Article
Cardiac & Cardiovascular Systems
Silje S. Kooijman, Anthonie L. Duijnhouwer, Roland R. J. van Kimmenade, Arie P. J. van Dijk, Esther Hink, Menko-Jan de Boer, Janneke Timmermans, Jolien W. Roos-Hesselink
Summary: The study found that pregnancy in women with Turner syndrome does not lead to a significant increase in ascending aortic diameter or an increased risk of dissection. Factors such as the presence of a bicuspid aortic valve, monosomy X karyotype, or oocyte donation did not have a significant impact on aortic diameter change. No aortic complications were observed during pregnancy or in the first 6 months after delivery. Based on these findings, it appears that pregnancy in Turner syndrome women is safe.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jasmine Grewal, Anne Marie Valente, Alexander C. Egbe, Fred M. Wu, Eric V. Krieger, Virginia P. Sybert, Iris M. van Hagen, Luc M. Beauchesne, Fred H. Rodriguez, Craig S. Broberg, Anitha John, Elisa A. Bradley, Jolien W. Roos-Hesselink
Summary: This study provides insights into pregnancy outcomes in women with Turner syndrome. Pregnancy in women with TS without structural heart disease does not increase the risk of cardiovascular outcomes. For women with TS with structural heart disease, pregnancy may not be as prohibitive as previously thought, but ongoing evaluation is necessary.
Article
Medicine, General & Internal
Sapthami Nadesapillai, Femke Mol, Simone L. Broer, Linda B. P. M. Stevens Brentjens, Marieke O. Verhoeven, Karst Y. Heida, Mariette Goddijn, Ron J. T. van Golde, Annelies M. E. Bos, Sanne van der Coelen, Ronald Peek, Didi D. M. Braat, Janielle A. E. M. van der Velden, Kathrin Fleischer, Michelle Nisolle
Summary: Oocyte vitrification is a feasible option for fertility preservation in women with Turner syndrome, especially those with 46,XX cell lines or sufficient ovarian reserve. The cumulative number of vitrified oocytes is significantly correlated with AMH, AFC, XX cell percentage, and FSH. However, it is too early to draw conclusions about the utilization of vitrified oocytes in women with Turner syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Genetics & Heredity
Carole-Anne Whigham, Beverley Vollenhoven, Amanda J. Vincent
Summary: Turner syndrome is a common chromosomal abnormality in females, causing ovarian insufficiency and infertility. Early diagnosis and hormone replacement therapy are crucial for improving reproductive outcomes. While some women can conceive naturally, many require assisted reproductive technology.
PRENATAL DIAGNOSIS
(2023)
Review
Obstetrics & Gynecology
S. Brouillet, N. Ranisavljevic, C. Sonigo, E. Haquet, S. Bringer-Deutsch, V Loup-Cabaniols, S. Hamamah, M. Willems, T. Anahory
Summary: The oocyte cryopreservation strategy is not well suited for women with Turner syndrome due to their unique hormonal profile and chromosomal abnormalities, which make it difficult to collect a sufficient number of mature oocytes for fertility preservation.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Marie-Louise Van der Hoorn, Kim van Bentem, Eileen Lashley
Summary: This study aims to provide pre-pregnancy counseling information for healthcare workers regarding oocyte donation (OD) pregnancies. The study found that OD pregnancies have a higher risk of complications, including hypertensive disorders, cesarean section, preterm birth, postpartum hemorrhage, and low birth weight. Pre-pregnancy counseling is recommended to prevent complications in subsequent pregnancies, and women should be informed about the increased risk of complications during OD pregnancies. Other recommendations include the prophylactic use of aspirin during pregnancy and restriction to single embryo transfer.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Yan Jiang, Jing-Chuan Yuan, Ge Song, Xu-Hui Zhang, Sui-Bing Miao, Xiao-Hua Wu
Summary: This study compares the pregnancy outcomes and offspring follow-up between PCOS and non-PCOS recipients, and finds no significant difference between the two groups.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
M. Cauldwell, P. J. Steer, D. Adamson, C. Alexander, L. Allen, C. Bhagra, A. Bolger, S. Bonner, M. Calanchini, A. Carroll, R. Casey, S. Curtis, C. Head, K. English, L. Hudsmith, R. James, E. Joy, N. Keating, L. MacKiliop, F. McAuliffe, R. K. Morris, A. Mohan, K. Von Klemperer, M. Kaler, D. A. Rees, A. Shetty, F. Siddiqui, L. Simpson, L. Stocker, P. Timmons, S. Vause, H. E. Turner
Summary: Pregnancy in women with Turner syndrome is associated with major maternal cardiovascular risks, and thorough cardiovascular assessment and counseling should be conducted before pregnancy.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Pediatrics
Jasmine Aly, Paul Kruszka
Summary: Turner syndrome is the most common sex chromosome abnormality in females, with clinical features involving multiple organ systems and various dysfunctions. The lack of genotype/phenotype correlation studies limits the ability to provide accurate treatment guidance. However, advancements in genetic testing and analysis are rapidly improving our understanding of the genetic basis of the condition.
