Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells

Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8 + T Cell Terminal Differentiation and Loss of Multipotency

(2017) Simon M. Gray et al.   IMMUNITY

Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

(2016) Sumiyo Morita et al.   NATURE BIOTECHNOLOGY

The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation

(2015) Michel DuPage et al.   IMMUNITY

Thymic stromal lymphopoietin signaling in CD4+ T cells is required for TH2 memory

(2015) Qun Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes

(2015) Atsushi Onodera et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetics of T cells regulated by Polycomb/Trithorax molecules

(2015) Atsushi Onodera et al.   TRENDS IN MOLECULAR MEDICINE

Granzyme A activates another way to die

(2015) Judy Lieberman   IMMUNOLOGICAL REVIEWS

The polycomb repressive complex 2 governs life and death of peripheral T cells

(2014) Y. Zhang et al.   BLOOD

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

(2014) Aaron Arvey et al.   NATURE IMMUNOLOGY

Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

(2014) Y. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis

(2014) Makoto Kuwahara et al.   Nature Communications

The Polycomb Protein Ezh2 Regulates Differentiation and Plasticity of CD4+ T Helper Type 1 and Type 2 Cells

(2013) Damon J. Tumes et al.   IMMUNITY

The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis

(2013) Meiqin Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity

(2013) Tetsuya Sasaki et al.   PLoS One

Menin: a scaffold protein that controls gene expression and cell signaling

(2013) Smita Matkar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pathogenic memory type Th2 cells in allergic inflammation

(2013) Yusuke Endo et al.   TRENDS IN IMMUNOLOGY

Memory CD4+ T Cells: fate determination, positive feedback and plasticity

(2012) Hidehiro Yamane et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

(2012) Rhys S. Allan et al.   NATURE

Maintaining differentiated cellular identity

(2012) Johan Holmberg et al.   NATURE REVIEWS GENETICS

The contribution of epigenetic memory to immunologic memory

(2011) Valerie P Zediak et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genome-Wide Analysis Reveals Unique Regulation of Transcription of Th2-Specific Genes by GATA3

(2011) S. Horiuchi et al.   JOURNAL OF IMMUNOLOGY

Hierarchical IL-5 Expression Defines a Subpopulation of Highly Differentiated Human Th2 Cells

(2011) B. Upadhyaya et al.   JOURNAL OF IMMUNOLOGY

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development

(2010) Y. Nakata et al.   BLOOD

GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness

(2010) Chan C. Whiting et al.   FEBS Journal

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance ofGATA3expression in T helper type 2 cells

(2010) Atsushi Onodera et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polycomb Group Gene Product Ring1B Regulates Th2-Driven Airway Inflammation through the Inhibition of Bim-Mediated Apoptosis of Effector Th2 Cells in the Lung

(2010) A. Suzuki et al.   JOURNAL OF IMMUNOLOGY

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

(2009) Chongzhi Zang et al.   BIOINFORMATICS

Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells

(2009) Yasuto Araki et al.   IMMUNITY

CD69 Controls the Pathogenesis of Allergic Airway Inflammation

(2009) T. Miki-Hosokawa et al.   JOURNAL OF IMMUNOLOGY

Therapeutic manipulation of immune tolerance in allergic disease

(2009) Mübeccel Akdis et al.   NATURE REVIEWS DRUG DISCOVERY

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Transcriptional Regulation ofGata3in T Helper Cells by the Integrated Activities of Transcription Factors Downstream of the Interleukin-4 Receptor and T Cell Receptor

(2008) Eyal J. Scheinman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bmi1 regulates memory CD4 T cell survival via repression of theNoxagene

(2008) Masakatsu Yamashita et al.   JOURNAL OF EXPERIMENTAL MEDICINE