Article
Plant Sciences
Xingyu Lv, Yuqi Lin, Xi Zhu, Xiujun Cai
Summary: In this study, it was found that Isoalantolactone (IAL), a compound derived from Inula helenium L., has inhibitory effects on gallbladder cancer (GBC). IAL can inhibit the proliferation, migration, and invasion of GBC cells, promote cell apoptosis, and exert its effects by inhibiting the ERK signaling pathway. Animal experiments also confirmed that IAL can suppress the growth of gallbladder tumors.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Fisheries
Yuehong Zhao, Xiaoli Zhang, Xiaona Zhang, Guoqing Shen, Weiwei Li, Qun Wang
Summary: This study found that integrin01 regulates the survival of Chinese mitten crab hemocytes by activating the FAK/ERK signaling cascade, and reducing the phosphorylation of ERK can enhance apoptosis.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Cell Biology
Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Munch, Steffen Lemke, Silke Kowar, Melanie Boerries
Summary: This study comprehensively characterized a panel of patient-derived BRAFV600E positive melanoma cell lines and found that a decrease in sensitivity to MAPK/ERK pathway inhibition corresponded with increased migratory potential and the acquisition of stem cell-like properties. Additionally, it was discovered that increased activity of the PI3K/AKT pathway lead to a decreased dependency on MAPK/ERK signaling in melanoma cells.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Dermatology
Kyung-Il Kim, Kyung Eun Jung, Young-Bin Shin, Chang-Deok Kim, Tae-Jin Yoon
Summary: In this study, we conducted a large-scale screening test on drugs approved for other diseases to find pigmentation-modulating agents. Among the potential drugs, sorafenib was selected for further investigation on its effect on pigmentation in melanoma cells. The results showed that sorafenib promoted pigmentation by increasing the melanin content and tyrosinase activity. Mechanistic studies revealed that this effect was mediated by the activation of beta-catenin signaling through the regulation of GSK3 beta phosphorylation.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Cell Biology
Bas Ponsioen, Jasmin B. Post, Julian R. Buissant des Amorie, Dimitrios Laskaris, Ravian L. van Ineveld, Simone Kersten, Andrea Bertotti, Francesco Sassi, Francois Sipieter, Benjamin Cappe, Sander Mertens, Ingrid Verlaan-Klink, Sylvia F. Boj, Rob G. J. Vries, Holger Rehmann, Peter Vandenabeele, Franck B. Riquet, Livio Trusolino, Johannes L. Bos, Hugo J. G. Snippert
Summary: The study illustrates how EGFR activity enhances signal transduction efficiency in KRAS or BRAF mutant MAPK pathways, revealing a potential mechanism for using EGFR inhibitors in colorectal cancer with KRAS and BRAF mutations.
NATURE CELL BIOLOGY
(2021)
Article
Oncology
Weijie Xie, Shulin Li, Huan Guo, Jiawei Zhang, Menjiang Tu, Rui Wang, Bingling Lin, Yuqi Wu, Xiangwei Wang
Summary: FEN1 is upregulated in prostate cancer and promotes cell growth, while AR plays a critical role in prostate cancer. This study reveals that AR downregulates FEN1 expression through the ERK/ELK1 signaling pathway, leading to improved sensitivity of prostate cancer cells to DTX.
Review
Behavioral Sciences
Joy D. Iroegbu, Olayemi K. Ijomone, Omowumi M. Femi-Akinlosotu, Omamuyovwi M. Ijomone
Summary: The ERK/MAPK signaling pathway plays a crucial role in neurodevelopment, particularly in the development of neural progenitor cells and the proper formation of the nervous system. It is associated with various neurodevelopmental disorders, highlighting its significance in understanding the pathology of these disorders and identifying potential novel therapeutic targets.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Oncology
Hyuk Moon, Simon Weonsang Ro
Summary: The MAPK/ERK signaling pathway is frequently activated in liver cancer, with alternative mechanisms other than genetic mutations driving its activation. Recent studies have focused on understanding the cellular and molecular mechanisms involved in the activation of the MAPK/ERK signaling pathway in HCC, suggesting potential therapeutic strategies targeting this pathway.
