Article
Cell Biology
Dan Li, Mingjun San, Jing Zhang, Anlan Yang, Wanhua Xie, Yang Chen, Xiaodan Lu, Yuntao Zhang, Mingyue Zhao, Xuechao Feng, Yaowu Zheng
Summary: The study using a transgenic mouse model of OXTR overexpression found that OXTR can promote mammary hyperplasia and tumorigenesis, as well as creating a microenvironment that promotes tumor growth, providing potential for targeted therapy in HER2-type breast cancer.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Feifei Guo, Lingyu Li, Wang Yang, Ji-fan Hu, Jiuwei Cui
Summary: Genomic instability is a key feature of cancer, potentially promoting tumorigenesis by increasing gene destruction and loss of genome integrity. Studies have shown that long noncoding RNAs play a significant role in regulating genomic stability.
Review
Oncology
Esther Lee, Jacky Cheung, Agnieszka B. Bialkowska
Summary: Kruppel-like factors (KLFs) are transcription factors that regulate various biological processes and participate in disease development and progression. KLF4 and KLF5, two significant members of this family, play crucial roles in embryogenesis, differentiation, and tumorigenesis. They maintain tissue homeostasis, regulate inflammation and response to injury, and have important functions in a variety of cancers. Recent studies have provided new insights into their opposing roles and mechanisms in gene expression, cellular function, and tumorigenesis. This review will focus on the roles of KLF4 and KLF5 in colorectal cancer, which can contribute to the development of targeted cancer therapy.
Article
Cell Biology
You-hong Wang, Zhen Guo, Liang An, Yong Zhou, Heng Xu, Jing Xiong, Zhao-qian Liu, Xiao-ping Chen, Hong-hao Zhou, Xiong Li, Tao Liu, Wei-hua Huang, Wei Zhang
Summary: This study found that LINC-PINT is significantly downregulated in nasopharyngeal cancer tissues compared to rhinitis tissues, and low LINC-PINT expressions are associated with poorer prognosis in patients receiving radiotherapy. LINC-PINT plays a functional role in inhibiting malignant phenotypes and sensitizing cancer cells to irradiation in vitro and in vivo. Mechanistically, LINC-PINT inhibits DNA damage repair through the ATM/ATR-Chk1/Chk2 signaling pathways and increases radiosensitivity by interacting with DNA-PKcs.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Rifat Ara Najnin, Md Rasel Al Mahmud, Md Maminur Rahman, Shunichi Takeda, Hiroyuki Sasanuma, Hisashi Tanaka, Yasuhiro Murakawa, Naoto Shimizu, Salma Akter, Masatoshi Takagi, Takuro Sunada, Shusuke Akamatsu, Gang He, Junji Itou, Masakazu Toi, Mary Miyaji, Kimiko M. Tsutsui, Scott Keeney, Shintaro Yamada
Summary: ATM gene mutation carriers have a higher risk of developing estrogen-receptor-positive breast cancer (BC). ATM is involved in the early transcriptional response to estrogens through its interaction with topoisomerase II (TOP2) and helps in the repair of TOP2-DNA double-strand breaks (DSBs). Defective repair of TOP2-dependent DSBs after estrogen exposure leads to changes in enhancer activation and overexpression of genes, including the c-MYC oncogene.
Article
Multidisciplinary Sciences
Qing Tong, Dong Yan, Yan Cao, Xiaogang Dong, Yimamumaimaitijiang Abula, Huan Yang, Panpan Kong, Mingyu Yi
Summary: NVS-ZP7-4, a novel chemical reagent targeting ZIP7, shows anti-tumor effects on HCC by inhibiting cell proliferation, migration, and invasion, and the activation of PI3K/AKT pathway. It serves as a promising therapeutic target for HCC.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Xiong Liu, Feng Bai, Yuchan Wang, Chuying Wang, Ho Lam Chan, Chenglong Zheng, Jian Fang, Wei-Guo Zhu, Xin-Hai Pei
Summary: BLBCs are highly aggressive breast cancers enriched with cancer stem cells. Loss of Gata3 up-regulates Fra1 and downregulates c-FOS, leading to activation of EMT and promotion of mammary tumor initiation and metastasis.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Nour L. Mozaffari, Fabio Pagliarulo, Alessandro A. Sartori
Summary: Human CtIP plays a crucial role in DNA repair, contributing to both genome integrity maintenance and oncogenic chromosomal translocations. Additionally, CtIP is involved in transcriptional regulation, DNA damage checkpoint signaling, and replication fork protection pathways.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexander Zhuravlev, Alejandro Cruz, Vladislav Aksenov, Alexey Golovanov, Jose M. Lluch, Hartmut Kuhn, Angels Gonzalez-Lafont, Igor Ivanov
Summary: This study investigates the functionality of ALOX15 in different cancer and inflammation models, and suggests that certain derivatives can inhibit its catalytic activity. Through computational simulations, the researchers identified a common pharmacophore that is critical for this allosteric inhibition.
Article
Multidisciplinary Sciences
Holly Holliday, Daniel Roden, Simon Junankar, Sunny Z. Wu, Laura A. Baker, Christoph Krisp, Chia-Ling Chan, Andrea McFarland, Joanna N. Skhinas, Thomas R. Cox, Bhupinder Pal, Nicholas D. Huntington, Christopher J. Ormandy, Jason S. Carroll, Jane Visvader, Mark P. Molloy, Alexander Swarbrick
Summary: ID4 functions as a repressor of myoepithelial differentiation in mammary basal cells by regulating gene expression, antagonizing HEB transcriptional activity, and promoting appropriate tissue morphogenesis. During pregnancy, downregulation of ID4 modulates genes regulated by HEB, promoting specialization of basal cells into myoepithelial cells.
