Article
Biochemistry & Molecular Biology
Hafiza Amna Younus, Muhammad Saeed, Abid Mahmood, Muhammad Siraj Khan Jadoon, Abdul Hameed, Asnuzilawati Asari, Habsah Mohamad, Julie Pelletier, Jean Sevigny, Jamshed Iqbal, Mariya al-Rashida
Summary: This study describes the synthesis of highly selective inhibitors for human intestinal alkaline phosphatase (h-IAP) and human tissue non-specific alkaline phosphatase (h-TNAP), and evaluates their inhibitory activities against other nucleotidases. These inhibitors hold therapeutic potential and contribute to our understanding of the selective activation and/or inhibition of nucleotidase enzymes in different cells and tissues.
BIOORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Rabab S. Jassas, Nafeesa Naeem, Amina Sadiq, Rabia Mehmood, Noof A. Alenazi, Munirah M. Al-Rooqi, Ehsan Ullah Mughal, Reem I. Alsantali, Saleh A. Ahmed
Summary: Heterocycles are a class of compounds that effectively inhibit alkaline phosphatase (AP), an enzyme crucial for various physiological processes and linked to diseases like cancer and osteoporosis. Inhibition of AP by binding to its active site has been observed, with imidazoles, pyrazoles, and pyridines showing promise as potential therapeutics. Further research is needed for the development of more potent and selective AP inhibitors and understanding their mechanisms.
Review
Pharmacology & Pharmacy
Herbert Zimmermann
Summary: Ectonucleotidases play a crucial role in purinergic signaling by controlling the duration of purinergic receptor agonist activity and producing hydrolysis products as additional ligands. Research has identified numerous ectoenzymes with broad substrate specificity, which can also hydrolyze nucleotides.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Gustavo Machado das Neves, Luciano Porto Kagami, Ana Maria Oliveira Battastini, Fabricio Figueiro, Vera Lucia Eifler-Lima
Summary: Purinergic signaling is being explored as a potential therapeutic approach for cancer treatment. ATP acts as a chemotactic agent and has in vitro antineoplastic activity, while adenosine functions as an immunosuppressor and is associated with neoangiogenesis, vasculogenesis, and evasion from the immune system. Inhibitors of ecto-5'-NT can prevent tumor progression, lower adenosine concentrations, and impede cancer growth by preventing immune system evasion.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Asmaa M. Sayed, Fatma A. Taher, Mohammad R. K. Abdel-Samad, Mohamed S. A. El-Gaby, Khaled El-Adl, Nashwa M. Saleh
Summary: A novel series of sulfonamide derivatives containing hydrazone were synthesized and evaluated for their anticancer activities. Some compounds showed high sensitivity in HepG2 cells and good inhibitory activity against VEGFR-2.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Arunapriya Lakkadi, Srimai Vuppala, Venkatesh Nampally, Jaeyoung Kim, Kiduk Kim, Joonkyung Jang, Parthasarathy Tigulla
Summary: This article investigates the antioxidant and anti-inflammatory activities of 15 novel chromone derivatives. The antioxidant activity of these compounds was evaluated using a spectrophotometric method and the mechanism of action was discussed using Density functional theory calculations. Molecular docking and dynamics simulations were performed to study the compounds' interaction with the COX2 enzyme. The results show that compounds B3 and B8 exhibit both strong antioxidant activity and COX2 inhibition.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Narges Hosseini Nasab, Hussain Raza, Rok Su Shim, Mubashir Hassan, Andrzej Kloczkowski, Song Ja Kim
Summary: A series of pyrazolo-oxothiazolidine derivatives were synthesized and evaluated for their inhibitory activity against alkaline phosphatase. The most potent compound, 7g, demonstrated strong inhibition and non-competitive binding with the enzyme. These compounds also exhibited antioxidant activity and showed no toxicity to human osteosarcoma cells at a certain concentration. Computational research confirmed their good binding affinity with alkaline phosphatase, suggesting their potential as selective inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Naeem Mustafa, Pervaiz Ali Channar, Muhammad Sarfraz, Aamer Saeed, Syeda Abida Ejaz, Mubashir Aziz, Fatmah Ali Alasmary, Hanadi Yaqob Alsoqair, Hussain Raza, Song Ja Kim, Asad Hamad
