Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways
出版年份 2020 全文链接
标题
Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways
作者
关键词
Iguratimod, Rheumatoid arthritis, Osteoclastogenesis, NF-κB, TNF-α
出版物
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 90, Issue -, Pages 107219
出版商
Elsevier BV
发表日期
2020-12-09
DOI
10.1016/j.intimp.2020.107219
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Constant hypoxia inhibits osteoclast differentiation and bone resorption by regulating phosphorylation of JNK and IκBα
- (2019) Zhenzhen Ma et al. INFLAMMATION RESEARCH
- The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice
- (2019) Xiangde Zhao et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Clinical deep remission and related factors in a large cohort of patients with rheumatoid arthritis
- (2019) Jia-Jia Liu et al. CHINESE MEDICAL JOURNAL
- Ovariectomy increases RANKL protein expression in bone marrow adipocytes of C3H/HeJ mice.
- (2019) Kerensa M. Beekman et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- TNF-alpha: promotes or restrains osteoclastogenesis and inflammatory bone resorption?
- (2018) Baohong Zhao CRITICAL REVIEWS IN IMMUNOLOGY
- Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways
- (2018) Chang-hong Li et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Safety and effectiveness of iguratimod in patients with rheumatoid arthritis: Final report of a 52-week, multicenter postmarketing surveillance study
- (2018) Tsuneyo Mimori et al. Modern Rheumatology
- Iguratimod, a synthetic disease modifying anti-rheumatic drug inhibiting the activation of NF-κB and production of RANKL: its efficacy, radiographic changes, safety and predictors over two years’ treatment for Japanese rheumatoid arthritis patients
- (2018) Koichiro Ishikawa et al. Modern Rheumatology
- The three-year efficacy of iguratimod in clinical daily practice in patients with rheumatoid arthritis
- (2018) Takahito Suto et al. Modern Rheumatology
- RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors
- (2017) Zhenqiang Yao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pathogenetic insights from the treatment of rheumatoid arthritis
- (2017) Iain B McInnes et al. LANCET
- Iguratimod prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator-activated receptor-γ
- (2017) Ying-Xing Wu et al. Molecular Medicine Reports
- Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases
- (2017) Michael Croft et al. Nature Reviews Rheumatology
- Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
- (2017) Carmen Streicher et al. Scientific Reports
- The usage of biological DMARDs and clinical remission of rheumatoid arthritis in China: a real-world large scale study
- (2016) Yuan An et al. CLINICAL RHEUMATOLOGY
- Iguratimod (T-614) suppresses RANKL-induced osteoclast differentiation and migration in RAW264.7 cells via NF-κB and MAPK pathways
- (2016) Ke Gan et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Subclinical Synovitis Assessed by Ultrasound Predicts Flare and Progressive Bone Erosion in Rheumatoid Arthritis Patients with Clinical Remission: A Systematic Review and Metaanalysis
- (2016) J. Han et al. JOURNAL OF RHEUMATOLOGY
- Biologic therapies and bone loss in rheumatoid arthritis
- (2016) C. A. F. Zerbini et al. OSTEOPOROSIS INTERNATIONAL
- Interleukin 26 suppresses receptor activator of nuclear factor κB ligand induced osteoclastogenesis via down-regulation of nuclear factor of activated T-cells, cytoplasmic 1 and nuclear factor κB activity
- (2016) Yi-Jen Peng et al. RHEUMATOLOGY
- RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis
- (2016) William O'Brien et al. Arthritis & Rheumatology
- Iguratimod for the treatment of rheumatoid arthritis in Japan
- (2015) Keiichi Tanaka et al. Expert Review of Clinical Immunology
- 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
- (2015) Jasvinder A. Singh et al. ARTHRITIS CARE & RESEARCH
- Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone ResorptionIn VitroandIn Vivo
- (2013) Hideki Kitaura et al. Clinical & Developmental Immunology
- Burden of disease in treated rheumatoid arthritis patients: Going beyond the joint
- (2013) Maurizio Cutolo et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-activated protein kinase/activator protein 1 and Ca2+-nuclear fact
- (2012) Xian Wu et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment
- (2012) Georg Schett et al. Nature Reviews Rheumatology
- Acceleration of onset of collagen-induced arthritis by intra-articular injection of tumour necrosis factor or transforming growth factor-beta
- (2010) W. O. COOPER et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- CXC Chemokine Ligand 2 Induced by Receptor Activator of NF- B Ligand Enhances Osteoclastogenesis
- (2010) J. Ha et al. JOURNAL OF IMMUNOLOGY
- Multicenter, randomized, double-blind, controlled trial of treatment of active rheumatoid arthritis with T-614 compared with methotrexate
- (2009) Liang-jing Lu et al. ARTHRITIS AND RHEUMATISM
- PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival
- (2008) Elizabeth W. Bradley et al. JOURNAL OF CELLULAR PHYSIOLOGY
- T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis
- (2008) Fang Du et al. ARTHRITIS RESEARCH & THERAPY
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