Article
Multidisciplinary Sciences
Anna Maria Nuzzo, Domenica Giuffrida, Laura Moretti, Paola Re, Giorgio Grassi, Guido Menato, Alessandro Rolfo
Summary: This study compared the expression of anti-angiogenic sFlt1 and pro-angiogenic PlGF in placenta and maternal blood in GDM, GDM-PE, CTRL, and PE cases. The results showed higher sFlt1/PlGF values in GDM-PE maternal blood, decreased PlGF gene expression in GDM, PE, and GDM-PE placentae, and increased PlGF protein levels in GDM and GDM-PE placentae. Additionally, sFlt1 gene expression was higher in PE placentae, while sFlt1 protein expression was lower in GDM-PE placentae. These findings suggest a potential link between sFlt1 overproduction and PE onset in GDM pregnancies.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Ulla Sovio, Francesca Gaccioli, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: Slowing of fetal growth and biomarkers of placental insufficiency were associated with an increased probability of early onset of spontaneous term labor.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Peripheral Vascular Disease
Rebekka Vogtmann, Jacqueline Heupel, Florian Herse, Mahsa Matin, Henning Hagmann, Ivo Bendix, Kristin Kraeker, Ralf Dechend, Elke Winterhager, Rainer Kimmig, Angela Koeninger, Alexandra Gellhaus
Summary: By overexpressing hsFLT1 in mice, the study found that circulating maternal hsFLT1 is sufficient to induce typical maternal preeclampsia-like symptoms, impairing spiral artery remodeling independently from the fetoplacental compartment.
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Hao Yang, Fang Guo, Qin Guo, Yifei Wang, Ping He, Hongbo Zhang, Shuaiyu Wang
Summary: The sFlt1/PlGF ratio is a useful parameter for the diagnosis of preeclampsia, showing good performance in distinguishing preeclampsia from other hypertensive disorders of pregnancy and predicting adverse outcomes. PlGF and sFlt1/PlGF ratio are worth implementing in the clinical management of women with preeclampsia.
CLINICA CHIMICA ACTA
(2022)
Review
Medicine, General & Internal
Ioakeim Sapantzoglou, Angeliki Rouvali, Antonios Koutras, Maria Ioanna Chatziioannou, Ioannis Prokopakis, Zacharias Fasoulakis, Eleftherios Zachariou, Athanasios Douligeris, Anastasia Mortaki, Paraskevas Perros, Thomas Ntounis, Vasilios Pergialiotis, Ekaterini Domali, Stavros Athanasiou, George Daskalakis, Alexandros Rodolakis, Periklis Panagopoulos, Kalliopi I. I. Pappa
Summary: Twin pregnancies have a higher risk of developing PE compared to singletons, and the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, and timing of delivery. This systematic review aimed to summarize the data on sFLT1, PlGF, and their ratios in twin pregnancies and investigate their association with PE development, adverse pregnancy outcomes, and timing of delivery. The review found that sFLT1 levels and the sFLT1/PIGF ratio were higher in twins, especially in the third trimester, while PlGF levels were higher before the third trimester and then showed no difference or were even lower than in singletons. The sFLT1/PIGF ratio is an independent marker of adverse outcomes and is inversely associated with the mean time until delivery. Further research is needed to establish optimal sFLT1/PIGF cut-off values and stratify the risk in twin pregnancies.
MEDICINA-LITHUANIA
(2023)
Article
Biochemistry & Molecular Biology
Eun S. Park, Sehee Kim, Derek C. Yao, Jude P. J. Savarraj, Huimahn Alex Choi, Peng Roc Chen, Eunhee Kim
Summary: This study found that sENG induces microglia to produce angiogenic/inflammatory factors and may be involved in the development of vascular malformations in brain arteriovenous malformations (bAVMs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Rugina Neuman, Langeza Saleh, Koen Verdonk, Anton H. van den Meiracker, Henk Russcher, Herold J. Metselaar, Willy Visser, A. H. Jan Danser
Summary: The study indicates that PlGF production is significantly upregulated in AFLP patients, mainly originating from the placenta. Compared to other disease groups, AFLP patients have significantly elevated levels of PlGF, which rapidly decline postpartum.