Summary: Deposition of hydroxyapatite or alkaline phosphate crystals on soft tissues leads to pathological calcification diseases, and alkaline phosphatase inhibitors have potential role in eradicating these diseases. A series of novel quinolinyl iminothiazolines was synthesized and evaluated for alkaline phosphatase inhibition potential. Compound N-benzamide quinolinyl iminothiazoline (6g) exhibited the maximum inhibitory effect and can be suggested for further testing.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Hajer Ben Hlima, Ameny Farhat, Sarra Akermi, Bassem Khemakhem, Youssef Ben Halima, Philippe Michaud, Imen Fendri, Slim Abdelkafi
Summary: This study used a combination of structure modelling, in silico docking, and pharmacokinetics prediction to identify algae compounds with potential to inhibit the SARS-CoV-2 main protease. The results showed high affinity of several algal molecules to interact with the protein active site and suggested their prospects as potential drug candidates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Enja Schneider, Riekje Winzer, Anne Rissiek, Isabell Ricklefs, Catherine Meyer-Schwesinger, Franz L. Ricklefs, Andreas Bauche, Jochen Behrends, Rudolph Reimer, Santra Brenna, Hauke Wasielewski, Melchior Lauten, Bjorn Rissiek, Berta Puig, Filippo Cortesi, Tim Magnus, Ralf Fliegert, Christa E. Mueller, Nicola Gagliani, Eva Tolosa
Summary: Immune cells at sites of inflammation are continuously activated by local antigens and cytokines, and regulatory mechanisms must be enacted to control inflammation. Human effector CD8 T cells contribute to adenosine production by releasing CD73-containing extracellular vesicles, which suppress immune responses independently of regulatory T cells. The study suggests that these extracellular vesicles derived from CD8 T cells serve as intrinsic regulators of immune responses in inflamed tissues.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Hao Zhang, Guo-Ying Chen, Zheng-Ming Qian, Wen-Jia Li, Chun-Hong Li, Yuan-Jia Hu, Feng-Qing Yang
Summary: A method for enzyme activity detection and inhibitory activity evaluation based on ALP-mediated reaction in a personal glucose meter (PGM) was developed. The method allows direct quantification of compounds' effects on ALP using PGM, showing different inhibitory or promotion effects. The study validates the accuracy and reliability of PGM in enzyme activity assessment.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Marialuigia Fantacuzzi, Marialucia Gallorini, Nicola Gambacorta, Alessandra Ammazzalorso, Zeineb Aturki, Marwa Balaha, Simone Carradori, Letizia Giampietro, Cristina Maccallini, Amelia Cataldi, Orazio Nicolotti, Rosa Amoroso, Barbara De Filippis
Summary: Sulfonate derivatives of Resveratrol showed greater activity than sulfonamide bioisosteres in aromatase inhibition, with good antiproliferative activity on the MCF7 cell line. Electronic and lipophilic properties may play different roles in promoting biological responses for sulfonates and sulfonamides.
Article
Biochemistry & Molecular Biology
Marialuigia Fantacuzzi, Ilaria D'Agostino, Simone Carradori, Francesco Liguori, Fabrizio Carta, Mariangela Agamennone, Andrea Angeli, Filomena Sannio, Jean-Denis Docquier, Clemente Capasso, Claudiu T. Supuran
Summary: Vibrio cholerae, a pathogen responsible for life-threatening infections in low-income countries, has developed resistance to antibacterial drugs. Researchers have identified carbonic anhydrases (CAs) encoded by V. cholerae as potential pharmacological targets. They have developed a large library of CAs inhibitors with different flexibility degrees and found compounds with strong inhibition against Vch alpha CA. Computational studies have provided insights into the inhibitory activity and isoform selectivity of these compounds.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Milorad Dragic, Andjela Stekic, Milica Zeljkovic, Marina Zaric Kontic, Katarina Mihajlovic, Marija Adzic, Ivana Grkovic, Nadezda Nedeljkovic
Summary: This study demonstrates changes in the distribution and expression of adenosine-metabolizing enzymes and adenosine receptor subtype A(2A) in the hippocampus and cortex of male rats from early to late adulthood. These changes suggest that adaptive alterations in adenosine signaling in neuronal elements early in life may be responsible for later glial enhancement and neurodegeneration.
NEUROCHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Siraj Khan Jadoon, Julie Pelletier, Jean Sevigny, Jamshed Iqbal
Summary: This article investigates the potential of substituted indole acetic acid sulfonate derivatives as ectonucleotidase inhibitors, showing that these compounds can inhibit tumor development and immune evasion, and have selectivity and potency.
Article
Parasitology
Walmir da Silva, Isadora Cunha Ribeiro, Joice de Melo Agripino, Victor Hugo Ferraz da Silva, Luciana Angelo de Souza, Tatiana Aparecida Oliveira, Gustavo Costa Bressan, Raphael de Souza Vasconcellos, Carole Dumas, Julie Pelletier, Jean Sevigny, Barbara Papadopoulou, Juliana Lopes Rangel Fietto
Summary: Leishmania infantum can modulate the host immune response to its own favor. By overexpressing or abolishing the expression of LiNTPDase1 and LiNTPDase2, we found that they play important roles in parasite growth in culture and macrophage infection.
Article
Cell Biology
Liliana I. Sous Naasani, Jean Sevigny, Veronique J. Moulin, Marcia Rosangela Wink
Summary: In this study, the impact of purinergic receptor agonists on wound healing was investigated using self-assembled skin substitutes (SASS). The results showed that treatment with UTP accelerated wound healing, increased proliferation of keratinocytes and fibroblasts, and did not affect skin quality. Furthermore, the presence of ectoenzymes NTPDase1 and NPP1 in the wounded skin suggests their involvement in the wound healing process. Although these results are preliminary, they highlight the importance of understanding the role of extracellular nucleotides in skin healing and the need for further experiments to determine the underlying mechanisms.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Chemistry, Physical
B. Aysha Rifana, Johanan Christian Prasana, Naiyf S. Alharbi, Ghulam Abbas, S. Muthu
Summary: Ethyl Gallate is a phytochemical molecule found in maprange mango seeds that has significant biological effects, including anti-autoimmune behavior. The study provides insights into the molecular structure and biological activity of Ethyl Gallate, and explores its potential association with the discovery of rheumatoid arthritis medication.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
G. Vijayakumari, N. Iyandurai, A. Thamarai, Jamal M. Khaled, Ghulam Abbas, S. Muthu
Summary: This study used spectral data analysis and density functional theory simulation to explore the impact of the compound on biology and medicine, and found that clemastine is the most effective anti-allergic drug for use in contemporary therapeutic targets.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Dona Benny, Johanan Christian Prasana, Jamal M. Khaled, Ghulam Abbas, S. Muthu
Summary: This research involves experimental, computational, and biological evaluations of a tetrazole derivative. The compound shows potential as an anticonvulsant without causing toxicity.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Immunology
Vittoria Lopez, H. J. Maximilian Schuh, Salahuddin Mirza, Victoria J. Vaassen, Michael S. Schmidt, Katharina Sylvester, Riham M. Idris, Christian Renn, Laura Schaekel, Julie Pelletier, Jean Sevigny, Annamaria Naggi, Bjoern Scheffler, Sang-Yong Lee, Gerd Bendas, Christa E. Mueller
Summary: The study discovered that heparin and its derivatives are potent and selective allosteric inhibitors of the poorly investigated ectonucleotidase NPP1. The inhibition of NPP1 by heparins may contribute to their anti-cancer effects and could lead to improved therapeutics for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zahid Hussain Zaigham, Saif Ullah, Julie Pelletier, Jean Sevigny, Jamshed Iqbal, Abbas Hassan
Summary: The aim of this research is to synthesize sulfamoyl-benzamides as selective inhibitors of h-NTPDases. Various sulfonamides and carboxamides with biologically relevant substituents were synthesized and screened for their inhibitory activity against h-NTPDases isoforms. The most potent inhibitors were identified for each isoform, and molecular docking studies showed significant interactions with the target proteins.
