Article
Biochemistry & Molecular Biology
Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Tzu-Ching Shih, Chung-Min Yeh, Tso-Fu Wang, Ray-Jade Chen, Yu-Chun Chang, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study aimed to explore a tumor suppressive compound that can enhance the efficacy of Gefitinib treatment in lung cancer. Through in vitro and in vivo experiments, it was found that the combination of Daidzein and Gefitinib synergistically induced apoptosis and cell cycle arrest, effectively inhibiting lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Ophthalmology
Stephen Tuft, Tobi F. Somerville, Ji-Peng Olivia Li, Timothy Neal, Surjo De, Malcolm J. Horsburgh, Joanne L. Fothergill, Daniel Foulkes, Stephen Kaye
Summary: Bacterial keratitis is a common corneal infection that can lead to severe visual loss, but there are uncertainties surrounding its diagnosis criteria and bacterial resistance. Current treatment strategies and research are primarily based on systemic administration data, without sufficient consideration for local corneal concentrations and biological activity.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yuliu Zhang, Jianping Du, Xiaofan Duan, Wei Peng, Lei Lv, Zhiyu Chen, Yumei Zhang
Summary: In this study, RIPK1 expression was found to significantly contribute to cisplatin-induced apoptosis in human ESCC cells. Reduced RIPK1 expression promoted cell proliferation, while overexpressed RIPK1 facilitated apoptosis. Mechanistic investigations revealed that inhibition of RIPK1 proliferation in ESCC cells was regulated through activation of the c-Jun NH2-terminal kinase signaling pathway, leading to mitochondrial damage, ATP depletion, and increased reactive oxygen species generation.
Article
Ophthalmology
Sanjay Marasini, Odunayo O. Mugisho, Simon Swift, Hannah Read, Ilva D. Rupenthal, Simon J. Dean, Jennifer P. Craig
Summary: The study found that a single 15-second UVC exposure did not significantly induce CPD formation in vitro on human corneal epithelial cells, but continuous exposure for 3 days resulted in more CPD formation. In vivo experiments showed that three consecutive daily doses of 15-second UVC exposure were safe with respect to CPD formation, whereas a single 300-second exposure caused extensive CPD formation.
Article
Cell Biology
Yijing Ren, Cheng Lv, Jing Zhang, Beibei Zhang, Bei Yue, Xiaoping Luo, Zhilun Yu, Hao Wang, Junyu Ren, Zhengtao Wang, Wei Dou
Summary: Alantolactone (ATL) exhibits inhibitory effects on cell activities, induces apoptosis, and inhibits colony formation in colorectal cancer. It also reduces cell migration and invasion capabilities. Furthermore, ATL demonstrates significant anti-tumor effects in vivo models.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, General & Internal
Jeremy J. Hoffman, Reena Yadav, Sandip Das Sanyam, Pankaj Chaudhary, Abhishek Roshan, Sanjay K. Singh, Sailesh K. Mishra, Simon Arunga, Victor H. Hu, David Macleod, Astrid Leck, Matthew J. Burton
Summary: This study describes the health-seeking journey for patients with microbial keratitis in Nepal and identifies factors associated with delay.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Yuka Okada, Takayoshi Sumioka, Peter S. Reinach, Masayasu Miyajima, Shizuya Saika
Summary: Maintaining corneal transparency is crucial for normal vision, and the pathogenic responses during corneal wound healing can lead to opacification. Studies have shown that different transient receptor potential channel (TRP) isoforms play important roles in mediating the control of conventional ocular tissue under normal and pathological conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Hari Kumar Peguda, Saabah B. Mahbub, Tashi Doma Sherpa, Dinesh Subedi, Abbas Habibalahi, Ayad G. Anwer, Zi Gu, Mark D. P. Willcox, Ewa M. Goldys, Nicole A. Carnt
Summary: This study investigated the effect of antibiotics and anesthetic drugs on the autofluorescence patterns of Acanthamoeba and bacteria that cause keratitis. Fluorescence spectroscopy was found to differentiate Acanthamoeba from bacteria in vitro, highlighting the potential for diagnostic use. Further research is needed to assess the fluorescence patterns of different strains and the effects of anti-amoebic drugs before in vivo testing.