CURRENT OPINION IN PEDIATRICS
(2022)
Article
Immunology
Chiara Agostinis, Gabriella Zito, Miriam Toffoli, Isabel Peterlunger, Livia Simoni, Andrea Balduit, Erica Curtolo, Alessandro Mangogna, Beatrice Belmonte, Davide Vacca, Federico Romano, Tamara Stampalija, Tiziana Salviato, Federica Defendi, Nicoletta Di Simone, Uday Kishore, Giuseppe Ricci, Roberta Bulla
Summary: C1q is essential in pregnancy, and its deficiency can lead to pregnancy failure. Anti-C1q autoantibodies are present in various diseases and in the general population. Recent evidence suggests an increased risk of PE in women undergoing ART. This study found that PE patients have lower levels of anti-C1q, and ART pregnancies showed similar levels of C1q and anti-C1q compared to PE patients. The findings suggest an immunological dysfunction at the fetal-maternal interface in ART pregnancies, with C1q deposition in placentae. Anti-C1q may have a physiological role in pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Summary: Technology and evolving regulatory framework have led to changes in medical terminology, particularly in describing the relationships between gamete and embryo donors and recipients. The use of social media and DNA testing has made it necessary to move away from terms like "known" and "anonymous" and adopt more accurate terms like "directed" and "nonidentified".
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
J. Altmann, J. Kummer, F. Herse, L. Hellmeyer, D. Schlembach, W. Henrich, A. Weichert
Summary: Despite being illegal in Germany, oocyte donation pregnancies are on the rise, with many women opting to keep the origin of the pregnancies a secret. This study evaluated maternal and neonatal outcomes of oocyte donation pregnancies in three large obstetric care units in Berlin, showing a high risk of adverse outcomes such as preeclampsia, preterm delivery, Cesarean section, and peripartum hemorrhage.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Cell Biology
Jing Zhao, Bixia Huang, Ning Li, Xiaofei Wang, Bin Xu, Yanping Li
Summary: The decline in female fertility with age is attributed to a decrease in oocyte quality. The association between advanced maternal age (AMA) and a decline in endometrial receptivity (ER) is still debated. A systematic review and meta-analysis were conducted to assess this relationship. The analysis of 18 studies showed a trend of lower clinical pregnancy rate (CPR) and implantation rate (IR) in women with AMA, although not statistically significant. Infertile women with AMA had significantly higher miscarriage rate (MR) and lower live birth rate (LBR). This suggests that AMA is associated with a decline in ER.
Article
Immunology
Xuezi Tian, Kaveri T. S. Aiyer, Johanna M. Kapsenberg, Dave L. Roelen, Marie-Louise van der Hoorn, Michael Eikmans
Summary: Uncomplicated oocyte donation (OD) pregnancies exhibit a higher proportion of CD163-positive cells in decidual macrophages compared to non-OD in vitro fertilization (IVF) pregnancies, potentially indicating a need for a local type 2 macrophage-related mechanism to compensate for higher fetal-maternal HLA mismatch load.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Juliette Krop, Xuezi Tian, Marie-Louise van der Hoorn, Michael Eikmans
Summary: Pregnancy involves complex interactions between the maternal immune system and the fetus, particularly in the placenta where macrophages play a crucial role in maintaining tissue homeostasis and repairing damaged tissues. Recent research has revealed a greater diversity of macrophage phenotypes than previously thought, and their interactions with trophoblasts and T cells have been found to vary throughout different trimesters of pregnancy. Understanding the role of macrophages could have implications for pregnancies with HLA incompatibility and recurrent pregnancy loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Obstetrics & Gynecology
Loic Sentilhes, Catherine Deneux-Tharaux, Ian Roberts, Katharine Ker
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Marion Groussolles, Norbert Winer, Loic Sentilhes, Florence Biquart, Mona Massoud, Alexandre J. Vivanti, Hanane Bouchghoul, Patrick Rozenberg, Pascale Olivier, Raoul Desbriere, Celine Chauleur, Franck Perrotin, Frederic Coatleven, Florent Fuchs, Florence Bretelle, Vassilis Tsatsaris, Laurent J. Salomon, Nicolas Sananes, Gilles Kayem, Veronique Houflin-Debarge, Thomas Schmitz, Guillaume Benoist, Catherine Arnaud, Virginie Ehlinger, Christophe Vayssiere
Summary: This study found that the use of the Arabin pessary in twin pregnancies with a short cervix did not significantly reduce adverse neonatal outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Loic Sentilhes, Catherine Deneux-Tharaux, Gilles Kayem
