Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates

The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1

(2021) Bing Rao et al.   Science Advances

Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease

(2020) Jakub Began et al.   EMBO JOURNAL

Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations

(2020) Jan Škerle et al.   BIOPHYSICAL JOURNAL

Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

(2020) Claudia C Schmidt et al.   eLife

The role of rhomboid superfamily members in protein homeostasis: Mechanistic insight and physiological implications

(2020) Rachel R. Kandel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation

(2020) Sonya Neal et al.   iScience

Phosphatidylglyerol Lipid Binding at the Active Site of an Intramembrane Protease

(2020) Ana-Nicoleta Bondar   JOURNAL OF MEMBRANE BIOLOGY

Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis

(2019) Justin T. Marinko et al.   CHEMICAL REVIEWS

Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion

(2019) Alex J. B. Kreutzberger et al.   SCIENCE

Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

(2019) Doralicia Casares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ICE plasmids: combining the ease of yeast recombination cloning with the stability of genomic integration

(2019) Matthew P. Flagg et al.   YEAST

Protein quality control in the secretory pathway

(2019) Zhihao Sun et al.   JOURNAL OF CELL BIOLOGY

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

(2019) Brian G Peterson et al.   eLife

Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges

(2019) Sicari et al.   Cells

“Mallostery”—ligand-dependent protein misfolding enables physiological regulation by ERAD

(2018) Margaret A Wangeline et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins

(2018) Sonya Neal et al.   MOLECULAR CELL

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

ER: the Silk Road of interorganellar communication

(2018) Jin-Zheng Wang et al.   CURRENT OPINION IN PLANT BIOLOGY

The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities

(2018) Anežka Tichá et al.   TRENDS IN BIOCHEMICAL SCIENCES

Single-Molecule Analyses Reveal Rhomboid Proteins Are Strict and Functional Monomers in the Membrane

(2018) Alex J.B. Kreutzberger et al.   BIOPHYSICAL JOURNAL

Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope

(2018) Adrian B. Mehrtash et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Cdc48 “Retrochaperone” Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates

(2017) Sonya Neal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How does the exosite of rhomboid protease affect substrate processing and inhibition?

(2017) Michael Shokhen et al.   PROTEIN SCIENCE

Improvements to the APBS biomolecular solvation software suite

(2017) Elizabeth Jurrus et al.   PROTEIN SCIENCE

A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP

(2016) Jiwon Hwang et al.   EMBO JOURNAL

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Direct and essential function for Hrd3 in ER-associated degradation

(2016) Nidhi Vashistha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactive rhomboid proteins: New mechanisms with implications in health and disease

(2016) Marius K. Lemberg et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Stepwise Versus Concerted Mechanisms in General-Base Catalysis by Serine Proteases

(2015) Neta Uritsky et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

(2015) Robert T. McGibbon et al.   BIOPHYSICAL JOURNAL

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures

(2014) S. Zoll et al.   EMBO JOURNAL

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance

(2014) Dönem Avci et al.   MOLECULAR CELL

Untangling structure–function relationships in the rhomboid family of intramembrane proteases

(2013) Cory L. Brooks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

(2013) Ombretta Foresti et al.   eLife

Finding the will and the way of ERAD substrate retrotranslocation

(2012) Randolph Y Hampton et al.   CURRENT OPINION IN CELL BIOLOGY

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets

(2012) Michitaka Suzuki et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins

(2012) Lina Fleig et al.   MOLECULAR CELL

Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD

(2012) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Internal Water-Retention Site in the Rhomboid Intramembrane Protease GlpG Ensures Catalytic Efficiency

(2012) Yanzi Zhou et al.   STRUCTURE

Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics

(2012) Syed M Moin et al.   eLife

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dfm1 Forms Distinct Complexes with Cdc48 and the ER Ubiquitin Ligases and Is Required for ERAD

(2010) Alexandra Stolz et al.   TRAFFIC

Protein Quality Control as a Strategy for Cellular Regulation: Lessons from Ubiquitin-Mediated Regulation of the Sterol Pathway

(2009) Randolph Y. Hampton et al.   CHEMICAL REVIEWS

In VitroAnalysis of Hrd1p-mediated Retrotranslocation of Its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase

(2009) Renee M. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase

(2009) Brian K. Sato et al.   MOLECULAR CELL

Rhomboid Protease Dynamics and Lipid Interactions

(2009) Ana-Nicoleta Bondar et al.   STRUCTURE

The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p

(2008) Veit Goder et al.   FEBS LETTERS

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY