Article
Chemistry, Medicinal
Praveen Kumar, Laxmi Tripathi
Summary: A prototype of potent anticonvulsant molecules, 2-(1,3-benzodioxol-5-yloxy)-N'-[substituted]-acetohydrazides SA 110, was designed and synthesized, showing good binding affinity with molecular targets of epilepsy and high protection rates in mice, making it a potential candidate for antiepileptic therapy against partial seizures.
MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Miyanou Rosales-Hurtado, Valentin Duvauchelle, David Benimelis, Maya Ogawa-Okada, Naofumi Yamamoto, Patrick Meffre, Hendrik Szurmant, Zohra Benfodda
Summary: This study successfully synthesized a variety of antibacterial derivatives using microwave-assisted synthesis and found that two compounds exhibited good activity against pathogenic bacteria while being non-toxic and biodegradable to environmental bacteria.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Organic
Wan Xu, Jichang Wei, Kun Tang, Zhiying Ma, Jianwu Shi, Chunli Li, Hua Wang
Summary: This study demonstrates the facile and efficient construction of four thiophene/selenophene-based windmill-shaped triple [6]helicenes. By replacing S with Se, the crystal-packing patterns and emission properties of the helicenes can be precisely modulated.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Victorino Vallejos Gonzalez, Justin Kahle, Christopher Huessler, Robin Heckershoff, A. Stephen K. Hashmi, Bernhard Birenheide, Adrian Hauser, Joachim Podlech
Summary: This paper describes the synthesis of three penta- and three hexahelicenes containing two terminal thiophene units. The syntheses of pentahelicenes involved the 1,4-bisalkynylation of a benzene precursor and double Suzuki coupling in the 2,3-position to introduce thiophene units. The ortho,ortho' fusion yielding the final products was achieved with catalysts such as platinum(II) chloride or JohnPhos-complexed gold(I). A similar approach was used for the synthesis of hexahelicenes, starting with a naphthalene derivative and involving 2,7-bisalkynylation and subsequent double Suzuki coupling. The ortho,ortho' fusion to the respective hexahelicenes was achieved using platinum(II) chloride or, preferably, indium(III) chloride. UV/Vis spectra and cyclic voltammograms were recorded, and HOMO/LUMO gaps were calculated using DFT methods for all helicenes.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Engineering, Environmental
Tianxu Zhang, Sujuan Zhao, Fengfeng Dong, Yibo Jia, Xin Chen, Yumeng Sun, Lingyan Zhu
Summary: In this study, it was found that exposure to 6:6 PFPiA led to anxiety-like symptoms in zebrafish, which may be related to gut inflammation caused by gut microbiome imbalance. In addition, PFPiA also damaged the blood-brain barrier, stimulated neuroinflammation, and caused apoptosis and neural injury in the brain. The use of an inhibitor reduced inflammatory responses and anxiety-like behavior, highlighting the key role of the gut-brain axis in the neurotoxicity of PFPiA.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Milena Mlakic, Ilijana Odak, Ivan Faraho, Martina Bosnar, Mihailo Banjanac, Zlata Lasic, Zeljko Marinic, Danijela Baric, Irena Skoric
Summary: This research focuses on the synthesis, photochemistry, and computational study of new cis- and trans-isomers of amino-thienostilbenes. The goal is to evaluate their production efficiency, acid resistance, electronic structure, photoreactivity, photophysical characteristics, and potential biological activity. The results show that the synthesized trans-aminostilbenes have similar absorbance wavelengths compared to organic dyes, while their functionalized cis-isomers and photocyclization products are potential cholinesterase inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geosciences, Multidisciplinary
C. Sens-Schoenfelder, K. Bataille, M. Bianchi
Summary: A new precursor phase called PKPab precursor is observed before the PKPab wave at epicentral distances larger than 155 degrees, resulting from scattering in D''. This precursor is the earliest teleseismic signal at distances larger than 155 degrees, as PKPdf waves are strongly attenuated in the inner core at frequencies between 4 Hz and 8 Hz used here. The sensitivity of the PKPab precursor is mostly related to scattering along the closest PKPbc path between the seismic source and receiver.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Article
Chemistry, Organic
Renzhen Fan, Tian Du, Yiyang Xu, Cheng Wang, Tingting Xu, Yi Han, Chunyan Chi, Yunfeng Deng, Yanhou Geng
Summary: A convergent route was used to synthesize quinoidal compounds with high yields of 85-93%. By subsequent rearrangement/dehydroxylation and oxidation, a series of thiophene-based quinoids with indandione or oxindole terminal groups were successfully synthesized. This strategy allows for the synthesis of quinoidal compounds with tunable properties by using versatile central and terminal units.
Article
Chemistry, Organic
Linting Di, Jie Yang, Weiguo Tang, Lizhi Gai, Zhikuan Zhou, Hua Lu
Summary: The addition of sufficient-electron heterocycle rings to the BODIPY core resulted in red or near infrared emission. The synthesis of nonsymmetric benzo[a]fused and thiophene/thieno[3,2-b]thiophene[b]fused BODIPY derivatives with a reactive site allowed for the development of new compounds through nucleophilic substitution reactions. X-ray crystallographic analysis revealed a planar core structure with pi-pi interactions, and changes in absorption and emission were rationalized through density functional theory calculations.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Walaa Hamada Abd-Allah, Mostafa Abd El-Mohsen Anwar, Eman R. Mohammed, Marawan A. Elbaset, Samir M. El Moghazy
Summary: A new series of derivatives were synthesized and tested for their anticonvulsant activity, neurotoxicity, liver enzymes, and neurochemical assay. The screening showed varying anticonvulsant potential, particularly in chemically induced seizures. Compound 6d and 6e exhibited the highest potency in ScPTZ test. Compound 6e was even more potent than the reference drugs phenobarbital and Ethosuximide. The results suggest that the newly synthesized compounds have potential for further development as anticonvulsants.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Yuanyuan Wu, Zhipeng Sun, Tingting Wang, Yan Wang, Liang Zhong, Fanli Kong
Summary: The anti-inflammatory agent MaR1 has been found to ameliorate cognitive dysfunction, Tau hyperphosphorylation, and synaptic protein reduction induced by repeated exposure to sevoflurane during the postnatal period. The protective effect of MaR1 is mediated through the JAK2/STAT3/IL-6 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Behayilu S. Desalegn, Nika Bekri, Fekadu G. Hone, Dinsefa M. Andoshe, Wendimagegn Mammo, Zelalem Abdissa, Gurthwin Bosman, Newayemedhin A. Tegegne
Summary: Three low band gap copolymers with different alkyl side chains were synthesized and their thermal stability was found to be highly dependent on the lengths of the side chains. The optimization of side chains in P2 led to higher thermal stability compared to P3 and P1. The results highlight the importance of alkyl side chain optimization for the stability of copolymers.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Ammar Khelifa Baghdouche, Mounia Guergouri, Mustapha Bencharif, Leila Bencharif
Summary: Three new monomers containing fluorene and thiophene derivatives moieties were synthesized and electrochemically polymerized. The corresponding polymers were characterized and it was found that PME has lower oxidation potentials and band gap values compared to PMT and PMBT.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Chunmei Zhao, Zhiying Ma, Chunli Li, Li Xu, Hua Wang
Summary: A novel racemate and enantiomer of binaphthylcyclooctaterthiophene (BN-COTh) were synthesized and investigated for their crystal structures, spectroscopic behaviors, chiral resolution, and characteristics. The enantiomer of (R,R, R)-BN-COTh exhibited unique intermolecular interactions in crystal, forming a larger and extended assembly packing along the b-axis.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Ayun Luo, Nicolas Duchemin, Xiuming Wang, Hongxia Zhou, Fanming Zeng, Xue Zhao, Weina Yu, Kexin Yang, Yun Jin Hu
Summary: In this study, we have successfully synthesized thiophene and its derivatives on-DNA via cascade iodination, Cadiot-Chodkiewicz coupling, and heterocyclization using the reactivity of alkynes. This approach, being the first of its kind, leads to the generation of diverse and unprecedented structures and chemical properties, which can serve as significant motifs in drug discovery for molecular recognition agents in DEL screening.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Physical
D. R. Vinayakumara, Sandeep Kumar, Airody Vasudeva Adhikari
JOURNAL OF MOLECULAR LIQUIDS
(2019)
Article
Chemistry, Physical
D. R. Vinayakumara, Sandeep Kumar, S. Krishna Prasad, Airody Vasudeva Adhikari
JOURNAL OF MOLECULAR LIQUIDS
(2019)
Article
Chemistry, Physical
Sachin Poojary, Madhukara Acharya, Abdul Ajees Abdul Salam, Dhananjaya Kekuda, Upendra Nayek, Madan S. Kumar, Airody Vasudeva Adhikari, Dhanya Sunil
JOURNAL OF MOLECULAR LIQUIDS
(2019)
Article
Chemistry, Physical
Rajalakshmi Kesavan, Fathy Attia, Rui Su, P. Anees, Ahmed El-Shafei, Airody Vasudeva Adhikari
JOURNAL OF PHYSICAL CHEMISTRY C
(2019)
Article
Chemistry, Applied
Naveenchandra Pilicode, Praveen Naik, K. M. Nimith, Madhukara Acharya, M. N. Satyanarayan, Airody Vasudeva Adhikari
Article
Energy & Fuels
Kavya S. Keremane, Sateesh Prathapani, Lew Jia Haur, Damodaran Bahulayan, Airody Vasudeva Adhikari, Anish Priyadarshi, Subodh G. Mhaisalkar
Article
Biochemistry & Molecular Biology
Kavya S. Keremane, Rathnamala Rao, Airody Vasudeva Adhikari
Summary: This study presents the molecular design, synthesis, and characterization of two novel D-A-D-A-D structured 9-(2-ethylhexyl)-9H-carbazoles as potential low-cost organic hole-transporting materials. Various investigations, including structural, photophysical, thermal, electrochemical, and theoretical studies, have been conducted to understand their properties and potential applications in high-performance perovskite solar cells.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Engineering, Chemical
Naveenchandra Pilicode, Praveen Naik, Airody Vasudeva Adhikari
POLYMER ENGINEERING AND SCIENCE
(2020)
Article
Polymer Science
Naveenchandra Pilicode, Praveen Naik, K. M. Nimith, Madhukara Acharya, M. N. Satyanarayan, Airody Vasudeva Adhikari
Summary: Four new Schiff-base type conjugative polymers were synthesized and characterized for their potential application in polymer light-emitting diodes. These polymers exhibited good film-forming ability and favorable photophysical behaviors, with stable blue electroluminescence demonstrated in the constructed devices.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Chemistry, Physical
Kavya S. Keremane, Sateesh Prathapani, Lew Jia Haur, Annalisa Bruno, Anish Priyadarshi, Airody Vasudeva Adhikari, Subodh G. Mhaisalkar
Summary: The study presents the fabrication of highly efficient large-area carbon-based perovskite solar cells using CsBr-modified TiO2 as an electron transport material, showing enhanced stability and performance. These devices exhibit high short-circuit current density and stability under different temperature and humidity conditions.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Kavya S. Keremane, Aurelien Planchat, Yann Pellegrin, Denis Jacquemin, Fabrice Odobel, Airody Vasudeva Adhikari
Summary: Finding efficient p-type sensitizers for NiO photocathodes is a challenge for developing low-cost tandem dye-sensitized solar cells. In this study, six new organic dyes were designed and synthesized for sensitizing mesoporous p-type semiconductor NiO in p-type DSSCs. Optical studies showed that these dyes exhibited suitable absorption and emission features, with thermodynamic parameters favoring charge transfer involving NiO. One of the dyes achieved the highest power conversion efficiency in the devices.
Article
Chemistry, Physical
Kavya S. Keremane, Yann Pellegrin, Aurelien Planchat, Denis Jacquemin, Fabrice Odobel, Airody Vasudeva Adhikari
Summary: We report the design, synthesis, and characterization of two new carbazole-based organic dyes PC1-2 as potential sensitizers for p-type dye-sensitized solar cells. PC1 exhibited better performance compared to PC2, with a higher power conversion efficiency of 0.027%.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Applied
K. S. Vishrutha, Hidayath Ulla, M. Raveendra Kiran, Badekai Ramachandra Bhat, Airody Vasudeva Adhikari
Summary: A series of novel D-A-D type conjugated dyes (Py-CyP1-7) with a strongly electron-withdrawing cyano-pyridone scaffold (A) linked to highly electron-donating pyrene unit (D) and varied auxiliary donors (D) were designed and synthesized for green organic light-emitting diodes (OLEDs). The efficiency of these hybrids as green emitters was validated through theoretical, optical, electrochemical, and thermal studies. Finally, the dyes were used as sole and dopant emitters in OLEDs, and the OLED with 3 wt % Py-CyP4 in the CBP host exhibited maximum efficiencies of 14.38 cd A ¡1, 12.04 lm W ¡1, and 5.91%.
Article
Chemistry, Physical
Kavya S. Keremane, Islam M. Abdellah, Praveen Naik, Ahmed El-Shafei, Airody Vasudeva Adhikari
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Article
Chemistry, Multidisciplinary
Naveenchandra Pilicode, Praveen Naik, Madhukara Acharya, Airody Vasudeva Adhikari
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)