Article
Biochemistry & Molecular Biology
Xiujun Fan, Shanmugam Muruganandan, Philemon D. Shallie, Sabita Dhal, Matthew Petitt, Nihar R. Nayak
Summary: VEGF signaling is crucial for maintaining the homeostasis of the maternal vascular space in mouse placenta through modulation of TGC development and differentiation, similar to its effect on endothelial cells in other vascular beds.
Review
Biochemistry & Molecular Biology
Matej Vicen, Ivone Cristina Igreja Sa, Katarina Tripska, Barbora Vitverova, Iveta Najmanova, Samira Eissazadeh, Stanislav Micuda, Petr Nachtigal
Summary: Membrane endoglin (Eng) and soluble endoglin (sEng) play important roles in metabolic syndrome-related disorders, including endothelial dysfunction, arterial hypertension, hyperglycemia, and diabetes. Reduced Eng expression is a hallmark of chronic pathologies related to metabolic syndrome, while sEng is considered a biomarker of preeclampsia.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Meddy N. Bongers-Karmaoui, Vincent W. V. Jaddoe, Romy Gaillard
Summary: This study found that maternal angiogenic factors in the first half of pregnancy are not associated with childhood blood pressure and vascular development in the total population. Only in children born preterm, higher maternal second trimester PlGF concentrations are associated with lower childhood diastolic blood pressure.
Article
Cell Biology
Georgia Margioula-Siarkou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Kosmas Margaritis, Eleftherios Vavoulidis, Giuseppe Gullo, Maria Alexandratou, Konstantinos Dinas, Alexandros Sotiriadis, Georgios Mavromatidis
Summary: Preeclampsia, a leading cause of maternal and fetal morbidity and mortality, involves dysfunction of the placenta leading to imbalance of angiogenic and anti-angiogenic factors. Endoglin and soluble endoglin play significant roles in the pathophysiology of preeclampsia by interfering with signaling pathways that regulate angiogenesis and endothelial function. Further research is needed to explore the potential prognostic, diagnostic, and therapeutic implications of these molecules in clinical management of preeclampsia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Fan Chou, Yu-Hsuan Lan, Jun-Han Hsiao, Chiao-Yun Chen, Pei-Yu Chou, Ming-Jyh Sheu
Summary: Curcumin and demethoxycurcumin demonstrated antiangiogenic activity via the inhibition of endoglin/Smad1 signaling. Combination treatment with curcuminoids and semaxanib is expected to reverse semaxanib resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Nadia Calabriso, Eleonora Stanca, Alessio Rochira, Fabrizio Damiano, Laura Giannotti, Benedetta Di Chiara Stanca, Marika Massaro, Egeria Scoditti, Christian Demitri, Paola Nitti, Andrea Palermo, Luisa Siculella, Maria Annunziata Carluccio
Summary: The experimental study found that CGFs contain important pro-angiogenic factors that promote endothelial cell migration, tube structure formation, and the expression of multiple angiogenic mediators by endothelial cells. This suggests that CGFs promote endothelial angiogenesis through their soluble and cellular components, making them a potential biomaterial for therapeutic vasculogenesis in the field of tissue regeneration.
