Review
Biochemistry & Molecular Biology
Tae Jin Kim, Young Hwa Lee, Kyo Chul Koo
Summary: The androgen receptor (AR) plays a crucial role in the development and progression of prostate cancer (PCa), and treatment for hormone-sensitive prostate cancer (HSPC) relies heavily on androgen deprivation therapy (ADT). Despite most patients progressing to castration-resistant prostate cancer (CRPC), studies suggest that manipulating alternative molecular pathways can help improve current treatments and develop novel therapies for CRPC management.
Article
Cell Biology
Zheyu Zhang, Zezhong Mou, Chenyang Xu, Siqi Wu, Xiyu Dai, Xinan Chen, Yuxi Ou, Yiling Chen, Chen Yang, Haowen Jiang
Summary: circRNA hsa_circ_0007813 is upregulated in bladder cancer and associated with aggressive tumor characteristics and poor prognosis. Knockdown of hsa_circ_0007813 inhibits proliferation, migration, and invasiveness of bladder cancer cells by regulating IGF2R expression via hsa-miR-361-3p sponging, revealing a potential therapeutic target for bladder cancer.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Zhenlin Huang, Bo Tang, Yinhui Yang, Zhaogang Yang, Lei Shi, Yang Bai, Binyuan Yan, R. Jeffrey Karnes, Jun Zhang, Rafael Jimenez, Liguo Wang, Qiang Wei, Jinjian Yang, Wanhai Xu, Zhankui Jia, Haojie Huang
Summary: The study identifies a previously unrecognized tumor suppressive role of the inflammation-activated MAP3K7-IKKβ axis in degrading AR protein. Additionally, the findings suggest that aberrant elevation of AR protein could serve as a prognostic biomarker and therapeutic target for MAP3K7-deficient prostate cancer.
Article
Multidisciplinary Sciences
Ayesha A. Shafi, Chris M. McNair, Jennifer J. McCann, Mohammed Alshalalfa, Anton Shostak, Tesa M. Severson, Yanyun Zhu, Andre Bergman, Nicolas Gordon, Amy C. Mandigo, Saswati N. Chand, Peter Gallagher, Emanuela Dylgjeri, Talya S. Laufer, Irina A. Vasilevskaya, Matthew J. Schiewer, Michael Brunner, Felix Y. Feng, Wilbert Zwart, Karen E. Knudsen
Summary: CRY1, a transcriptional coregulator associated with the circadian clock, is identified as a tumor specific regulator of DNA repair. It is androgen-responsive, stabilized by genomic insult, and promotes DNA repair and cell survival through temporal transcriptional regulation. These findings nominate CRY1 as a new therapeutic target for cancer treatment.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Kumiko Taguchi, Nozomu Kaneko, Kanami Okudaira, Takayuki Matsumoto, Tsuneo Kobayashi
Summary: This study demonstrated that GLP-1 can improve impaired insulin-induced relaxation in diabetic mice by enhancing endothelium-dependent vasorelaxation and NO production. GLP-1 inhibits GRK2 activity and promotes beta-arrestin2 translocation, affecting insulin signaling and Akt activation, thereby regulating vascular relaxation responses.
Article
Pharmacology & Pharmacy
Yixin Zhang, Peilan Zhou, Fengfeng Lu, Ruibin Su, Zehui Gong
Summary: Overexpression of A20-binding inhibitor of nuclear factor-kappa B (ABIN-1) attenuated morphine tolerance and dependence in mice, likely through facilitating beta-arrestin2 degradation. ABIN-1 targeted beta-arrestin2 to regulate morphine tolerance, suggesting it as a potential therapeutic target for alleviating morphine tolerance and dependence.
MOLECULAR PHARMACOLOGY
(2021)
Article
Oncology
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang
Summary: The study identifies B7-H3 as an immune checkpoint overexpressed in prostate cancer, particularly in metastatic castration-resistant prostate cancer (mCRPC). Enzalutamide-resistant mCRPC cells show increased expression of B7-H3, and it is associated with resistance signaling pathways. The gene network of B7-H3 is strongly correlated with androgen receptor (AR) and its co-factors, suggesting potential therapeutic targets for mCRPC.
NPJ PRECISION ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Polina Isaikina, Ivana Petrovic, Roman P. Jakob, Parishmita Sarma, Ashutosh Ranjan, Minakshi Baruah, Vineet Panwalkar, Timm Maier, Arun K. Shukla, Stephan Grzesiek
Summary: Non-visual arrestins, arrestin2 and arrestin3, interact with various GPCRs through different phosphorylation patterns, resulting in distinct functional outcomes. In this study, we characterized the interactions between phosphorylated CCR5 and arrestin2. We discovered new phosphorylation sites on CCR5 that are necessary for stable arrestin2 complex formation. The identified motif is responsible for robust arrestin2 recruitment in many other GPCRs. Our findings provide insights into the specificity of arrestin2 and arrestin3 isoforms and shed light on the molecular basis of arrestin signaling.
Article
Biotechnology & Applied Microbiology
Xi Hong, Liang Mao, Luwei Xu, Qiang Hu, Ruipeng Jia
Summary: PSMA plays a crucial role in prostate cancer, and its knockdown leads to metabolic disorder and abnormal transcription, resulting in inhibition of tumor cell proliferation and metastasis.
