Article
Clinical Neurology
Hugo Soulier, Francois Mauguiere, Helene Catenoix, Alexandra Montavont, Jean Isnard, Marc Hermier, Marc Guenot, Sylvain Rheims, Laure Mazzola
Summary: This study aims to explore visceral sensations and their processing mechanism in the brain during epileptic seizures. Through electrical stimulation and observation of responses, it was found that visceral and emotional sensations are mainly associated with operculo-insulolimbic structures. Additionally, specific brain structures were found to be involved at different degrees depending on the type of visceral response.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Fu-Chao Zhang, Ying-Xue Wei, Rui-Xia Weng, Qi-Ya Xu, Rui Li, Yang Yu, Guang-Yin Xu
Summary: This study identified a novel PVT-IC neural circuit playing a critical role in colorectal visceral pain in a mouse model of IBS. This work will strengthen fundamental research on the involvement of central nervous system in visceral hyperalgesia and provide potential therapeutic targets toward effective treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ning-Ning Ji, Lei Du, Ying Wang, Ke Wu, Zi-Yang Chen, Rong Hua, Yong-Mei Zhang
Summary: Visceral hypersensitivity in irritable bowel syndrome is associated with the downregulation of membrane SK2 in the hypothalamic paraventricular nucleus. Activation of SK2 may alleviate visceral hypersensitivity, suggesting SK2 activators as a potential intervention for visceral pain.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Takuto Hamaoka, Urs A. Leuenberger, Cheryl Blaha, Jonathan Carter Luck, Lawrence I. Sinoway, Jian Cui
Summary: The venous distension reflex (VDR) is a pressor response evoked by peripheral venous distension and is accompanied by increased muscle sympathetic nerve activity (MSNA). This study investigated the effects of VDR on baroreflex sensitivity (BRS) and found that VDR increased sympathetic BRS and decreased cardiovagal BRS. These changes in baroreflex function contribute to the modulation of MSNA and BP during limb venous distension.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Biology
Alys R. Clark, Hanna Fontinha, John Thompson, Sophie Couper, Devanshi Jani, Ali Mirjalili, Laura Bennet, Peter Stone
Summary: Pregnancy leads to significant changes in the maternal cardiovascular-circulatory system, which are necessary for the adaptions required during pregnancy and lactation. This study focuses on the maternal cardiovascular autonomic responses to pregnancy and position, and shows that these responses change significantly throughout gestation. The study also highlights the impact of position on maternal hemodynamic parameters, specifically the relationship between supine position and compression of the inferior vena cava. Overall, this research provides new insights into the physiology of physiological stressors related to position during pregnancy.
Article
Neurosciences
Tri Huu Doan, Yuma Sato, Masayuki Matsumoto, Tadachika Koganezawa
Summary: The lateral habenula regulates autonomic cardiovascular responses through activation of different neural pathways including cardiac parasympathetic nerves and cardiovascular sympathetic nerves. The stimulation effects of lateral habenula are likely mediated by 5-HT1A and 5-HT2 receptors, while other 5-HT receptors do not affect its actions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Zoe K. Sarafis, Jordan W. Squair, Otto F. Barak, Geoff B. Coombs, Jan Elaine Soriano, Kelly A. Larkin-Kaiser, Amanda H. X. Lee, Alex Hansen, Maro Vodopic, Rinaldo Romac, Christopher Grant, Rebecca Charbonneau, Tanja Mijacika, Andrei V. Krassioukov, Philip N. Ainslie, Zeljko Dujic, Aaron A. Phillips
Summary: Cervical spinal cord injury (SCI) leads to impaired common carotid artery (CCA) responsiveness and increases the risk of cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Neurosciences
QingQing Wang, Sonia Garcia Caraballo, Grigori Rychkov, Alice E. McGovern, Stuart B. Mazzone, Stuart M. Brierley, Andrea M. Harrington
Summary: This study compared the central circuits of vagal and spinal afferent pathways in the transmission of colorectal nociceptive information. The results showed differences in the projections and activation of neurons between the two pathways, as well as differences in their response to pressure intensity.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Review
Clinical Neurology
Jens Jordan, Ulrich Limper, Jens Tank
Summary: This review provides an overview of human autonomic research under real and simulated space conditions, with a focus on orthostatic intolerance. Postflight orthostatic intolerance is commonly observed in astronauts and could pose major risks during landing. In addition, this research has implications for patients with disorders affecting cardiovascular autonomic control on Earth.
