kathleen L. Berkner, Kurt W. Runge
Article
Hematology
Mark A. Rishavy, Kevin W. Hallgren, Lee Wilson, Savita Singh, Kurt W. Runge, Kathleen L. Berkner
Article
Genetics & Heredity
Jinyu Wang, Haitao Zhang, Mohammed Al Shibar, Belinda Willard, Alo Ray, Kurt W. Runge
Article
Biochemistry & Molecular Biology
Jinyu Wang, Jessica R. Eisenstatt, Julien Audry, Kristen Cornelius, Matthew Shaughnessy, Kathleen L. Berkner, Kurt W. Runge
MOLECULAR AND CELLULAR BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Mark A. Rishavy, Kevin W. Hallgren, Lee A. Wilson, Aisulu Usubalieva, Kurt W. Runge, Kathleen L. Berkner
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Multidisciplinary Sciences
Bo-Ruei Chen, Yanhui Li, Jessica R. Eisenstatt, Kurt W. Runge
Article
Multidisciplinary Sciences
Mark E. Corkins, Margot May, Kate M. Ehrensberger, Ya-Mei Hu, Yi-Hsuan Liu, Sean D. Bloor, Blair Jenkins, Kurt W. Runge, Amanda J. Bird
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Hematology
Mark A. Rishavy, Kevin W. Hallgren, Haitao Zhang, Kurt W. Runge, Kathleen L. Berkner
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2019)
Article
Genetics & Heredity
Hiroyuki Irie, Io Yamamoto, Yusuke Tarumoto, Sanki Tashiro, Kurt W. Runge, Fuyuki Ishikawa
Review
Biochemistry & Molecular Biology
Kathleen L. Berkner, Kurt W. Runge
Summary: This article discusses the characteristics and functions of vitamin K-dependent proteins, as well as the process of vitamin K cycle. Vitamin K-dependent proteins play important roles in hemostasis and other physiological activities, and disruption of carboxylation may lead to diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Mark A. Rishavy, Kevin W. Hallgren, Lee A. Wilson, James M. Hiznay, Kurt W. Runge, Kathleen L. Berkner
Summary: This study reveals the essentiality of processivity to VKD protein function and explains the mechanism of disease caused by disrupted processivity through the study of GGCX mutants.
Review
Genetics & Heredity
Kurt W. Runge, Yanhui Li