Article
Energy & Fuels
Ewelina Kruszczak, Hanna Kierzkowska-Pawlak
Summary: The study investigated the rates of CO2 absorption in aqueous solutions of N-methyl-1,3-propanediamine (MAPA) and its mixture with N,N-diethylethanolamine (DEEA). The results showed that low concentrations of MAPA in DEEA solutions significantly accelerated the rate of CO2 absorption, indicating its potential as an efficient CO2 absorbent.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
F. Hamoud, Y. Bedouh, S. M. Ramsh, E. S. Khrabrova
Summary: The three-component condensation of urea with formaldehyde and propane-1,3-diamine in specific molar ratios resulted in the formation of tricyclic compounds. Similarly, condensation of urea with different diamines also led to the synthesis of tricyclic products with multiple nitrogen-containing rings.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anton A. Ulantikov, Konstantin A. Brylev, Taisiya S. Sukhikh, Yuri Mironov, Viktoria K. Muravieva, Yakov M. Gayfulin
Summary: A series of new octahedral rhenium cluster complexes were synthesized and investigated, showing that the difference in the electronic structure of the ligands has a fundamental effect on the properties of the complexes. The complexes with bpp ligand exhibit higher photoluminescence performance.
Article
Chemistry, Multidisciplinary
N. Z. Akopyan, A. G. Agababyan, Z. A. Ovasyan, A. U. Isakhanyan, A. S. Grigoryan, K. G. Navoyan, G. Gasparyan, H. A. Panosyan
Summary: The corresponding beta-amino-ketones and 2,2'-{1,omega-alkane-diylbis[oxy-4, 1-phenylene (3-oxo-3,1-propanediyl)imino]} bisbenzamides were synthesized and their anti-MAO activity was studied.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rei Ishihara, Kota Okamura, Yuki Yoshimura, Satoshi Ueno
Summary: A facile synthesis method for ketones was developed through the diamine-promoted deacylation of 2-alkyl-1,3-diketones. The highly regioselective formation of aryl ketones was achieved by efficiently deacylating 2-alkyl-1-arylbutane-1,3-diones in the presence of 2,2-dimethylpropane-1,3-diamines, which exhibited different regioselectivity compared to the conventional retro-Claisen conditions.
Article
Chemistry, Inorganic & Nuclear
Yunan Zhang, Jiuyi Sun, Lixin Liu, Miao Huang, Liang Chang, Yuanyuan Ji, Yanru Feng, Lili Wu, Lei Zhang, Yunjie Zhang, Dongyu Zou, Yingli Liu, Xin Su
Summary: A novel PMo12O40-Bpp supramolecular compound was utilized as a catalyst for synthesizing aspirin, achieving high yield and selectivity after optimization. The catalyst exhibited good stability and recyclability in pharmaceutical esterification, offering new insights for green pharmaceutical chemistry.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Georgios I. Papoutsidakis, Vitaly Buckin
Summary: This paper describes the application of High-Resolution Ultrasonic Spectroscopy for real-time, non-destructive, precision monitoring of enzymatic hydrolysis of polysaccharides in aqueous solutions. The technique provides time profiles of various parameters including glycosidic bonds hydrolyzed, degree of hydrolysis, average degree of polymerization, and molar mass of hydrolysates produced. The limiting precision of the technique in measuring the concentration of glycosidic bonds hydrolyzed is at the level of 0.01 m mol kg(-1).
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Medicinal
Mikhail Krasavin, Daniil Zhukovsky, Igor Solovyev, Darina Barkhatova, Dmitry Dar'in, Denia Frank, Giada Martinelli, Lilia Weizel, Anna Proschak, Marco Rotter, Jan S. Kramer, Steffen Brunst, Thomas A. Wichelhaus, Ewgenij Proschak
Summary: Diversity-oriented synthesis is a valuable approach for discovering novel drug lead structures in Medicinal Chemistry. This study describes a DOS-compatible method for synthesizing compounds with a free thiol moiety, leading to the identification of novel potent MBL inhibitors with antibiotic adjuvant activity through biochemical and biological evaluation.
Article
Chemistry, Multidisciplinary
Guizhou Yue, Dan Jiang, Zhengjie Dou, Sicheng Li, Juhua Feng, Li Zhang, Huabao Chen, Chunping Yang, Zhongqiong Yin, Xu Song, Xiaoxia Liang, Xianxiang Wang, Cuifen Lu
Summary: The umpolung Michael addition of isatin N,N'-cyclic azomethine imine 1,3-dipoles with chalcones yields 3,3-disubstituted oxindole derivatives in moderate to excellent yields within a short reaction time. Unusual Michael adducts are obtained in moderate to high yields with varying diastereoselectivities.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Jialin Wu, Xuan Liu, Rumeng Zhang, Liting Kong, Fu Li, Zhaojun Wu, Jianbin Zhang
Summary: This study systematically reports the physical data and intermolecular interactions of 1,2-propane diamine and 1,3-butanediol binary mixtures, providing valuable insights into the properties of the mixture.
JOURNAL OF SOLUTION CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Luca Scapinello, Guglielmo Vesco, Luca Nardo, Angelo Maspero, Federico Vavassori, Simona Galli, Andrea Penoni
Summary: The newly synthesized zinc complex exhibits a zincoxane molecular structure with high affinity for hard nucleophiles, especially in interactions with DNA. The complex also shows stability in coordination with DMSO and holds potential for the development of optimized drug substances for anticancer applications.
Article
Chemistry, Multidisciplinary
Amarnath Bollu, Prajnanandan Giri, Nihar Ranjan Dalabehera, Asmita Rani Asmi, Nagendra K. Sharma
Summary: Ampyrone is a compound with therapeutic values such as analgesic, anti-inflammatory, and antipyretic effects. It has excellent hydrogen bonding sites and can be used as a potential scaffold for supramolecular self-assembly. Recent studies have shown that one of its amino acids, O-alkylated ampyrone, can form organogels under specific conditions. The formation and morphology of these organogels are studied using various techniques such as NMR, FT-IR, SEM, TEM, Powder-XRD, and TGA. Conformation analysis suggests that intermolecular hydrogen bonding plays a role in the formation of these organogels. APA-peptides derived from ampyrone are promising peptidomimetics for organogel formation.
FRONTIERS IN CHEMISTRY
(2022)
Article
Thermodynamics
Pan Zhang, Yanxi Ji, Wenya Li, Lihua Xu, Lemeng Wang, Dong Fu
Summary: This study measured and analyzed the viscosities, activation energies, and CO2 diffusion coefficients of different amine compounds in DEAE solutions. The results showed that the DEAE-BDA absorbent has lower viscosity, higher CO2 diffusion coefficient, and lower activation energy, indicating better application potential.
JOURNAL OF CHEMICAL THERMODYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Yu-Mei Hao
Summary: A mononuclear copper(II) complex and a phenolato-bridged trinuclear zinc(II) complex have been synthesized and characterized, with their crystal structures determined. The antibacterial activities of the complexes were tested against Staphylococcus aureus, Escherichia coli, and Candida parapsilosis.
ACTA CHIMICA SLOVENICA
(2021)
Article
Chemistry, Multidisciplinary
Chunlin Zhou, Xinchao Wang, Lei Yang, Lei Fu, Gang Li
Summary: This study reports a method of using light to drive a regioselective carbocarboxylation reaction between CO2 and aryl and alkyl halides. This method allows for the rapid and highly regioselective synthesis of complex β,γ-unsaturated carboxylic acids.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)