Article
Biology
Galen F. Gao, Dajiang Liu, Xiaowei Zhan, Bo Li
Summary: In this study, a method for identifying KIR allele variants from whole exome sequencing data was developed. The researchers discovered novel associations between these variants and various molecular and clinical correlates.
Review
Immunology
Sarah Nersesian, Emily B. Carter, Stacey N. Lee, Lauren P. Westhaver, Jeanette E. Boudreau
Summary: NK cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors, which may be key to comprehensive cancer control. Strategies to leverage their naturally occurring diversity and agility have not yet been developed. Their receptors and signaling pathways play important roles in cancer and potential as targets for immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Khadijeh Dizaji Asl, Kobra Velaei, Ali Rafat, Hamid Tayefi Nasrabadi, Ali Akbar Movassaghpour, Majid Mahdavi, Hojjatollah Nozad Charoudeh
Summary: NK cells play a crucial role in diseases through the interaction between KIR and MHC-I molecules. Researchers are focusing on understanding the molecular mechanisms of KIR-MHC-I interaction to enhance disease treatment strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Edoardo Giussani, Andrea Binatti, Giulia Calabretto, Vanessa Rebecca Gasparini, Antonella Teramo, Cristina Vicenzetto, Gregorio Barila, Monica Facco, Alessandro Coppe, Gianpietro Semenzato, Stefania Bortoluzzi, Renato Zambello
Summary: Large granular lymphocyte leukemias (LGLL) are sustained by proliferating cytotoxic T cells or NK cells, with the etiology partly related to viral agents. Different hypotheses have been proposed regarding the role of viruses, such as the presence of Epstein Barr Virus (EBV) in aggressive NK leukemias but not in indolent CLPD-NK. New data analysis failed to identify viral sequences in CLPD-NK, suggesting a complex relationship between viral agents and NK cell activation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Vlad Andrei Cianga, Lydia Campos Catafal, Petru Cianga, Mariana Pavel Tanasa, Mohamad Cherry, Phillipe Collet, Emmanuelle Tavernier, Denis Guyotat, Cristina Rusu, Carmen Mariana Aanei
Summary: The study investigated NK cell maturation in bone marrow under different conditions and found impaired NK cell antitumor response and phenotypic shift in MDS and AML settings. The results suggest immune response failure during myeloid malignancy pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Nicole F. Bernard, Khlood Alsulami, Erik Pavey, Franck P. Dupuy
Summary: NK cells play a role in protecting against HIV infection by rapidly activating and exerting antiviral activity when interacting with HIV-infected cells and non-self cells. Understanding this mechanism may inform strategies to prevent HIV infection.
Article
Virology
Alok K. Tembhurne, Amita Maheshwari, Himangi Warke, Hemangi Chaudhari, Shilpa C. Kerkar, Kedar Deodhar, Bharat Rekhi, Jayanti Mania-Pramanik
Summary: This study investigates the role of killer cell immunoglobulin-like receptors (KIRs) in cervical cancer among Indian women. The findings suggest that KIR2DS5, the C4T4 subset, and activating KIR genes are susceptible factors or positively associated with cervical cancer. Additionally, KIR2DL5B may have a protective association against cervical cancer, while KIR2DL1 and KIR2DL3 frequencies have important implications in healthy controls and HPV-infected women, respectively.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Fadwa Albalawi, Fadwa M. Alkhulaifi, Jameel Al-Tamimi, Lamjed Mansour, Yusra Tashkandy, Suliman Yousef Alomar
Summary: The study aimed to investigate the association of 16 KIR complexes and HLA-C1 and C2 ligands with the genetic predisposition and development of Acute Lymphoblastic Leukemia (AML) in Saudi Arabian patients. The results showed significant differences in KIR genotype frequency between AML patients and healthy controls. KIR2DL1, KIR2DL5, and KIR2DS2 were significantly increased in patients, while KIR 2DL3, KIR2DS4, and KIR2DL2 were elevated in healthy controls.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj
Summary: Every type of cancer tissue is more susceptible to viral infection, which has been utilized as a new anti-cancer therapy using oncolytic viruses (OVs). OVs selectively infect and destroy cancer cells while causing no harm to the host. Research focuses on the interaction between OVs and the host immune system, particularly the role of dendritic cells (DCs) and natural killer (NK) cells in the therapeutic response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Obstetrics & Gynecology
Indra Diaz-Hernandez, Diana Alecsandru, Juan Antonio Garcia-Velasco, Francisco Dominguez
Summary: uNK cells play a crucial role in embryo implantation and successful pregnancy. Their functions are closely related to interactions with extravillous trophoblast cells and spiral arteries, regulating vascular function, controlling trophoblast invasion, and promoting placental development. Certain KIR/HLA-C combinations have been associated with recurrent miscarriage, pre-eclampsia, and foetal growth restriction.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Multidisciplinary Sciences
Hanan M. Alharbi, Afrah F. Alkhuriji, Suliman Y. Alomar, Zainb A. Babay, Alaa A. Alnafjan, Hussah M. Alobaid, Wazirah G. Allharbi, Lamjed A. Mansour
Summary: The aim of this study was to investigate the genetic polymorphisms of the KIR and HLA-C genes and their association with PCO and RSA. The results showed a significant decrease in the recurrences of KIR3DL1, 2DS4ins, 2DL2, and KIR2DS2 in RSA-PCO women compared to healthy controls. The study also found a preventive effect of certain KIR-HLA-C combinations in both PCO and RSA-PCO groups. However, KIR2DL1 was identified as a risk factor for PCO and RSA in the presence of HLA-C2 ligand.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Nobuyo Yawata, Mariko Shirane, Kaing Woon, Xinru Lim, Hidenori Tanaka, Yoh-Ichi Kawano, Makoto Yawata, Soon-Phaik Chee, Jay Siak, Koh-Hei Sonoda
Summary: CMV-AU patients exhibit specific immunogenetic features, leading to NK cells co-expressing CD57/KLRG1/NKG2C in response to CMV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Francesco Colucci
Summary: I argue in this review that reproduction was a driving force in the evolution of NK cell education, which is set by interactions between inhibitory receptors and self-MHC. The maternal immune system's tolerance of the semiallogeneic fetus is a fascinating question. Tissue lymphocytes, like uterine NK cells, do not attack the mismatched fetus and its placenta, but instead help the local vasculature tolerate changes necessary to nourish the fetus.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Delphine M. Depierreux, Jens Kieckbusch, Norman Shreeve, Delia A. Hawkes, Bryan Marsh, Robert Blelloch, Andrew Sharkey, Francesco Colucci
Summary: Reproductive immunology focuses on understanding how the maternal immune system supports fetal growth. Maternal uterine natural killer (uNK) cells, in partnership with fetal trophoblast cells, regulate physiological vascular changes in the uterus to build the placenta and sustain fetal growth. The education of uNK cells by maternal MHC-I is crucial for optimal fetal growth.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)