Article
Clinical Neurology
Antonio Sanchez-Rodriguez, Isabel Martinez-Rodriguez, Pascual Sanchez-Juan, Maria Sierra, Isabel Gonzalez-Aramburu, Maria Rivera-Sanchez, Javier Andres-Pacheco, Angela Gutierrez-Gonzalez, Adrian Garcia-Hernandez, Jorge Madera, Manuel Delgado-Alvarado, Jon Infante
Summary: Following an 8-year follow-up, it was found that 16% of carriers of the LRRK2-G2019S mutation had converted to Parkinson's disease. PD converters had lower striatal DaT binding at baseline compared to non-converters. While DaT-SPECT imaging shows potential for monitoring the premotor stage of the disease, its ability to predict phenoconversion is limited at the individual level.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Jonathan R. Isaacson, Salima Brillman, Nisha Chhabria, Stuart H. Isaacson
Summary: DaTscan imaging proves to be valuable in determining the presence of NSDD in various clinical scenarios. It significantly impacts both altering or confirming clinical diagnosis and guiding treatment adjustments.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Chi-Jung Tsai, Chuang-Hsin Chiu, Yu-Yeh Kuo, Wen-Sheng Huang, Tsung-Hsun Yu, Leo Garcia Flores, Skye Hsin-Hsien Yeh, Kuo-Hsing Ma
Summary: Numerous studies have confirmed that MDMA produces long-lasting changes to the density of the serotonin reuptake transporter (SERT). Amitriptyline has been shown to increase SERT binding and serotonergic fiber density, indicating its potential neuroprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Jeremy McGale, Sakshi Khurana, Alice Huang, Tina Roa, Randy Yeh, Dorsa Shirini, Parth Doshi, Abanoub Nakhla, Maria Bebawy, David Khalil, Andrew Lotfalla, Hayley Higgins, Amit Gulati, Antoine Girard, Francois-Clement Bidard, Laurence Champion, Phuong Duong, Laurent Dercle, Romain-David Seban
Summary: HER2-positive breast cancer, characterized by amplification of the HER2 gene, is associated with aggressive tumor growth, increased metastatic risk, and poorer prognosis compared to other subtypes. HER2 expression is a crucial tumor feature for breast cancer diagnosis and treatment. Advancements in HER2 in vivo imaging techniques like PET and SPECT may enhance the role of HER2 status in guiding breast cancer management, enabling determination of tumor size, location, and evaluation of treatment effectiveness. This review explores the current and future role of HER2 imaging in personalized care for breast cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Olga Krasnovskaya, Aina Kononova, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Elena Beloglazkina
Summary: There are over 55 million people with dementia worldwide and nearly 10 million new cases every year. Alzheimer's disease is the most common neurodegenerative disease that causes personality changes, cognitive impairment, memory loss, and physical disability. Early detection methods are important for early treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Sophie J. Mueller, Vanessa Teckentrup, Ignacio Rebollo, Manfred Hallschmid, Nils B. Kroemer
Summary: This study investigated the acute increase of stomach-brain coupling by non-invasively stimulating vagal afferent projections to the brain. The results showed that the coupling between the stomach and brain was increased through the NTS-midbrain pathway, indicating the effective modulation of communication between the brain and the body by vago-vagal signaling. These findings may contribute to a better understanding of the role of vagal afferents in orchestrating the recruitment of the gastric network and could lead to the development of novel neuro-modulatory treatments.
Article
Clinical Neurology
Maria Salsone, Gennarina Arabia, Grazia Annesi, Monica Gagliardi, Rita Nistico, Fabiana Novellino, Luigi Ferini-Strambi, Andrea Quattrone, Aldo Quattrone
Summary: Structural abnormalities in the thalami and basal ganglia, specifically marked iron accumulation, were found in hereditary aceruloplasminemia carriers. Interesting, the globus pallidus was not affected by iron accumulation over time. Functional imaging showed reduced putaminal DAT uptake and damage to the nigrostriatal presynaptic dopaminergic system, while the cardiac sympathetic system remained preserved in this rare inherited disorder.
NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Takuya Toyonaga, Arman Fesharaki-Zadeh, Stephen M. Strittmatter, Richard E. Carson, Zhengxin Cai
Summary: The development of novel PET imaging agents for SV2A allowed for the in vivo detection of synaptic density changes, and preclinical SV2A PET imaging in animal models provides supporting information. This article discusses key considerations when designing preclinical SV2A PET imaging studies and strategies for data analysis, as well as the challenges and opportunities in small animal SV2A PET imaging.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
George Crisan, Nastasia Sanda Moldovean-Cioroianu, Diana-Gabriela Timaru, Gabriel Andries, Calin Cainap, Vasile Chis
Summary: Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are imaging techniques that use radioactive tracers. PET is mainly used for measuring metabolic processes, blood flow, and chemical composition, while SPECT is used for diagnosing conditions such as strokes, bone diseases, and infections. This article provides a systematic review of the scientific literature on PET/SPECT radiotracers and gives an overview of the research conducted in the past decade, with a focus on novel radiopharmaceuticals for medical imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Atsushi Yagishita, Shin'ichiro Takeda, Kazunobu Ohnuki, Miho Katsuragawa, Oltea Sampetrean, Hirofumi Fujii, Tadayuki Takahashi
Summary: In this study, we developed a high-spatial-resolution and high-energy-resolution small animal SPECT scanner called CdTe-DSD SPECT-I. Using this scanner, we achieved successful multi-tracer SPECT imaging of submillimetre targets and dual-tracer in vivo imaging of submillimetre metastatic lesions, producing clear and quantitative images.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Clemens Neudorfer, Daniel Kroneberg, Bassam Al-Fatly, Lukas Goede, Dorothee Kuebler, Katharina Faust, Ursula van Rienen, Anna Tietze, Thomas Picht, Todd M. Herrington, Erik H. Middlebrooks, Andrea Kuhn, Gerd-Helge Schneider, Andreas Horn
Summary: Using FGATIR sequences, this study identified a thalamic hypointensity as a potential visual marker for deep brain stimulation (DBS). By analyzing 65 patients with essential tremor, the clinical utility of the hypointensity marker was validated, and it was found to predict the clinical outcome of DBS treatment.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
J. Lanzone, M. Boscarino, T. Tufo, G. Di Lorenzo, L. Ricci, G. Colicchio, V. Di Lazzaro, M. Tombini, G. Assenza
Summary: This study used qEEG analysis to investigate the impact of VNS cycles on brain network activity in patients with epilepsy. The study found no differences in spectral activity, but consistent changes in network organization, most notably in the slow EEG bands.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Ryota Kobayashi, Shinobu Kawakatsu, Makoto Ohba, Daichi Morioka, Masafumi Kanoto, Koichi Otani
Summary: Abnormal findings on dopamine transporter single photon emission computed tomography were observed in patients with FTLD-MND, which may manifest even before the onset of MND symptoms.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Nuclear Science & Technology
Hankyeol Song, In Soo Kang, Kyu Bom Kim, Chanwoo Park, Min Kyu Baek, Seongyeon Lee, Yong Hyun Chung
Summary: A novel rectangular-shaped PET system with an adjustable gantry (AGPET) has been developed, utilizing a new depth of interaction (DOI) method and digital time pickoff method. Experimental results demonstrate that the AGPET system provides higher sensitivity and resolution for small animal imaging.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carsten S. Kramer, Antonia Dimitrakopoulou-Strauss
Summary: Immunotherapy has revolutionized the treatment of certain cancer types, but conventional methods for assessing treatment response pose challenges. This study analyzed published tracers and found that most target PD-L1, PD-1, CTLA-4, and CD8 receptors using antibodies or their fragments. It also identified a lack of innovation in tracer development.
