Article
Cell Biology
Yoshitaka Nagashima, Yusuke Nishimura, Fumiharu Ohka, Kaoru Eguchi, Kosuke Aoki, Hiroshi Ito, Tomoya Nishii, Takahiro Oyama, Masahito Hara, Yotaro Kitano, Hirano Masaki, Toshihiko Wakabayashi, Atsushi Natsume
Summary: Genetic mutations, including IDH and H3F3A mutations, play a significant role in the functional prognosis of spinal cord gliomas. Grade I and II gliomas tend to show improved functional outcomes after surgery, while grade III/IV gliomas may experience deterioration. Spinal glioma progenitor cells with H3F3A mutations are associated with accelerated tumor-related spinal cord injury and functional impairment, whereas the presence of IDH mutations suggests a relatively favorable functional prognosis.
Review
Biochemistry & Molecular Biology
Femke Mussen, Jana Van Broeckhoven, Niels Hellings, Melissa Schepers, Tim Vanmierlo
Summary: Traumatic spinal cord injury (SCI) is characterized by severe neuroinflammation and hampered neuroregeneration. Current therapies have limited effectiveness, so new strategies targeting the initial inflammatory reactions and promoting endogenous repair are crucial. Adenosine monophosphate (cAMP) regulates these processes and inhibiting its hydrolyzing enzyme phosphodiesterase (PDE) has shown promise in modulating inflammation and promoting regeneration. This review focuses on the immunomodulatory and neuroregenerative role of cAMP-specific PDE inhibition in SCI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Muhibullah S. Tora, Stewart G. Neill, Yuliya Lakhina, Hemza Assed, Michelle Zhang, Purva P. Nagarajan, Thais Federici, Juanmarco Gutierrez, Kimberly B. Hoang, Yuhong Du, Kecheng Lei, Nicholas M. Boulis
Summary: This study found heterogeneity in microenvironmental features in a high-grade spinal cord glioma (SCG) model, with increased oxidative stress, proliferation, inflammatory cytokines, neovascularization, and decreased but still present staining for hypoxic markers at the tumor edge. These findings support the utility of this model as a means for investigating therapeutic approaches targeting the more aggressive and surgically unresectable tumor border.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Neurosciences
Gang Zhou, Zhiyan Wang, Shiyuan Han, Xiaokun Chen, Zhimin Li, Xianghui Hu, Yongning Li, Jun Gao
Summary: Spinal cord injury (SCI) leads to various pathological processes that hinder neural regeneration. Increasing intracellular cAMP activity has been shown to promote neuronal survival and axonal regrowth after SCI. Recent studies have also highlighted the importance of cAMP signaling in regulating glial cell function and shown synergetic effects when combined with other treatments for SCI recovery.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Purva P. Nagarajan, Muhibullah S. Tora, Stewart G. Neill, Thais Federici, Pavlos Texakalidis, Anthony Donsante, Peter Canoll, Kecheng Lei, Nicholas M. Boulis
Summary: Intramedullary spinal cord tumors are rare and difficult to study, but using a combination of gene knockdowns, researchers were able to induce high-grade glioma development in spinal cords in minipigs. This study evaluated the efficiency of different lentiviral vector combinations in producing high-grade spinal cord gliomas in rats. Different vector combinations resulted in varying tumor growth rates and characteristics, with the triple cocktail of PDGF-B, HRAS, and sh-p53 showing the most significant tumor growth and proliferation. These findings suggest that the rat model of spinal cord glioma could be a valuable tool for evaluating therapeutic strategies in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Lei Cheng, Fan Zhang, Xingang Zhao, Leiming Wang, Wanru Duan, Jian Guan, Kai Wang, Zhenlei Liu, Xingwen Wang, Zuowei Wang, Hao Wu, Zan Chen, Lianghong Teng, Yifei Li, Fei Xiao, Tao Fan, Fengzeng Jian
Summary: This study analyzed the genomic sequencing of primary spinal cord astrocytoma (SCA) to characterize its mutational landscape. The study identified 12 driver genes and three rare mutated driver genes. It also observed genetic mutations associated with the risk of brain glioma and recurrent amplification of the CDK4 gene in the 12q14.1 region. Additionally, mutations in the cell cycle pathway were found in 39.2% of patients. Overall, SCAs share a significant degree of somatic mutation landscape with brainstem glioma.
