Article
Immunology
Rachael M. Wilson, Jean M. Walker, Kingsley Yin
Summary: Probiotics like Lactobacillaceae strains show antimicrobial and immunomodulatory activity. CFF derived from different concentrations of live Lactobacillus acidophilus inhibit biofilm formation and possess varying effects on immune cells, with high concentration CFF inducing NF-kappa B expression and TNF alpha production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Yue Wu, Yunjiao Yang, Lan Wang, Yiding Chen, Xuke Han, Lisha Sun, Huizhen Chen, Qiu Chen
Summary: Osteoporosis is a bone disease characterized by low bone quality and density, causing bone fragility and vulnerability to fractures. Increased osteoclast differentiation and activity contribute to bone loss, a common manifestation of osteoporosis. The TNF-a/NF-κB inflammatory pathway plays a key role in regulating osteoclast formation, along with the classical RANKL/RANK/OPG pathway. Probiotics, particularly Bifidobacterium, have shown potential beneficial effects on bone health by modulating this pathway. This review discusses the molecular mechanisms of the TNF-a/NF-κB pathway in osteoclast formation and explores the secretions produced by Bifidobacterium, providing new directions for future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Garcia-Fernandez, Colette Reinhold, Nurcan Ueceyler, Claudia Sommer
Summary: Polyneuropathy (PNP) refers to diseases of the peripheral nervous system, with 50% of cases presenting with neuropathic pain. Certain types of PNP show pain restricted to the distal leg skin, indicating a local regulatory process leading to pain. This study suggests that a pro-inflammatory pathway mediated by NF-κB may contribute to pain development in patients with painful PNP. Our findings support the hypothesis of local inflammatory processes involved in pain in PNP, and suggest disrupted anti-inflammatory pathways in inflammatory PNP involving TRPV1 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Huanhuan Xu, Chunxia Gan, Zemin Xiang, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu, Jun Sheng, Xuanjun Wang
Summary: The tumor necrosis factor alpha (TNF-a)-TNF-a receptor (TNFR) interaction is crucial in the development of autoimmune diseases like rheumatoid arthritis, making it an important target for drug discovery. This study found that (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, can bind to TNF-a, TNFR1, and TNFR2 and disrupt their interactions. This leads to inhibition of TNF-a-induced cell death and NF-kB signaling pathway, suggesting that regular consumption of EGCG in green tea could potentially be used as a therapeutic agent for TNF-a-associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
So-Jung Jin, Youngju Song, Hong Shik Park, Kye Won Park, SeungGwan Lee, Hee Kang
Summary: This study reveals that harmine can effectively modulate the inflammatory response in macrophages by regulating the activity of NF-kappa B, JNK, and STAT1. It shows potential therapeutic significance in the treatment of infectious inflammation.
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, the post-translational modification of Tollip by ubiquitination was identified. Tollip interacts with RNF167 and RNF167 functions as the E3 ligase to attach poly-ubiquitin chains to Tollip. The ubiquitination of Tollip plays a crucial role in TNF-alpha signaling.
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, ubiquitination was identified as a post-translational modification on Tollip, and RNF167 was found to be the potential E3 ligase for Tollip. Tollip's ubiquitination plays a crucial role in TNF-a signaling.
Article
Pharmacology & Pharmacy
Weiwei Yuan, Jinxi Huang, Shanshan Hou, Huahua Li, Liangyu Bie, Beibei Chen, Gaofeng Li, Yang Zhou, Xiaobing Chen
Summary: The study found that pretreatment of gastric cancer cells with triptolide can enhance its anti-tumor effect. This effect is dependent on the disruption of the H19/miR-204-5p/NF-kappa B/FLIP axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao, Jin-xia Zhao
Summary: Iguratimod has been shown to inhibit osteoclast formation and bone resorption by interfering with signaling pathways, preventing bone loss in animal models. It also dampened TNF-alpha-induced osteoclastogenesis and disrupted nuclear translocation, providing promising evidence for its therapeutic application against RA and bone loss prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sho Inoue, Yuki Inahashi, Makoto Itakura, Gen Inoue, Kyoko Muneshige, Tomoyasu Hirose, Masato Iwatsuki, Masashi Takaso, Masayuki Miyagi, Kentaro Uchida
Summary: This study found that Medermycin (MED) can reduce inflammatory reactions in synovial cells and inhibit the expression of proinflammatory cytokines. Further experiments demonstrated that MED can also inhibit the activation of NF?B and Akt, thereby modulating the inflammatory response. These results highlight the potential therapeutic value of MED in managing inflammatory conditions in osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
James M. Murphy, Kyuho Jeong, Donna L. Cioffi, Pamela Moore Campbell, Hanjoong Jo, Eun-Young Erin Ahn, Ssang-Taek Steve Lim
Summary: The study reveals that focal adhesion kinase (FAK) plays a crucial role in regulating sustained NF-kappa B activation in endothelial cells (ECs) stimulated by tumor necrosis factor-alpha (TNF-alpha). Inhibition of FAK disrupts the formation of TNF-alpha receptor complex-I (TNFRC-I) and diminishes recruitment of downstream proteins, leading to reduced NF-kappa B activity. Targeting FAK may hold promise for treating chronic inflammatory diseases.