Article
Chemistry, Multidisciplinary
Munazza Mohsin, Shumail Farhan, Naveed Ahmad, Asif Hassan Raza, Zohra Nazir Kayani, Syed Hassan Mujtaba Jafri, Rizwan Raza
Summary: Solid oxide fuel cells (SOFCs) offer efficient direct electrochemical conversion of hydrocarbon-based fuels like natural gas into electricity. However, utilizing natural gas with Ni-based anodes poses a challenge due to carbon deposition. This study prepared NixCe1-xO2-delta using a sol-gel technique and found that Ni(0.6)Ce(0.4)O(2-delta)d exhibited the highest electronic conductivity and catalytic activity for SOFCs. Furthermore, it achieved a maximum power density comparable to other electrodes. This research demonstrates the potential of Ni-doped ceria as an anode material in SOFCs due to its efficient catalytic properties and resistance against coke formation.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Henri Joel Mbah Ngantchou, Rizwan Raza, Edwin Akongnwi Nforna, John Lambi Ngolui, Tauqir A. Sherazi
Summary: Transition metal doped apatite La10Si6-xCoxO27-delta and La10Si5.2Co0.4Ni0.4O27-delta were synthesized by co-precipitation method followed by sintering. The conductivity of the samples increased with the content of Co2+ doping and was further increased by co-doping of Ni2+. The co-doped sample (La10Si5.2Co0.4Ni0.4O27-delta) exhibited the highest conductivity and achieved the maximum power density, making it a potential electrolyte candidate for solid oxide fuel cell application.
Meeting Abstract
Endocrinology & Metabolism
Ilian Radichev, Jean Sevigny, Julie Pelletier, Clayton Mathews, Kurt Griffin, Alexei Savinov
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Liliana Ivet Sous Naasani, Jessica Gonsalves Azevedoa, Jean Sevigny, Tiago Franco de Oliveira, Silvya Stuchi Maria-Engler, Marcia Rosangela Wink
Summary: This study reveals the expression and function of ectonucleotidases in human epidermal melanocytes, suggesting their involvement in regulating nucleotide levels in the skin microenvironment.
BIOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Chemistry, Physical
A. Herlin Shamina, V. Bena Jothy, Mohd Asif, Malik Nasibullah, Naiyf S. Alharbi, Ghulam Abbas, S. Muthu
Summary: This article reports the one-pot synthesis of (E)-5-bromo-3-(phenylimino)indolin-2-one compound, and validates it using density functional theory. It also evaluates the compound's anticancer activity and demonstrates its antimicrobial properties through molecular docking. The article further analyzes the stability and properties of the compound in different solvents using experimental and theoretical data.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
P. Manikandan, M. Kumar, S. Chithra, A. Jeelani, Jamal M. Khaled, Ghulam Abbas, S. Muthu
Summary: This study analyzes the optimal structure and vibrational assignments of a new compound using the DFT method. Experimental and theoretical methods were employed to validate the results. The compound shows promising pharmacological properties and can be further investigated as a potential drug molecule.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Siraj Khan Jadoon, Julie Pelletier, Jean Sevigny, Jamshed Iqbal
Summary: This article investigates the potential of substituted indole acetic acid sulfonate derivatives as ectonucleotidase inhibitors, showing that these compounds can inhibit tumor development and immune evasion, and have selectivity and potency.
Article
Chemistry, Physical
K. Parveen Begaum, T. Prabhu, S. Kaleeswaran, Shine Kadaikunnan, Ghulam Abbas, S. Muthu, Irem Kestek, Aysen Alaman Agar, Emine Berrin Poyraz, Necmi Dege
Summary: In this study, a Schiff base compound was successfully synthesized and characterized, and its properties were comprehensively investigated using computational methods. The results of vibrational analysis and theoretical calculations were in good agreement with experimental data. Furthermore, the compound showed potential pharmaceutical properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