Article
Medicine, General & Internal
Jeongah Shin, Woo Young Son, Kyong Jin Cho, Chang Rae Rho
Summary: Fungal keratitis caused by Trichosporon asahii is rare and can develop following ptosis surgery. Prompt diagnosis and treatment are crucial in managing the condition, and identification and correction of risk factors such as recent lid surgery and chronic keratitis can be beneficial.
Article
Microbiology
Sarah Atta, Chandrashan Perera, Regis P. Kowalski, Vishal Jhanji
Summary: Fungal keratitis (FK) is a challenging condition to diagnose and treat. This retrospective study reviewed FK cases at a medical center in Pennsylvania, USA, and found that the most common risk factors were contact lens use, recent ocular trauma/abrasion, and history of ocular surgery. The majority of cases were treated with topical and oral voriconazole, and surgical management was necessary in some cases.
Review
Ophthalmology
Stephanie Hiu Ling Poon, William Ho Lam Wong, Amy Cheuk Yin Lo, Hao Yuan, Chien-Fu Chen, Vishal Jhanji, Yau Kei Chan, Kendrick Co Shih
Summary: Herpes simplex keratitis (HSK) is a major cause of visual impairment worldwide, with no established diagnostic criteria leading to challenges in accurate diagnosis. Current diagnostic methods, including PCR and protein detection, have varying levels of accuracy in identifying HSK. Newer techniques like multiplex dot hybridization assay show promise as point-of-care preliminary diagnostic tools.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Pharmacology & Pharmacy
Huihui Wang, Chuangyu Wen, Siyu Chen, Weiqian Li, Qiyuan Qin, Lu He, Fang Wang, Junxiong Chen, Weibiao Ye, Wende Li, Junsheng Peng, Xiangling Yang, Huanliang Liu
Summary: The study demonstrates that chaetocin induces apoptosis in CRC cells by causing ROS accumulation and activating the JNK/c-Jun pathway, while also down-regulating CD47 expression and enhancing macrophages phagocytosis of CRC cells. Additionally, chaetocin inhibits tumor growth in CRC xenograft models, suggesting its potential as a candidate for CRC chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Eric C. Ledbetter, Longying Dong
Summary: This study found that the intact and traumatized feline cornea is highly susceptible to Acanthamoeba castellanii binding and invasion, compared to other host species. The feline cornea does not require a previous epithelial defect for Acanthamoeba binding.
Article
Infectious Diseases
Srikanth Dumpati, Shehzad A. Naroo, Sunil Shah, Debarun Dutta
Summary: This study assessed the antimicrobial activity of a UVC device against microorganisms related to contact lens adverse events. The results showed that UVC exposure had a high antimicrobial efficacy and could be used for lens disinfection.
Article
Ophthalmology
Tomas E. Meijome, Rachel Wozniak, Linda Kang, Lyna Azzouz, Leslie M. Niziol, William L. Johnson, Matthias Kriegel, Maria A. Woodward
Summary: This study explored the use of slit lamp photography (SLP) images to objectively and quantitatively measure the severity of bacterial keratitis (BK) in mouse models. The results showed that the stromal infiltrate (SI) area in SLP images correlated positively with clinical severity grades and bacterial burden. This method may provide an objective, quantitative, and repeatable assessment of BK disease severity.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Letter
Dermatology
Ryotaro Torai, Teruhiko Makino, Yu Matsui, Tadamichi Shimizu
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Shohei Kitayama, Teruhiko Makino, Megumi Mizawa, Tadamichi Shimizu
JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Megumi Mizawa, Teruhiko Makino, Fumina Furukawa, Ryotaro Torai, Tadamichi Shimizu
JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Teruhiko Makino, Hiromu Sugiyama, Miyako Oshima, Megumi Mizawa Id, Tadamichi Shimizu
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Teruhiko Makino, Kazuya Kataoka, Shohei Kitayama, Megumi Mizawa, Tadamichi Shimizu
JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Dermatology
Teruhiko Makino, Yoshiyuki Terada, Megumi Mizawa, Keiichi Hirono, Yuichi Adachi, Satomi Aoki, Akiharu Kubo, Tadamichi Shimizu
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Letter
Dermatology
Shohei Kitayama, Teruhiko Makino, Ryotaro Torai, Megumi Mizawa, Tadamichi Shimizu
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Infectious Diseases
Takamitsu Ohnishi, Shinichi Watanabe, Tetsuya Matsumoto, Hiroshi Yotsuyanagi, Junko Sato, Intestu Kobayashi, Shin Iinuma, Takashi Nagayama, Shuichiro Shibuya, Natsuki Ogawa, Ken Iozumi, Yasuyuki Nakajima, Yukiko Kurikawa, Motoko Kobayashi, Koma Matsuo, Hideyuki Ishikawa, Tadamichi Shimizu, Kiyohiro Tsutsui, Tatsuyoshi Kawamura, Ryuhei Okuyama, Mariko Seishima, Yoichi Akita, Chikatoshi Kasugai, Katsuaki Yano, Yasuhiko Tamada, Kimihiko Mizutani, Kenji Kabashima, Nanako Yamada, Masami Ikeda
Summary: The present study compared trends in antimicrobial resistance patterns in pathogens isolated from skin and soft-tissue infections (SSTIs) in Japan with those of a nationwide survey conducted in 2013. The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) did not differ significantly between the present study and the 2013 survey. However, the prevalence of methicillin-resistant coagulase-negative staphylococci (MRCNS) was higher in the present study compared to the 2013 survey. The susceptibility profiles of MRSA and MRCNS to various antibiotics were not significantly different between the two surveys. Continuous monitoring is important for guiding the appropriate treatment of SSTIs.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Dermatology
Shohei Kitayama, Teruhiko Makino, Ayumi Yoto, Shuichi Mori, Fumina Furukawa, Ryotaro Torai, Megumi Mizawa, Tadamichi Shimizu
Summary: We report the first case of FIP1L1-PDGFRA fusion gene-positive cells detected in a skin lesion from a patient with FIP1L1-PDGFRA fusion gene-positive hypereosinophilic syndrome (HES). This finding suggests that the infiltration of neoplastic eosinophils with the FIP1L1-PDGFRA fusion gene in the skin may contribute to the development of skin lesions. HES is a heterogeneous group of diseases characterized by persistent hypereosinophilia and organ damage, where the FIP1L1-PDGFRA fusion gene is found in a subset of patients.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Megumi Mizawa, Teruhiko Makino, Miyako Oshima, Masao Hayashi, Tadamichi Shimizu
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Shohei Kitayama, Teruhiko Makino, Masao Hayashi, Megumi Mizawa, Norito Ishii, Takashi Hashimoto, Tadamichi Shimizu
Summary: In this study, fluorescence overlay antigen mapping was used to diagnose an anti-p200 pemphigoid patient and found that the patient's IgG signals were co-localized with laminin β1. Fluorescence overlay antigen mapping may be useful for diagnosing anti-p200 pemphigoid.
JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Kazuya Kataoka, Teruhiko Makino, Shuichi Mori, Fumina Furukawa, Ryotaro Torai, Kazushi Anzawa, Kiminobu Takeda, Akira Shimizu, Tadamichi Shimizu
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Shohei Kitayama, Teruhiko Makino, Kazuya Kataoka, Shuichi Mori, Fumina Furukawa, Ryotaro Torai, Megumi Mizawa, Tadamichi Shimizu
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Shohei Kitayama, Teruhiko Makino, Masao Hayashi, Fumina Furukawa, Ryotaro Torai, Megumi Mizawa, Norito Ishii, Takashi Hashimoto, Tadamichi Shimizu
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nao Yamagishi, Jun-ichiro Takahashi, Yue Zhou, Satoru Yokoyama, Teruhiko Makino, Tadamichi Shimizu, Hiroaki Sakurai
Summary: 9,10-Phenanthrenequinone is a polycyclic aromatic hydrocarbon present in air pollutants, which leads to excessive production of reactive oxygen species. Recent studies have shown that 9,10-Phenanthrenequinone activates epidermal growth factor receptor by inhibiting protein tyrosine phosphatase 1B. Additionally, it induces non-canonical regulation of EGFR through the activation of mitogen-activated protein kinase.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)