Article
Biochemistry & Molecular Biology
Sumit Siddharth, Panjamurthy Kuppusamy, Qitong Wu, Arumugam Nagalingam, Neeraj K. Saxena, Dipali Sharma
Summary: Hepatocellular carcinoma (HCC) is a malignant tumor with increasing incidence and mortality rates, and there is a lack of effective therapeutic options for advanced HCC. This study found that the combination of low-dose sorafenib and non-toxic dose of metformin can effectively inhibit the growth and migration potential of HCC cells, enhance the efficacy of sorafenib, and inhibit the MAPK/ERK/Stat3 signaling pathway. The results of in vivo studies also supported these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ping Kuang, Hengmin Cui, Li Yu
Summary: This study investigated the mechanism of fluorosis on the growth system using qRT-PCR and WB methods. The results showed that NaF inhibited the proliferation and development of splenic cells and activated the Ras-Raf-MEK-ERK signaling pathway. However, it failed to activate ERK, leading to the disruption of cell regulation and suppressed spleen development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Sheryl Erica Fernandes, Deepak Kumar Saini
Summary: The study examined the roles of three major kinases in regulating nitric oxide levels in senescent cells, revealing differential regulation compared to non-senescent cells. Through infection assays, an inter-regulatory network unique to infected senescent cells was established, showing how key signalling networks may be rewired in senescent cells rendering them phenotypically different.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Xitao Zhang, Tianlai Liu, Jinlin Huang, Jianping He
Summary: This study revealed that PICALM promotes CRC progression through the ERK/MAPK signaling pathway, highlighting its potential as a therapeutic target in clinical applications.
CANCER CELL INTERNATIONAL
(2022)
Review
Plant Sciences
Mrinalini Manna, Balakrishnan Rengasamy, Alok Krishna Sinha
Summary: The mitogen-activated protein kinase (MAPK) pathway is crucial for plant growth, development, and stress adaptation. This review summarizes recent advancements in understanding the roles of MAPK signaling in plant stress tolerance, architecture, and yield. MAPK signaling interacts with reactive oxygen species (ROS) and abscisic acid (ABA) signaling to modulate abiotic stress responses. Additionally, MAPK pathway plays an important role in plant pathogen defense and shaping plant architecture and yield. This makes MAPK pathway a valuable target for crop improvement, and various strategies to manipulate MAPK signaling components are discussed for designing future crops with enhanced physiology and phenotypes.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Chemistry, Medicinal
Yan Lan, Yu-Kun Zheng, Liu-Yi Wu, Zi-Jun Zhou, Ruo-Xin Guan, Heng Xu, Ji-Yuan Tu, Xin Gu, Rui Wang, Nan Jiang, Yuan Wu, Cheng-Ren Shu, Zhong-Shi Zhou
Summary: The alcohol extract of Polygonum cuspidatum (PC) has been found to have anti-inflammatory and analgesic effects, potentially through the inhibition of the MAPK/ERK signaling pathway in the spinal cord.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Environmental Sciences
Yeyi Xiao, Jie Wang, Jingneng Wang, Haifei Wang, Shenglong Wu, Wenbin Bao
Summary: This study investigates the role of the Notch1 signaling pathway in protecting against DON exposure. Inhibiting Notch1 signaling increases oxidative stress, cell apoptosis, reduces autophagy, and exacerbates cell inflammation after DON exposure. The findings provide a basis for further research on the mechanism of DON.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Letter
Dermatology
Clemence Bertold, Philippe Martel, Thierry Passeron, Philippe Bahadoran
Summary: The presence of pigmented circles around hair follicles is a key feature in diagnosing lentigo maligna and benign pigmented macules. In this case report, reflectance confocal microscopy was used to diagnose pigmented demodicosis instead of lentigo maligna, avoiding an unnecessary biopsy and shedding light on the mechanisms of hyperpigmentation.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
David Alvarez Martinez, Clemence Bertold, Florence Le Duff, Philippe Bahadoran, Thierry Passeron
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Editorial Material
Dermatology
Wei Liu, Jean Krutmann, Yan Tian, Corinne Granger, Jaime Piquero-Casals, Carles Trullas, Thierry Passeron, Henry W. Lim, Wei Lai
Summary: The medical literature on aesthetic dermatology has largely overlooked the needs of patients with darker skin types, who have different concerns and priorities. In Chinese individuals, pigment alteration is a major concern as it is associated with aging and a cultural beauty standard of fair skin. Non-invasive cosmetic procedures like lasers and injections are also popular in China, but can lead to hyperpigmentation as a side effect in this population. It is important to consider and tailor approaches to address both primary concerns of photoaging and the side effects of cosmetic treatments.