NEUROLOGICAL SCIENCES
(2022)
Article
Critical Care Medicine
Matthew C. Tattersall, Christina M. Hughey, Thomas M. Piasecki, Claudia E. Korcarz, Kristin M. Hansen, Nancy R. Ott, Nathan Sandbo, Michael C. Fiore, Timothy B. Baker, James H. Stein
Summary: This study aimed to investigate the acute cardiovascular and pulmonary effects of long-term electronic cigarette use. The results showed that compared to control participants, electronic cigarette users experienced worsened blood pressure, heart rate, and heart rate variability after vaping, as well as vasoconstriction, impaired exercise tolerance, and increased airflow obstruction.
Article
Physiology
Tristan W. Dorey, Matthias Walter, Andrei V. Krassioukov
Summary: The study examined the effects of intradetrusor onabotulinumtoxinA injections on heart rate and heart rate variability in individuals with spinal cord injury during urodynamic studies. It was found that the injections led to improvements in autonomic nervous system function, resulting in reduced abnormalities in heart rate responses.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Hiromichi Tsushima, Yanli Zhang, Tomohiko Muratsubaki, Motoyori Kanazawa, Shin Fukudo
Summary: Visceral pain and anxiety may be related to the interaction of oxytocin and CRH in neurons in the brain.
NEUROSCIENCE RESEARCH
(2021)
Article
Medicine, General & Internal
Esteban Jorge-Galarza, Margarita Torres-Tamayo, Maria del Rocio Martinez-Alvarado, Berenice Pena-Aparicio, Carmen Gonzalez-Salazar, Juan Reyes-Barrera, Manuel Sierra-Beltran, Erika Fajardo-Flores, Andrey Kostin, J. Antonio Gonzalez-Hermosillo
Summary: Autonomic dysfunction is common in long-standing type 2 diabetes patients. The study evaluated autonomic cardiovascular responses through passive orthostatic challenge along the diabetes continuum, finding that cardiovascular autonomic neuropathy is the only abnormality detected in newly diagnosed type 2 diabetes patients and is associated with fasting glucose and HbA1c values.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cell Biology
Taiz F. S. Brasil, Ivaldo J. A. Belem-Filho, Eduardo A. T. Fortaleza, Jose Antunes-Rodrigues, Fernando M. A. Correa
Summary: The renin-angiotensin system (RAS) is involved in cardiovascular and hydroelectrolytic control, being associated with the development of hypertension. The restraint stress (RS) model induces an increase in angiotensin-II contents in the circulation and CNS, as well as an increased expression of AT-1 receptors in CNS structures related to stress, facilitating the cardiovascular response caused by stress. The modulation of autonomic, neuroendocrine, and functional RS-caused alterations by RAS via the AT-1 receptor may be a potential pharmacological strategy to treat cardiovascular consequences of stress.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Leonardo Kesrouani Lemos, Carlos Alberto Toledo Teixeira Filho, Fernanda Santana dos Santos, Taise Mendes Biral, Allysie Priscilla de Souza Cavina, Eduardo Pizzo Junior, Silas de Oliveira Damasceno, Julia Waszczuk Vendrame, Carlos Marcelo Pastre, Franciele Marques Vanderlei
Summary: This study compared the autonomic and cardiovascular responses after eccentric exercise with and without blood flow restriction (BFR) of different loads. The results showed that eccentric exercise with or without BFR did not cause autonomic and cardiovascular imbalance in post-exercise recovery.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Joan Antoni Fernandez-Blanco, Javier Estevez, Terez Shea-Donohue, Vicente Martinez, Patri Vergara
JOURNAL OF CROHNS & COLITIS
(2015)
Article
Gastroenterology & Hepatology
Ferran Jardi, Monica Aguilera, Patri Vergara, Vicente Martinez
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2015)
Article
Gastroenterology & Hepatology
