Article
Pharmacology & Pharmacy
Jiang-Hui Wang, Fan-Li Lin, Jinying Chen, Linxin Zhu, Yu-Fan Chuang, Leilei Tu, Chenkai Ma, Damien Ling, Alex W. Hewitt, Ching-Li Tseng, Manisha H. Shah, Bang V. Bui, Peter van Wijngaarden, Gregory J. Dusting, Peng-Yuan Wang, Guei-Sheung Liu
Summary: TAK1 plays a regulatory role in inflammatory stimuli-induced endothelial activation and angiogenesis. Inhibition of TAK1 by 5Z-7-oxozeaenol attenuates aberrant retinal angiogenesis in a rat model of oxygen-induced retinopathy. These findings suggest that targeting TAK1 may have therapeutic potential for the treatment of retinal neovascular pathologies.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Cell Biology
Kun Zhao, Yaping Jiang, Jing Zhang, Jing Shi, Pengxiang Zheng, Chuanxi Yang, Yihui Chen
Summary: In this study, celastrol, a bioactive compound, was used to treat retinopathy of prematurity (ROP) and was found to alleviate pathological neovascularization in the retina by suppressing inflammation and angiogenesis.
Article
Ophthalmology
Haiyan Xu, Bing Yang, Zewen Ren, Dongjing Wu, Andina Hu, Jie Hu
Summary: This study investigates the role of the miR-429-HPSE-VEGF pathway in hypoxia-induced retinal neovascularization. The results show that miR-429 plays a crucial role by inhibiting the HPSE-VEGF pathway in this process. Overexpression of miR-429 reversed the effects of hypoxia on HREC functions and significantly reduced the expression of VEGF. In vivo experiments demonstrated that miR-429 overexpression decreased retinal neovascularization indicators. These findings highlight the importance of miR-429 and its potential therapeutic value in retinal diseases.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Pediatrics
Shaomin Su, Peicen Zou, Guangran Yang, Yajuan Wang, Lei Liu, Ying Liu, Jinjing Zhang, Yijun Ding
Summary: Propranolol alleviates retinopathy of prematurity by downregulating HIF-1α through the PI3K/Akt/ERK pathway, reducing abnormal vascular formation and leakage. This study elucidates the therapeutic mechanism of propranolol and provides a new approach for treating ROP.
PEDIATRIC RESEARCH
(2023)
Review
Medicine, General & Internal
Alessandro Arrigo, Emanuela Aragona, Francesco Bandello
Summary: Diabetic retinopathy is a common complication of diabetes that can cause visual impairment. Anti-VEGF therapies have significantly improved the management of proliferative diabetic retinopathy. The role of anti-VEGF as a substitute for laser treatment or as a combination therapy is still debated. Overall, anti-VEGF treatments are considered the first-line choice for diabetic retinopathy management.
ANNALS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ziqi Yang, Biyan Ni, Tian Zhou, Zijing Huang, Hong Zhou, Yang Zhou, Shiya Lin, Chang He, Xialin Liu
Summary: This study discovered an unexpected anti-angiogenic effect of large diameter intravitreal punctures, which significantly suppressed retinal neovascularization, improved oxygenation, and reduced inflammatory responses. Lowering intraocular pressure may be a promising therapeutic avenue for treating retinal neovascular diseases.
Article
Ophthalmology
Xiaoyu Tang, Kaixuan Cui, Xi Lu, Peiqi Wu, Shanshan Yu, Boyu Yang, Yue Xu, Xiaoling Liang
Summary: Using animal models and in vitro cell experiments, it was found that KC7F2 effectively inhibits retinal neovascularization by suppressing the HIF1α-VEGF pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Zijing Huang, Tsz Kin Ng, Weiqi Chen, Xiaowei Sun, Dingguo Huang, Dezhi Zheng, Jingsheng Yi, Yanxuan Xu, Xi Zhuang, Shaolang Chen
Summary: The study demonstrated that Nattokinase (NK) has anti-angiogenic effects against retinal neovascularization by modulating Nrf2/HO-1, glial activation, and neuroinflammation, providing a promising alternative treatment strategy for retinal neovascularization.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Na Zhao, Xiao Gui, Qian Fang, Rui Zhang, Weiye Zhu, Haorui Zhang, Qing Li, Yukun Zhou, Jiawei Zhao, Xiao Cui, Guangping Gao, Huipeng Tang, Ni Shen, Taoyong Chen, Hongyuan Song, Wei Shen
Summary: The study found that Graphene Quantum Dots (GQDs) are biocompatible nanomaterials that can inhibit proliferation, migration, tube formation, and sprouting of human umbilical vein endothelial cells in a dose-dependent manner, and can inhibit pathological retinal neovascularization in an oxygen-induced retinopathy model. The data suggest that GQDs disrupt the periostin/ERK pathway and subsequent cell cycle regulation. This signaling pathway was confirmed in an OIR mouse model.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiang-Hui Wang, Yu-Fan Chuang, Jinying Chen, Vikrant Singh, Fan-Li Lin, Richard Wilson, Leilei Tu, Chenkai Ma, Raymond C. B. Wong, Peng-Yuan Wang, Jingxiang Zhong, Alex W. Hewitt, Peter van Wijngaarden, Gregory J. Dusting, Guei-Sheung Liu
Summary: In this study, we found that miR-143-3p was significantly downregulated in a rat model of oxygen-induced retinopathy. Injection of synthetic miR-143 mimics could effectively improve retinal neovascularization. miR-143 negatively impacted endothelial cell activity through regulating cell-matrix adhesion and mediating hypoxia-inducible factor-1 signaling.
NUCLEIC ACID THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jesus Eduardo Rojo Arias, Vanessa Elisabeth Englmaier, Jozsef Jaszai
Summary: AFL modulates retinal inflammation in response to hypoxia by regulating the morphology of microglial cells, suggesting potential therapeutic effects beyond microvascular regeneration in retinal diseases.
Article
Multidisciplinary Sciences
Anna Hillenmayer, Christian M. Wertheimer, Arie Geerlof, Kirsten H. Eibl, Siegfried Priglinger, Claudia Priglinger, Andreas Ohlmann
Summary: This study found that hr-GAL1 and 3 can inhibit the proliferation, migration, and apoptosis of human retinal microvascular endothelial cells, and have inhibitory effects on angiogenesis. However, hr-GAL1 and 3 do not show toxic effects on HRMEC. In addition, hr-GAL1 and 3 treatment can activate the proangiogenic Wnt/β-catenin signaling pathway.
Article
Medicine, General & Internal
Yedi Zhou, Bingyan Li, Zicong Wang, Wei Tan, Jingling Zou, Haixiang Zhou, Yuting Cai, Jie Liu, Yan He, Shigeo Yoshida, Yun Li
Summary: This study identified the involvement of N6-methyladenosine (m6A) methylated circular RNAs (circRNAs) in ischemia-induced pathological neovascularization in the retina. Gene function analysis showed that hyper-methylated circRNAs were involved in cellular processes and protein binding, while hypo-methylated circRNAs were involved in cellular biosynthetic processes and nuclear binding. These findings shed light on the potential roles of m6A methylation in circRNA regulatory functions in the pathogenesis of retinal neovascularization.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Immunology
Syed A. H. Zaidi, Tahira Lemtalsi, Zhimin Xu, Isabella Santana, Porsche Sandow, Leila Labazi, Robert W. Caldwell, Ruth B. Caldwell, Modesto A. Rojas
Summary: This study investigates the efficacy of targeting the cholesterol metabolizing enzyme ACAT1 in limiting pathological retinal neovascularization during ischemic retinopathy. The results show that inhibiting ACAT1 can reduce the expression of inflammatory mediators and the formation of pathological retinal neovascularization. ACAT1 is therefore identified as an important regulator of cholesterol metabolism in ischemic retinopathy.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Cell Biology
Bo Shen, Brian Estevez, Zheng Xu, Barry Kreutz, Andrei Karginov, Yanyan Bai, Feng Qian, Urao Norifumi, Deane Mosher, Xiaoping Du
MOLECULAR BIOLOGY OF THE CELL
(2015)
Article
Ophthalmology
Xia Bai, Junpeng Luo, Xiaofeng Zhang, Jingjing Han, Zhaoyue Wang, Jingcheng Miao, Yanyan Bai
OPHTHALMIC RESEARCH
(2017)
Article
Hematology
Yanyan Bai, Zhaoyue Wang, Xia Bai, Ziqiang Yu, Lijuan Cao, Wei Zhang, Changgeng Ruan
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Yun-Zheng Le, Yanyan Bai, Meili Zhu, Lixin Zheng
JOURNAL OF NEUROCHEMISTRY
(2010)
Article
Oncology
Yanyan Bai, Jian-xing Ma, Junjing Guo, Juanjuan Wang, Meili Zhu, Ying Chen, Yun-Zheng Le
JOURNAL OF PATHOLOGY
(2009)
Article
Cell Biology
Aiming Pang, Ni Cheng, Yujie Cui, Yanyan Bai, Zhigang Hong, M. Keegan Delaney, Yaping Zhang, Claire Chang, Can Wang, Chang Liu, Paola Leon Plata, Alexander Zakharov, Kasim Kabirov, Jalees Rehman, Randal A. Skidgel, Asrar B. Malik, Ying Liu, Aleksander Lyubimov, Minyi Gu, Xiaoping Du
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Hematology
Zheng Xu, Ying Liang, M. Keegan Delaney, Yaping Zhang, Kyungho Kim, Jing Li, Yanyan Bai, Jaehyung Cho, Masuko Ushio-Fukai, Ni Cheng, Xiaoping Du
Summary: Research has shown that outside-in signaling activates mainly NOX2-mediated ROS generation, which triggers Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Ophthalmology
Jyotirmoy Kusari, Edwin Padillo, Sheila X. Zhou, Yanyan Bai, Juanjuan Wang, Zhiming Song, Meili Zhu, Yun-Zheng Le, Daniel W. Gil
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2011)