Article
Ophthalmology
Min Zhang, Jiayi Yang, Kaibao Ji, Xuejun He, Tao He, Yiqiao Xing
Summary: Inhibition of p66Shc expression can protect retinal ganglion cells (RGCs) from ischemia-induced apoptosis and preserve retinal function by acting through the Akt pathway.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Ru Zhao, Tao He, Yiqiao Xing, Jinyuan Luo
Summary: This study finds that COG1410 regulates the state of microglia and protects retinal ganglion cells in retinal ischemia-reperfusion injury, showing promising potential for the treatment of eye diseases.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Ophthalmology
Jing Xu, Yuyan Guo, Qiong Liu, Hui Yang, Ming Ma, Jian Yu, Linjiang Chen, Chunlian Ou, Xiaohui Liu, Jing Wu
Summary: In this study, it was found that PGB can protect RGCs from apoptosis induced by RIR injury by activating the Akt/GSK3/3//3-catenin pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Federica Conti, Giovanni Luca Romano, Chiara Maria Eandi, Mario Damiano Toro, Robert Rejdak, Giulia Di Benedetto, Francesca Lazzara, Renato Bernardini, Filippo Drago, Giuseppina Cantarella, Claudio Bucolo
Summary: The study demonstrated that brimonidine effectively protected the function of RGCs in mouse eyes and regulated the inflammatory biomarkers induced by retinal ischemia reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Siyu Zeng, Lei Du, Guojing Lu, Yiqiao Xing
Summary: In this study, it was found that cellular repressor of E1A-stimulated genes (CREG) protected retinal ganglion cells (RGCs) from ischemia-reperfusion injury (RIRI) by activating the Akt signaling pathway and regulating apoptotic proteins. CREG also improved retinal function and visual acuity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Giovanni Luca Romano, Lucia Gozzo, Oriana Maria Maurel, Serena Di Martino, Valentina Riolo, Vincenzo Micale, Filippo Drago, Claudio Bucolo
Summary: The topical ocular administration of FLX was found to have a neuroprotective effect in a mouse model of acute retinal damage, as it counteracted the damage of retinal ganglion cells and preserved retinal function. FLX treatment also reduced the production of pro-inflammatory molecules elicited by retinal injury. Further studies are needed to support the use of FLX as a neuroprotective agent in retinal degenerative diseases.
Article
Neurosciences
Nafiseh Seyed Hosseini Fin, Dana Georgevsky, Maria B. Sukkar, S. Mojtaba Golzan
Summary: Glaucoma is a progressive neurodegenerative disease associated with the accumulation of amyloid-beta (Ass) proteins in the ganglion cell layer (GCL) and subsequent loss of retinal ganglion cells (RGC). This study investigated the role of the receptor for advanced glycation end product (RAGE)-Ass axis in RGC loss in experimental glaucoma. The results showed that RAGE(-/-) mice were protected against RGC loss following retinal ischemia, and intravitreal injection of oligomeric Ass accelerated RGC loss in wild-type (WT) mice but not in RAGE(-/-) mice.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Panagiotis Chronopoulos, Caroline Manicam, Jenia Kouchek Zadeh, Panagiotis Laspas, Johanna Charlotte Unkrig, Marie Luise Goebel, Aytan Musayeva, Norbert Pfeiffer, Matthias Oelze, Andreas Daiber, Huige Li, Ning Xia, Adrian Gericke
Summary: This study demonstrates that resveratrol has a protective effect against ischemia-reperfusion injury in the murine retina, reducing the loss of retinal ganglion cells and endothelial dysfunction of retinal blood vessels. This protective effect may be achieved by suppressing upregulation of nitric oxide synthase 2 and alleviating nitro-oxidative stress.
Article
Biochemistry & Molecular Biology
Defu Wu, Qi An, Hengjing Ji, Jinyue Dai, Lingge Suo, Chun Zhang
Summary: This study analyzed changes in lipid profile using a retinal ischemia-reperfusion model and found that the injury caused alterations in 338 lipid molecules, potentially leading to retinal tissue damage. The study also identified characteristic changes in certain lipids, which may serve as potential biomarkers for assessing the severity of retinal injury and therapeutic interventions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Ciriaco Corral-Domenge, Pedro de la Villa, Alicia Mansilla, Francisco Germain
Summary: The retina, as part of the central nervous system, is crucial for understanding the health and functioning of both the retina itself and the entire central nervous system. The neurons known as ganglion cells are responsible for processing and transmitting light information, and the degeneration of these cells can lead to irreversible blindness or impaired vision. Research into the subtypes of these ganglion cells and the identification of cell death pathways is essential for understanding degenerative processes and developing prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Bailey G. Hannon, Andrew J. Feola, Brandon G. Gerberich, A. Thomas Read, Mark R. Prausnitz, C. Ross Ethier, Machelle T. Pardue
Summary: This study explores the potential of using electroretinography to detect ischemic damage in animal models of glaucoma. It suggests that criteria based on ERG testing may provide more objective and robust exclusion criteria in future glaucoma studies, as intermittent IOP measurements may fail to detect ischemia and exclude animals with IOP spikes that do not induce ischemic damage.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Polymer Science
Ke Yao, Xin Liang, Guiyang Zhang, Yan Rong, Qiuxiang Zhang, Qiaobo Liao, Hong Zhang, Kai Xi, Junming Wang
Summary: In this study, covalent organic framework (COF) nanoparticles were investigated for their potential use in the local treatment of glaucoma. The results showed that COF could protect retinal ganglion cells (RGCs) and serve as a carrier for delayed release of the medication rapamycin. The COF-Rapa formulation effectively reduced RGCs death, improved retinal function, and alleviated inflammation in an animal model of glaucoma retinopathy.
Article
Ophthalmology
Hyemin Seong, Joo Yeon Jeong, Jinhyun Ryu, Juyeong Park, Yong-Seop Han, Hyun-Kyung Cho, Seong Jae Kim, Jong Moon Park, Sang Soo Kang, Seong Wook Seo
Summary: This study confirms the changes in proteins related to hypoxia-induced retinal cell death and suggests that resveratrol could be a potential therapeutic agent for treating ischemic injury-related eye diseases by targeting the expression of ErbB2 and MDM2.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stefania Vernazza, Francesco Oddone, Sara Tirendi, Anna Maria Bassi
Summary: Glaucoma is a neurodegenerative disease that causes damage to retinal ganglion cells and results in permanent vision loss. While Intra Ocular Pressure (IOP) is the main therapeutic target, other pathological conditions and neuroprotective therapeutic approaches also play important roles in the disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Abduqodir H. Toychiev, Khulan Batsuuri, Miduturu Srinivas
Summary: The study revealed an increase in Cx43 expression and GJ coupling in retinal astrocytes during retinal ischemia/reperfusion injury, leading to exacerbate RGC loss. Deleting astrocytic Cx43 improved neuronal survival in acute ischemia, while pharmacological inhibition of GJ coupling provided neuroprotection in the injury condition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)