Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Review
Medicine, General & Internal
Ryan Tsz-Hei Tse, Hongda Zhao, Christine Yim-Ping Wong, Carol Ka-Lo Cheng, Angel Wing-Yan Kong, Qiang Peng, Peter Ka-Fung Chiu, Chi-Fai Ng, Jeremy Yuen-Chun Teoh
Summary: Urinary cell-free DNA (ucfDNA) is a promising tool for bladder cancer detection and molecular classification, as it can differentiate bladder cancer patients from healthy controls based on its molecular features and identify unique genetic features of bladder cancer. Additionally, ucfDNA exhibits significant differences in non-muscle-invasive and muscle-invasive bladder cancers, showing its potential for future applications in the field.
Review
Biochemistry & Molecular Biology
Dai Koguchi, Kazumasa Matsumoto, Izuru Shiba, Takahiro Harano, Satoshi Okuda, Kohei Mori, Shuhei Hirano, Kazuki Kitajima, Masaomi Ikeda, Masatsugu Iwamura
Summary: Early detection of bladder cancer is crucial, but current screening methods have limited diagnostic accuracy. Liquid biopsy, including CTCs, ucfDNA, and umiRNA, has shown promise as a complementary diagnostic tool. However, more research is needed to validate its clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Leihong Deng, Haichao Chao, Huanhuan Deng, Zhaojun Yu, Rongsong Zhao, Longwu Huang, Yun Gong, Yueting Zhu, Qingping Wang, Feng Li, Lirong Liu, Lei He, Zhimin Tang, Caizhi Liao, Yan Qi, Xianshu Wang, Tao Zeng, Hongzhi Zou
Summary: A single-target DNA methylation test has been developed for the detection of bladder cancer in urine samples. The test showed high sensitivity and specificity for both primary and recurring bladder cancer. It has the potential to be an effective tool for early detection of bladder cancer.
Review
Biochemistry & Molecular Biology
Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Imilia Ismail, Learn-Han Lee, Nurul Syakima Ab Mutalib
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide, and microRNAs play a significant role in its occurrence and progression. However, the methylation profiles of microRNAs in colorectal cancer patients are still unknown. Methylation is an important factor in cancer detection, and this review aims to provide insight into the current understanding of microRNA methylation in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Periklis Koukourikis, Maria Papaioannou, Petros Georgopoulos, Ioannis Apostolidis, Stavroula Pervana, Apostolos Apostolidis
Summary: Neurogenic bladder patients are at higher risk for advanced-stage bladder cancer, so it's important to develop non-invasive screening methods. A study found that changes in certain tumor-suppressing genes associated with bladder cancer were significantly more frequent in neurogenic bladder patients, especially in males. Biopsies showed a high percentage of chronic inflammation. Larger long-term studies are needed to establish the value of this non-invasive method in screening and diagnosis, as well as possible associations between gene changes, chronic inflammation, and bladder cancer in the neurogenic population.
Article
Oncology
Monica Cappetta, Lucia Fernandez, Lucia Brignoni, Nora Artagaveytia, Carolina Bonilla, Miguel Lopez, Manel Esteller, Bernardo Bertoni, Maria Berdasco
Summary: Human diversity poses a challenge in the development of robust worldwide biomarkers in oncology, with epigenetic variability linked to genetic backgrounds, lifestyles, and environmental exposures. In a study of sporadic breast cancer in Uruguay, a panel of 38 differentially methylated CpG positions was identified, with CYFIP1 methylation as a potential novel epigenetic biomarker for breast cancer in the Uruguayan population.
MOLECULAR ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zhuonan Liu, Tianshui Sun, Zhe Zhang, Jianbin Bi, Chuize Kong
Summary: Glucose metabolism and DNA methylation are important in cancers. A prognostic signature for bladder cancer was established using 18 genes associated with glucose metabolism and DNA methylation. Two genes (UCHL1 and PYCR1) were shown to enhance the malignant characteristics of bladder cancer cells.
Article
Oncology
Douglas G. Ward, Laura Baxter, Sascha Ott, Naheema S. Gordon, Junhui Wang, Prashant Patel, Kim Piechocki, Lee Silcock, Chris Sale, Maurice P. Zeegers, K. K. Cheng, Nicholas D. James, Richard T. Bryan
Summary: Mutational analysis of urinary DNA can accurately detect and monitor bladder cancer, providing a noninvasive method for diagnosis and surveillance.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Urology & Nephrology
Petros Georgopoulos, Maria Papaioannou, Soultana Markopoulou, Aikaterini Fragou, George Kouvatseas, Apostolos Apostolidis
Summary: This study aimed to investigate frequent changes in DNA methylation in bladder cancer (BCa) patients and examine the diagnostic accuracy of a panel of DNA methylation biomarkers in a Greek clinical setting. The results showed that DNA methylation of the genes RASSF1, RARB, DAPK, TERT, and APC in urine samples could potentially serve as urine biomarkers for the diagnosis of BCa, with RASSF1 showing promising specificity and sensitivity in distinguishing BCa patients from controls. Further studies are needed to develop a geographically adjusted diagnostic biomarker for BCa.