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Loic Sentilhes, Aurelien Seco, Elie Azria, Gael Beucher, Marie-Pierre Bonnet, Bernard Branger, Lionel Carbillon, Coralie Chiesa, Catherine Crenn-Hebert, Michel Dreyfus, Corinne Dupont, Jeanne Fresson, Cyril Huissoud, Bruno Langer, Olivier Morel, Sophie Patrier, Franck Perrotin, Pierre Raynal, Patrick Rozenberg, Rene-Charles Rudigoz, Francoise Vendittelli, Norbert Winer, Catherine Deneux-Tharaux, Gilles Kayem
Summary: Conservative management for women with placenta accreta spectrum undergoing cesarean delivery is associated with a lower risk of transfusion of >4 units of packed red blood cells within 6 months compared to cesarean hysterectomy. However, there may be potential complications associated with conservative management.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Loic Sentilhes, Gilles Kayem, Catherine Deneux-Tharaux
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Deborah Secchi, Julia Alberic, Sophie Gobillot, Adrien Ghenassia, Matthieu Roustit, Celine Chauleur, Pascale Hoffmann, Tiphaine Raia-Barjat
Summary: In women with a history of previous cesarean section and unfavorable cervix, cervical ripening with a double-balloon catheter increases the rate of vaginal birth compared to induction with oxytocin alone, without increasing the risk of uterine rupture.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Pathology
Maroa Dridi, Alexandra Papoudou-Bai, Panagiotis Kanavaros, Marine Perard, Alix Clemenson, Celine Chauleur, Michel Peoc'h, Georgia Karpathiou
Summary: This retrospective study investigated the immune microenvironment of gestational trophoblastic diseases. It found significant differences in the composition of immune cells between partial and complete moles, with the latter showing a higher infiltrate of cells with immunosuppressive phenotypes.
Review
Obstetrics & Gynecology
David Laville, Laurent Martin, Celine Chauleur, Ahmed Mehdi, Michel Peoc'h, Georgia Karpathiou
Summary: Florid lymphoid hyperplasias of the lower female genital tract, also known as pseudolymphoma or lymphoma-like lesions, are rare benign lesions that can be misdiagnosed. This report reviews the available literature on these lesions and highlights their benign nature to avoid misdiagnosis and complications due to overtreating.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2022)
Letter
Pathology
Georgia Karpathiou, Celine Chauleur, Tiphanie Picot, Sofia Achour, Thomas Corsini, Mojgan Devouassoux-Shisheboran, Michel Peoc'h
Letter
Pathology
Georgia Karpathiou, Celine Chauleur, Laure Mathonat, Maroa Dridi, Tiphanie Picot, Mojgan Devouassoux-Shisheboran, Michel Peoc'h
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Letter
Obstetrics & Gynecology
Loic Sentilhes, Catherine Deneux-Tharaux, Gilles Kayem
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Georgia Karpathiou, Maroa Dridi, Alexandra Papoudou-Bai, Marine Perard, Alix Clemenson, Celine Chauleur, Michel Peoc'h
Summary: Autophagy is involved in both normal and pathological pregnancies, but its role in hydatidiform moles (HM) is unclear. This study examined the expression of autophagy markers LC3B and p62 in 36 HM samples and compared them to 19 nonmolar pregnancies. LC3B was found in almost half of the villi and p62 was found in almost all villi. LC3B expression was significantly higher in complete HM compared to partial HM. There were also different expression patterns of LC3B in trophoblast layers. Overall, autophagic markers are present in HM and their expression differs between complete and partial moles.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2023)
Article
Pathology
Georgia Karpathiou, Viviana Sramek, Sami Dagher, Mousa Mobarki, Maroa Dridi, Tiphanie Picot, Celine Chauleur, Michel Peoc'h
Summary: MECA-79 is expressed in high endothelial venules (HEVs) and tumor cells in endometrial endometrioid adenocarcinoma. It is positively associated with higher grade tumors and inversely associated with parametrial invasion.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Obstetrics & Gynecology
Sara Fernandez, Beatrice Trombert-Paviot, Tiphaine Raia-Barjat, Celine Chauleur
Summary: The implementation of the ERAS program in gynecological oncology surgery resulted in a reduction in length of stay, an increase in outpatient rate, a decrease in complication rate in minimally invasive surgery, and no increase in the readmission rate. Overall, patient satisfaction was high.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)