Article
Obstetrics & Gynecology
Jessica M. Faupel-Badger, Thomas F. McElrath, Michele Lauria, Lauren C. Houghton, Kee-Hak Lim, Samuel Parry, David Cantonwine, Gabriel Lai, S. Ananth Karumanchi, Robert N. Hoover, Rebecca Troisi
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Article
Education, Scientific Disciplines
Jessica M. Faupel-Badger, Kimberley Raue, David E. Nelson, Sophia Tsakraklides
CBE-LIFE SCIENCES EDUCATION
(2015)
Article
Oncology
Melinda S. Yates, Shine Chang, Hwa-Young Lee, Jessica Faupel-Badger, Carrie Cameron
JOURNAL OF CANCER EDUCATION
(2018)
Review
Oncology
Brid M. Ryan, Jessica M. Faupel-Badger
SEMINARS IN ONCOLOGY
(2016)
Article
Oncology
David E. Nelson, Jessica M. Faupel-Badger, Grant Izmirlian
JOURNAL OF CANCER EDUCATION
(2019)
Review
Oncology
David E. Nelson, Jessica Faupel-Badger, Siobhan Phillips, Britni Belcher, Shine Chang, David B. Abrams, Barnett S. Kramer, Mary C. White, Michael O'Malley, Arti P. Varanasi, Carol J. Fabian, Jonathan S. Wiest, Graham A. Colditz, Kara Hall, Peter G. Shields, Jeffrey N. Weitzel
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2014)
Editorial Material
Oncology
Jessica Faupel-Badger, Carrie Cameron, Shine Chang
JOURNAL OF CANCER EDUCATION
(2014)
Article
Multidisciplinary Sciences
Jessica M. Faupel-Badger, David E. Nelson, Grant Izmirlian, Katherine H. Ross, Kimberley Raue, Sophia Tsakraklides, Atsushi Miyaoka, Maura Spiegelman
Article
Multidisciplinary Sciences
Jessica M. Faupel-Badger, David E. Nelson, Grant Izmirlian
Article
Oncology
Jessica M. Faupel-Badger, Maire A. Duggan, Mark E. Sherman, Montserrat Garcia-Closas, Xiaohong R. Yang, Jolanta Lissowska, Louise A. Brinton, Beata Peplonska, Barbara K. Vonderhaar, Jonine D. Figueroa
Article
Oncology
Neetu Chawla, Deanna L. Kepka, Brandy M. Heckman-Stoddard, Hisani N. Horne, Ashley S. Felix, Patricia Luhn, Colleen Pelser, Jonathan Barkley, Jessica M. Faupel-Badger
JOURNAL OF ONCOLOGY PRACTICE
(2013)
Article
Education, Scientific Disciplines
Brittany Haynes, Kyle Brimacombe, Christy Hare, Jessica Faupel-Badger
CBE-LIFE SCIENCES EDUCATION
(2020)
Review
Medicine, Research & Experimental
Jessica M. Faupel-Badger, Amanda L. Vogel, Christopher P. Austin, Joni L. Rutter
Summary: This article offers considerations for developing new educational opportunities for a diverse and skilled translational science workforce based on decades of advances and experiential knowledge. It emphasizes the need for new education approaches that distill key concepts and practices in translational science from past and ongoing research initiatives. The National Center for Advancing Translational Sciences (NCATS) has developed guiding principles for translational science and is disseminating them through new education activities aiming to reach a broad scientific audience.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Amanda L. Vogel, Shadab F. Hussain, Jessica M. Faupel-Badger
Summary: The need for education activities in translational science (TS) to overcome scientific and operational bottlenecks was addressed through an online case study-based course offered by the National Center for Advancing Translational Sciences in 2020. The evaluation showed significant increases in TS knowledge and positive attitudes about team science in translational research (TR) among students, indicating the effectiveness of the course in conveying TS concepts and enhancing professional interests.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Jessica M. Faupel-Badger, Amanda L. Vogel, Shadab F. Hussain, Christopher P. Austin, Matthew D. Hall, Elizabeth Ness, Philip Sanderson, Pramod S. Terse, Xin Xu, Krishna Balakrishnan, Samarjit Patnaik, Juan J. Marugan, Udo Rudloff, Marc Ferrer
Summary: Translational science innovations address challenges, accelerate progress, and generate solutions for human health needs. Examining successes through an education lens can identify core principles and practices. The National Center for Advancing Translational Sciences teaches these principles through online courses.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)