Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

(2011) Lucie Krausova et al.   BIOCHEMICAL PHARMACOLOGY

Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2

(2011) Naoki Watanabe   INTERNATIONAL JOURNAL OF ONCOLOGY

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

(2011) Hongwei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet

(2011) Tomohiro Rogi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells

(2011) Juan Pablo Rigalli et al.   TOXICOLOGY

Variation of sesamin, sesamolin and tocopherols in sesame (Sesamum indicum L.) seeds and oil products in Thailand

(2010) Nuchanart Rangkadilok et al.   FOOD CHEMISTRY

Sesamin Inhibits Macrophage-Induced Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 Expression and Proangiogenic Activity in Breast Cancer Cells

(2010) Chun-Chung Lee et al.   INFLAMMATION

Camptothecin Attenuates Cytochrome P450 3A4 Induction by Blocking the Activation of Human Pregnane X Receptor

(2010) Y. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products

(2010) Kuzhuvelil B. Harikumar et al.   MOLECULAR CANCER RESEARCH

Genotoxicity evaluation of sesamin and episesamin

(2010) Hisako Hori et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Antihypertensive Effects of Sesamin in Humans

(2009) Takashi MIYAWAKI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer

(2008) D. Gupta et al.   CLINICAL CANCER RESEARCH

General Framework for the Prediction of Oral Drug Interactions Caused by CYP3A4 Induction from In Vivo Information

(2008) Yoshiyuki Ohno et al.   CLINICAL PHARMACOKINETICS

Interplay of Pregnane X receptor with Other Nuclear Receptors on Gene Regulation

(2008) Yun-Ping Lim et al.   Drug Metabolism and Pharmacokinetics

Comparative cytotoxicity of alachlor, acetochlor, and metolachlor herbicides in isolated rat and cryopreserved human hepatocytes

(2008) Vijay M. Kale et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4α interaction

(2008) Yun-Ping Lim et al.   Pharmacogenetics and Genomics

The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor

(2007) Hongwei Wang et al.   MOLECULAR ENDOCRINOLOGY