Article
Nutrition & Dietetics
Amar van Laar, Charlotte Grootaert, Andreja Rajkovic, Tom Desmet, Koen Beerens, John Van Camp
Summary: Rare sugars have potential as sugar replacers and their impact on metabolism and insulin sensitivity was investigated. Glucose and fructose increased acidification rate and impaired glucose uptake in certain cells, while rare disaccharides had delayed digestion and minimal effect on insulin-stimulated glucose uptake. Further research is needed to confirm their beneficial impact on insulin sensitivity in humans.
Review
Endocrinology & Metabolism
Eva Guerrero-Hreins, Claire J. Foldi, Brian J. Oldfield, Aneta Stefanidis, Priya Sumithran, Robyn M. Brown
Summary: Bariatric surgery leads to long-term weight loss and improved metabolic phenotype by affecting the gut-brain axis. However, the impact of the surgery on disordered eating behaviors is not well understood, and understanding this is crucial for improving treatment outcomes for people with obesity.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Thomas M. Barber, Georgios Valsamakis, George Mastorakos, Petra Hanson, Ioannis Kyrou, Harpal S. Randeva, Martin O. Weickert
Summary: Our gut microbiota have co-evolved with us over a long period of time, playing a crucial role in our overall health and influencing various bodily processes. The microbiota-gut-brain axis is a dominant communication pathway with far-reaching implications for our well-being. Dietary composition, particularly in modern Western diets, can directly impact the abundance and diversity of gut microbiota, leading to dysbiosis and potential health issues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Sijia Fan, Weiwei Guo, Dan Xiao, Mengyuan Guan, Tiepeng Liao, Sufang Peng, Airong Feng, Ziyi Wang, Hao Yin, Min Li, Jue Chen, Wei Xiong
Summary: Alterations in intestinal microbiota contribute to excessive intake of palatable foods in individuals with overeating disorders. Stress and dieting history lead to changes in the microbiota and intestinal metabolism, resulting in hyperactivation of the gut-brain axis and the development of overeating disorder symptoms.
Article
Psychiatry
Emily E. Noble, Christine A. Olson, Elizabeth Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa Liu, Andrea Suarez, Roshonda B. Jones, Claire de la Serre, Xia Yang, Elaine Y. Hsiao, Scott E. Kanoski
Summary: Research indicates that excessive early life consumption of sugar negatively impacts memory function in rats during adulthood, affecting hippocampal-dependent memory function and altering the gut microbiome, including the abundance of specific Parabacteroides species. Enrichment of these bacterial taxa during adolescence impairs hippocampal-dependent memory in adulthood, while early life sugar consumption and Parabacteroides microbial enrichment lead to alterations in gene expression related to intracellular kinase, neurotransmitter signaling, metabolic function, neurodegenerative disease, and dopaminergic signaling pathways.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Pediatrics
Emmanuella Magriplis, George Michas, Evgenia Petridi, George P. Chrousos, Eleftheria Roma, Vassiliki Benetou, Nikos Cholopoulos, Renata Micha, Demosthenes Panagiotakos, Antonis Zampelas
Summary: The study found that excessive sugar intake increases the likelihood of youth overweight/obesity, mainly from sources like sweets and processed grains; high sugar intake also raises the probability of becoming obese.
Review
Microbiology
Livia H. Morais, Henry L. Schreiber, Sarkis K. Mazmanian
Summary: This Review discusses the intricate and potentially important connections between the gut microbiota and the brain, involving bidirectional communication along the gut-brain axis. Emerging evidence suggests that disruptions in microbial communities may be implicated in neurological disorders, with animal models providing valuable insights into the pathways linking the gut and the brain which could have tangible impacts on human health.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Food Science & Technology
Chuan-Qi Chu, Lei-lei Yu, Wei Chen, Feng-Wei Tian, Qi-Xiao Zhai
Summary: This study discusses the impact of various dietary patterns on Parkinson's disease, highlighting the benefits of the Mediterranean diet in reducing PD risk, calorie restriction and fasting-mimicking diets in neuroprotection, and ketogenic and protein-restricted diets in improving motor impairment.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mengsheng Tang, Xiaoran Song, Weiwei Zhong, Yan Xie, Yanan Liu, Xin Zhang
Summary: Circadian rhythms are crucial in regulating sleep patterns, and increasing dietary fiber intake can help ameliorate sleep disorders. Gut flora communicates with sleep through the gut-brain axis, playing a significant role in modulating sleep disorders.
