Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease

GGCX mutations show different responses to vitamin K thereby determining the severity of the hemorrhagic phenotype in VKCFD1 patients

(2021) Suvoshree Ghosh et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Perspective: Evidence before Enthusiasm—A Critical Review of the Potential Cardiovascular Benefits of Vitamin K

(2021) M Kyla Shea et al.   Advances in Nutrition

Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes

(2020) Anne-Caroline Jeannin et al.   PLoS One

Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity

(2020) Chaomin Li et al.   Adipocyte

Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy

(2020) Shuang Li et al.   Blood Advances

Gamma-glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins

(2020) Zhenyu Hao et al.   BLOOD

A dual role for GRP in cardiovascular disease

(2019) Carla S. B. Viegas et al.   Aging-US

Circulating phylloquinone, inactive Matrix Gla protein and coronary heart disease risk: A two-sample Mendelian Randomization study

(2019) Sabine R. Zwakenberg et al.   CLINICAL NUTRITION

High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam

(2019) Marcos D. Machado-Fragua et al.   EUROPEAN JOURNAL OF NUTRITION

Exon 2 Skipping Eliminates Gamma‐Glutamyl Carboxylase Activity, Indicating a Partial Splicing Defect in a Patient with Vitamin K Clotting Factor Deficiency

(2019) Mark A Rishavy et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study

(2019) Fang‐Fei Wei et al.   Journal of the American Heart Association

Evaluation of inactive Matrix-Gla-Protein (MGP) as a biomarker for incident and recurrent kidney stones

(2019) Vincent Castiglione et al.   JOURNAL OF NEPHROLOGY

Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease

(2019) Ianthe Piscaer et al.   Journal of Clinical Medicine

The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial

(2019) Theodora Oikonomaki et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study

(2019) Zhenyu Hao et al.   HAEMATOLOGICA

Laboratory assessment of vitamin K status

(2019) David John Card et al.   JOURNAL OF CLINICAL PATHOLOGY

Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential

(2019) Tomás Patrick Griffin et al.   Scientific Reports

Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase

(2018) Mark A. Rishavy et al.   BLOOD

Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome

(2018) Kana N. Miyata et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling

(2018) Brecht A. Willems et al.   Scientific Reports

VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues

(2018) Julie Lacombe et al.   Nutrients

Pseudoxanthoma Elasticum as a Paradigm of Heritable Ectopic Mineralization Disorders

(2018) Qiaoli Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Vitamin K–Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis

(2017) Sagar U. Nigwekar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vitamin K–Dependent Protein S: Beyond the Protein C Pathway

(2017) Björn Dahlbäck   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Prevalence and Effects of Functional Vitamin K Insufficiency: The PREVEND Study

(2017) Ineke Riphagen et al.   Nutrients

Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders

(2016) J.-K. Tie et al.   BLOOD

The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles

(2016) Kaisa E. Happonen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Warfarin and vitamin K compete for binding to Phe55 in human VKOR

(2016) Katrin J Czogalla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Warfarin and vitamin K compete for binding to Phe55 in human VKOR

(2016) Katrin J Czogalla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Concepts and Controversies in Evaluating Vitamin K Status in Population-Based Studies

(2016) M. Shea et al.   Nutrients

Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis

(2015) M. N. Aghourian et al.   BLOOD

Decreased Local and Systematic Matrix Gla Protein (MGP) Expression and its Link to Radiographic Progression in Ankylosing Spondylitis Patients

(2015) Dai-He Li et al.   Clinical Laboratory

Gamma-Carboxylation and Fragmentation of Osteocalcin in Human Serum Defined by Mass Spectrometry

(2015) Douglas S. Rehder et al.   MOLECULAR & CELLULAR PROTEOMICS

The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study

(2015) M.K. Shea et al.   OSTEOARTHRITIS AND CARTILAGE

Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain

(2015) Michael Caspers et al.   THROMBOSIS RESEARCH

TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

(2014) J. H. M. van der Meer et al.   BLOOD

Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis

(2014) Martin J. Shearer et al.   JOURNAL OF LIPID RESEARCH

Gla-Rich Protein Is a Potential New Vitamin K Target in Cancer: Evidences for a Direct GRP-Mineral Interaction

(2014) Carla S. B. Viegas et al.   Biomed Research International

Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice

(2013) Brian O. Ingram et al.   BIOCHEMICAL JOURNAL

The Vitamin K Oxidoreductase Is a Multimer That Efficiently Reduces Vitamin K Epoxide to Hydroquinone to Allow Vitamin K-dependent Protein Carboxylation

(2013) Mark A. Rishavy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VKORC1L1, an Enzyme Rescuing the Vitamin K 2,3-Epoxide Reductase Activity in Some Extrahepatic Tissues during Anticoagulation Therapy

(2013) Abdessalem Hammed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectopic mineralization disorders of the extracellular matrix of connective tissue: Molecular genetics and pathomechanisms of aberrant calcification

(2013) Qiaoli Li et al.   MATRIX BIOLOGY

New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations

(2013) Benjamin Matagrin et al.   FEBS Open Bio

Vascular Gas6 contributes to thrombogenesis and promotes tissue factor up-regulation after vessel injury in mice

(2012) R. S. Robins et al.   BLOOD

Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists

(2012) Martijn L.L. Chatrou et al.   BLOOD REVIEWS

Molecular Basis for Recognition of Dilysine Trafficking Motifs by COPI

(2012) Lauren P. Jackson et al.   DEVELOPMENTAL CELL

Methylation of γ-Carboxylated Glu (Gla) Allows Detection by Liquid Chromatography–Mass Spectrometry and the Identification of Gla Residues in the γ-Glutamyl Carboxylase

(2012) K. W. Hallgren et al.   JOURNAL OF PROTEOME RESEARCH

VKORC1mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity

(2012) A. HODROGE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype

(2012) Leon J. Schurgers et al.   PLoS One

Vitamin K Oxygenation, Glutamate Carboxylation, and Processivity: Defining the Three Critical Facets of Catalysis by the Vitamin K–Dependent Carboxylase

(2012) Mark A. Rishavy et al.   Advances in Nutrition

Vitamin K Nutrition, Metabolism, and Requirements: Current Concepts and Future Research

(2012) Martin J. Shearer et al.   Advances in Nutrition

Ucma is not necessary for normal development of the mouse skeleton

(2011) Nicole Eitzinger et al.   BONE

Association of Warfarin Use With Valvular and Vascular Calcification: A Review

(2011) Chandrasekar Palaniswamy et al.   CLINICAL CARDIOLOGY

Matrix Gla Protein Inhibits Ectopic Calcification by a Direct Interaction with Hydroxyapatite Crystals

(2011) Jason O’Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment

(2010) M. WATZKA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners

(2010) S. Schulman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species

(2010) Ellen Cranenburg et al.   THROMBOSIS AND HAEMOSTASIS

Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion

(2009) M. Souri et al.   BLOOD

Does Prolonged Warfarin Exposure Potentiate Coronary Calcification in Humans? Results of the Warfarin and Coronary Calcification Study

(2009) Todd C. Villines et al.   CALCIFIED TISSUE INTERNATIONAL

Warfarin use and the risk of valvular calcification

(2009) R. G. LERNER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding

(2009) Gabriele Spohn et al.   THROMBOSIS AND HAEMOSTASIS

Co-Existent Pseudoxanthoma Elasticum and Vitamin K-Dependent Coagulation Factor Deficiency

(2008) Qiaoli Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Insight into the Coupling Mechanism of the Vitamin K-Dependent Carboxylase: Mutation of Histidine 160 Disrupts Glutamic Acid Carbanion Formation and Efficient Coupling of Vitamin K Epoxidation to Glutamic Acid Carboxylation†

(2008) Mark A. Rishavy et al.   BIOCHEMISTRY

Mutations in the GGCX and ABCC6 Genes in a Family with Pseudoxanthoma Elasticum-Like Phenotypes

(2008) Qiaoli Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY