From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound

dl-3n-Butylphthalide Promotes Angiogenesis Via the Extracellular Signal-regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase/Akt-endothelial Nitric Oxide Synthase Signaling Pathways

(2012) Xi-lin Lu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent

(2012) In Kei Lam et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ethanolic Extract of Fructus Alpinia oxyphylla Protects Against 6-Hydroxydopamine-Induced Damage of PC12 Cells In Vitro and Dopaminergic Neurons in Zebrafish

(2011) Zai-Jun Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Tocotrienols fight cancer by targeting multiple cell signaling pathways

(2011) Ramaswamy Kannappan et al.   Genes and Nutrition

Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model

(2011) Kai Heng Lam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis

(2011) You-Cheng Hseu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro

(2011) Ho Yan Gloria Tse et al.   JOURNAL OF ETHNOPHARMACOLOGY

Turmeric and Laurel Aqueous Extracts Exhibit In Vitro Anti-Atherosclerotic Activity and In Vivo Hypolipidemic Effects in a Zebrafish Model

(2011) Seori Jin et al.   JOURNAL OF MEDICINAL FOOD

Transcriptional profiling of angiogenesis activities of calycosin in zebrafish

(2011) Shang Li et al.   Molecular BioSystems

Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae

(2011) Zhen Hua Li et al.   Molecular BioSystems

Search for Neutral Minimal Supersymmetric Standard Model Higgs Bosons Decaying to Tau Pairs inppCollisions ats=7  TeV

(2011) S. Chatrchyan et al.   PHYSICAL REVIEW LETTERS

Chemical modulation of memory formation in larval zebrafish

(2011) M. A. Wolman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics

(2011) S. O. Siu et al.   PROTEOMICS

Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae

(2011) Guang Hu et al.   XENOBIOTICA

Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage

(2011) Meiwei Wang et al.   Chinese Medicine

In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives

(2010) Kohei Watanabe et al.   BMC NEUROSCIENCE

Early Outcome of Acute Ischemic Stroke in Hyperlipidemic Patients Under Atorvastatin Versus Simvastatin

(2010) Yair Lampl et al.   CLINICAL NEUROPHARMACOLOGY

Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity

(2010) E. Gjini et al.   Disease Models & Mechanisms

Alterations in the distribution of GABAA receptorsin epilepsy

(2010) Carolyn R. Houser et al.   EPILEPSIA

An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 α-ethinylestradiol in zebrafish (Danio rerio)

(2010) Marijke De Wit et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish

(2010) Lee   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Oxidized Cholesteryl Esters and Phospholipids in Zebrafish Larvae Fed a High Cholesterol Diet

(2010) Longhou Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model

(2010) Deepa Alex et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

(2010) David Kokel et al.   Nature Chemical Biology

Phenomics: the next challenge

(2010) David Houle et al.   NATURE REVIEWS GENETICS

Calycosin Promotes Angiogenesis Involving Estrogen Receptor and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Zebrafish and HUVEC

(2010) Jing Yan Tang et al.   PLoS One

Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion

(2010) J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rasagiline: A novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

(2010) Orly Weinreb et al.   PROGRESS IN NEUROBIOLOGY

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

(2010) J. Rihel et al.   SCIENCE

In vitro effects of antiepileptic drugs on acetylcholinesterase and ectonucleotidase activities in zebrafish (Danio rerio) brain

(2010) A.M. Siebel et al.   TOXICOLOGY IN VITRO

Deletion of the WD40 Domain of LRRK2 in Zebrafish Causes Parkinsonism-Like Loss of Neurons and Locomotive Defect

(2010) Donglai Sheng et al.   PLoS Genetics

Meta-analysis of Comparative Efficacy of Increasing Dose of Atorvastatin Versus Rosuvastatin Versus Simvastatin on Lowering Levels of Atherogenic Lipids (from VOYAGER)

(2009) Stephen J. Nicholls et al.   AMERICAN JOURNAL OF CARDIOLOGY

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)

(2009) L. Flinn et al.   BRAIN

Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish

(2009) Konstantin Stoletov et al.   CIRCULATION RESEARCH

Vascular morphogenesis: a Wnt for every vessel?

(2009) Claudio Areias Franco et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells

(2009) Yu-Tzu Shih et al.   Evidence-based Complementary and Alternative Medicine

Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation

(2009) Deepa Alex et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cardiovascular and renal toxicity during angiogenesis inhibition: clinical and mechanistic aspects

(2009) Mariëtte HW Kappers et al.   JOURNAL OF HYPERTENSION

Design, Synthesis, and Examination of Neuron Protective Properties of Alkenylated and Amidated Dehydro-Silybin Derivatives†

(2009) Lei Xiang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Resveratrol (Trans-3,5,4'-trihydroxystilbene) Induces Silent Mating Type Information Regulation-1 and Down-Regulates Nuclear Transcription Factor- B Activation to Abrogate Dextran Sulfate Sodium-Induced Colitis

(2009) U. P. Singh et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

In vivo imaging of zebrafish digestive organ function using multiple quenched fluorescent reporters

(2008) Kotaro Hama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pharmacologically induced angiogenesis in transgenic zebrafish

(2008) Michael Raghunath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIα and cAMP-response element binding protein in the pentylenetetrazol-kindled rats

(2008) Pei Wang et al.   BRAIN RESEARCH

Biomarkers for exposure to estrogenic compounds: Gene expression analysis in zebrafish (Danio rerio)

(2008) Ulf Kausch et al.   ENVIRONMENTAL TOXICOLOGY

Fibroblast growth factor 2-induced angiogenesis in zebrafish: the zebrafish yolk membrane (ZFYM) angiogenesis assay

(2008) Stefania Nicoli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues

(2008) Ibrahim Meteoglu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Zebrafish as a new animal model for movement disorders

(2008) Laura Flinn et al.   JOURNAL OF NEUROCHEMISTRY

MPTP and MPP+ target specific aminergic cell populations in larval zebrafish

(2008) V Sallinen et al.   JOURNAL OF NEUROCHEMISTRY

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Angiogenic effect of saponin extract fromPanax notoginsengon HUVECsin vitroand zebrafishin vivo

(2008) Si-Jia Hong et al.   PHYTOTHERAPY RESEARCH

Hypoxia-Induced Retinal Angiogenesis in Zebrafish as a Model to Study Retinopathy

(2008) Renhai Cao et al.   PLoS One

Understanding epilepsy through network modeling

(2008) A. A. Prinz   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Validation of the use of zebrafish larvae in visual safety assessment

(2008) F.M. Richards et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

(2008) Stéphane Berghmans et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs

(2008) Matthew J. Winter et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Functional and developmental analysis of the blood–brain barrier in zebrafish

(2007) Jae-Yeon Jeong et al.   BRAIN RESEARCH BULLETIN

Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish

(2007) Lu Wen et al.   DEVELOPMENTAL BIOLOGY

Evaluation of zebrafish embryos as a model for assessing inhibition of hERG

(2007) S.W. Mittelstadt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS