Article
Pharmacology & Pharmacy
Giovanni Luca Romano, Lucia Gozzo, Oriana Maria Maurel, Serena Di Martino, Valentina Riolo, Vincenzo Micale, Filippo Drago, Claudio Bucolo
Summary: The topical ocular administration of FLX was found to have a neuroprotective effect in a mouse model of acute retinal damage, as it counteracted the damage of retinal ganglion cells and preserved retinal function. FLX treatment also reduced the production of pro-inflammatory molecules elicited by retinal injury. Further studies are needed to support the use of FLX as a neuroprotective agent in retinal degenerative diseases.
Article
Clinical Neurology
Longfei Wu, Ming Wei, Bohao Zhang, Bowei Zhang, Jian Chen, Sifei Wang, Leilei Luo, Shuling Liu, Sijie Li, Changhong Ren, David C. Hess, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study investigated the safety and tolerability of direct ischemic postconditioning (IPostC) in both a dog model and patients with acute ischemic stroke treated with thrombectomy, and found it to be safe, feasible, and tolerable.
Article
Ophthalmology
Kaibao Ji, Zongyuan Li, Yiming Lei, Wanxin Xu, Lingyi Ouyang, Tao He, Yiqiao Xing
Summary: The study demonstrated that resveratrol can mitigate retinal ischemic injury induced RGC loss and retinal function impairment by inhibiting the HIF-1a/VEGF and p38/p53 pathways while activating the PI3K/Akt pathway.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Min Zhang, Jiayi Yang, Kaibao Ji, Xuejun He, Tao He, Yiqiao Xing
Summary: Inhibition of p66Shc expression can protect retinal ganglion cells (RGCs) from ischemia-induced apoptosis and preserve retinal function by acting through the Akt pathway.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Panagiotis Chronopoulos, Caroline Manicam, Jenia Kouchek Zadeh, Panagiotis Laspas, Johanna Charlotte Unkrig, Marie Luise Goebel, Aytan Musayeva, Norbert Pfeiffer, Matthias Oelze, Andreas Daiber, Huige Li, Ning Xia, Adrian Gericke
Summary: This study demonstrates that resveratrol has a protective effect against ischemia-reperfusion injury in the murine retina, reducing the loss of retinal ganglion cells and endothelial dysfunction of retinal blood vessels. This protective effect may be achieved by suppressing upregulation of nitric oxide synthase 2 and alleviating nitro-oxidative stress.
Article
Immunology
Haiyun Guo, Ze Fan, Shiquan Wang, Lina Ma, Jin Wang, Doutong Yu, Zhen Zhang, Lin Wu, Zhengwu Peng, Wenming Liu, Wugang Hou, Yanhui Cai
Summary: The mobilization of astrocytic glycogen inhibits A1-like astrocytes and enhances A2-like astrocytes during reperfusion, leading to reduced reactive oxygen species levels and increased production of NADPH and glutathione. This neuroprotection is mediated through ROS-mediated NF-kappa B inhibition and STAT3 activation, presenting a promising metabolic target for brain reperfusion injury in ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Hematology
Nirav Dhanesha, Rakesh B. Patel, Prakash Doddapattar, Madankumar Ghatge, Gagan D. Flora, Manish Jain, Daniel Thedens, Heena Olalde, Mariia Kumskova, Enrique C. Leira, Anil K. Chauhan
Summary: This study found that nuclear pyruvate kinase muscle 2 (PKM2) is upregulated in neutrophils after ischemic stroke, promoting inflammatory response. By genetically deleting PKM2 in myeloid cells, the study showed reduced inflammation and damage after stroke. Furthermore, inhibiting PKM2 nuclear translocation improved functional outcomes after stroke.
Article
Immunology
Yunhong Shi, Yidan Liu, Caiqing Wu, Xiuxing Liu, Wenfei Hu, Zhenlan Yang, Zhidong Li, Yangyang Li, Caibin Deng, Kun Wei, Chenyang Gu, Xuhao Chen, Wenru Su, Yehong Zhuo
Summary: Through single-cell RNA sequencing and molecular docking experiments, it was found that N,N-dimethyl-3 beta-hydroxycholenamide (DMHCA) could suppress inflammatory gene expression, restore retinal structure, and potentially be used as a treatment strategy against retinal ischemia-reperfusion (RIR) injury. The study also identified Ninj1 as a key player in microglia-mediated inflammation and demonstrated that DMHCA exerted its anti-inflammatory effect by downregulating Ninj1 expression.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Coral Torres-Querol, Manuel Quintana-Luque, Gloria Arque, Francisco Purroy
Summary: Remote ischemic conditioning (RIC) is a promising therapeutic approach for ischemic stroke patients, with proven efficacy in reducing infarct size through different applications in preclinical animal models.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Abduqodir H. Toychiev, Khulan Batsuuri, Miduturu Srinivas
Summary: The study revealed an increase in Cx43 expression and GJ coupling in retinal astrocytes during retinal ischemia/reperfusion injury, leading to exacerbate RGC loss. Deleting astrocytic Cx43 improved neuronal survival in acute ischemia, while pharmacological inhibition of GJ coupling provided neuroprotection in the injury condition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Junkai Tan, Guo Liu, Chunlin Lan, Iok-Hou Pang, Xiaolin Luo, Shen Wu, Ning Fan, Jingxue Zhang, Ningli Wang, Xuyang Liu
Summary: The study demonstrates that LV-mediated C3 transgene expression has neuroprotective effects on retinal ischemia/reperfusion injury in rats, potentially serving as a novel neuroprotective approach for certain retinopathies.
Article
Chemistry, Multidisciplinary
Raquel Boia, Paul A. N. Dias, Caridad Galindo-Romero, Hugo D. Ferreira, Ines D. Aires, Manuel Vidal-Sanz, Marta Agudo-Barriuso, Rui Bernardes, Paulo F. Santos, Herminio C. de Sousa, Antonio Francisco Ambrosio, Mara E. M. Braga, Ana Raquel Santiago
Summary: The use of PCL implants loaded with selective A3R agonists has shown to effectively protect RGCs and improve their function, although it does not prevent retinal thinning due to transient ischemia.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, Research & Experimental
Jiaojiao Wei, Lili Zhang, Kaicheng Wu, Jian Yu, Fengjuan Gao, Jingyi Cheng, Ting Zhang, Xujiao Zhou, Yuan Zong, Xiaojing Huang, Chunhui Jiang
Summary: This study found that both endogenous and exogenous cannabinoids can regulate the contraction and dilation of retinal capillaries, and this effect is related to changes in cell width.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Rosario Amato, Alessio Canovai, Alberto Melecchi, Salvatore Pezzino, Roberta Corsaro, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli, Maurizio Cammalleri
Summary: Studies have shown that the combination of lutein and C3G can prevent oxidative stress, inflammation, gliotic and apoptotic responses caused by LD, thus protecting photoreceptor cells more effectively than each component alone. Furthermore, they can improve dysfunctional electroretinogram and enhance rod and cone photoreceptor responses.
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)
