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Multidisciplinary Sciences
Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Katsuhiko Ono, Yukio Fujiwara, Sunao Iyoda, Fan-Yan Wei, Kazuaki Monde, Kazuko Seto, Makoto Ohnishi, Hiroyuki Oshiumi, Takaaki Akaike, Tomohiro Sawa
Summary: SubAB inhibits the activation of the NLRP3 inflammasome and the production of interleukins in murine macrophages through ER stress signaling, which may be associated with the survival and pathogenicity of STEC strains in hosts.
Article
Biochemistry & Molecular Biology
Kei Miyano, Shuichiro Okamoto, Mizuho Kajikawa, Takuya Kiyohara, Chikage Kawai, Akira Yamauchi, Futoshi Kuribayashi
Summary: This study characterized missense mutations in p22(phoX) (L51Q, L52P, E53V, and P55R) that enhance the degradation of the protein in the endoplasmic reticulum (ER) and its binding to Derlin-1, a component of ER-associated degradation (ERAD). These mutations contribute to chronic granulomatous disease (CGD). The oxidation of Cys-50 appears to regulate the degradation of p22(phoX) and its interaction with Derlin-1.
Article
Multidisciplinary Sciences
Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Hideki Nishitoh
Summary: A study found that chemical chaperones can alleviate brain atrophy and motor dysfunction by improving brain cholesterol biosynthesis, offering a promising therapeutic strategy for neurodegenerative diseases.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Qin Yang, Xi Chen, Yanfang Zhang, Sha Hu, Fengjiao Hu, Yongping Huang, Tengfei Ma, Heng Hu, Han Tian, Song Tian, Yan-Xiao Ji, Zhi-Gang She, Peng Zhang, Xiao-Jing Zhang, Yufeng Hu, Hailong Yang, Yufeng Yuan, Hongliang Li
Summary: The study demonstrated that RNF5 inhibits the progression of NASH by targeting HRD1 in the ubiquitin-mediated proteasomal pathway, providing new insights into the pathogenesis of NASH and potential strategies for prevention and treatment.
Review
Oncology
Maximilian Ruschig, Andrea L. J. Marschall
Summary: Numerous toxins demonstrate routes for proteins to translocate from the extracellular space to the cytosol. Understanding these routes is important for therapeutic applications such as anti-toxin treatments, toxin-based drug delivery, and targeted delivery. While toxin routes may have lower delivery efficiencies, they can still be effective for certain applications, especially if the delivered cargoes have amplification effects or require only a small number of molecules. The mechanisms by which toxins enter cells may also affect their technological utility.
Article
Environmental Sciences
Junjun Peng, Xueyan Dai, Huiqin Fan, Chenghong Xing, Yu Zhuang, Xiaona Gao, Huabin Cao, Guoliang Hu, Fan Yang
Summary: Copper (Cu) at high levels can cause harm to the host physiology, specifically resulting in nephrotoxicity, although the exact mechanism remains unclear. This study explored the relationship between mitochondria-associated ER membranes (MAM) and Cu-induced kidney mitochondrial dysfunction and ER stress. The findings revealed that excessive Cu disrupted MAM integrity, leading to MAM dysfunction, mitochondrial dysfunction, and ER stress, contributing to Cu-induced nephrotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Keizo Takao, Tsuyoshi Miyakawa, Yosuke Matsushita, Toyomasa Katagiri, Akira Futatsugi, Yohei Shinmyo, Hiroshi Kawasaki, Juro Sakai, Kazutaka Shiomi, Masamitsu Nakazato, Kohsuke Takeda, Katsuhiko Mikoshiba, Hidde L. Ploegh, Hidenori Ichijo, Hideki Nishitoh
Summary: Derlin family members play a crucial role in brain development, with the lack of Derlin-1 or Derlin-2 resulting in developmental defects and motor control issues, along with an impact on cholesterol biosynthesis.