F. Jardi, J. A. Fernandez-Blanco, V. Martinez, P. Vergara
NEUROGASTROENTEROLOGY AND MOTILITY
(2016)
Editorial Material
Cell Biology
Maria-Angeles Aller, Natalia Arias, Vicente Martinez, Patri Vergara, Jaime Arias
INFLAMMATION RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Evangelina Teran-Ventura, Monica Aguilera, Patri Vergara, Vicente Martinez
JOURNAL OF CROHNS & COLITIS
(2014)
Article
Gastroenterology & Hepatology
Ferran Jardi, Joan A. Fernandez-Blanco, Vicente Martinez, Patri Vergara
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Gastroenterology & Hepatology
Maria-Angeles Aller, Vicente Martinez, Ana Arias, Maria-Paz Nava, Valentin Cuervas-Mons, Patri Vergara, Jaime Arias
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2019)
Review
Biochemistry & Molecular Biology
Vicente Martinez, Amaia Iriondo De-Hond, Francesca Borrelli, Raffaele Capasso, Maria Dolores del Castillo, Raquel Abalo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Jose Antonio Uranga, Vicente Martinez, Raquel Abalo
Article
Biochemistry & Molecular Biology
Marina Ferrer, Monica Aguilera, Vicente Martinez
Summary: In a mouse study, rifaximin did not significantly alter gut commensal microbiota and Toll-like receptors in healthy mice, showing only minor changes and no modulation of the immune system. These findings suggest a potential modulatory role of rifaximin in inflammatory and dysbiotic gut conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Sergio Lopez-Estevez, Georgia Gris, Beatriz de la Puente, Alicia Carceller, Vicente Martinez
Summary: Sigma-1 receptors play an important role in intestinal inflammation-associated referred hyperalgesia, with knockout mice showing significant attenuation in inflammation associated hypersensitivity. The absence of sigma(1)Rs had little impact on colitis generation and progression, but did show reduction in edema and down-regulation of iNOS gene expression during the chronic phase.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Sergio Lopez-Estevez, Josep Manuel Lopez-Torrellardona, Marc Parera, Vicente Martinez
Summary: This study explores the validity of DSS-induced colitis in rats as a model to mimic chronic intestinal hypersensitivity. The results indicate that DSS-induced colitis can generate a long-lasting state of visceral hypersensitivity and reproduce the changes in intestinal sensitivity characteristics of inflammatory and functional gastrointestinal disorders in humans. This research is of great importance for the development of new pharmacological treatments against visceral pain.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Biochemistry & Molecular Biology
Javier Estevez, Vicente Martinez
Summary: Toll-like receptors (TLRs) play a role in microbial regulation of gastrointestinal functions, including the epithelial barrier function (EBF). This study investigated the effects of TLR7 stimulation on colonic EBF in rats. Results showed that TLR7 stimulation with imiquimod had a pro-barrier effect, while the combination with dimethyl sulfoxide (DMSO) had a detrimental effect on EBF. These effects were not associated with changes in gene expression or distribution of tight junction-related proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Lorena Ortega Moreno, Ana Bagues, Vicente Martinez, Raquel Abalo
Summary: Parkinson's disease (PD) is a severe neurodegenerative disease with disabling motor alterations diagnosed at a late stage, along with early non-motor symptoms like constipation. Current treatments only reduce motor symptoms with drawbacks, so new approaches targeting PD etiopathogeny and biomarkers are needed. Gastrointestinal origins of PD, modulation of gut microbiome, and lipidomics as a tool for personalized analysis show promise in understanding and treating PD.
Article
Gastroenterology & Hepatology
M. Aguilera, M. Cerda-Cuellar, V. Martinez