DERMATOLOGY AND THERAPY
(2023)
Article
Dermatology
Hanene Bzioueche, Katia Boniface, Claire Drullion, Sandrine Marchetti, Berengere Chignon-Sicard, Laura Sormani, Stephane Rocchi, Julien Seneschal, Thierry Passeron, Meri K. Tulic
Summary: Vitiligo is an autoimmune disease characterized by melanocyte loss and white patches on the skin. This study demonstrates that house dust mite (HDM) can induce inflammatory responses and melanocyte detachment in vitiligo through protease activity. HDM may act as an external source of pathogen-associated molecular pattern molecules in vitiligo, and MMP-9 inhibitors could be potential therapeutic targets. Furthermore, studying specific vitiligo endophenotypes can help understand the environmental contribution to the disease.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Thierry Passeron
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
David Alvarez Martinez, Elodie Long-Mira, Thierry Passeron, Philippe Bahadoran
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Adrien Sanchez, Elisa Demonchy, Mathieu Buscot, Nathalie Cardot-Leccia, Kamel Lagha, Henri Montaudie, Thierry Passeron
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Julie Bulsei, Eric Fontas, Thierry Passeron
Summary: This study assessed the socioeconomic status (SES) of HS patients using the French DEPrivation index (FDep) and found a significant association between HS and low SES in the adult population. In children aged 7-17, low SES was associated with obesity and tobacco consumption, but no association with HS was observed after matching for these confounding factors.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
F. Flament, D. G. Mercurio, E. Catalan, E. Bouhadanna, C. Delaunay, D. F. Miranda, T. Passeron
Summary: This study aimed to evaluate the effectiveness of a photoprotective product in counteracting the aging process of different skin types. The results showed that daily application of a high photoprotective product significantly slowed down skin aging.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Corinne Granger, Thierry Passeron, Carles Trullas, Muzzammil Hosenally, Bibi Nusayha Sokeechand, Jean Krutmann, Henry W. Lim
Summary: This study compared the differences in erythema and pigmentation responses of Chinese and White European individuals to three different sunscreens in outdoor conditions. The findings showed that White Europeans had a higher incidence of erythema response and a higher rate of photoprotection failure, especially with SPF 15 and 30 sunscreens. Therefore, ethnicity should be taken into account when making recommendations for sun safety.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Letter
Dermatology
Julie Bulsei, Eric Fontas, Thomas Hubiche, Thierry Passeron
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Clemence Bertold, Eric Fontas, Tanya Singh, Nadia Gastaut, Sandra Ruitort, Sylvia Wehrlen Pugliese, Thierry Passeron
Summary: This study aimed to assess the efficacy and tolerance of a New Trio (NT) combination compared to Kligman's trio (KT) in treating melasma. The results showed that both the NT and KT groups demonstrated significant improvement in mMASI after 12 weeks, with the NT group showing a more significant improvement. Therefore, the NT combination can be considered as an effective treatment option for melasma with better tolerance.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
T. Passeron, H. W. Lim, C. L. Goh, H. Y. Kang, C. Ribeyre, A. -l. Demessant-Flavigny, C. Le Floc'h, D. Kerob, J. Krutmann, C. Comte, B. Dreno, M. T. Leccia
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Julien Seneschal, Reinhart Speeckaert, Alain Taieb, Albert Wolkerstorfer, Thierry Passeron, Amit G. Pandya, Henry W. Lim, Khaled Ezzedine, Youwen Zhou, Flora Xiang, Steven Thng, Atsushi Tanemura, Tamio Suzuki, David Rosmarin, Michelle Rodrigues, Noufal Raboobee, Georg Pliszewski, Davinder Parsad, Naoki Oiso, Paul Monteiro, Jean Marie Meurant, Nicolle Maquignon, Harvey Lui, Caroline Le Poole, Giovanni Leone, Ai-Young Lee, Eric Lan, Ichiro Katayama, Richard Huggins, Sang Ho Oh, John E. Harris, Iltefat H. Hamzavi, Somesh Gupta, Pearl Grimes, Boon Kee Goh, Deepti Ghia, Samia Esmat, Viktoria Eleftheriadou, Markus Boehm, Laila Benzekri, Marcel Bekkenk, Jung Min Bae, Augustin Alomar, Marwa Abdallah, Mauro Picardo, Nanja Van Geel
Summary: This study presents internationally agreed-upon expert-based recommendations for the treatment of vitiligo, including the use of topical and systemic therapies, phototherapies, intervention strategies, and the status of innovative therapies. The development of new treatments for vitiligo is ongoing.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Manon Blaise, Gilles Poissonnet, Nathalie Cardot-Leccia, Anne Sudaka, Marine Velin, Madleen Chassang, Micheline Razzouk-Cadet, Alexandra Picard-Gauci, Thierry Passeron, Henri Montaudie
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
