Article
Chemistry, Inorganic & Nuclear
Jin Wang, Yu-Ting Wang, Jiang-Nan Chang, Ming-Xue Li
Summary: The article describes the synthesis and characterization of two nickel complexes of 2-acetylpyrazine thiosemicarbazone, and studies their antibacterial activities. It was found that one of the complexes showed effective antimicrobial activity against tested bacteria, and that complex 2 exhibited inhibitory activity against human hepatocellular carcinoma HepG2 cells. Additionally, toxicity study showed that complex 2 had the highest tumor cell selectivity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Jin Wang, Zhi-Meng Zhang, Ming-Xue Li
Summary: The synthesis of four metal complexes and their antimicrobial and cytotoxic activities were investigated in this study. The results showed that the antibacterial activity of cadmium (II) and antimony (III) complexes was enhanced compared to their ligands, with Cd2 and Sb2 demonstrating effective antibacterial activity and Cd2 showing the most effective antiproliferative activity against HepG2 cells.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Azadeh Mirzaahmadi, Seyed Abolfazl Hosseini-Yazdi, Majid Mahdavi, Michal Dusek, Valcav. Eigner, Morgane Poupon
Summary: New water-soluble Zn(II) and Ni(II) complexes, synthesized and characterized in this study, exhibit good solubility and stability in aqueous media. These complexes show potential anticancer activity in cell experiments.
Article
Biochemistry & Molecular Biology
Monica Martinez-Estevez, Soledad Garcia-Fontan, Saray Argibay-Otero, Inmaculada Prieto, Ezequiel M. Vazquez-Lopez
Summary: In this study, the reaction between [Ru2Cl2(mu-Cl)(2)(eta(6)-p-cymene)(2)] and two thiosemicarbazones was investigated. The resulting cationic complexes were isolated and characterized. The study revealed the presence of two isomers in the triflate salts and only one isomer in the chloride. X-ray crystallography confirmed this finding. The coordination of the thiosemicarbazone ligand to the ruthenium center was also demonstrated.
Article
Chemistry, Inorganic & Nuclear
Chinmoy Biswas, Arnab Chatterjee, Vinu Vijayan, Chandra Shekhar Purohit, Manikantan Syamala Kiran, Rajarshi Ghosh
Summary: This article reports the synthesis and structural characterization of a dinuclear silver(I) complex 1, which exhibits selective anticancer activity against liver cancer cells. The anticancer activity of 1 is achieved through induction of mitochondrial death via Reactive Oxygen Species (ROS).
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Violeta Jevtovic, Asma K. Alshamari, Dejan Milenkovic, Jasmina Dimitric Markovic, Zoran Markovic, Dusan Dimic
Summary: Thiosemicarbazones and their metal complexes were studied for their structural properties and biological activities, demonstrating their potential as anticancer agents. Four pyridoxal-thiosemicarbazone (PLTSC) complexes with Fe, Co, Ni, and Cu were analyzed, focusing on the donor atom-metal interactions. The geometry, crystallographic structures, and intermolecular interactions were investigated, determining the specific interactions based on the structure and number of PLTSC units. The binding of the complexes to proteins and DNA was analyzed, and cytotoxicity tests showed that Cu-PLTSC exhibited the highest affinity towards DNA and proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Huijuan Jia, Mengyuan Niu, Rui Sun, Ai Wang, Yan-Bo Wu, Liping Lu, Miaoli Zhu, Sisi Feng, Caixia Yuan
Summary: In this study, a new cobalt complex was synthesized and characterized. The crystal structure determination revealed a distorted octahedral structure. The cobalt complex showed potential anti-diabetes activity by inhibiting the activity of TCPTP and exhibited low cytotoxicity to cancer cells and normal cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Cristina Gonzalez-Garcia, Cristina Garcia-Pascual, Rodrigo Buron, David G. Calatayud, Josefina Perles, M. Antonia Mendiola, Elena Lopez-Torres
Summary: In this study, a new dissymmetric bis(thiosemicarbazone) ligand was prepared and characterized. The reactivity of this ligand and the hybrid isopropylthiosemicarbazone/naphtoylhydrazone with zinc(II), copper(II), and nickel(II) nitrates was explored. The results showed that the deprotonation of the ligand could not be selectively controlled. Additionally, different supramolecular architectures were formed based on the degree of deprotonation of the ligands and the presence of nitrate ions.
