Article
Multidisciplinary Sciences
Jack Cheng, Lee-Fen Hsu, Ying-Hsu Juan, Hsin-Ping Liu, Wei-Yong Lin
Summary: This study provided pathway-targeting gene matrixes for fruit fly based on Reactome and KEGG databases, validated using expression profiling containing neurons or glia of fruit flies. The study identified characteristic neuronal and glial pathways, including mRNA splicing and endocytosis. The feasibility of Reactome and KEGG gene matrix files was generated and validated, benefiting future profiling studies using Drosophila.
Article
Biology
Qiangqiang Liu, Qian Luo, Jianyu Feng, Yanping Zhao, Biao Ma, Hongcheng Cheng, Tian Zhao, Hong Lei, Chenglong Mu, Linbo Chen, Yuanyuan Meng, Jiaojiao Zhang, Yijia Long, Jingyi Su, Guo Chen, Yanjun Li, Gang Hu, Xudong Liao, Quan Chen, Yushan Zhu
Summary: The ubiquitination-mediated degradation of DBC1 is regulated by the E3 ubiquitin ligase SIAH2 and deubiquitinase OTUD5 under hypoxic stress. SIAH2 knockout inhibited tumor cell proliferation and migration, which could be rescued by double knockout of SIAH2/CCAR2.
Editorial Material
Biochemistry & Molecular Biology
Chris T. Ho, Stephanie L. Gupton
Summary: The shape of a neuron undergoes significant changes in development. A recent study reveals the existence of a novel septin cytoskeleton network that plays a critical role in establishing proper neuronal morphology.
Article
Neurosciences
Jiun-Min Hsu, Yunsik Kang, Megan M. Corty, Danielle Mathieson, Owen M. Peters, Marc R. Freeman
Summary: This study reveals the effects of nervous system injury on functional connectivity and finds that axotomy leads to impaired axon transport and reduced signal transduction in bystander neurons. The research also identifies a critical role for dSarm and glia in signaling and functional recovery in the injured nervous system.
Article
Anatomy & Morphology
Yongbo Hu, Yiming He, Wei Liu, Shun Yu, Yabing Wei, Shaohua Bai, Yu Su, Bin Xiao
Summary: SIAH2 acts as an oncogene in colorectal cancer, promoting tumor proliferation, migration, and invasion. It activates the PI3K/AKT signaling pathway and is regulated by PTEN loss.
Review
Biochemistry & Molecular Biology
Panagiota Mavroeidi, Maria Vetsi, Dimitra Dionysopoulou, Maria Xilouri
Summary: Exosomes play an important role in the progression of alpha-synuclein-related pathology by facilitating the spread of pathological alpha-synuclein or activating immune cells. Their content varies depending on their origin and recipient cells, and they can serve as diagnostic biomarkers for early disease detection and as scaffolds for delivering therapeutic agents.
Article
Cell Biology
Ruiyi Yuan, Younghee Hahn, Max H. Stempel, David K. Sidibe, Olivia Laxton, Jessica Chen, Aditi Kulkarni, Sandra Maday
Summary: Neurons and astrocytes have unique requirements for quality control pathways, such as autophagy and the UPS, to maintain proper function and survival. This study investigated the relationship between autophagy and the proteasome in primary astrocytes and neurons, and found that proteasome inhibition did not robustly upregulate autophagy. Instead, astrocytes formed Ub-positive aggregates in response to UPS inhibition, but these structures were not efficiently degraded by autophagy. Additionally, neurons were more vulnerable to proteotoxic stress compared to astrocytes.
Article
Multidisciplinary Sciences
Ekin Bolukbasi, Nathaniel S. Woodling, Dobril K. Ivanov, Jennifer Adcott, Andrea Foley, Arjunan Rajasingam, Lauren M. Gittings, Benjamin Aleyakpo, Teresa Niccoli, Janet M. Thornton, Linda Partridge
Summary: Reduced activity of the insulin/insulin-like growth factor signaling pathway has been shown to increase healthy lifespan in various animal species. In the adult nervous system of Drosophila, specific transcription factors like neuronal FKH and glial FOXO play independent roles in extending healthy lifespan. The importance of cell type-specific mapping of transcription factor activity for preserving healthy function with age is highlighted in this study.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Jordan A. Munroe, Mubarak H. Syed, Chris Q. Doe
Summary: This study focuses on the mechanism of exiting quiescence in Drosophila brain neuroblasts, particularly type II neuroblasts. Researchers found that Insulin-like growth factor II mRNA-binding protein (Imp) plays an important role in the exit from quiescence in type II neuroblasts.
Article
Chemistry, Multidisciplinary
Jing-pei Liang, Yuan-ming He, Yao-li Cui, Yue-ning Sun, Gui-song He, Zhi-gang Zhu, Xin-liang Mao
Summary: In this study, it was found that proteasomal inhibitors (PIs) induce a novel type of cell death called pyroptosis in multiple myeloma (MM) through the GSDME pathway. The mitochondrial BAX/GSDME pathway was identified as the mechanism through which PIs trigger pyroptosis in MM cells. Combined treatment with Bcl-2 and proteasome inhibitors can increase therapeutic efficiency through induction of pyroptosis in MM cells.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Biotechnology & Applied Microbiology
Kathryn M. Kim, Mentor Thaqi, Daniel A. Peterson, Robert A. Marr
Summary: Cellular direct reprogramming offers advantages over induced pluripotent stem cell reprogramming, with a focus on modeling neurological diseases and exploring potential treatments. Various somatic cell types have shown promise in being reprogrammed into induced neurons, indicating the potential for subtype-specific production and therapeutic applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Neurosciences
Bernadetta Bilska, Milena Damulewicz, Terence Al L. Abaquita, Elzbieta Pyza
Summary: This study investigated the effects of changes in heme oxygenase (HO) levels in neurons and glial cells on adult Drosophila melanogaster. The results showed that the survival, lifespan, locomotor activity, and sleep of adult flies were influenced by the level of HO, the timing of expression, cell types, sex, and age. HO levels in neurons and glia need to be maintained at an appropriate physiological level during development to ensure the well-being of adults. The downregulation of ho in the brain can be compensated by ho expression in the retina.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Lingling Jiao, Xiaolan Li, Yuxiang Luo, Junfen Wei, Xulong Ding, Huan Xiong, Xuesong Liu, Peng Lei
Summary: Different brain cells exhibit varying sensitivities to ferroptosis, possibly due to differential regulation of iron metabolism and the ability to handle iron. Elucidating the cell death patterns of these cells can provide a theoretical basis for inhibiting the death of brain cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Immunology
Nicholas R. W. Cleland, Saif I. Al-Juboori, Evgenia Dobrinskikh, Kimberley D. Bruce
Summary: Neurodegenerative diseases such as AD, PD, and MS lack true disease-modifying therapies and currently available treatments only address symptoms. Recent studies show that cellular metabolic alterations are closely linked to disease progression in these disorders, highlighting the need for alternative strategies targeting metabolic mechanisms.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Eva Martinez-Pinilla, Nuria Rubio-Sardon, Rafael Pelaez, Enrique Garcia-Alvarez, Eva del Valle, Jorge Tolivia, Ignacio M. Larrayoz, Ana Navarro
Summary: Apolipoprotein D overexpression is commonly seen in neurodegenerative conditions, sparking interest in its role in diseases like multiple sclerosis. This study shows that increasing levels of Apo D may prevent the neurotoxic effects of cuprizone, a toxin used to model MS, suggesting a potential avenue for neuroprotection in MS-related conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
