Transition-Metal-Catalyzed Hydroamination and Carboamination Reactions of Anthranilic Allenamides as a Route to 2-Vinyl- and 2-(α-Styryl)quinazolin-4-one Derivatives

2-Vinyl- and 2-(a-styryl)quinazolin-4-ones have been synthesized by intramolecular gold-catalyzed hydroamination and palladium-catalyzed carboamination of anthranilic allenamides, easily prepared by prototropic isomerization of the corresponding propargylamides. These procedures, which lead to N-Boc-protected quinazolinones, represent a more flexible alternative to the reported palladium-catalyzedamination of anthranilic allylamides, achievable only from N-tosylallylamides.