Article
Pharmacology & Pharmacy
Nghia Trong Vo, Saki Sasaki, Yasunobu Miyake, Nhan Trung Nguyen, Phu Hoang Dang, Mai Thanh Thi Nguyen, Takao Kataoka
Summary: Alpha-conidendrin inhibits the expression of ICAM-1 in lung adenocarcinoma cells and interferes with the NF-κB signaling pathway induced by TNF-α.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
George Notas, Athanasios Panagiotopoulos, Rodanthi Vamvoukaki, Konstantina Kalyvianaki, Foteini Kiagiadaki, Alexandra Deli, Marilena Kampa, Elias Castanas
Summary: ER alpha 36 collaborates with GPER1 to inhibit NF kappa B-mediated inflammation and ER alpha 66 actions in breast cancer cells. Particularly, this effect is more significant in the absence of ER alpha 66. Moreover, overexpression of ER alpha 36 enhances the inhibitory effect of estrogen on inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Milton Roy, Rajesh Singh
Summary: TRIMs, as RING domain-containing E3 ligases, are involved in regulating the NF-kappa B pathway and may lead to unique outcomes in different pathophysiological conditions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiuying Zhang, Qilei Chen, Jia Zhao, Wei Zhao, Ni Fan, Yu Wang, Hubiao Chen, Jianhui Rong
Summary: This study aimed to investigate the cardioprotective activity of the herbal medicine formula Baoyuan Decoction (BYD), identify the active compounds and molecular targets. The results showed that BYD effectively reduced infarct size and preserved cardiac functions. Network pharmacology analysis revealed that BYD might control cardiac inflammation through targeting the TNF-alpha/NF-kappa B pathway and other related pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Ophthalmology
Dimitra Makrynioti, Zoi Zagoriti, Constantinos Koutsojannis, Philip B. Morgan, George Lagoumintzis
CONTACT LENS & ANTERIOR EYE
(2020)
Article
Biochemistry & Molecular Biology
Dimitris G. Mintis, Anastasia Chasapi, Konstantinos Poulas, George Lagoumintzis, Christos T. Chasapis
Article
Food Science & Technology
George Lagoumintzis, Christos T. Chasapis, Nikolaos Alexandris, Dimitrios Kouretas, Socrates Tzartos, Elias Eliopoulos, Konstantinos Farsalinos, Konstantinos Poulas
Summary: Smokers have lower likelihood of being diagnosed with or hospitalized for COVID-19, but face higher odds for adverse outcomes once hospitalized. The interaction between SARS-CoV-2 Spike glycoprotein and human alpha 7 nAChR involves toxin-like sequences and binding sites, which may have implications for potential therapeutic strategies.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Genetics & Heredity
Apostolia Topaloudi, Zoi Zagoriti, Alyssa Camille Flint, Melanie Belle Martinez, Zhiyu Yang, Fotis Tsetsos, Yiolanda-Panayiota Christou, George Lagoumintzis, Evangelia Yannaki, Eleni Zamba-Papanicolaou, John Tzartos, Xanthippi Tsekmekidou, Kalliopi Kotsa, Efstratios Maltezos, Nikolaos Papanas, Dimitrios Papazoglou, Ploumis Passadakis, Athanasios Roumeliotis, Stefanos Roumeliotis, Marios Theodoridis, Elias Thodis, Stylianos Panagoutsos, John Yovos, John Stamatoyannopoulos, Konstantinos Poulas, Kleopas Kleopa, Socrates Tzartos, Marianthi Georgitsi, Peristera Paschou
Summary: A genome-wide association study was conducted on the largest MG dataset to date, confirming the association of TNFRSF11A with MG and identifying AGRN as a novel susceptibility gene. The study revealed genetic correlations between MG and T1D, RA, ATD, and late-onset vitiligo, as well as multiple risk loci that appear pleiotropic across MG and related disorders. The findings suggest shared underlying genetic mechanisms among these autoimmune disorders.
JOURNAL OF MEDICAL GENETICS
(2022)
Editorial Material
Microbiology
Dionysios V. Chartoumpekis, Apostolos Zaravinos, Yiorgos Apidianakis, George Lagoumintzis
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Panagiota Xaplanteri, Dimitrios S. Serpanos, Ellie Dorva, Tatiana Beqo-Rokaj, Eleni Papadogeorgaki, Alexandra Lekkou
Summary: This study presents a case of Bacillus simplex infection, in which the microorganism entered the patient's body through a farm work-related penetrating trauma. The patient fully recovered after treatment. The authors concluded that B. simplex was the most probable culprit of the infection. This is the second probable case of B. simplex infection described worldwide, and the first in Greece.
Article
Biochemistry & Molecular Biology
George I. Habeos, Fotini Filippopoulou, Evagelia E. Habeos, Electra Kalaitzopoulou, Marianna Skipitari, Polyxeni Papadea, George Lagoumintzis, Athanasios Niarchos, Christos D. Georgiou, Dionysios V. Chartoumpekis
Summary: This study found that calorie restriction during pregnancy can induce the expression of antioxidant genes in the fetal liver, and this induction is at least partially dependent on the Nrf2 signaling pathway. This finding highlights the importance of further investigating the physiological significance of this phenomenon.
Article
Microbiology
Panagiota Xaplanteri, Nikiforos Rodis, Charalampos Potsios
Summary: The innate immune response relies on the action of macrophages, which are abundant in the subepithelial lamina propria of the intestine mucosa and play a critical role. The balance between gut microbiota and M2 macrophages is crucial for gut health and homeostasis, with the microbiota being able to change macrophage phenotype. In the case of invasive enteric parasitic infections like amebic colitis and giardiasis, the phenotype of macrophages changes to a pro-inflammatory state through direct contact with the parasites.
Review
Environmental Sciences
Charikleia Papaioannou, George Geladakis, Vasiliki Kommata, Costas Batargias, George Lagoumintzis
Summary: Environmental pollution is a significant global problem, and pharmaceutical pollution is an emerging threat. Pharmaceuticals enter aquatic environments through various pathways, leading to their accumulation and potential harm to ecosystems. Modern biomonitoring methods, such as environmental DNA metabarcoding, are valuable for assessing and monitoring the ecotoxicological effects of pharmaceutical pollution.
Article
Health Care Sciences & Services
Pavlos Angelopoulos, Anastasios Diakoronas, Dimitrios Panagiotopoulos, Maria Tsekoura, Panagiota Xaplanteri, Dimitra Koumoundourou, Farzaneh Saki, Evdokia Billis, Elias Tsepis, Konstantinos Fousekis
Summary: This study investigated the effects of cold-water immersion (CWI) and sports massage on delayed-onset muscle soreness (DOMS) in amateur athletes. The results showed that CWI improves pain sensation, and the combination of sports massage and CWI also leads to a significant reduction in pain. However, these interventions do not affect other important adaptations of DOMS.
Article
Toxicology
Nikolaos Alexandris, George Lagoumintzis, Christos T. Chasapis, Demetres D. Leonidas, Georgios E. Papadopoulos, Socrates J. Tzartos, Aristidis Tsatsakis, Elias Eliopoulos, Konstantinos Poulas, Konstantinos Farsalinos
Summary: The study suggests a potential link between low smoking rates and COVID-19, indicating the crucial role of the Nicotinic Cholinergic System. By preventing the binding of the SARS-CoV-2 Spike glycoprotein to nAChRs, it may alleviate severe symptoms in COVID-19 patients.
TOXICOLOGY REPORTS
(2021)
Review
Surgery
Konstantinos S. Papadopoulos, Konstantinos Strigklis, Kleoniki Kordeni, Panagiota Xaplanteri, Georgios Zacharis
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2020)
Article
Surgery
Panagiota Xaplanteri, Nada Zacharis, Charalampos Potsios, Georgios Zacharis
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2020)
Review
Infectious Diseases
Achilleas Nikolakopoulos, Nikolaos Koutsogiannis, Panagiota Xaplanteri, Charalambos Gogos, Fevronia Kolonitsiou, Alexandra Lekkou
CASE REPORTS IN INFECTIOUS DISEASES
(2019)
Article
Environmental Sciences
Spyros Lampos, Evangelia Kostenidou, Konstantinos Farsalinos, Zoi Zagoriti, Aristeidis Ntoukas, Konstantinos Dalamarinis, Panagiotis Savranakis, George Lagoumintzis, Konstantinos Poulas