Article
Chemistry, Physical
Swarup Kumar Tarai, Arup Tarai, Saikat Mandal, Bhaskar Nath, Ipsita Som, Rituparna Bhaduri, Arka Bagchi, Solanki Sarkar, Arunima Biswas, Sankar Ch. Moi
Summary: The bidentate ligand thiosemicarbazone (H3L) and its Ni(II) complex were synthesized and characterized. The complexes have square planar geometry and show binding abilities with DNA and BSA. The DFT/TD-DFT simulations and theoretical analysis provided insights into the reactivity, bonding mode, and bio-molecular affinity of the compounds. The compounds also demonstrated antiproliferative activity and cell death mechanisms against HEK293 and MCF-7 cell lines.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Ahmed A. E. Mourad, Youstina W. Rizzk, Islam Zaki, Faten Z. Mohammed, Mohammed El Behery
Summary: A series of hybrid organic nitrogen compounds were synthesized and confirmed through spectroscopic techniques, showing potent antitumor activity by inducing cell cycle arrest and apoptosis in cancer cells. The compounds also exhibited strong inhibitory effects against beta-tubulin polymerization and topoisomerase up enzyme.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Inorganic & Nuclear
E. S. Cakmakci, E. Subasi, E. Ozturk, A. Sahiner, B. Sen Yuksel
Summary: Metal(II) complexes including Co(II), Ni(II), Pd(II) and Zn(II) were synthesized and characterized. These complexes were obtained by reacting metal(II) chlorides with the ligand. The structures and properties of these complexes were determined by various characterization techniques including elemental analysis, FT-IR, 1H NMR, and single crystal X-ray diffraction.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Inorganic & Nuclear
Elif Avcu Altiparmak, Sibel Yazar, Namik Ozdemir, Tulay Bal-Demirci, Bahri Ulkuseven
Summary: Copper(II) and nickel(II) mixed ligand complexes synthesized from 4-methoxysalicylaldehyde-N-phenylthiosemicarbazone and 3,5-lutidine were characterized using various techniques, showing antioxidant capacity for both the ligand and its metal complexes.
Article
Chemistry, Inorganic & Nuclear
Jebiti Haribabu, Nithya Balakrishnan, Srividya Swaminathan, Jerome Peter, Dasararaju Gayathri, Cesar Echeverria, Nattamai Bhuvanesh, Ramasamy Karvembu
Summary: A new water-soluble binuclear organometallic Ru-p-cymene complex was synthesized and showed superior anticancer activity against various cancer cells compared to cisplatin, as well as potential antiviral activity by binding to viral proteins.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Polymer Science
Roman Nickisch, Peter Conen, Michael A. R. Meier
Summary: This study presents an easy access to thermoplastic polythiosemicarbazones (polyTSCs) through condensation reaction, resulting in a variety of polymers and copolymers that were thoroughly characterized. The polymerization proceeds at room temperature with broad moiety tolerance, and the synthesized polymers exhibit good thermal stability.
Article
Chemistry, Applied
Ferdane Danisman Kalindemirtas, Busra Kaya, Mustafa Bener, Onur Sahin, Serap Erdem Kuruca, Tulay Bal Demirci, Bahri Ulkuseven
Summary: Nine iron(III) complexes were synthesized and tested for their cytotoxicity and radical scavenging activities. Among them, complexes Fe2, Fe5, Fe7, and Fe8 showed remarkable cytotoxic effects on K562 and P3HR1 cells at low concentrations, and also exhibited competitive ROS scavenging activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Jielin Huang, Jing Liu, Lina Tian, Xiangli Li, Xinqi Ma, Xin Yu, Quanhui Guo, Junwei Zhao
Summary: This study introduces a novel modified solvothermal strategy to synthesize carbon-coated Zr3+-ZrO2 composites with enhanced visible light absorption and photocatalytic degradation of tetracycline. Results demonstrate that the carbon-coated Zr3+-ZrO2 composites exhibit efficient visible light photocatalytic performance and recyclable stability. The possible photocatalytic mechanism and degradation pathways of antibiotics under visible light irradiation were also proposed in detail.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Lulu Liu, Jun Jiang, Guoping Liu, Xiaodan Jia, Junwei Zhao, Lijuan Chen, Peng Yang
Summary: Two types of Ln-included selenotungstates were synthesized by controlling the Ln nature, forming complex structures bridged by organic ligands and Ln clusters. These materials were used to prepare aptasensors with two-dimensional thin film structure for OTA detection, showing potential application in biological and clinical analyses.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Jili Li, Junwei Zhao, Chunjuan Tang, Tiekun Jia, Jianhua Hou, Chuanbao Cao, Youqi Zhu
Summary: The study introduced an ultrathin spinel Li4Ti5O12 (LTO) coating on lithium-rich layered oxides Li1.2Ni0.2Mn0.6O2 (LLNMO), forming a heteroepitaxial structure that reduced oxygen loss, phase transformation, capacity decline, and voltage fading. The cathode with this heteroepitaxial structure demonstrated superior electrochemical performance, indicating that epitaxial spinel LTO coating can effectively stabilize oxygen framework and improve the cathode's cycling stability and rate capability in next generation LIBs.
JOURNAL OF POWER SOURCES
(2021)
Article
Chemistry, Multidisciplinary
Yulu Yang, Wenjie Wu, Ya Wang, Jiao Liu, Ningxu Li, Yulong Fan, Shiyang Zhang, Qingsong Dong, Junwei Zhao, Jingyang Niu, Qingchao Liu, Zhaomin Hao
Summary: In this study, a new bimetallic catalyst Cu-Pb with synergistic interplay is reported, which shows enhanced catalytic activity and selectivity for the two-electron oxygen reduction reaction. In-depth evidence, including DFT calculations, electrochemical signals, in-situ Raman, and H2O2-proof work, support the catalytic favor of Cu-Pb towards 2e(-) ORR.
Article
Biophysics
Junwei Zhao, Qian Zhang, Wenquan Liu, Guiye Shan, Xin Wang
Summary: This study successfully synthesized biocompatible BSA-coated Ag2S nanoparticles as photothermal agents for cancer therapy. The nanoparticles exhibited high photothermal conversion efficiency and strong absorption, effectively inducing apoptosis in tumor cells with excellent killing effect. The research provided a simple and reproducible method to fabricate water-soluble and biocompatible Ag2S nanoparticles, offering new insights for designing functional nanoparticles for photothermal therapy of tumors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Jinjiang Xue, Qiong Liao, Man Luo, Chenfeng Hua, Junwei Zhao, Gangfeng Yu, Xiangyu Chen, Xueru Li, Xinchun Zhang, Ruiguo Ran, Fanghui Lu, Yingxiong Wang, Liangjun Qiao
Summary: Cigarette smoke-induced oxidative stress disrupts fibronectin assembly during angiogenesis, and this effect is primarily mediated by hyperactive NRF2-STAT3 signaling.
Article
Geosciences, Multidisciplinary
Senlin Yin, Lei Zhao, Yu Lin, Baiyu Zhu, Junwei Zhao, Leli Cheng
Summary: This study uses unmanned aerial vehicle oblique photogrammetry to quantitatively evaluate steep carbonate outcrops and successfully establish a three-dimensional digital outcrop model and quantitative geological database. The results provide a basis for studying the stratigraphic architecture of the outcrop and reveal information about the regional geological evolution through various analysis methods and models.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Tiantian Gong, Jun Jian, Sen Yang, Jiancai Liu, Lijuan Chen, Junwei Zhao
Summary: In this study, a novel type of lanthanide incorporated polyoxometalates was synthesized using a dual-heteroatom-directed strategy. The resulting materials showed potential application as fluorescence probes for high-sensitivity detection of the neurotransmitter dopamine.