Article
Chemistry, Analytical
Krzysztof Ossolinski, Tomasz Ruman, Valerie Copie, Brian P. Tripet, Artur Kolodziej, Aneta Plaza-Altamer, Anna Ossolinska, Tadeusz Ossolinski, Anna Nieczaj, Joanna Niziol
Summary: This study investigated polar metabolite profiles in urine samples from BC patients and normal controls using NMR and LDI-MS and identified potential markers for bladder cancer. The metabolites were able to distinguish urine samples from BC and NCs individuals, and correlate with tumor stages and grades. The findings suggest that these metabolite markers may be useful for non-invasive detection and monitoring of bladder cancer.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Oncology
Ravindran Ragavi, Panneerselvam Muthukumaran, Srividhya Nandagopal, Dinesh Kumar Ahirwar, Sojit Tomo, Sanjeev Misra, Giulia Guerriero, Kamla Kant Shukla
Summary: Prostate cancer (CaP) is the second leading cause of cancer death and its clinical behavior varies widely. It is crucial to search for the molecular basis and markers for early diagnosis of CaP since the etiology of most cases is not yet fully understood. Epigenetic modifications play a key role in prostate tumorigenesis, including changes in DNA methylation patterns, histone modifications, miRNAs, and lncRNAs. These epigenetic defects may be caused by dysregulated expression of the epigenetic machinery, affecting the expression of important genes and potentially serving as diagnostic markers and therapeutic targets for CaP in the future. Further validation studies are needed to confirm the present results and transform basic research into clinical practice.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Cell Biology
Ning Zhao, Maozu Guo, Chunlong Zhang, Chunyu Wang, Kuanquan Wang
Summary: In this study, pan-cancer analysis was conducted to uncover specific and common patterns of long non-coding RNA (lncRNA) methylation in 23 cancer types. Several lncRNAs were identified as diagnostic biomarkers for specific cancer types, and two lncRNAs were identified as pan-cancer biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrea Maugeri, Martina Barchitta, Roberta Magnano San Lio, Giovanni Li Destri, Antonella Agodi, Guido Basile
Summary: Studies have shown that accelerated biological aging is positively associated with cancer risk and mortality, while assessing epigenetic age may help monitor individuals at risk for CRC. Additionally, aberrant epigenetic aging could potentially identify CRC patients with high recurrence risk and poor treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Matsui Takeshi, Susumu Tsutsumi, Yutaka Naito, Masanori Nojima, Etsuko Iio, Akihiro Tamori, Shoji Kubo, Tatsuya Ide, Yasuteru Kondo, Yuichiro Eguchi, Atsumasa Komori, Mitsuo Shimada, Tohru Utsunomiya, Koichi Kimura, Yoichi Hiasa, Takahiro Ochiya, Yasuhito Tanaka
JOURNAL OF HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Yuichiro Suzuki, Tokuma Tanuma, Masanori Nojima, Gota Sudo, Masakazu Akahonai, Hidetaka Hamamoto, Hironori Aoki, Taku Harada, Akio Katanuma, Hiroshi Nakase
GASTROINTESTINAL ENDOSCOPY
(2020)
Article
Biochemical Research Methods
Masaki Suzuki, Atsushi Muroi, Masanori Nojima, Ayumi Numata, Hirotaka Takasaki, Rika Sakai, Tomoyuki Yokose, Yohei Miyagi, Naohiko Koshikawa
PROTEOMICS CLINICAL APPLICATIONS
(2020)
Letter
Medicine, General & Internal
Yoji Takeuchi, Takuji Kawamura, Masanori Nojima
ANNALS OF INTERNAL MEDICINE
(2019)
Article
Surgery
Shuhei Miura, Yoshihiko Kurimoto, Ryushi Maruyama, Takahiko Masuda, Yohsuke Yanase, Yutaka Iba, Masanori Nojima, Akira Yamada
ANNALS OF VASCULAR SURGERY
(2020)
Article
Oncology
Yasushi Adachi, Masanori Nojima, Mitsuru Mori, Ryogo Himori, Toshiyuki Kubo, Hiro-O Yamano, Yingsong Lin, Kenji Wakai, Akiko Tamakoshi
CANCER PREVENTION RESEARCH
(2020)
Correction
Genetics & Heredity
Tsuneo Ikenoue, Masami Arai, Chikashi Ishioka, Takeo Iwama, Satoshi Kaneko, Nagahide Matsubara, Yoshihiro Moriya, Tadashi Nomizu, Kokichi Sugano, Kazuo Tamura, Naohiro Tomita, Teruhiko Yoshida, Kenichi Sugihara, Hiromu Naruse, Kiyoshi Yamaguchi, Masanori Nojima, Yusuke Nakamura, Yoichi Furukawa
