Review
Biochemistry & Molecular Biology
Fionn O'Leary, Matthew Campbell
Summary: The blood-retina barrier (BRB) separates the systemic circulation from the retina, consisting of the inner blood-retina barrier (iBRB) and the outer blood-retina barrier (oBRB). The integrity of the BRB is crucial for maintaining the function and structural integrity of the retina. Tight junction proteins play a key role in the iBRB, and disruption of the BRB can lead to retinal diseases.
Review
Medicine, Research & Experimental
Xiangyi Zheng, Beida Ren, Ying Gao
Summary: Tight junctions (TJs) play a crucial role in intercellular connections. Abnormal expression of TJ-related proteins can lead to TJ destruction, structural damage, and dysfunction of endothelial and epithelial cells, which are associated with the occurrence and progression of various diseases. The blood-brain barrier (BBB) damage and dysfunction are significant pathological features of stroke, and TJs have a direct impact on BBB integrity. This article discusses the structure, function, regulatory mechanisms, and therapeutic potential of BBB TJs in ischemic stroke.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Atul K. Srivastava, Bharat Somireddy Venkata, Yan Y. Sweat, Heather R. Rizzo, Lea Jean-Francois, Li Zuo, Kathleen W. Kurgan, Patrick Moore, Nitesh Shashikanth, Izabela Smok, Joseph R. Sachleben, Jerrold R. Turner, Stephen C. Meredith
Summary: This study investigates the effects of S408 phosphorylation on occludin protein structure and demonstrates its role in regulating intercellular junction function through interactions with other components.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Geriatrics & Gerontology
Liangliang Huang, Yan Chen, Rui Liu, Binbin Li, Xuan Fei, Xiang Li, Ge Liu, Yunman Li, Baohui Xu, Weirong Fang
Summary: Increased expression of P-gp after ischemic injury leads to dysfunction and hyperpermeability of the BBB by suppressing Akt/mTOR-induced endothelial autophagy.
Article
Food Science & Technology
Yunika Mayangsari, Mayu Okudaira, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Research showed that DMF can enhance intestinal TJ barrier integrity by increasing the expression of occludin and claudin-1, while reducing the expression of claudin-2. This regulation involves the induction of occludin protein translation via mTOR and silencing Cldn2 mRNA via miR-16-5p.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Neurosciences
Xiaoying Qin, Jianing Wang, Shujian Chen, Gang Liu, Chaoran Wu, Qunyu Lv, Xinran He, Xianshu Bai, Wenhui Huang, Hong Liao
Summary: The role and mechanism of p75 neurotrophin receptor (p75(NTR)) in blood-brain barrier (BBB) disruption after acute cerebral ischemia were investigated in this study. Genetic knockdown or pharmacological inhibition of p75(NTR) attenuated brain damage and BBB leakage in a mouse model of ischemic stroke. Astrocyte-specific knockdown of p75(NTR) significantly improved BBB disruption, brain tissue damage, and neurological functions. Activation of NF-kappa B and HIF-1 alpha signals by astrocytic p75(NTR) upregulated MMP-9 and VEGF expression, leading to tight junction degradation. The findings suggest that p75(NTR) could be a potential therapeutic target for the treatment of ischemic stroke.
Article
Biochemistry & Molecular Biology
Fei Yu, Michael L. Ko, Gladys Y-P Ko
Summary: Diabetic retinopathy is a chronic complication associated with diabetes and about 60% of type 2 diabetes patients will develop this condition. Research indicates that decreased miR-150 and upregulated ELK1 in the retina contribute to photoreceptor apoptosis, with the translocation of pELK1(T417) appearing to be a crucial step in diabetic insult-induced photoreceptor apoptosis.
Article
Multidisciplinary Sciences
Ilke De Boeck, Stijn Wittouck, Katleen Martens, Irina Spacova, Eline Cauwenberghs, Camille Nina Allonsius, Jennifer Joerissen, Sander Wuyts, Wannes Van Beeck, Jelle Dillen, Peter A. Bron, Brecht Steelant, Peter W. Hellings, Olivier M. Vanderveken, Sarah Lebeer
Summary: The study found Dolosigranulum pigrum to be a species clearly associated with nasal health, mainly present in the human nasal cavity. The strain exhibits antimicrobial activity, decreases inflammation, and protects nasal barrier function, showing potential as a topical live biotherapeutic product.
Article
Chemistry, Multidisciplinary
Sofie Van Den Broucke, Jeroen A. J. Vanoirbeek, Rita Derua, Peter H. M. Hoet, Manosij Ghosh
Summary: This study investigated the impact of environmental and occupational irritants on the airway epithelial barrier using an in vitro coculture model. The findings suggest that graphene nanoparticles have a negative effect on the epithelial barrier, possibly due to slight alterations in tight junction organization.
Article
Medicine, Research & Experimental
Shuguang Wu, Ting Guo, Wenxuan Qi, Yuyu Li, Jie Gu, Cui Liu, Yuehong Sha, Baocheng Yang, Shuqun Hu, Xuemei Zong
Summary: The study demonstrates that curcumin pretreatment can ameliorate ischemic stroke injury by protecting BBB integrity and synaptic remodeling, as well as inhibiting inflammatory responses.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ling Chen, Xiao-lin Zhong, Wen-yu Cao, Ming-li Mao, Dan-dan Liu, Wen-jia Liu, Xu-yu Zu, Jiang-hua Liu
Summary: In this study, the role and mechanism of IGF2 in ulcerative colitis were investigated using a mouse model. The results showed that IGF2 can alleviate colon injury and inflammation caused by ulcerative colitis by downregulating the cGAS-Sting pathway, thus maintaining colonic stemness and barrier integrity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Immunology
Yingman Liu, Wenxuan Huang, Jiaqi Wang, Jiaojiao Ma, Manman Zhang, Xiaoying Lu, Jie Liu, Yurong Kou
Summary: Periodontal disease, considered a common inflammatory disease, is believed to contribute to the development of gastrointestinal diseases and other systemic diseases by affecting the intestinal barrier through periodontal pathogens. This review summarizes studies on the effects of periodontal pathogens on the intestinal barrier, potentially shedding light on the link between periodontitis and gastrointestinal diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Zachary M. Slifer, B. Radha Krishnan, Jay Madan, Anthony T. Blikslager
Summary: Larazotide acetate (LA) is a peptide with eight amino acids that acts as a tight junction regulator to restore intestinal barrier function, currently undergoing phase III clinical trials for celiac disease patients. It is believed to work by reducing zonulin-induced barrier permeability increase and is associated with actin filaments tension.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Vanessa Konigs, Sandra Pierre, Martin Schicht, Jessica Welss, Lisa Hahnefeld, Vittoria Rimola, Elke Lutjen-Drecoll, Gerd Geisslinger, Klaus Scholich
Summary: Activation of GPR40 reduces blood-nerve barrier permeability and reverses diabetes-induced hypersensitivity.
Article
Cell Biology
Bo Shen, Brian Estevez, Zheng Xu, Barry Kreutz, Andrei Karginov, Yanyan Bai, Feng Qian, Urao Norifumi, Deane Mosher, Xiaoping Du
MOLECULAR BIOLOGY OF THE CELL
(2015)
Article
Pathology
Yanyan Bai, Xia Bai, Zhaoyue Wang, Xiaofeng Zhang, Changgeng Ruan, Jingcheng Miao
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2011)
Article
Hematology
Yanyan Bai, Zhaoyue Wang, Xia Bai, Ziqiang Yu, Lijuan Cao, Wei Zhang, Changgeng Ruan
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Yun-Zheng Le, Yanyan Bai, Meili Zhu, Lixin Zheng
JOURNAL OF NEUROCHEMISTRY
(2010)
Article
Oncology
Yanyan Bai, Jian-xing Ma, Junjing Guo, Juanjuan Wang, Meili Zhu, Ying Chen, Yun-Zheng Le
JOURNAL OF PATHOLOGY
(2009)
Article
Cell Biology
Aiming Pang, Ni Cheng, Yujie Cui, Yanyan Bai, Zhigang Hong, M. Keegan Delaney, Yaping Zhang, Claire Chang, Can Wang, Chang Liu, Paola Leon Plata, Alexander Zakharov, Kasim Kabirov, Jalees Rehman, Randal A. Skidgel, Asrar B. Malik, Ying Liu, Aleksander Lyubimov, Minyi Gu, Xiaoping Du
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Hematology
Zheng Xu, Ying Liang, M. Keegan Delaney, Yaping Zhang, Kyungho Kim, Jing Li, Yanyan Bai, Jaehyung Cho, Masuko Ushio-Fukai, Ni Cheng, Xiaoping Du
Summary: Research has shown that outside-in signaling activates mainly NOX2-mediated ROS generation, which triggers Syk-dependent secondary platelet activation, adhesion, and thrombosis with minimal effect on hemostasis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Ophthalmology
Jyotirmoy Kusari, Edwin Padillo, Sheila X. Zhou, Yanyan Bai, Juanjuan Wang, Zhiming Song, Meili Zhu, Yun-Zheng Le, Daniel W. Gil
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2011)