INORGANIC CHEMISTRY
(2022)
Review
Environmental Sciences
Hui Dong, Haiming Yu, Rongxiao Xu, Weimin Cheng, Yuxi Ye, Sen Xie, Junwei Zhao, Yu Cheng
Summary: Coal mine pollution poses a serious threat to mine safety and the health of miners. Chemical dust suppressants can effectively reduce coal dust concentration and prevent dust re-entrainment. This paper discusses the research progress of traditional dust suppressants and the development of new types of suppressants. Compound and environment-friendly suppressants have become the research focus, and new materials like microbe suppressants and nanomaterials have emerged. However, there are still challenges such as high cost and complex preparation technology.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Junwei Zhao, Dongsheng Yu, Wenqing Zhang, Zijian Wang, Yujiang Wang
Summary: In this study, a helical triboelectric nanogenerator (H-TENG) based on the helical structure of biodegradable polylactic acid was designed using 3D printing technology to achieve energy acquisition. When the H-TENG is pressed rhythmically with one hand, the output open-circuit voltage, short-circuit current and charge transfer density can reach 395 V, 28 μA and 36 μC/m2 respectively, which can light 300 LEDs in series. By connecting a simple rectifier and selecting a suitable capacitor, the H-TENG can independently and stably power portable electronic products, such as digital watches and calculators. Especially, as an electronic switch, the device enabled a high current amplification through the Darlington transistor circuit. These results demonstrated the potential applications of the H-TENG in biomechanical energy collection, sensing and human-machine interaction.
CURRENT APPLIED PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Junwei Zhao, Yujiang Wang, Bo Wang, Yuetan Sun, Haoqiang Lv, Zijian Wang, Wenqing Zhang, Yongdong Jiang
Summary: With the development of intelligent wearable electronic products, new requirements are put forward for large-scale production and durable power supplies and sensors. Herein, a flexible and stretchable single-electrode triboelectric nanogenerator (TENG) based on a medical conductive hydrogel (MCH) has been fabricated for biomechanical energy harvesting and electronic switches. The obtained MCH-TENG encapsulated by silicone rubber as an electrification layer demonstrated high electrical output performances.
Article
Materials Science, Multidisciplinary
Bao-Xing Zeng, Guo-Ping Liu, Yu-Jiao Hao, Zhuo Chen, Li-Juan Chen, Jun-Wei Zhao
Summary: A multi-Ce-III encapsulated phospho(III)tungstate decorated material was synthesized, which showed a unique structure. The material was further combined with carboxyl-functionalized multi-walled carbon nanotubes to develop an electrochemical sensor for the detection of noradrenaline.
Article
Chemistry, Physical
Wenjie Wu, Yulu Yang, Yitong Wang, Tiantian Lu, Qingsong Dong, Junwei Zhao, Jingyang Niu, Qingchao Liu, Zhaomin Hao, Shuyan Song
Summary: The study reveals the excellent activity of defective Cu-Bi catalyst in electrosynthesis of urea, achieving high urea concentration and faradaic efficiency. Isotope tracing experiments and theoretical calculations further confirm the potential of defective Cu-Bi catalyst in the co-reduction of N-2 and CO2.
Article
Chemistry, Inorganic & Nuclear
Nizi Song, Yanzhou Li, Yanying Wang, Menglu Wang, Mengling Liu, Lijuan Chen, Junwei Zhao
Summary: Polyoxometalate chemistry has enabled the synthesis of a novel complex aggregate incorporating phosphite and tellurotungstate, which can be converted into nano-materials and composite with NH2-graphene for sensor and enzymatic sensing applications. The resulting nano-composite exhibits excellent detection performance and stability, demonstrating its potential for electrochemical sensor applications.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Junwei Zhao, Yujiang Wang, Xiaojiang Song, Anqi Zhou, Yunfei Ma, Xin Wang
Summary: The study presents a flexible single-electrode TENG based on polyester conductive cloth for harvesting human motion energy to power LEDs and portable electronics. This technology achieves high output performance and can be used to monitor subtle signals of human physiological activities.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
