☆ 4.7 Article

Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cr (III), Mn (III) and Fe (III) macrocyclic complexes

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)

期刊

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

卷 52, 期 -, 页码 269-274

出版社

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

DOI: 10.1016/j.ejmech.2012.03.025

关键词

Schiff base; Macrocyclic; Complexes; Antimicrobial activity; Spectroscopic study

类别

Chemistry, Medicinal

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摘要

A Schiff base ligand was synthesized by reacting 1,4-dicarbonyl-phenyl-dihydrazide and chromene-2,3-dione (2:2) and a series of metal complexes with this new ligand were synthesized by reaction with Cr (III), Mn (III), and Fe (III) metal salt in methanolic medium. The Schiff base ligand and its metal complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structure configuration has been determined by various spectroscopic (electronic. IR. H-1 NMR, C-13 NMR, GCMS) techniques. Electronic spectra of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential. Crown Copyright (C) 2012 Published by Elsevier Masson SAS. All rights reserved.

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