Article
Chemistry, Applied
Jennica Moller, Christina Kannigadu, Janine Aucamp, Moegamat C. Joseph, Andrew J. Swarts, David D. N'Da
Summary: Leishmaniasis is a widespread zoonotic disease that requires new and effective treatments. The current treatments have limitations such as toxicity, variable efficacy, and resistance. Ferrocenylazine derivatives show promising antileishmanial activity and could be potential new agents for treating leishmaniasis.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Hamdan AlMohammed, Amal Khudair Khalaf, Aishah E. Albalawi, Abdullah D. Alanazi, Parastoo Baharvand, Ali Moghaddam, Hossein Mahmoudvand
Summary: This study reviewed the preclinical studies on the anti-leishmanial activity of chitosan and chitosan-based particles against various Leishmania species. The findings suggest that chitosan and its derivatives show promising in vitro and in vivo anti-leishmanial activity, indicating their potential as alternatives for treating leishmaniasis. Further research, especially in clinical settings, is necessary to confirm these results.
Article
Microbiology
Chin-Fung Chan, Zhen Liu, Iris L. K. Wong, Xianliang Zhao, Zaofeng Yang, Jiale Zheng, Marianne M. Lee, Michael K. Chan, Tak Hang Chan, Larry M. C. Chow
Summary: A library of 38 novel flavonoid compounds linked with amines were synthesized, with the most promising candidate FM09h showing potent in vitro activity against parasites causing cutaneous leishmaniasis. In a mouse model, intralesional injection of FM09h demonstrated a promising effect in reducing footpad lesion thickness, comparable to sodium stibogluconate.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Parasitology
Janine Aucamp, David D. N'Da
Summary: The overlapping distribution of malaria and leishmaniasis increases the risk for comorbidity and there is a need for new anti-infective drugs to treat these diseases and coinfections.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soheila Molaei, Ghazaleh Farhadi, Mina Talezari, Negin Gholizadeh, Karim Mahnam, Ali Keivanloo, Saghi Sepehri
Summary: Novel hybrids with 1,2,3-triazole and polyhydroquinoline scaffolds were successfully synthesized by multicomponent reaction followed through click reaction. Their anti-leishmanial activity was evaluated and three hybrids showed the highest activity with low cytotoxicity. Molecular docking and dynamics simulations were performed to explore possible mechanisms.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Alberto A. Robles-Loaiza, Edgar A. Pinos-Tamayo, Bruno Mendes, Catia Teixeira, Claudia Alves, Paula Gomes, Jose R. Almeida
Summary: Peptide-based drugs are recognized by the pharmaceutical industry for their potential in developing innovative therapies, including for conditions like leishmaniasis. This review details over one hundred peptides and their biochemical and structural characteristics, as well as their potential use in designing antileishmanial drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mohini Soni, Gaurava Srivastava, Karthik Ramalingam, Anil Kumar Shakya, Mohammad Imran Siddiqi, J. Venkatesh Pratap
Summary: Leishmaniasis, caused by Leishmania, is a disease affecting millions of people in endemic areas. Current therapies have limitations and the need for novel therapeutic molecules is urgent. In this study, structure-based high throughput drug discovery was used to identify two potential inhibitors of Leishmania HSK, which effectively induced mortality in the parasite and showed promising specificity and efficacy.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Parasitology
Gustavo Goncalves, Monique Paiva Campos, Alessandra Silva Goncalves, Lia Carolina Soares Medeiros, Fabiano Borges Figueiredo
Summary: The study showed that treating a dog with Miltefosine and allopurinol resulted in increased resistance of L. infantum to Miltefosine and amphotericin B, as well as an increase in metacyclogenesis rate. Further research with a larger sample size of L. infantum strains is recommended.
PARASITES & VECTORS
(2021)
Article
Biology
Hossein Mahmoudvand, Amal Khudair Khalaf, Pouya Zareh Rajabi, Nooshin Karbasian, Javad Ghasemian Yadegari
Summary: This study aimed to investigate the leishmanicidal effects, cellular mechanisms, and cytotoxicity of formononetin (FMN) against Leishmania tropica. The MTT assay was used to evaluate the leishmanicidal effects of FMN on promastigotes, and its cytotoxicity effects on J774-A1 macrophage cells were examined. The levels of nitric oxide (NO), IFN-γ, and iNOS mRNA expression in infected J774-A1 macrophage cells were determined using the Griess reaction assay and quantitative real-time PCR.
BMC RESEARCH NOTES
(2023)
Article
Parasitology
A. D. Alanazi, A. E. Albalawi, H. I. Almohammed, A. F. Shater
Summary: This study investigated the in vitro and in vivo effects of the Stachys lavandulifolia methanolic extract (SLME) against Leishmania major infection. The results showed that SLME had potent effects in eliminating and controlling Leishmania parasites, making it a potential alternative medicine for treating Leishmaniasis.
TROPICAL BIOMEDICINE
(2022)
Article
Biochemical Research Methods
Joana Pissarra, Juli Pagniez, Elodie Petitdidier, Martial Seveno, Oana Vigy, Rachel Bras-Goncalves, Jean-Loup Lemesre, Philippe Holzmuller
Summary: Leishmaniasis is a significant parasitic disease that threatens the lives of 1 billion people every year. In this study, the total protein content of the secretomes produced by seven different Leishmania species was analyzed, revealing the common core secretome and highlighting the importance of secreted proteins in the pathogenesis of the disease.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Chemistry, Medicinal
Nathalia S. de Oliveira, Luana G. de Souza, Vitor M. de Almeida, Arielly R. R. Barreto, Felipe Carvalho-Gondim, Edgar Schaeffer, Osvaldo A. Santos-Filho, Bartira Rossi-Bergmann, Alcides J. M. da Silva
Summary: In this study, a series of sulfonamide-chalcone hybrids were synthesized and tested for their activity against Leishmania parasites. Three compounds showed good antileishmanial activity and high activity against intracellular amastigotes.
ARCHIV DER PHARMAZIE
(2023)
Article
Pharmacology & Pharmacy
Gideon D. Badenhorst, Christina Kannigadu, Janine Aucamp, David D. N'Da
Summary: Leishmaniasis is a neglected tropical disease, and new drugs are needed to overcome the limitations of current treatments. This study synthesized a series of nifuroxazide analogues and identified compounds 1l, 2c, and 2d as potential candidates with antileishmanial activity.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Parasitology
Sara Rahimi, Ali Khamesipour, Amir Ahmad Akhavan, Javad Rafinejad, Reza Ahmadkhaniaha, Mahmood Bakhtiyari, Arshad Veysi, Kamran Akbarzadeh
Summary: The study found that larval saliva and hemolymph of L. sericata have acceptable leishmanicidal properties against L. tropica.
PARASITES & VECTORS
(2021)
Article
Chemistry, Medicinal
Nonkululeko H. Zuma, Janine Aucamp, Maryna Viljoen, David D. N'Da
Summary: Leishmaniasis is a common parasitic infection, especially prevalent among populations in low-income developing countries. The lack of effective vaccines means that chemotherapy is the primary treatment method. However, current antileishmanial drugs are limited due to their toxicity and drug-resistant strains. Therefore, there is a need for new and effective antileishmanial agents. In this study, a series of nitrofurantoin-triazole hybrids were synthesized and evaluated for their activity and cytotoxicity. One derivative, featuring a propargyl moiety, showed the highest activity against the causative pathogens of visceral leishmaniasis, with no toxicity to human cells. This compound has potential as an alternative therapy and warrants further investigation.
Article
Computer Science, Information Systems
Kusum Yadav, Elham Kareri, Shoayee Dlaim Alotaibi, Wattana Viriyasitavat, Gaurav Dhiman, Amandeep Kaur
Summary: This article focuses on the technical advantages, attack methods and classifications, as well as the distinctions between different encryption algorithms of federated learning. It also reviews the research on privacy protection and security mechanisms in federated learning, and identifies difficulties and opportunities.
ENTERPRISE INFORMATION SYSTEMS
(2023)
Review
Chemistry, Multidisciplinary
Kai Kikuchi, Liam D. Adair, Jiarun Lin, Elizabeth J. New, Amandeep Kaur
Summary: This article introduces the importance of decoding cellular processes and discusses how super-resolution imaging technologies and fluorescent probes can be used for visualization. The evaluation and discussion of single-molecule localization microscopy guide the design and adoption of next-generation fluorescent probes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Medicine, Research & Experimental
Sukhchain Kaur, Rubal, Satveer Kaur, Amandeep Kaur, Sandeep Kaur, Sushil Gupta, Sunil Mittal, Monisha Dhiman
Summary: The present study aims to understand the complex interaction between oxidative stress, inflammation and antioxidant system in hypertension. It is observed that metabolic markers are altered in hypertensive subjects, showing increased oxidative and inflammatory profiles and compromised antioxidant status compared to normotensive subjects. Correlation analysis validates the involvement of inflammation and oxidative stress in impaired endothelial function and vital organ damage.