JOURNAL OF HUMAN GENETICS
(2020)
Article
Multidisciplinary Sciences
Muneyoshi Futami, Keisuke Suzuki, Satomi Kato, Saori Ohmae, Yoshio Tahara, Masanori Nojima, Yoichi Imai, Takayuki Mimura, Yoshihiro Watanabe, Arinobu Tojo
Article
Oncology
Yasush Adachi, Masanori Nojima, Mitsuru Mori, Toshiyuki Kubo, Noriyuki Akutsu, Yasushi Sasaki, Hiroshi Nakase, Yingsong Lin, Youichi Kurozawa, Kenji Wakai, Akiko Tamakoshi
Summary: This study analyzed the association between serum sFas levels and the incidence of liver cancer. The results showed that high levels of sFas were associated with an increased risk of liver cancer. These findings suggest that sFas may serve as a biomarker for assessing liver cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Anesthesiology
Aya Watahabe, Naoki Shimada, Hiroto Ishiki, Noriko Fujiwara, Masanori Nojima, Arinobu Tojo
Summary: Younger age and pancreatic cancer are associated with higher requirements of fentanyl patch in terminally ill cancer patients. Patients with pancreatic cancer require more frequent adjustment of the medication dosage near death.
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Noriko Fujiwara, Naoki Shimada, Masanori Nojima, Keisuke Ariyoshi, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane
Summary: This study identified factors associated with home death in Japan, including being unmarried, unemployed male, and having a high drinking level in male. Cardiovascular disease, cerebrovascular disease, and external factors were significantly associated with home death, while the risk of home death for cancer patients tended to be lower.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kenji Watanabe, Masanori Nojima, Hiroshi Nakase, Toshiyuki Sato, Minoru Matsuura, Nobuo Aoyama, Taku Kobayashi, Hirotake Sakuraba, Masakazu Nishishita, Kaoru Yokoyama, Motohiro Esaki, Fumihito Hirai, Masakazu Nagahori, Sohachi Nanjo, Teppei Omori, Satoshi Tanida, Yoshihiro Yokoyama, Kei Moriya, Atsuo Maemoto, Osamu Handa, Naoki Ohmiya, Kiichiro Tsuchiya, Shinichiro Shinzaki, Shingo Kato, Toshio Uraoka, Hiroki Tanaka, Noritaka Takatsu, Atsushi Nishida, Junji Umeno, Masanao Nakamura, Yoshiyuki Mishima, Mikihiro Fujiya, Kenji Tsuchida, Sakiko Hiraoka, Makoto Okabe, Takahiko Toyonaga, Katsuyoshi Matsuoka, Akira Andoh, Yoshio Hirota, Tadakazu Hisamatsu, J COMBAT Study Grp
Summary: The degree of immune response to COVID-19 vaccination in IBD patients varies. Most IBD patients showed a sufficient immune response, while some had persistently low response. Factors such as age and medication were associated with the immune response.
JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Immunology
Motoki Amai, Masanori Nojima, Yoshikazu Yuki, Hiroshi Kiyono, Fumitaka Nagamura
Summary: To assess safety in vaccine development, stricter grading scales are required. However, concern exists that their strictness may lead to an overestimation of some adverse events. An analysis of a phase I clinical trial of a preventive vaccine revealed that the occurrence of certain adverse events differed when assessed using FDA grading scale compared to reference intervals. The criteria for hypernatremia and hypokalemia were lower and higher, respectively, than most standards.
Article
Oncology
Yasushi Adachi, Masanori Nojima, Mitsuru Mori, Hiro-o Yamano, Yasushi Sasaki, Hiroshi Nakase, Yingsong Lin, Kenji Wakai, JACC Study
Summary: The findings suggest that serum SOD activity is inversely correlated with the risk of colorectal carcinoma, particularly in men and individuals with rectal cancer or left-sided CRC.
CANCER EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tomoya Iida, Daisuke Hirayama, Naoki Minami, Minoru Matsuura, Kohei Wagatsuma, Kentaro Kawakami, Kanna Nagaishi, Masanori Nojima, Hiroki Ikeuchi, Seiichi Hirota, Ryutaro Shirakawa, Hisanori Horiuchi, Hiroshi Nakase
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2020)