Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems

Cox2 and β-Catenin/T-cell Factor Signaling Intestinalize Human Esophageal Keratinocytes When Cultured under Organotypic Conditions

(2015) Jianping Kong et al.   NEOPLASIA

Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model

(2014) Fransisca Leonard   ALTEX-Alternatives to Animal Experimentation

Intestinal organoids as tissue surrogates for toxicological and pharmacological studies

(2013) Anton Kuratnik et al.   BIOCHEMICAL PHARMACOLOGY

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

ADAR1 is essential for intestinal homeostasis and stem cell maintenance

(2013) W Qiu et al.   Cell Death & Disease

Human enteroids: preclinical models of non-inflammatory diarrhea

(2013) Olga Kovbasnjuk et al.   Stem Cell Research & Therapy

Functional Cftr in crypt epithelium of organotypic enteroid cultures from murine small intestine

(2012) Jinghua Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A nomenclature for intestinal in vitro cultures

(2012) Matthias Stelzner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Genomic studies of GVHD—lessons learned thus far

(2012) C Ting et al.   BONE MARROW TRANSPLANTATION

Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

(2012) Michael Quante et al.   CANCER CELL

Barrett’s to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer

(2012) Sarah L. Picardo et al.   DIGESTIVE SURGERY

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture

(2012) Jiri Kalabis et al.   Nature Protocols

Immune aspects of the pathogenesis of inflammatory bowel disease

(2012) Tadakazu Hisamatsu et al.   PHARMACOLOGY & THERAPEUTICS

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Intussusception due to inflammatory fibroid polyp: A case report and comprehensive literature review

(2012) Sami Akbulut   WORLD JOURNAL OF GASTROENTEROLOGY

The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin

(2011) Casey T. Weaver et al.   Annual Review of Pathology-Mechanisms of Disease

Th17-related cytokines: new players in the control of chronic intestinal inflammation

(2011) Ivan Monteleone et al.   BMC Medicine

Role of Notch signaling in colon homeostasis and carcinogenesis

(2011) Shingo Miyamoto et al.   CANCER SCIENCE

Expression of IFN-γ and IL-4 in the Esophageal Mucosa of Patients with Reflux Esophagitis and Barrett’s Esophagus and Their Relationship with Endoscopic and Histologic Grading

(2011) Ying-Qiang Zhong et al.   DIGESTIVE DISEASES AND SCIENCES

Stem cell self-renewal in intestinal crypt

(2011) Benjamin D. Simons et al.   EXPERIMENTAL CELL RESEARCH

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor

(2011) Anna M Nicholson et al.   GUT

Development and characterization of an organotypic model of Barrett's esophagus

(2011) Rachelle E. Kosoff et al.   JOURNAL OF CELLULAR PHYSIOLOGY

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Th-2 cytokines in the development of Barrett’s esophagus in rats

(2011) Yukie Kohata et al.   JOURNAL OF GASTROENTEROLOGY

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

Incidence of Adenocarcinoma among Patients with Barrett's Esophagus

(2011) Frederik Hvid-Jensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ectopic Cdx2 Expression in Murine Esophagus Models an Intermediate Stage in the Emergence of Barrett's Esophagus

(2011) Jianping Kong et al.   PLoS One

Intestinal Subepithelial Myofibroblasts Support in vitro and in vivo Growth of Human Small Intestinal Epithelium

(2011) Nicholas Lahar et al.   PLoS One

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease

(2010) M. M. Heimesaat et al.   GUT

HNF4α and CDH1 are associated with ulcerative colitis in a Dutch cohort

(2010) Suzanne van Sommeren et al.   INFLAMMATORY BOWEL DISEASES

A Three-Dimensional Coculture of Enterocytes, Monocytes and Dendritic Cells To Model Inflamed Intestinal Mucosa in Vitro

(2010) Fransisca Leonard et al.   MOLECULAR PHARMACEUTICS

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

The Protective Role of Host Toll-Like Receptor-4 in Acute Graft-Versus-Host Disease

(2010) Takehito Imado et al.   TRANSPLANTATION

A Microfluidic System to Evaluate Intestinal Absorption

(2009) Yuki IMURA et al.   ANALYTICAL SCIENCES

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

The intestine-specific transcription factor Cdx2 inhibits β-catenin/TCF transcriptional activity by disrupting the β-catenin–TCF protein complex

(2009) Rong-Jun Guo et al.   CARCINOGENESIS

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

(2009) Fang Zhao et al.   DEVELOPMENTAL BIOLOGY

Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2

(2009) Nan Gao et al.   DEVELOPMENTAL CELL

Immortalized Epithelial Cells Derived From Human Colon Biopsies Express Stem Cell Markers and Differentiate In Vitro

(2009) Andres I. Roig et al.   GASTROENTEROLOGY

Increased number and activation of colonic macrophages in pediatric patients with untreated Crohnʼs disease

(2009) Gøri Perminow et al.   INFLAMMATORY BOWEL DISEASES

The Immunological Impact of Genetic Drift in the B10.BR Congenic Inbred Mouse Strain

(2009) S. L. Fanning et al.   JOURNAL OF IMMUNOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia

(2009) Benjamin J. Colleypriest et al.   TRENDS IN MOLECULAR MEDICINE

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease

(2008) T. Yi et al.   BLOOD

In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations

(2008) M. J. Carlson et al.   BLOOD

Induction of intestinalization in human esophageal keratinocytes is a multistep process

(2008) Jianping Kong et al.   CARCINOGENESIS

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

The Effect of Retinoic Acid and Deoxycholic Acid on the Differentiation of Primary Human Esophageal Keratinocytes

(2008) Gordon Cooke et al.   DIGESTIVE DISEASES AND SCIENCES

Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease

(2008) Isao Tawara et al.   EXPERIMENTAL HEMATOLOGY

Direct Health Care Costs of Crohn's Disease and Ulcerative Colitis in US Children and Adults

(2008) Michael D. Kappelman et al.   GASTROENTEROLOGY

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP

Repression of the Desmocollin 2 Gene Expression in Human Colon Cancer Cells Is Relieved by the Homeodomain Transcription Factors Cdx1 and Cdx2

(2008) S. Funakoshi et al.   MOLECULAR CANCER RESEARCH

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Cdx1 and c-Myc Foster the Initiation of Transdifferentiation of the Normal Esophageal Squamous Epithelium toward Barrett's Esophagus

(2008) Douglas B. Stairs et al.   PLoS One

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE