期刊
DRUG METABOLISM AND PHARMACOKINETICS
卷 23, 期 1, 页码 14-21出版社
JAPANESE SOC STUDY XENOBIOTICS
DOI: 10.2133/dmpk.23.14
关键词
pregnane X receptor (PXR); farnesoid X receptor (FXR); small heterodimer partner (SHP); hepatocyte nuclear factor-4 alpha (HNF-4 alpha); liver X receptor (LXR); glucocorticoid receptor (GR); constitutive androstane receptor (CAR)
Human body needs to protect itself from a diverse array of harmful chemicals. These chemicals are also involved in drug metabolism, enzyme induction, and can cause adverse drug-drug interactions. Being a member of nuclear receptors (NRs), pregnane X receptor (PXR) has recently emerged as transcriptional regulators of cytochrome P450 (CYP) and transporters expression so as to against xenobiotics exposure. This review describes some common nuclear receptors, i.e. farnesoid X receptor (FXR), small heterodimer partner (SHP), hepatocyte nuclear factor-4 alpha (HNF-4 alpha), liver X receptor (LXR), glucocorticoid receptor (GR), constitutive androstane receptor (CAR) that crosstalk with PXR and involvement of coregulators thus control target genes expression.
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