Article
Biochemistry & Molecular Biology
Akanksha Srivastava, Arvind Kumar, Subhankar Biswas, Rajender Kumar, Vaibhav Srivastava, Hema Rajaram, Yogesh Mishra
Summary: This study revealed the role of a global regulator, LexA, in modulating the gamma-radiation stress response of the cyanobacterium Anabaena. Proteome analysis of Anabaena strains subjected to gamma-radiation showed differential accumulation of 41 proteins, corresponding to 29 distinct proteins, with LexA regulating 27 of the corresponding genes. The regulated genes were mainly involved in photosynthesis, carbon assimilation, and oxidative stress alleviation. The study also found that LexA influenced photosynthesis and thylakoid membrane proteome even under normal growth conditions, indicating its role in stress response management.
Letter
Oncology
Barina Aqil, Amandeep Kaur, Josean Ramos, Madina Sukhanova, Shuo Ma, Juehua Gao, Xinyan Lu, Yi-Hua Chen, Qing Chen
LEUKEMIA & LYMPHOMA
(2023)
Review
Biochemistry & Molecular Biology
Ashita Bisht, Dinesh Kumar Saini, Baljeet Kaur, Ritu Batra, Sandeep Kaur, Ishveen Kaur, Suruchi Jindal, Palvi Malik, Pawanjit Kaur Sandhu, Amandeep Kaur, Balwinder Singh Gill, Shabir Hussain Wani, Balwinder Kaur, Reyazul Rouf Mir, Karansher Singh Sandhu, Kadambot H. M. Siddique
Summary: This review summarizes the regulatory and defense mechanisms in soybean against biotic stresses, including marker resources, quantitative trait loci, and marker-trait associations. It discusses the differential expression of genes and proteins reported in transcriptomics and proteomics studies, as well as the role of signaling pathways and metabolites reported in metabolomics studies. Recent advances in omics technologies provide opportunities to enhance biotic stress resistance in soybean by altering gene regulation and/or other regulatory networks. The use of 'integrated omics' is suggested to precisely understand soybean's response to different biotic stresses, but challenges in integrating multi-omics for functional gene analysis and cultivar development need to be addressed.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Horticulture
Srijana Panta, Biting Zhou, Lan Zhu, Niels Maness, Charles Rohla, Lucas Costa, Yiannis Ampatzidis, Charles Fontainer, Amandeep Kaur, Lu Zhang
Summary: The objective of this research was to compare different non-linear growth models and determine which best fits the growth and development of the pecan nut components. The findings suggest that the Gompertz model best describes the growth of the embryo and shuck, while the Logistic model performs slightly better in modeling shell growth and the shuck for the two-year data. The results provide guidance for pecan growers in fine tuning irrigation, thinning, and pest management based on an integrated growth model.
SCIENTIA HORTICULTURAE
(2023)
Article
Nanoscience & Nanotechnology
Bhawna, Mrinmoy Roy, Amandeep Kaur, Aftab Alam, M. Aslam
Summary: Surface-tailored lead-free halide double-perovskite (Cs2AgBiX6) thin films were used to study ion migration. A thin surface layer of BiOBr/Cl was intentionally grown on the halide films through annealing. The films were physically stacked to activate halide ion migration, resulting in homogenization of the ions and formation of a mixed phase. Absorption studies showed a redshift and a blueshift in spectra, indicating the migration of Br- and Cl- ions. XRD and XPS analysis confirmed the presence of Bi-O bonds and the migration of Cl- and Br- ions between the films. The rate constant for bromide ion diffusion increased with temperature, following Arrhenius behavior with an activation energy of 0.42 eV. The slow ion migration in Cs2AgBiBr6/Cl6 films suggests stability and high-quality.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Sukhmani Mann, Anupamjeet Kaur, Amandeep Kaur, Nitesh Priyadarshi, Bhupesh Goyal, Nitin Kumar Singhal, Deepti Goyal
Summary: Amyloid-fi (Afi) aggregation is crucial in the pathogenesis of Alzheimer's disease (AD). A series of triazole-peptide conjugates have been designed and evaluated as potential ligands targeting AD. DS2, a peptidomimetic, shows the best inhibitory activity against Afi aggregation. It not only disaggregates preformed Afi42 fibrils, but also reduces oxidative stress and Afi-induced toxicity.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mandeep Kaur, Hafiz Muzzammel Rehman, Gurmeet Kaur, Amandeep Kaur, Manisha Bansal
Summary: A new series of linker-based derivatives of non-steroidal anti-inflammatory drugs were synthesized and characterized. The study focused on understanding the switch in the anti-inflammatory and anticancer activity of compounds 8 and 10 through in-silico and in-vitro studies. The molecular docking study showed the importance of hetero atoms and proper alignment in the binding pocket for bioactivity. Compound 8 exhibited better inhibitory activity against the COX-2 target site, possibly due to the presence of 1,3-dicarbonyl interactions, whereas compound 10 showed increased potency towards anticancer activity. In-vitro assays confirmed the results obtained from the in-silico study.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rajender Kumar
Summary: Lipases have diverse substrate specificity and can be modulated at the structural and functional level for improved versions. The structural analysis of microbial lipases provides insights into the characteristics of alkaliphilic and thermophilic lipases, such as conformational changes and solvent exposure of the active site. The integration of stability features from thermophilic lipases into alkaliphilic lipases can lead to the design of novel thermo-alkaliphilic lipases.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Poonam Dhiman, Poongodi Manoharan, Umesh Kumar Lilhore, Roobaea Alroobaea, Amandeep Kaur, Celestine Iwendi, Majed Alsafyani, Abdullah M. Baqasah, Kaamran Raahemifar
Summary: This research presents a precise fruit disease identification model based on context data fusion with Faster-CNN in an edge computing environment. The goal is to develop an accurate, efficient, and trustworthy fruit disease detection model, a critical component of autonomous food production in a robotic edge platform. Through deep learning models, different diseases of citrus fruits are identified using visual data from near-infrared (NIFR) and RGB patterns, achieving high accuracy.
EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING
(2023)
Article
Green & Sustainable Science & Technology
Poonam Dhiman, Amandeep Kaur, Yasir Hamid, Eatedal Alabdulkreem, Hela Elmannai, Nedal Ababneh
Summary: In this study, an efficient model for citrus fruit disease prediction is proposed, which combines deep learning models CNN and LSTM with edge computing. By employing an enhanced feature-extraction mechanism and a feature-fusion subsystem, significant recognition on edge computing devices with retaining citrus fruit disease detection accuracy is achieved. The proposed CNN-LSTM model achieves an accuracy rate of 97.18% with Magnitude-Based Pruning and 98.25% with Magnitude-Based Pruning with Post Quantization, outperforming the existing CNN method.
Review
Green & Sustainable Science & Technology
Poonam Dhiman, Amandeep Kaur, V. R. Balasaraswathi, Yonis Gulzar, Ali A. Alwan, Yasir Hamid
Summary: This paper systematically reviews studies that employ machine learning, deep learning, and statistical techniques for the prediction, detection, and classification of citrus fruit diseases. Out of 78 selected papers, commonly used techniques include hyperspectral imaging systems for image acquisition, thresholding for image processing, support vector machine (SVM) models for machine learning, convolutional neural network (CNN) architectures for deep learning, principal component analysis (PCA) as a statistical model, and classification accuracy as evaluation parameters. The color feature in the RGB color space is the most popularly used feature. Comparative analysis identifies SVM as the best among ML methods, ANN as the best among neural networks, CNN as the best among deep learning methods, and linear discriminant analysis (LDA) as the best among statistical techniques. The paper concludes with meta-analysis, limitations, and future research directions.
Article
Biology
Ajaj Ahmed, Narendra Kumar Dabi, Swati Verma, Praveen Gehlot, Praveen Purohit, Rajender Kumar, Gautam Kumar Meghwanshi
Summary: The present work screened thermotolerant bacteria from Thar Desert environmental samples for lipase activity and catalytic efficiencies. The selected lipases showed thermos-alkaliphilic properties and efficiently synthesized biodiesel from waste cooking oils. These lipases have potential applications in biodiesel production, synthesis of esters, and remediation of environmental pollutants.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