Article
Chemistry, Multidisciplinary
Shiting Zhao, Tao Nie, Lei Li, Qiaoyun Long, Ping Gu, Yuwei Zhang, Wei Sun, Zexin Lin, Qing Liu, Yue Qi, Wei Wang, Mengyuan Xie, Kerry Loomes, Chenleng Cai, Donghai Wu, Hannah Xiaoyan Hui
Summary: PRDM16 is a dominant activator of brown and beige adipocytes. The regulation of PRDM16 expression is not fully understood. Androgen receptor (AR) is negatively correlated with PRDM16 expression. Sex differences in PRDM16 mRNA expression are observed in human WAT, with females having higher expression than males. Androgen-AR signaling inhibits PRDM16 expression and beige adipocyte browning. AR directly binds to the intronic region of PRDM16, but not to Ucp1 and other browning-related genes. Adipocyte-specific deletion of Ar promotes beige cell biogenesis, while adipocyte-specific overexpression of AR attenuates white adipose beiging.
Article
Cell Biology
Sofia Cardenas, Cecilia Colombero, Mariana Cruz, Eduardo Mormandi, Adeniyi Michael Adebesin, John R. Falck, Susana Nowicki
Summary: The membrane receptor GPR75 plays a role in regulating the expression and transcriptional activity of androgen receptor (AR) in prostate cancer (PCa) cells mediated by 20-hydroxyeicosatetraenoic acid (20-HETE). This suggests that targeting 20-HETE/GPR75 could be a potential strategy to limit the expression of AR-driven phenotype in PCa cells.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mu Lv, Juanjuan Yu, Yan Huang, Jie Ma, Jun Xiang, Yanqiu Wang, Linxia Li, Zhenbo Zhang, Hong Liao
Summary: Uterine diseases, such as endometriosis and uterine fibroids, have a significant impact on women's health. Androgens, primarily synthesized in the ovaries and adrenal glands, play a crucial role in the development of these diseases. However, further research is needed to understand the signaling pathways involved and develop targeted therapeutic strategies.
Article
Biochemistry & Molecular Biology
Sarah El Kharraz, Vanessa Dubois, Martin E. van Royen, Adriaan B. Houtsmuller, Ekatarina Pavlova, Nina Atanassova, Tien Nguyen, Arnout Voet, Roy Eerlings, Florian Handle, Stefan Prekovic, Elien Smeets, Lisa Moris, Wout Devlies, Claes Ohlsson, Matti Poutanen, Kevin J. Verstrepen, Geert Carmeliet, Kaisa-Mari Launonen, Laura Helminen, Jorma J. Palvimo, Claude Libert, Dirk Vanderschueren, Christine Helsen, Frank Claessens
Summary: Dimerization of the ligand-binding domain of the androgen receptor (AR) is crucial for transcriptional regulation and proper functioning of AR. Mutations disrupting LBD dimerization can lead to significant effects, as demonstrated in a mouse model in this study.
Article
Biochemistry & Molecular Biology
Yingxuan Wang, Zhiran Fan, Chanjuan Xu, Xiaole Yan, Yanzhao Zhou, Zhihua Qiu, Qingchen Yuan, Jiayu Zheng, Yuhua Liao, Xiao Chen
Summary: The study demonstrates that McAb-ATR ameliorates atherosclerosis by regulating beta-arrestin2 without affecting G(q) or G(i)(2/i3) pathways, suggesting its potential as a novel strategy for treating atherosclerosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Editorial Material
Multidisciplinary Sciences
Hamsa Thayele Purayil, Yehia Daaka
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Jude Masannat, Hamsa Thayele Purayil, Yushan Zhang, Michelle Russin, Iqbal Mahmud, Wanju Kim, Daiqing Liao, Yehia Daaka
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Yu Qin, Anindya Dey, Hamsa Thayele Purayil, Yehia Daaka
Article
Chemistry, Multidisciplinary
Thayele Purayil Hamsa, Punathil Thejass, Girija Kuttan
DRUG AND CHEMICAL TOXICOLOGY
(2011)
Article
Pharmacology & Pharmacy
T. P. Hamsa, Girija Kuttan
EUROPEAN JOURNAL OF PHARMACOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Xiaojie Ma, Laura Espana-Serrano, Wan-ju Kim, Hamsa Thayele Purayil, Zhongzhen Nie, Yehia Daaka
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Integrative & Complementary Medicine
Thayele Purayil Hamsa, Girija Kuttan
Article
Biochemistry & Molecular Biology
Hamsa Thayele Purayil, Yushan Zhang, Joseph B. Black, Raad Gharaibeh, Yehia Daaka
Summary: This study identified beta Arrestin 1 (beta Arr1) as a regulator of androgen receptor (AR) function in castration-resistant prostate cancer (CRPC). Beta Arr1 forms a complex with AR and beta Catenin in the nucleus, enhancing AR transcriptional function in CRPC. Depletion of beta Arr1 attenuates PC cell and tumor growth, while restoring nuclear beta Arr1 expression restores these processes. Targeting beta Arr1-regulated AR transcriptional function may lead to the development of new drugs for lethal CRPC.
Article
Oncology
Archana Mukhopadhyay, Laura E. Hanold, Hamsa Thayele Purayil, Solomon A. Gisemba, Sanjeewa N. Senadheera, Jane V. Aldrich
CANCER BIOLOGY & THERAPY
(2017)
Article
Oncology
Yushan Zhang, Hamsa Thayele Purayil, Joseph B. Black, Francis Fetto, Lauren D. Lynch, Jude N. Masannat, Yehia Daaka