Asymmetric Synthesis of 3,4-Disubstituted Proline Derivatives: Application in Synthesis of Hepatitis C Virus Protease Inhibitor Telaprevir

Asymmetric Michael Reaction Catalyzed by Proline Lithium Salt: Efficient Synthesis ofL-Proline and Isoindoloisoquinolinone Derivatives

(2013) Kun Xu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid

(2013) Bettina Bakonyi et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Asymmetric Synthesis of a Bicyclic Amino Acid as a Core Structure of Telaprevir

(2012) Seiji Shirakawa et al.   ChemCatChem

Effect of Sterically Demanding Substituents on the Conformational Stability of the Collagen Triple Helix

(2012) Roman S. Erdmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization

(2012) Tao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual Amine and Palladium Catalysis in Diastereo- and Enantioselective Allene Carbocyclization Reactions

(2012) Meiling Li et al.   ORGANIC LETTERS

Incorporation of cis- and trans-4,5-Difluoromethanoprolines into Polypeptides

(2012) Vladimir S. Kubyshkin et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of 3-Substituted Proline Derivatives by Using Phase-Transfer-Catalyzed Conjugate Addition

(2012) Yan Liu et al.   Asian Journal of Organic Chemistry

Organocatalytic Asymmetric Additions tomeso-Anhydrides and Azlactones

(2011) Zaida Rodriguez-Docampo et al.   ChemCatChem

Boceprevir for Untreated Chronic HCV Genotype 1 Infection

(2011) Fred Poordad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir for Retreatment of HCV Infection

(2011) Stefan Zeuzem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lewis acid promoted intramolecular (3 + 2) ‘cycloadditions’ of methyleneaziridines with alkene and alkyne acceptors

(2011) Karen Griffin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Decarboxylative Strecker Reaction

(2011) Deepankar Das et al.   ORGANIC LETTERS

Total Synthesis of (±)-Kainic Acid: A Photochemical C–H Carbamoylation Approach

(2011) Takuma Kamon et al.   ORGANIC LETTERS

Synthesis and Characterization of Novel Bi- and Tricyclic α-Amino Acids

(2011) Matthew R. Johnson et al.   SYNTHETIC COMMUNICATIONS

A New Structural Motif for Bifunctional Brønsted Acid/Base Organocatalysis

(2010) Vijay N. Wakchaure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Biocatalytic Oxidative Desymmetrization of Substituted Pyrrolidines

(2010) Valentin Köhler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions

(2010) Anass Znabet et al.   CHEMICAL COMMUNICATIONS

Chiral Silver Amide-Catalyzed Enantioselective [3 + 2] Cycloaddition of α-Aminophosphonates with Olefins

(2010) Yasuhiro Yamashita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial

(2010) Paul Y Kwo et al.   LANCET

New Chiral Ferrocenyl P,S-Ligands for Highly Diastereo-/Enantioselective Catalytic [3 + 2] Cycloaddition of Azomethine Ylides with Cyclic and Acyclic Enones

(2010) Cheng Zhang et al.   ORGANIC LETTERS

Enantioselective Total Synthesis of (−)-α-Kainic Acid

(2010) Andreas Farwick et al.   ORGANIC LETTERS

In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in Rats

(2009) François Maltais et al.   JOURNAL OF MEDICINAL CHEMISTRY

Telaprevir and Peginterferon with or without Ribavirin for Chronic HCV Infection

(2009) Christophe Hézode et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir with Peginterferon and Ribavirin for Chronic HCV Genotype 1 Infection

(2009) John G. McHutchison et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides Catalyzed by Copper(I)/TF-BiphamPhos Complexes

(2008) Chun-Jiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Organocatalytic Three-Component 1,3-Dipolar Cycloaddition: Control of Stereochemistry via a Chiral Brønsted Acid Activated Dipole

(2008) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Axially Chiral BINIM and Ni(II)-Catalyzed Highly Enantioselective 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides andN-Arylmaleimides

(2007) Jing-Wen Shi et al.   JOURNAL OF ORGANIC CHEMISTRY