Article
Nutrition & Dietetics
Anat Yaskolka Meir, Kieran Tuohy, Martin von Bergen, Rosa Krajmalnik-Brown, Uwe Heinig, Hila Zelicha, Gal Tsaban, Ehud Rinott, Alon Kaplan, Asaph Aharoni, Lydia Zeibich, Debbie Chang, Blake Dirks, Camilla Diotallevi, Panagiotis Arapitsas, Urska Vrhovsek, Uta Ceglarek, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Beatrice Engelmann, Miri Lapidot, Monica Colt, Qi Sun, Iris Shai
Summary: The study found that Wolffia globosa 'Mankai' is rich in various unique potent polyphenols that may impact the metabolomic-gut-clinical axis. Human trials showed that Mankai-related polyphenols were significantly elevated in the green Mediterranean diet group compared to other groups, with specific polyphenols directly linked to clinical weight-related changes.
Review
Food Science & Technology
Xiaoran Song, Laiyou Wang, Yanan Liu, Xin Zhang, Peifang Weng, Lianliang Liu, Ruilin Zhang, Zufang Wu
Summary: This article explores the harm and impact of obesity, discusses the complex relationship between the gut microbiome and metabolism, and proposes a method to combat obesity through the microbiota-gut-brain axis. It also summarizes the potential of major metabolites in dietary metabolism to fight against obesity. Additionally, the article reviews the ample evidence regarding the microbiota-gut-brain axis as a regulator of obesity.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Food Science & Technology
Zhongxing Chu, Zuomin Hu, Yi Luo, Yaping Zhou, Feiyan Yang, Feijun Luo
Summary: An imbalance in energy consumption and expenditure leads to obesity, which is characterized by adipose accumulation and chronic inflammation. The gut microbiota has been shown to mediate the relationship between high-fat diet consumption and obesity development. Changes in the gut microbiota can affect the host's energy levels, inflammation, lipid metabolism, and insulin sensitivity. The gut-liver axis, a bidirectional relationship between the gut and its microbiota and the liver, plays an important role in fat metabolism. Lignans, as essential plant components, have potential lipid-lowering properties and can regulate the gut microbiota and its metabolites, impacting signaling pathways related to fat synthesis and metabolism.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Gordon William Moran, Gita Thapaliya
Summary: Malnutrition is a significant issue in the management of inflammatory bowel disease (IBD), with a complex interplay between gut peptides, psychological, cognitive factors, disease symptoms, and inflammatory burden ultimately influencing eating behavior in patients with IBD. Patients with Crohn's disease may exhibit hedonic desires and emotional eating patterns to alleviate negative emotions, while impulsivity traits in IBD patients could lead them to prioritize immediate food rewards over long-term health concerns. Furthermore, alterations in gut-brain signaling due to upregulation of enteroendocrine cells’ peptide response to food intake in ileal inflammation may also play a role in appetite and eating behavior.
Review
Peripheral Vascular Disease
David L. Mattson, John Henry Dasinger, Justine M. Abais-Battad
Summary: Salt-sensitive hypertension in patients with high blood pressure is associated with higher morbidity, mortality, and renal damage compared to those with normal blood pressure or salt-resistant hypertension. Dietary components other than salt play a role in modulating hypertension, and immunity and inflammation are key factors that amplify the development of salt-sensitive hypertension.
Article
Chemistry, Applied
Stefano Renzetti, Irene A. F. van den Hoek, Ruud G. M. van der Sman
Summary: This study investigated the effects of sugars and sugar replacers on the gelatinization and pasting behavior of wheat starch. The intrinsic properties of plasticizers, such as molar volume density of effective hydroxyl groups and volumetric density of hydrogen bonds in sugar solutions, were proposed as factors controlling swelling and gelatinization behavior. Multiple transitions in starch gelatinization were related to different ranges of a solvation parameter, and deviations from model predictions were observed under certain conditions. Pasting behavior was found to be related to the molecular size and viscosity of plasticizers, as well as their hydrogen bonding ability.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
David Val-Laillet, Sylvie Guerin, Nicolas Coquery, Isabelle Nogret, Michele Formal, Veronique Rome, Laurence Le Normand, Paul Meurice, Gwenaelle Randuineau, Paul Guilloteau, Charles-Henri Malbert, Patricia Parnet, Jean-Paul Lalles, Jean-Pierre Segain
Article
Medicine, Research & Experimental
Charles-Henri Malbert, Mickael Genissel, Jean-Louis Divoux, Christine Henry
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Review
Agriculture, Dairy & Animal Science
D. Val-Laillet
Article
Radiology, Nuclear Medicine & Medical Imaging
Charles-Henri Malbert, Michael Horowitz, Richard L. Young
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Nutrition & Dietetics
Ryan Jalleh, Hung Pham, Chinmay S. Marathe, Tongzhi Wu, Madeline D. Buttfield, Seva Hatzinikolas, Charles H. Malbert, Rachael S. Rigda, Kylie Lange, Laurence G. Trahair, Christine Feinle-Bisset, Christopher K. Rayner, Michael Horowitz, Karen L. Jones
Article
Endocrinology & Metabolism
Charles-Henri Malbert, Alain Chauvin, Michael Horowitz, Karen L. Jones
Summary: In insulin-resistant animals, reduced GLP-1 receptor density leads to impaired inhibitory signaling in the portal sensor, resulting in a desensitization of vagal sensitivity to portal glucose.
Article
Neurosciences
Charles-Henri Malbert, David Val-Laillet, Paul Meurice, Jean-Paul Lalles, Jacques Delarue
Summary: The study evaluated the central effects of replacing saturated fatty acids with different types of PUFA in obesogenic diets. The results showed significant differences in BBB permeability and heart rate variability between the fish oil and lard groups, indicating detrimental effects of saturated fatty acid changes on heart rate variability.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Charles-Henri Malbert
Summary: An open-source solution using 3D-printable mechanical pieces and software tools was successfully applied for frameless stereotaxic targeting in pigs of varying weights. Localization was achieved using an IR camera and CT imaging, with positive targeting confirmed in the first trial for all subjects by radiopaque CT enhancement or actual recording of the STN electrophysiological signature.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Review
Integrative & Complementary Medicine
Xuwen Zhang, David Val-Laillet
Summary: Obesity and related diseases are a global threat to health, prompting increased interest in acupuncture, electroacupuncture, and related therapies due to their relatively low side effects. This study reviews various animal models used in obesity research over the past decade, assessing their advantages, disadvantages, and suitability for acupuncture and related therapies studies.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ambre Godet, Alexandra Fortier, Elise Bannier, Nicolas Coquery, David Val-Laillet
Summary: Emotional eating refers to the tendency to (over)eat in response to emotions. It involves the consumption of high-calorie palatable foods and can lead to eating disorders, metabolic disorders, and obesity. Although abnormal emotion processing is associated with emotional eating, the neural pathways involved are still not well-known.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Nutrition & Dietetics
Laurence Lacaze, Sarah Rochdi, Annaelle Couvert, Steve Touboulic, Sylvie Guerin, Gwenaelle Randuineau, David Martin, Veronique Rome, Charles-Henri Malbert, Frederic Derbre, David Val-Laillet, Ronan Thibault
Summary: This study successfully replicated the pathophysiology of marasmus malnutrition in Yucatan minipigs through a low-calorie/low-protein diet. It comprehensively examined body composition, gut microbiota, blood parameters, and muscle tissue. The findings indicate that this experimental model is valid for mimicking severe malnutrition and muscle atrophy associated with malnutrition in humans.
CLINICAL NUTRITION
(2022)
Article
Integrative & Complementary Medicine
Xuwen Zhang, Sylvie Guerin, Youenn Launay, Yann Serrand, Nicolas Coquery, David Val-Laillet
Summary: This study aimed to compare the gut-brain axis responses to acute electroacupuncture (EA) at different acupoint combinations in the minipig model. The results showed that acute EA can significantly modulate several physiological and metabolic parameters and induce different brain activity responses. The head-abdomen combination appears to be the most promising combination, with potential regulation on ghrelin levels and appetite.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ambre Godet, Yann Serrand, Alexandra Fortier, Brieuc Leger, Elise Bannier, David Val-Laillet, Nicolas Coquery
Summary: Neurofeedback training has the potential to prevent and treat brain and behavioral impairments, with the dorsolateral prefrontal cortex being an important region of interest. However, the use of functional near-infrared spectroscopy in neurofeedback training is sensitive to extracerebral vascularization, which can affect the accuracy of cortical activity measurements.
Article
Neurosciences
David Val-Laillet, Ameni Kanzari, Sylvie Guerin, Gwenaelle Randuineau, Nicolas Coquery
NEUROSCIENCE LETTERS
(2020)
Article
Endocrinology & Metabolism
Charles-Henri Malbert, Alain Chauvin, Michael Horowitz, Karen L. Jones
BMJ OPEN DIABETES RESEARCH & CARE
(2020)