Article
Biochemistry & Molecular Biology
David Val-Laillet, Sylvie Guerin, Nicolas Coquery, Isabelle Nogret, Michele Formal, Veronique Rome, Laurence Le Normand, Paul Meurice, Gwenaelle Randuineau, Paul Guilloteau, Charles-Henri Malbert, Patricia Parnet, Jean-Paul Lalles, Jean-Pierre Segain
Article
Biochemistry & Molecular Biology
Yentl Gautier, Isabelle Luneau, Nicolas Coquery, Paul Meurice, Charles-Henri Malbert, Sylvie Guerin, Bas Kemp, J. Elizabeth Bolhuis, Caroline Clouard, Isabelle Le Huerou-Luron, Sophie Blat, David Val-Laillet
Article
Endocrinology & Metabolism
Nam Q. Nguyen, Tamara L. Debreceni, Jenna E. Burgess, Max Bellon, Judith Wishart, Scott Standfield, Charles-Henri Malbert, Michael Horowitz
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Article
Endocrinology & Metabolism
Senda Bahri, Michael Horowitz, Charles-Henri Malbert
Article
Nutrition & Dietetics
Olivia Menard, Marie-Helene Famelart, Amelie Deglaire, Yann Le Gouar, Sylvie Guerin, Charles-Henri Malbert, Didier Dupont
Article
Radiology, Nuclear Medicine & Medical Imaging
Charles-Henri Malbert, Michael Horowitz, Richard L. Young
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Nutrition & Dietetics
Ryan Jalleh, Hung Pham, Chinmay S. Marathe, Tongzhi Wu, Madeline D. Buttfield, Seva Hatzinikolas, Charles H. Malbert, Rachael S. Rigda, Kylie Lange, Laurence G. Trahair, Christine Feinle-Bisset, Christopher K. Rayner, Michael Horowitz, Karen L. Jones
Article
Endocrinology & Metabolism
Charles-Henri Malbert, Alain Chauvin, Michael Horowitz, Karen L. Jones
Summary: In insulin-resistant animals, reduced GLP-1 receptor density leads to impaired inhibitory signaling in the portal sensor, resulting in a desensitization of vagal sensitivity to portal glucose.
Article
Neurosciences
Charles-Henri Malbert, David Val-Laillet, Paul Meurice, Jean-Paul Lalles, Jacques Delarue
Summary: The study evaluated the central effects of replacing saturated fatty acids with different types of PUFA in obesogenic diets. The results showed significant differences in BBB permeability and heart rate variability between the fish oil and lard groups, indicating detrimental effects of saturated fatty acid changes on heart rate variability.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Charles-Henri Malbert
Summary: An open-source solution using 3D-printable mechanical pieces and software tools was successfully applied for frameless stereotaxic targeting in pigs of varying weights. Localization was achieved using an IR camera and CT imaging, with positive targeting confirmed in the first trial for all subjects by radiopaque CT enhancement or actual recording of the STN electrophysiological signature.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Nutrition & Dietetics
Laurence Lacaze, Sarah Rochdi, Annaelle Couvert, Steve Touboulic, Sylvie Guerin, Gwenaelle Randuineau, David Martin, Veronique Rome, Charles-Henri Malbert, Frederic Derbre, David Val-Laillet, Ronan Thibault
Summary: This study successfully replicated the pathophysiology of marasmus malnutrition in Yucatan minipigs through a low-calorie/low-protein diet. It comprehensively examined body composition, gut microbiota, blood parameters, and muscle tissue. The findings indicate that this experimental model is valid for mimicking severe malnutrition and muscle atrophy associated with malnutrition in humans.
CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Charles-Henri Malbert, Alain Chauvin, Michael Horowitz, Karen L. Jones
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Clinical Neurology
Charles-Henri Malbert, Eric Bobillier, Chloe Picq, Jean-Louis Divoux, David Guiraud, Christine Henry
Article
Endocrinology & Metabolism
Charles-Henri Malbert, Chloe Picq, Jean-Louis Divoux, Christine Henry, Michael Horowitz