Article
Biochemistry & Molecular Biology
Wan-Ju Wu, Sue-Hong Wang, Chun-Chi Wu, Yi-An Su, Chin-Yin Chiang, Ching-Hong Lai, Tsung-Hsiang Wang, Tsung-Lin Cheng, Jia-Yu Kuo, Tsai-Ching Hsu, Ting-Hui Lin, Yi-Ju Lee
Summary: Th2 cytokines IL-4 and IL-13 play a key role in promoting cell proliferation and mammary gland development during pregnancy, with the signaling crosstalk between IL-4/IL-13 and insulin further enhancing this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ashley N. Chandra, Sayanthooran Saravanabavan, Gopala K. Rangan
Summary: DNA-PK may mediate kidney cyst growth in ADPKD through its effects on proliferation and survival, with the DNA-PK complex being overexpressed in human ADPKD and DNA-PKcs detected in the cyst lining epithelia. In vitro, DNA-PK kinase inhibitor NU7441 significantly reduced cyst growth and enhanced the anti-proliferative effects of sirolimus in ADPKD cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dominic Bazzano, Stephanie Lomonacol, Thomas E. Wilson
Summary: This study monitored the resection of the 5'-terminated strand at DNA double-strand breaks (DSBs) using high-throughput sequencing with molecular identifiers, revealing the roles of enzymes such as Mre11 and Exo1 in the process. Results showed a major Mre11-dependent cleavage position 60-70 bp from the DSB end and an Exo1-dependent pause point approximately 200 bp from the DSB.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Hayun Hayun, Razanah Hanifati, Annisa Diana Pratiwik
Summary: The study evaluated two aminomethyl derivatives of dehydrozingerone as lipoxygenase and xanthine oxidase inhibitors. Results showed that one compound had comparable lipoxygenase inhibitory activity to nordihydroguaiaretic acid, but weaker xanthine oxidase inhibitory activity than allopurinol. Computational studies were conducted to analyze the binding interactions between enzymes and compounds.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Genetics & Heredity
Natalie C. Senter, Andrew McCulley, Vladimir A. Kuznetsov, Wenyi Feng
Summary: This study investigates the correlation between chromosomal structural rearrangement breakpoints and DNA double-strand breaks (DSBs) in breast cancer cells. The researchers found that these events mostly occur in the pericentromeric region of chromosome 16q. Recurrent DSBs were also detected in both cancer and control cells. The study identifies potential oncogenes that may contribute to breast cancer progression.
Article
Biochemistry & Molecular Biology
Shaonly Samanta, Mary Chatterjee, Balaram Ghosh, M. Rajkumar, Ajay Rana, Malay Chatterjee
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2008)
Article
Biochemistry & Molecular Biology
Mary Chatterjee, M. Janarthan, R. Manivannan, Ajay Rana, Malay Chatterjee
CHEMICO-BIOLOGICAL INTERACTIONS
(2010)
Article
Biochemistry & Molecular Biology
Sangita Manna, Subhadeep Das, Mary Chatterjee, M. Janarthan, Malay Chatterjee
JOURNAL OF CELLULAR BIOCHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Mary Chatterjee, Subhadeep Das, Kaushik Roy, Malay Chatterjee
MOLECULAR CARCINOGENESIS
(2013)
Review
Biochemistry & Molecular Biology
Aishani Wadhawan, Mary Chatterjee, Gurpal Singh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biophysics
Mayank Garg, Mary Chatterjee, Amit L. Sharma, Suman Singh
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Chemistry, Medicinal
Samriti Rana, Joga Singh, Aishani Wadhawan, Archna Khanna, Gurpal Singh, Mary Chatterjee
Summary: This study evaluated the toxicological profile of biosurfactant encapsulated polymeric nanoparticles in mice, showing no significant toxicological effects and confirming the safety of the treatment.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Rohit Mundel, Tanya Thakur, Mary Chatterjee
Summary: Nanotechnology has the potential to revolutionize drug delivery by enabling targeted treatment with minimal side effects. The development of nanopolymer-based drug carriers allows for controlled release of therapeutic drugs, improving the effectiveness and safety of cancer treatment.
Article
Chemistry, Multidisciplinary
Aishani Wadhawan, Joga Singh, Himani Sharma, Shristi Handa, Gurpal Singh, Ravinder Kumar, Ravi Pratap Barnwal, Indu Pal Kaur, Mary Chatterjee
Summary: This study reports the cytotoxicity of polymeric nanoparticles of a novel biosurfactant from Candida parapsilosis on breast cancer cells. The controlled release of the biosurfactant was observed in the PLA-PEG copolymer nanoparticles, and folic acid as a targeting ligand enhanced the uptake and cytotoxicity of the nanoparticles.
Review
Neurosciences
Hema Kumari Alajangi, Mandeep Kaur, Akanksha Sharma, Sumedh Rana, Shipali Thakur, Mary Chatterjee, Neha Singla, Pradeep Kumar Jaiswal, Gurpal Singh, Ravi Pratap Barnwal
Summary: The integrity of the blood-brain barrier (BBB) is crucial for the normal functioning of the central nervous system (CNS). Nanotechnology-based approaches are being explored as alternatives to conventional methods for treating neurological diseases caused by BBB disruption. It is important to understand the characteristics of BBB for the discovery of new drugs that can effectively cross the barrier. This article discusses the building blocks of BBB, immune response activation upon breach of the barrier, autoimmune neurological disorders caused by BBB dysfunction, mechanisms of transport pathways across BBB, and novel strategies and alternative routes for drug delivery into CNS.
Article
Biochemistry & Molecular Biology
Mary Chatterjee, Parames C. Sil
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2007)