JOURNAL OF PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Chuanhao Li, Wenyuan Shen, Zhengyu Xu, Chao Li, Quan Liu, Yilin Pang, Junjin Li, Xiaoyu Wang, Zhishuo Wang, Shiqing Feng
Summary: Spinal cord injury (SCI) is a debilitating condition with limited treatment options. Celastrol, an anti-inflammatory compound extracted from Tripterygium wilfordii, has shown potential for treating SCI by promoting cAMP production and preventing apoptosis through the VIP-ADCYAP1R1-GNAS pathway. This study highlights celastrol as a promising therapeutic agent for SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Takashi Yagi, Masaki Mizuno, Hiroto Kageyama, Kotaro Tatebayashi, Toshiki Endo, Yasuhiro Takeshima, Motoyuki Iwasaki, Ryu Kurokawa, Keisuke Takai, Misao Nishikawa, Kazutoshi Hida
Summary: This study analyzed the clinical characteristics, treatment strategies, and surgical outcomes of subependymoma patients. The results showed that subependymomas have an indolent clinical course and eccentric location. Surgical treatment should prioritize functional preservation, as even subtotal resection has a good prognosis.
Article
Biotechnology & Applied Microbiology
Harnish Mukesh Naik, Swetha Kumar, Jayanth Venkatarama Reddy, Jacqueline E. E. Gonzalez, Brian O. O. McConnell, Venkata Gayatri Dhara, Tiexin Wang, Marcella Yu, Maciek Antoniewicz, Michael J. J. Betenbaugh
Summary: The aim of this study was to reduce lactate accumulation in CHO cell cultures by adding inhibitors to hexokinase-2 (HK2). 2-deoxy-d-glucose (2DG) and 5-thio-d-glucose (5TG) successfully reduced lactate accumulation with limited impact on CHO cell growth. Supplementation with these inhibitors also resulted in earlier peak titers of the recombinant protein EPO-Fc, increased consumption rates of certain metabolites, and alterations in N-glycosylation.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Clinical Neurology
Rui-Chao Chai, Hao Yan, Song-Yuan An, Bo Pang, Hui-Yuan Chen, Quan-Hua Mu, Ke-Nan Zhang, Yao-Wu Zhang, Yu-Qing Liu, Xing Liu, Zheng Zhao, Tao Jiang, Yong-Zhi Wang, Wen-Qing Jia
Summary: H3 K27-altered spinal cord glioma, a highly lethal pediatric-type tumor, has better prognosis compared to brain tumors. Molecular heterogeneity and various genetic alterations are observed in H3 K27M-mutant spinal cord astrocytoma. Higher number of copy number variants (CNV), chromosomal deletions, specific mutations and alterations in cell proliferative pathways are associated with worse survival. Histological type and molecular features can stratify the prognosis and management of H3 K27M-mutant spinal cord glioma.
Article
Biology
Afaf Bajjig, Pauline Michel-Flutot, Tiffany Migevent, Florence Cayetanot, Laurence Bodineau, Stephane Vinit, Isabelle Vivodtzev
Summary: This study used spinal cord contusion in mice to mimic human tetraplegia and found that the C3 model was an appropriate model for interventions aimed at restoring breathing following tetraplegia.
Article
Immunology
Peng Sun, Duo-Jiao Fan, Tao Fan, Xin Li, Xue-Ling Qi, Xin-Gang Zhao, Qi-Fei Gai
Summary: The study discusses the correlation between MGMT protein expression in spinal glioma cells and sensitivity to chemotherapy drugs, establishing a prediction method for drug sensitivity and providing a theoretical basis for determining optimal chemotherapy regimens for post-surgery patients. Chemotherapy post-surgery effectively delays tumor recurrence and prevents reoperation, with high progression-free survival rates. The regimen shows promising prospects with good safety and tolerability.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Veterinary Sciences
Kiyotaka Arai, Takamasa Itoi, Natsuki Akashi, Masahiro Miyabe, Keisuke Sugimoto, Akira Matsuda, Noritaka Maeta, Teppei Kanda, Kenji Kutara
Summary: This study performed diffusion tensor imaging (DTI) scans on adult Beagle dogs and analyzed DTI parameters in different regions. The results showed that DTI parameters significantly decreased in the caudal direction, but were not significantly correlated with vertebral levels. These findings contribute to the development of a clinical reference for evaluating spinal cord in dogs using DTI parameters.
VETERINARY SCIENCES
(2023)
Article
Oncology
Thomas Perwein, Martin Benesch, Daniela Kandels, Torsten Pietsch, Rene Schmidt, Franz Quehenberger, Brigitte Bison, Monika Warmuth-Metz, Beate Timmermann, Jurgen Krauss, Ulrich-Wilhelm Thomale, Rolf-Dieter Kortmann, Pablo Hernaiz Driever, Astrid Katharina Gnekow
Summary: The majority of pediatric patients with spinal cord low-grade glioma experienced disease progression, requiring multiple interventions for long-term disease control. Molecular testing may reveal therapeutic targets to improve outcomes.
Article
Clinical Neurology
Yong-Zhi Wang, Yao-Wu Zhang, Wei-Hao Liu, Rui-Chao Chai, Ren Cao, Bo Wang, Song-Yuan An, Wen-Ju Jiang, Yu-Lun Xu, Jun Yang, Wen-Qing Jia
Summary: The study analyzed 44 patients with spinal cord DMG and found that patients with lower histological grade were older and had longer overall survival. All 30 tested tumors were IDH wild type, and 96% of cases presented with unmethylated O-6-methylguanine-DNA methyltransferase.
Article
Psychiatry
Guadalupe Rivero, Ane M. Gabilondo, Jesus A. Garcia-Sevilla, Romano La Harpe, Benito Morentin, J. Javier Meana
SCHIZOPHRENIA RESEARCH
(2015)
Article
Psychiatry
Guadalupe Rivero, Idoia Martin-Guerrero, Elena de Prado, Ane M. Gabilondo, Luis F. Callado, Jesus A. Garcia-Sevilla, Africa Garcia-Orad, J. Javier Meana
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2016)
Article
Clinical Neurology
Guadalupe Rivero, Ane M. Gabilondo, Jesus A. Garcia-Sevilla, Romano La Harpe, Luis F. Callado, J. Javier Meana
JOURNAL OF AFFECTIVE DISORDERS
(2014)
Article
Pharmacology & Pharmacy
Jamie McPherson, Guadalupe Rivero, Myma Baptist, Javier Llorente, Suleiman Al-Sabah, Cornelius Krasel, William L. Dewey, Chris P. Bailey, Elizabeth M. Rosethorne, Steven J. Charlton, Graeme Henderson, Eamonn Kelly
MOLECULAR PHARMACOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Guadalupe Rivero, Ane M. Gabilondo, Jesus A. Garcia-Sevilla, Romano La Harpe, Benito Morentin, J. Javier Meana
NEUROCHEMISTRY INTERNATIONAL
(2010)
Article
Neurosciences
Guadalupe Rivero, Ane M. Gabilondo, M. Julia Garcia-Fuster, Romano La Harpe, Jesus A. Garcia-Sevilla, J. Javier Meana
Article
Neurosciences
G. Rivero, A. M. Gabilondo, J. A. Garcia-Sevilla, L. F. Callado, R. La Harpe, B. Morentin, J. J. Meana
PSYCHOPHARMACOLOGY
(2013)
Meeting Abstract
Clinical Neurology
I. Brocos Mosquera, G. Rivero, B. Morentin, J. J. Meana, L. F. Callado
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
R. Diez-Alarcia, C. Muguruza, G. Rivero, A. Garcia-Bea, L. F. Callado, A. Martin, J. Llop, J. J. Meana
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Pharmacology & Pharmacy
G. Rivero, I. Brocos-Mosquera, J. J. Meana, L. F. Callado
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2018)
Meeting Abstract
Pharmacology & Pharmacy
G. Rivero, P. Miranda-Azpiazu, I Gil-Pisa, I Mollinedo, C. Muguruza
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2014)
Article
Pharmacology & Pharmacy
Javier Llorente, Sarah Withey, Guadalupe Rivero, Margaret Cunningham, Alex Cooke, Kunal Saxena, Jamie McPherson, Sue Oldfield, William L. Dewey, Chris P. Bailey, Eamonn Kelly, Graeme Henderson
MOLECULAR PHARMACOLOGY
(2013)
Article
Pharmacology & Pharmacy
Guadalupe Rivero, Javier Llorente, Jamie McPherson, Alex Cooke, Stuart J. Mundell, Craig A. McArdle, Elizabeth M. Rosethorne, Steven J. Charlton, Cornelius Krasel, Christopher P. Bailey, Graeme Henderson, Eamonn Kelly
MOLECULAR PHARMACOLOGY
(2012)
Meeting Abstract
Clinical Neurology
G. Rivero, C. Muguruza, V. Corzo, J. J. Meana, L. F. Callado
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)