Article
Environmental Sciences
Li Ma, Sirao Hai, Chenlong Wang, Chuangjiang Chen, Sajid Ur Rahman, Chang Zhao, Mansoor Ahmed Bazai, Shibin Feng, Xichun Wang
Summary: This study aimed to investigate the molecular mechanism of Zearalenone (ZEA)-induced dysfunction of mitochondria-associated endoplasmic reticulum membranes (MAM) in piglet Sertoli cells (SCs) through the endoplasmic reticulum stress (ERS) pathway. The results showed that ZEA damaged cell viability, disrupted MAM structure, and altered protein expression of various markers related to MAM function. The inhibition of ERS reduced the cytotoxicity of ZEA and restored the normal function of MAM in SCs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Kohta Miura, Riko Katsuki, Shusei Yoshida, Ren Ohta, Taku Tamura
Summary: ERAD is an essential process for maintaining cell function and preventing ER stress. EDEM1 was found to be involved in accelerating the degradation of EGFR via ERAD, highlighting its physiological role in maintaining specific target proteins and providing a potential approach to regulate the expression of clinically important proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xin Wen, Bin Su, Mingming Gao, Jiaqi Chen, Donglei Zhou, Hui You, Nannan Li, Shuaikang Chang, Xiaoyun Cheng, Chunhua Qian, Jingyang Gao, Peng Yang, Shen Qu, Le Bu
Summary: Our study reveals that lipocalin 2 (LCN2) plays a protective role in obese individuals, inhibiting cell apoptosis and improving inflammatory state by repressing endoplasmic reticulum stress, thereby alleviating gastric injury associated with obesity.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Anahita Nejatfard, Nicholas Wauer, Satarupa Bhaduri, Adam Conn, Saroj Gourkanti, Narinderbir Singh, Tiffany Kuo, Rachel Kandel, Rommie E. Amaro, Sonya E. Neal
Summary: A recent study identified a new protein, Dfm1, that plays a key role in retrotranslocation process, with conserved residues critical for this function. Additionally, it was found that Dfm1 possesses lipid thinning function to facilitate the removal of ER membrane substrates, a feature also conserved in its human homolog, Derlin-1.
Article
Agriculture, Dairy & Animal Science
Ming Li, Wei Yang, Jianan Wen, Juan J. Loor, Ahmad Aboragah, Jingjing Wang, Shuang Wang, Mingyang Li, Liyun Yu, Xilin Hou, Chuang Xu, Bingbing Zhang
Summary: The study found that ORAI1 is involved in the regulation of hepatic lipidosis via ER stress in dairy cows. Experimental evidence demonstrated a mechanistic link among calcium ions, fatty acids, and ER stress. Silencing or inhibiting ORAI1 led to decreased abundance of fatty acid synthesis and ER stress-related proteins in bovine hepatocytes.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
Summary: Brief Summary: The study demonstrates that pioglitazone selectively protects beta cells against high glucose-induced dysfunction by activating the AMPK and GLS1 axis, resulting in elevated GSH/GSSG ratio and inhibition of mitochondrial dysfunction.
Article
Food Science & Technology
Chongshan Dai, Subhajit Das Gupta, Zhanhui Wang, Haiyang Jiang, Tony Velkov, Jianzhong Shen
Summary: In this review, the authors summarized the current knowledge and challenges related to T-2 toxin-induced cardiotoxicity, and discussed potential treatment approaches. The cardiotoxicity caused by T-2 toxin involves various cellular pathways and mechanisms, including oxidative stress, mitochondrial dysfunction, and inflammatory responses. Antioxidant supplementation, induction of autophagy, and blockade of inflammatory signaling may provide protective effects against T-2 toxin-induced cardiac toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Geriatrics & Gerontology
Zeqin Wen, Qi Sun, Yunhan Shan, Wenqing Xie, Yilan Ding, Weiyang Wang, Ruixi Ye, Wenfeng Xiao, Yusheng Li
Summary: Osteoarthritis (OA) is a common degenerative joint disease that causes a significant socioeconomic burden. It is now recognized as a whole-joint disease involving various components such as cartilage, synovium, meniscus, and subchondral bone. Recent studies have shown that endoplasmic reticulum (ER) stress plays a role in the pathological changes of OA by affecting multiple cell types involved in joint homeostasis. Targeting ER stress has shown promise in alleviating OA progression, but further investigation is needed to develop effective treatments.