Review
Hematology
Emma C. Josefsson
Summary: This review focuses on the molecular regulation of intrinsic apoptosis in platelets, conditions associated with enhanced platelet death, ex vivo storage of platelets, and caveats related to the assessment of platelet apoptosis.
THROMBOSIS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Omer Keinan, Joseph M. Valentine, Haopeng Xiao, Sushil K. Mahata, Shannon M. Reilly, Mohammad Abu-Odeh, Julia H. Deluca, Benyamin Dadpey, Leslie Cho, Austin Pan, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Aldons J. Lusis, Markku Laakso, Edward T. Chouchani, Mikael Ryde'n, Alan R. Saltiel
Summary: Research indicates that catecholamines regulate UCP1 expression by affecting glycogen metabolism, and reveals the crucial regulatory role of glycogen in adipocytes, linking glucose metabolism to thermogenesis.
Article
Chemistry, Multidisciplinary
Peiyu Zhang, Martin Walko, Andrew J. Wilson
Summary: In this study, the authors demonstrate that dibromomaleimide staple scanning, using the HRK BH3 domain, can inform the design of BCL-x(L) selective peptidomimetic ligands. These HRK-inspired reagents could potentially be used as starting points for the development of therapeutics targeting BCL-x(L)-overexpressed cancers.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Yan Li, Kuiliang Zhang, Jinxin Liu, Shengnan Liu, Chenzhipeng Nie, Ying Yan, Yanming Guan, Mingcong Fan, Haifeng Qian, Hao Ying, Li Wang
Summary: Geniposide has been found to reduce body temperature and cold tolerance of mice by suppressing thermogenic genes in interscapular brown adipose tissue (iBAT) and inguinal white adipose tissue (iWAT). Additionally, geniposide suppresses thermogenic capacity of adipocytes in vitro and inhibits uncoupling protein 1 (UCP1) via regulating protein kinase A (PKA) signaling.
Article
Endocrinology & Metabolism
Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O. Bergo, Robin P. Choudhury, Myriam Aouadi, Juleen R. Zierath, Anna Krook, Niklas Mejhert, Mikael Ryden
Summary: This study reveals that an increased phosphocreatine/creatine ratio in white adipocytes contributes to AMP-activated protein kinase activity changes and promotes inflammation in obesity. Metabolomic and transcriptomic analysis of white adipose tissue samples from clinical cohorts and in vitro and in vivo models show that decreased phosphocreatine metabolism alters AMP-activated protein kinase activity by affecting ATP/ADP levels in white adipocytes. This disturbance leads to a pro-inflammatory profile characterized by increased production of chemokine (C-C motif) ligand 2 (CCL2). These findings provide new insights into the mechanisms driving white adipose tissue inflammation in obesity.
Article
Biochemistry & Molecular Biology
Halime Kalkavan, Mark J. Chen, Jeremy C. Crawford, Giovanni Quarato, Patrick Fitzgerald, Stephen W. G. Tait, Colin R. Goding, Douglas R. Green
Summary: Drug-tolerant persister cells can evade apoptosis and have the ability to colonize and metastasize. These cells also show increased sensitivity to ferroptosis. The release of cytochrome c plays a crucial role in the generation of these drug-tolerant persister cells.
Article
Cell Biology
Xiufeng Chu, Xiang Xiao, Guangchuan Wang, Ahmed Uosef, Xiaohua Lou, Preston Arnold, Yixuan Wang, Gangcheng Kong, Mou Wen, Laurie J. Minze, Xian C. C. Li
Summary: This study shows that the cytolytic activity of Gasdermin D N-terminal pore-forming domain (GD-NT) is negatively regulated by AMP-activated protein kinase (AMPK). AMPK phosphorylates GD-NT at serine 46, which alters its oligomerization and inhibits its pore-forming ability. The negative regulation of GD-NT by AMPK impacts its anti-tumor activity and promotes aggressive tumor growth.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Mayu Sun, Xueqi Ma, Wei Mu, Haonan Li, Xiaoming Zhao, Tengfei Zhu, Jingquan Li, Yongliang Yang, Haibing Zhang, Qian Ba, Hui Wang
Summary: This study identified Vemurafenib, an FDA-approved anti-cancer drug, as a potent inhibitor of necroptosis. By directly binding to receptor-interacting protein kinases 1 (RIPK1), Vemurafenib blocked their kinase activity and inhibited necroptosis. Furthermore, pre-treatment with Vemurafenib showed strong protection against necroptosis-associated diseases in vivo.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Paula Seixas da Costa, Patricia Severo Ramos, Christian Ferreira, Jerson Lima Silva, Tatiana El-Bacha, Eliane Fialho
Summary: This study demonstrated that the cytotoxic effect of resveratrol on MCF-7 cells might be associated with its pro-oxidant action, which inhibited CK2 activity, affecting cell viability and mitochondrial function.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Ryoka Uchiyama, Eriko Toyoda, Miki Maehara, Shiho Wasai, Haruka Omura, Masahiko Watanabe, Masato Sato
Summary: PRP purified using commercial kits can affect macrophage polarization, with APS having a higher concentration of M1 and M2 macrophage related factors. When PRP supernatants were added to monocyte-derived macrophages and M1 polarized macrophages, it was observed that PRPs suppressed M1 macrophage polarization and promoted M2 macrophage polarization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jianying Zhang, Feng Li, Tyler Augi, Kelly M. Williamson, Kentaro Onishi, MaCalus Hogan, Matthew D. Neal, James H-C Wang
Summary: Platelet-rich plasma (PRP) containing PLT HMGB1 plays a crucial role in tendon wound healing by reducing inflammation, increasing local HMGB1 levels, and recruiting stem cells to the injured area. The efficacy of PRP treatment for tendon injuries in clinics may be dependent on the presence of PLT HMGB1 in PRP preparations.
Article
Multidisciplinary Sciences
Qingwen Zhao, Chao Yu, Xiaoxuan Xu, Wenfang Jin, Zhe Zhang, Haiyan Huang, Yue Gao, Dongning Pan
Summary: YBX2 protein level in brown adipose tissue is induced by thermogenic stimuli through phosphorylation modification, and plays a crucial role in regulating glycolysis and thermogenesis by stabilizing YBX2.
Article
Multidisciplinary Sciences
Zihan Tang, Yanyan Xu, Yun Tan, Hui Shi, Peipei Jin, Yunqi Li, Jialin Teng, Honglei Liu, Haoyu Pan, Qiongyi Hu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Jianfen Meng, Zhuochao Zhou, Huihui Chi, Xuefeng Wang, Junling Liu, Yong Lu, Feng Liu, Jing Dai, Chengde Yang, Saijuan Chen, Tingting Liu
Summary: Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection. The E protein is found to be associated with coagulation disorders in COVID-19 patients and directly enhances platelet activation and thrombosis through a CD36/p38 MAPK/NF-kB signaling axis.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Bianza Moise Bakadia, Abeer Ahmed Qaed Ahmed, Lallepak Lamboni, Zhijun Shi, Biampata Mutu Mukole, Ruizhu Zheng, Mazono Pierre Mbang, Bi Zhang, Mario Gauthier, Guang Yang
Summary: The management of diabetic wounds is a challenge, but platelet-rich plasma (PRP) gel, PRP-derived exosomes (PRP-Exos), and mesenchymal stem cell-derived exosomes (MSC-Exos) have potential in wound treatment. However, their limitations include poor mechanical properties, short half-lives of growth factors (GFs), burst release of GFs and exosomes, and protease degradation. To overcome these limitations, dual-crosslinked hydrogels based on silk protein (SP) were developed, which showed improved mechanical properties and sustained release of GFs and exosomes. These hydrogels promoted diabetic wound healing by upregulating GF expression, down-regulating matrix metalloproteinase-9 expression, and promoting angiogenesis and re-epithelialization.
BIOACTIVE MATERIALS
(2023)
Review
Cell Biology
Takao Kataoka
Summary: Mitochondria play a crucial role in cellular stress responses, regulating cell death through fission and fusion cycles and mitophagy. BCL-RAMBO, a member of the BCL-2 family proteins, not only regulates apoptosis signaling at mitochondria but also serves as a mitophagy receptor, controlling mitochondrial fragmentation and mitophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yusuke Endo, Koutaro Yokote, Toshinori Nakayama
CELLULAR AND MOLECULAR LIFE SCIENCES
(2017)
Article
Immunology
Toshihiro Ito, Kiyoshi Hirahara, Atsushi Onodera, Ryo Koyama-Nasu, Ikuya Yano, Toshinori Nakayama
INTERNATIONAL IMMUNOLOGY
(2017)
Article
Immunology
Atsushi Onodera, Masahiro Kiuchi, Kota Kokubo, Miki Kato, Tomohiro Ogino, Shu Horiuchi, Urara Kanai, Kiyoshi Hirahara, Toshinori Nakayama
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Naoko Mato, Kiyoshi Hirahara, Tomomi Ichikawa, Jin Kumagai, Masayuki Nakayama, Hideaki Yamasawa, Masashi Bando, Koichi Hagiwara, Yukihiko Sugiyama, Toshinori Nakayama
SCIENTIFIC REPORTS
(2017)
Review
Allergy
Kenta Shinoda, Kiyoshi Hirahara, Toshinori Nakayama
ALLERGOLOGY INTERNATIONAL
(2017)
Review
Immunology
Yosuke Kurashima, Daiki Yamamoto, Sean Nelson, Satoshi Uematsu, Peter B. Ernst, Toshinori Nakayama, Hiroshi Kiyono
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Juergen Brueck, Julia Holstein, Ivana Glocova, Ursula Seidel, Julia Geisel, Toshio Kanno, Jin Kumagai, Naoko Mato, Stephan Sudowe, Katja Widmaier, Tobias Sinnberg, Amir S. Yazdi, Franziska C. Eberle, Kiyoshi Hirahara, Toshinori Nakayama, Martin Roecken, Kamran Ghoreschi
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Kazushige Obata-Ninomiya, Kenji Ishiwata, Hisanobu Nakano, Yusuke Endo, Tomomi Ichikawa, Atsushi Onodera, Kiyoshi Hirahara, Yoshitaka Okamoto, Hirotaka Kanuka, Toshinori Nakayama
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Immunology
Hiroyuki Hosokawa, Maria Koizumi, Kaori Masuhara, Maile Romero-Wolf, Tomoaki Tanaka, Toshinori Nakayama, Ellen Rothenberg
Summary: The transcription factors Runx1 and GATA3 have been found to regulate Spi1 expression levels in pro-T cells, controlling the repression of Spi1 during T lineage commitment. This regulation is achieved through a specific intronic silencing element in mouse Spi1.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Immunology
Atsushi Onodera, Masahiro Kiuchi, Kota Kokubo, Toshinori Nakayama
Summary: Epigenetic regulation is crucial for controlling inflammation in the immune system, with CxxC domain-containing proteins playing important roles as epigenetic readers and writers. By binding to non-methylated CpG sites, these proteins contribute to proper immune cell function and regulation in both T cells and macrophages.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Takahiro Nakajima, Toshio Kanno, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Damon J. Tumes, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Summary: The study reveals that pathogenic CD4(+) T cells in the lungs and skin exhibit high levels of ACC1. ACC1 regulates the inflammatory function of pathogenic CD4(+) T cell population to promote type 2 inflammation in the lungs and skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Shang L. Lian, Belgacem Mihi, Madoka Koyanagi, Toshinori Nakayama, Mark Bix
IMMUNITY INFLAMMATION AND DISEASE
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Toshinori Nakayama
Meeting Abstract
Biochemistry & Molecular Biology
Motoko Y. Kimura, Koji Hayashizaki, Toshinori Nakayama
Article
Oncology
Fumie Ihara, Daiju Sakurai, Atsushi Horinaka, Yuji Makita, Akira Fujikawa, Toshioki Sakurai, Kazuki Yamasaki, Naoki Kunii, Shinichiro Motohashi, Toshinori Nakayama, Yoshitaka Okamoto
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2017)